Details for: BARD1

Gene ID: 580

Symbol: BARD1

Ensembl ID: ENSG00000138376

Description: BRCA1 associated RING domain 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 101.0639
    Cell Significance Index: -15.7200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 67.7329
    Cell Significance Index: -17.1800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 40.7309
    Cell Significance Index: -19.2300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 40.5654
    Cell Significance Index: -16.4800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.2821
    Cell Significance Index: -16.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.6453
    Cell Significance Index: -19.2900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.6521
    Cell Significance Index: -17.8200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.0025
    Cell Significance Index: -19.7400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.9683
    Cell Significance Index: -15.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.8036
    Cell Significance Index: 101.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6608
    Cell Significance Index: 22.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.5690
    Cell Significance Index: 298.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.2291
    Cell Significance Index: 34.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.1874
    Cell Significance Index: 138.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9938
    Cell Significance Index: 21.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9671
    Cell Significance Index: 27.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8990
    Cell Significance Index: 24.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8966
    Cell Significance Index: 177.9300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8650
    Cell Significance Index: 94.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8557
    Cell Significance Index: 139.1700
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.8218
    Cell Significance Index: 6.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8197
    Cell Significance Index: 740.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7752
    Cell Significance Index: 46.5400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.6442
    Cell Significance Index: 16.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6428
    Cell Significance Index: 33.3900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6202
    Cell Significance Index: 73.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5122
    Cell Significance Index: 50.6700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4915
    Cell Significance Index: 17.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4459
    Cell Significance Index: 28.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3196
    Cell Significance Index: 22.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2550
    Cell Significance Index: 112.7300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.2497
    Cell Significance Index: 6.3800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.2359
    Cell Significance Index: 5.7600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.2306
    Cell Significance Index: 3.7200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2045
    Cell Significance Index: 4.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1861
    Cell Significance Index: 6.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1840
    Cell Significance Index: 4.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1796
    Cell Significance Index: 24.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1760
    Cell Significance Index: 21.6400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1602
    Cell Significance Index: 2.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1600
    Cell Significance Index: 12.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1576
    Cell Significance Index: 86.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1386
    Cell Significance Index: 3.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1383
    Cell Significance Index: 6.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1376
    Cell Significance Index: 24.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1095
    Cell Significance Index: 21.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0995
    Cell Significance Index: 12.7600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0854
    Cell Significance Index: 4.4500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0765
    Cell Significance Index: 2.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0694
    Cell Significance Index: 31.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0397
    Cell Significance Index: 74.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0362
    Cell Significance Index: 66.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0259
    Cell Significance Index: 3.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0220
    Cell Significance Index: 33.8100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0191
    Cell Significance Index: 1.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0117
    Cell Significance Index: 0.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0096
    Cell Significance Index: 6.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0089
    Cell Significance Index: 3.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0062
    Cell Significance Index: 8.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0014
    Cell Significance Index: -0.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0060
    Cell Significance Index: -0.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0068
    Cell Significance Index: -0.1800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0085
    Cell Significance Index: -5.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0138
    Cell Significance Index: -10.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0166
    Cell Significance Index: -12.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0203
    Cell Significance Index: -2.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0262
    Cell Significance Index: -19.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0271
    Cell Significance Index: -7.8100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0296
    Cell Significance Index: -0.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0317
    Cell Significance Index: -5.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0346
    Cell Significance Index: -21.6000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0349
    Cell Significance Index: -0.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0353
    Cell Significance Index: -19.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0494
    Cell Significance Index: -5.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0588
    Cell Significance Index: -6.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0736
    Cell Significance Index: -3.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1020
    Cell Significance Index: -21.4800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1031
    Cell Significance Index: -10.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1305
    Cell Significance Index: -4.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1499
    Cell Significance Index: -11.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1653
    Cell Significance Index: -4.4300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1978
    Cell Significance Index: -2.1500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2149
    Cell Significance Index: -17.0200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2382
    Cell Significance Index: -12.0400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2396
    Cell Significance Index: -2.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2566
    Cell Significance Index: -15.7300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2677
    Cell Significance Index: -3.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2724
    Cell Significance Index: -14.3000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2778
    Cell Significance Index: -8.1600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2856
    Cell Significance Index: -6.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2867
    Cell Significance Index: -19.2800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2879
    Cell Significance Index: -4.2500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2893
    Cell Significance Index: -4.3600
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.2981
    Cell Significance Index: -1.4500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2984
    Cell Significance Index: -9.7700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3047
    Cell Significance Index: -7.0400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3458
    Cell Significance Index: -7.3400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3530
    Cell Significance Index: -5.2900
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.3679
    Cell Significance Index: -2.3100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3761
    Cell Significance Index: -7.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The BARD1 gene is a member of the RING domain family of proteins, which are known for their E3 ubiquitin ligase activity. It is composed of three RING domains, which are essential for its function in the DNA damage response. BARD1 is highly expressed in cells with high proliferative capacities, such as germ cells, and is also found in various tissues, including the breast, ovary, and brain. The protein is characterized by its ability to interact with BRCA1, a tumor suppressor protein, and other components of the DNA damage response network. **Pathways and Functions:** BARD1 is involved in several key pathways that regulate DNA damage response, including: 1. **Homologous Recombination Repair (HRR):** BARD1 interacts with BRCA1 and other components of the HRR pathway to facilitate the repair of DNA double-strand breaks through homologous recombination. 2. **Non-Homologous End-Joining (NHEJ):** BARD1 is also involved in the NHEJ pathway, which is an alternative mechanism for repairing DNA double-strand breaks. 3. **Cell Cycle Checkpoints:** BARD1 regulates cell cycle checkpoints, such as the G2/M checkpoint, to prevent the propagation of damaged cells. 4. **Apoptosis Regulation:** BARD1 modulates apoptosis, or programmed cell death, in response to DNA damage. **Clinical Significance:** Mutations in the BARD1 gene have been associated with an increased risk of breast and ovarian cancers, particularly in individuals with BRCA1 mutations. BARD1 is also involved in the development of other cancers, including prostate, lung, and colon cancer. The protein's role in maintaining genomic stability makes it a potential target for cancer therapy. In addition to its role in cancer, BARD1 has been implicated in various other diseases, including: 1. **Neurodegenerative Disorders:** BARD1 has been linked to neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Autoimmune Diseases:** BARD1 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Metabolic Disorders:** BARD1 has been linked to metabolic disorders, such as diabetes and obesity. **Conclusion:** The BARD1 gene is a critical component of the DNA damage response network, playing a key role in maintaining genomic stability and preventing cancer. Its involvement in various diseases highlights the importance of understanding its function and regulation. Further research is needed to elucidate the mechanisms by which BARD1 regulates DNA damage response and to explore its potential as a therapeutic target for cancer and other diseases.

Genular Protein ID: 775548544

Symbol: BARD1_HUMAN

Name: BRCA1-associated RING domain protein 1

UniProtKB Accession Codes:

Q99728 F6MDH7 F6MDH8 F6MDH9 O43574 Q53SS5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 15 EMDB 7 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 36 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 20 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8944023

Title: Identification of a RING protein that can interact in vivo with the BRCA1 gene product.

PubMed ID: 8944023

DOI: 10.1038/ng1296-430

PubMed ID: 9425226

Title: Mutations in the BRCA1-associated RING domain (BARD1) gene in primary breast, ovarian and uterine cancers.

PubMed ID: 9425226

DOI: 10.1093/hmg/7.2.195

PubMed ID: 18089818

Title: Oncogenic BARD1 isoforms expressed in gynecological cancers.

PubMed ID: 18089818

DOI: 10.1158/0008-5472.can-07-2370

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10026184

Title: Mapping the functional domains of BRCA1. Interaction of the ring finger domains of BRCA1 and BARD1.

PubMed ID: 10026184

DOI: 10.1074/jbc.274.9.5659

PubMed ID: 10477523

Title: Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50.

PubMed ID: 10477523

DOI: 10.1126/science.285.5433.1576

PubMed ID: 12890688

Title: The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin.

PubMed ID: 12890688

DOI: 10.1074/jbc.c300249200

PubMed ID: 14976165

Title: BRCA1:BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair.

PubMed ID: 14976165

DOI: 10.1093/hmg/ddh095

PubMed ID: 17643122

Title: CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response.

PubMed ID: 17643122

DOI: 10.1038/nsmb1277

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19261749

Title: NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control.

PubMed ID: 19261749

DOI: 10.1101/gad.1770309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20351172

Title: The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function.

PubMed ID: 20351172

DOI: 10.1128/mcb.01056-09

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 11573085

Title: Structure of a BRCA1-BARD1 heterodimeric RING-RING complex.

PubMed ID: 11573085

DOI: 10.1038/nsb1001-833

PubMed ID: 17550235

Title: Crystal structure of the BARD1 BRCT domains.

PubMed ID: 17550235

DOI: 10.1021/bi700323t

PubMed ID: 18842000

Title: The BARD1 C-terminal domain structure and interactions with polyadenylation factor CstF-50.

PubMed ID: 18842000

DOI: 10.1021/bi801115g

PubMed ID: 18480049

Title: Crystal structure of the BARD1 ankyrin repeat domain and its functional consequences.

PubMed ID: 18480049

DOI: 10.1074/jbc.m802333200

Sequence Information:

  • Length: 777
  • Mass: 86648
  • Checksum: 95E2D904046B5646
  • Sequence:
    • MPDNRQPRNR QPRIRSGNEP RSAPAMEPDG RGAWAHSRAA LDRLEKLLRC SRCTNILREP 
VCLGGCEHIF CSNCVSDCIG TGCPVCYTPA WIQDLKINRQ LDSMIQLCSK LRNLLHDNEL 
SDLKEDKPRK SLFNDAGNKK NSIKMWFSPR SKKVRYVVSK ASVQTQPAIK KDASAQQDSY 
EFVSPSPPAD VSERAKKASA RSGKKQKKKT LAEINQKWNL EAEKEDGEFD SKEESKQKLV 
SFCSQPSVIS SPQINGEIDL LASGSLTESE CFGSLTEVSL PLAEQIESPD TKSRNEVVTP 
EKVCKNYLTS KKSLPLENNG KRGHHNRLSS PISKRCRTSI LSTSGDFVKQ TVPSENIPLP 
ECSSPPSCKR KVGGTSGRKN SNMSDEFISL SPGTPPSTLS SSSYRRVMSS PSAMKLLPNM 
AVKRNHRGET LLHIASIKGD IPSVEYLLQN GSDPNVKDHA GWTPLHEACN HGHLKVVELL 
LQHKALVNTT GYQNDSPLHD AAKNGHVDIV KLLLSYGASR NAVNIFGLRP VDYTDDESMK 
SLLLLPEKNE SSSASHCSVM NTGQRRDGPL VLIGSGLSSE QQKMLSELAV ILKAKKYTEF 
DSTVTHVVVP GDAVQSTLKC MLGILNGCWI LKFEWVKACL RRKVCEQEEK YEIPEGPRRS 
RLNREQLLPK LFDGCYFYLW GTFKHHPKDN LIKLVTAGGG QILSRKPKPD SDVTQTINTV 
AYHARPDSDQ RFCTQYIIYE DLCNYHPERV RQGKVWKAPS SWFIDCVMSF ELLPLDS

Genular Protein ID: 2632898752

Symbol: A0A087WZ19_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WZ19

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 2 GeneTree 1 HGNC 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 264
  • Mass: 30365
  • Checksum: DBCFE6853FCDC056
  • Sequence:
    • MPDNRQPRNR QPRIRSGNEP RSAPAMEPDG RGAWAHSRAA LDRLEKLLRC SRCTNILREP 
VCLGGCEHIF CSNCVSDCIG TGCPVCYTPA WIQDLKINRQ LDSMIQLCSK LRNLLHDNEL 
SGVKACLRRK VCEQEEKYEI PEGPRRSRLN REQLLPKLFD GCYFYLWGTF KHHPKDNLIK 
LVTAGGGQIL SRKPKPDSDV TQTINTVAYH ARPDSDQRFC TQYIIYEDLC NYHPERVRQG 
KVWKAPSSWF IDCVMSFELL PLDS

Genular Protein ID: 592413994

Symbol: F6MDI1_HUMAN

Name: N/A

UniProtKB Accession Codes:

F6MDI1

Database IDs:

ARBA 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 18089818

Title: Oncogenic BARD1 isoforms expressed in gynecological cancers.

PubMed ID: 18089818

DOI: 10.1158/0008-5472.CAN-07-2370

PubMed ID: 17556008

Title: Identification of BARD1 splice-isoforms involved in human trophoblast invasion.

PubMed ID: 17556008

DOI: 10.1016/j.biocel.2007.04.018

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 307
  • Mass: 35058
  • Checksum: 2FC7AF807CD518E3
  • Sequence:
    • MPDNRQPRNR QPRIRSGNEP RSAPAMEPDG RGAWAHSRAA LDRLEKLLRC SRCNIFGLRP 
VDYTDDESMK SLLLLPEKNE SSSASHCSVM NTGQRRDGPL VLIGSGLSSE QQKMLSELAV 
ILKAKKYTEF DSTVTHVVVP GDAVQSTLKC MLGILNGCWI LKFEWVKACL RRKVCEQEEK 
YEIPEGPRRS RLNREQLLPK LFDGCYFYLW GTFKHHPKDN LIKLVTAGGG QILSRKPKPD 
SDVTQTINTV AYHARPDSDQ RFCTQYIIYE DLCNYHPERV RQGKVWKAPS SWFIDCVMSF 
ELLPLDS

Genular Protein ID: 1035215371

Symbol: A0AVN2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0AVN2

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 3 IntAct 1 InterPro 8 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 7 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 2 SAM 1 SMART 2 SUPFAM 3

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 777
  • Mass: 86601
  • Checksum: 108C857D8D4818CE
  • Sequence:
    • MPDNRQPRNR QPRIRSGNEP RSASAMEPDG RGAWAHSRAA LDRLEKLLRC SRCTNILREP 
VCLGGCEHIF CSNCVSDCIG TGCPVCYTPA WIQDLKINRQ LDSMIQLCSK LRNLLHDNEL 
SDLKEDKPRK SLFNDAGNKK NSIKMWFSPR SKKVRYVVSK ASVQTQPAIK KDASAQQDSY 
EFVSPSPPAD VSERAKKASA RSGKKQKKKT LAEINQKWNL EAEKEDGEFD SKEESKQKLV 
SFCSQPSVIS SPQINGEIDL LASGSLTESE CFGSLTEVSL PLAEQIESPD TKSRNEVVTP 
EKVCKNYLTS KKSLPLENNG KRGHHNRLSS PISKRCRTSI LSTSGDFVKQ TVPSENIPLP 
ECSSPPSCKR KVGGTSGSKN SNMSDEFISL SPGTPPSTLS SSSYRRVMSS PSAMKLLPNM 
AVKRNHRGET LLHIASIKGD IPSVEYLLQN GSDPNVKDHA GWTPLHEACN HGHLKVVELL 
LQHKALVNTT GYQNDSPLHD AAKNGHMDIV KLLLSYGASR NAVNIFGLRP VDYTDDESMK 
SLLLLPEKNE SSSASHCSVM NTGQRRDGPL VLIGSGLSSE QQKMLSELAV ILKAKKYTEF 
DSTVTHVVVP GDAVQSTLKC MLGILNGCWI LKFEWVKACL RRKVCEQEEK YEIPEGPRRS 
RLNREQLLPK LFDGCYFYLW GTFKHHPKDN LIKLVTAGGG QILSRKPKPD SDVTQTINTV 
AYHARPDSDQ RFCTQYIIYE DLCNYHPERV RQGKVWKAPS SWFIDCVMSF ELLPLDS

Genular Protein ID: 1227380321

Symbol: C9IYG1_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9IYG1

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 326
  • Mass: 37132
  • Checksum: CFE9D72C593F2E3C
  • Sequence:
    • MPDNRQPRNR QPRIRSGNEP RSAPAMEPDG RGAWAHSRAA LDRLEKLLRC SRCTNILREP 
VCLGGCEHIF CSNIFGLRPV DYTDDESMKS LLLLPEKNES SSASHCSVMN TGQRRDGPLV 
LIGSGLSSEQ QKMLSELAVI LKAKKYTEFD STVTHVVVPG DAVQSTLKCM LGILNGCWIL 
KFEWVKACLR RKVCEQEEKY EIPEGPRRSR LNREQLLPKL FDGCYFYLWG TFKHHPKDNL 
IKLVTAGGGQ ILSRKPKPDS DVTQTINTVA YHARPDSDQR FCTQYIIYED LCNYHPERVR 
QGKVWKAPSS WFIDCVMSFE LLPLDS

Genular Protein ID: 4043846987

Symbol: F6MDI0_HUMAN

Name: N/A

UniProtKB Accession Codes:

F6MDI0

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 2 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 1 SUPFAM 2

Citations:

PubMed ID: 18089818

Title: Oncogenic BARD1 isoforms expressed in gynecological cancers.

PubMed ID: 18089818

DOI: 10.1158/0008-5472.CAN-07-2370

PubMed ID: 17556008

Title: Identification of BARD1 splice-isoforms involved in human trophoblast invasion.

PubMed ID: 17556008

DOI: 10.1016/j.biocel.2007.04.018

Sequence Information:

  • Length: 326
  • Mass: 37122
  • Checksum: 725F94B43488BDCC
  • Sequence:
    • MPDNRQPRNR QPRIRSGNEP RSASAMEPDG RGAWAHSRAA LDRLEKLLRC SRCTNILREP 
VCLGGCEHIF CSNIFGLRPV DYTDDESMKS LLLLPEKNES SSASHCSVMN TGQRRDGPLV 
LIGSGLSSEQ QKMLSELAVI LKAKKYTEFD STVTHVVVPG DAVQSTLKCM LGILNGCWIL 
KFEWVKACLR RKVCEQEEKY EIPEGPRRSR LNREQLLPKL FDGCYFYLWG TFKHHPKDNL 
IKLVTAGGGQ ILSRKPKPDS DVTQTINTVA YHARPDSDQR FCTQYIIYED LCNYHPERVR 
QGKVWKAPSS WFIDCVMSFE LLPLDS

Genular Protein ID: 3077981172

Symbol: F6MDI2_HUMAN

Name: N/A

UniProtKB Accession Codes:

F6MDI2

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 2 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 2

Citations:

PubMed ID: 18089818

Title: Oncogenic BARD1 isoforms expressed in gynecological cancers.

PubMed ID: 18089818

DOI: 10.1158/0008-5472.CAN-07-2370

PubMed ID: 17556008

Title: Identification of BARD1 splice-isoforms involved in human trophoblast invasion.

PubMed ID: 17556008

DOI: 10.1016/j.biocel.2007.04.018

Sequence Information:

  • Length: 255
  • Mass: 29332
  • Checksum: 90C3189F2F9A520F
  • Sequence:
    • MPDNRQPRNR QPRIRSGNEP RSASAMEPDG RGAWAHSRAA LDRLEKLLRC SRCTNILREP 
VCLGGCEHIF CSNCVSDCIG TGCPVCYTPA WIQDLKINRQ LDSMIQLCSK LRNLLHDNEL 
SGVKACLRRK VCEQEEKYEI PEGPRRSRLN REQLLPKLFD GCYFYLWGTF KHHPKDNLIK 
LVTAGGGQIL SRKPKPDSDV TQTINTVAYH ARPDSDQRFC TQYIIYEDLC NYHPERVRQG 
KVWKAPSSWF ILSLN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.