Details for: PTPRN
Associated with
Other Information
Genular Protein ID: 2363496477
Symbol: PTPRN_HUMAN
Name: Receptor-type tyrosine-protein phosphatase-like N
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8024693
Title: Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma.
PubMed ID: 8024693
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8144912
Title: Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases.
PubMed ID: 8144912
PubMed ID: 8641276
Title: ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules.
PubMed ID: 8641276
PubMed ID: 10457160
Title: Post-translational modifications of ICA512, a receptor tyrosine phosphatase-like protein of secretory granules.
PubMed ID: 10457160
PubMed ID: 11483505
Title: Dephosphorylation of beta2-syntrophin and Ca2+/mu-calpain-mediated cleavage of ICA512 upon stimulation of insulin secretion.
PubMed ID: 11483505
PubMed ID: 15596545
Title: Nuclear translocation of an ICA512 cytosolic fragment couples granule exocytosis and insulin expression in {beta}-cells.
PubMed ID: 15596545
PubMed ID: 16273344
PubMed ID: 16622421
Title: Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5.
PubMed ID: 16622421
DOI: 10.1038/ncb1395
PubMed ID: 18824546
Title: Regulation of insulin granule turnover in pancreatic beta-cells by cleaved ICA512.
PubMed ID: 18824546
PubMed ID: 18178618
Title: ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs.
PubMed ID: 18178618
PubMed ID: 20886068
Title: beta2-Syntrophin is a Cdk5 substrate that restrains the motility of insulin secretory granules.
PubMed ID: 20886068
PubMed ID: 22171320
Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.
PubMed ID: 22171320
PubMed ID: 24843546
Title: Sorting nexin 19 regulates the number of dense core vesicles in pancreatic beta-cells.
PubMed ID: 24843546
PubMed ID: 23234360
Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.
PubMed ID: 23234360
DOI: 10.1021/pr300963h
PubMed ID: 25561468
Title: Stability of proICA512/IA-2 and its targeting to insulin secretory granules require beta4-sheet-mediated dimerization of its ectodomain in the endoplasmic reticulum.
PubMed ID: 25561468
DOI: 10.1128/mcb.00994-14
PubMed ID: 26836020
Title: Biochemical, biophysical, and functional properties of ICA512/IA-2 RESP18 homology domain.
PubMed ID: 26836020
PubMed ID: 18058037
Title: Structural genomics of protein phosphatases.
PubMed ID: 18058037
PubMed ID: 18048354
Title: Structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2.
PubMed ID: 18048354
Sequence Information:
- Length: 979
- Mass: 105848
- Checksum: A852B9063D29399D
- Sequence:
MRRPRRPGGL GGSGGLRLLL CLLLLSSRPG GCSAVSAHGC LFDRRLCSHL EVCIQDGLFG QCQVGVGQAR PLLQVTSPVL QRLQGVLRQL MSQGLSWHDD LTQYVISQEM ERIPRLRPPE PRPRDRSGLA PKRPGPAGEL LLQDIPTGSA PAAQHRLPQP PVGKGGAGAS SSLSPLQAEL LPPLLEHLLL PPQPPHPSLS YEPALLQPYL FHQFGSRDGS RVSEGSPGMV SVGPLPKAEA PALFSRTASK GIFGDHPGHS YGDLPGPSPA QLFQDSGLLY LAQELPAPSR ARVPRLPEQG SSSRAEDSPE GYEKEGLGDR GEKPASPAVQ PDAALQRLAA VLAGYGVELR QLTPEQLSTL LTLLQLLPKG AGRNPGGVVN VGADIKKTME GPVEGRDTAE LPARTSPMPG HPTASPTSSE VQQVPSPVSS EPPKAARPPV TPVLLEKKSP LGQSQPTVAG QPSARPAAEE YGYIVTDQKP LSLAAGVKLL EILAEHVHMS SGSFINISVV GPALTFRIRH NEQNLSLADV TQQAGLVKSE LEAQTGLQIL QTGVGQREEA AAVLPQTAHS TSPMRSVLLT LVALAGVAGL LVALAVALCV RQHARQQDKE RLAALGPEGA HGDTTFEYQD LCRQHMATKS LFNRAEGPPE PSRVSSVSSQ FSDAAQASPS SHSSTPSWCE EPAQANMDIS TGHMILAYME DHLRNRDRLA KEWQALCAYQ AEPNTCATAQ GEGNIKKNRH PDFLPYDHAR IKLKVESSPS RSDYINASPI IEHDPRMPAY IATQGPLSHT IADFWQMVWE SGCTVIVMLT PLVEDGVKQC DRYWPDEGAS LYHVYEVNLV SEHIWCEDFL VRSFYLKNVQ TQETRTLTQF HFLSWPAEGT PASTRPLLDF RRKVNKCYRG RSCPIIVHCS DGAGRTGTYI LIDMVLNRMA KGVKEIDIAA TLEHVRDQRP GLVRSKDQFE FALTAVAEEV NAILKALPQ
Genular Protein ID: 3650930395
Symbol: Q96IA0_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 811
- Mass: 87841
- Checksum: 1CC9B2B4F9D2F5B3
- Sequence:
ASSSLSPLQA ELLPPLLEHL LLPPQPPHPS LSYEPALLQP YLFHQFGSRD GSRVSEGSPG MVSVGPLPKA EAPALFSRTA SKGIFGDHPG HSYGDLPGPS PAQLFQDSGL LYLAQELPAP SRARVPRLPE QGSSSRAEDS PEGYEKEGLG DRGEKPASPA VQPDAALQRL AAVLAGYGVE LRQLTPEQLS TLLTLLQLLP KGAGRNPGGV VNVGADIKKT MEGPVEGRDT AELPARTSPM PGHPTASPTS SEVQQVPSPV SSEPPKAARP PVTPVLLEKK SPLGQSQPTV AGQPSARPAA EEYGYIVTDQ KPLSLAAGVK LLEILAEHVH MSSGSFINIS VVGPALTFRI RHNEQNLSLA DVTQQAGLVK SELEAQTGLQ ILQTGVGQRE EAAAVLPQTA HSTSPMRSVL LTLVALAGVA GLLVALAVAL CVRQHARQQD KERLAALGPE GAHGDTTFEY QDLCRQHMAT KSLFNRAEGP PEPSRVSSVS SQFSDAAQAS PSSHSSTPSW CEEPAQANMD ISTGHMILAY MEDHLRNRDR LAKEWQALCA YQAEPNTCAT AQGEGNIKKN RHPDFLPYDH ARIKLKVESS PSRSDYINAS PIIEHDPRMP AYIATQGPLS HTIADFWQMV WESGCTVIVM LTPLVEDGVK QCDRYWPDEG ASLYHVYEVN LVSEHIWCED FLVRSFYLKN VQTQETRTLT QFHFLSWPAE GTPASTRPLL DFRRKVNKCY RGRSCPIIVH CSDGAGRTGT YILIDMVLNR MAKGVKEIDI AATLEHVRDQ RPGLVRSKDQ FEFALTAVAE EVNAILKALP Q
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.