Details for: BARD1

Gene ID: 580

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: BARD1

Ensembl ID: ENSG00000138376

Description: BRCA1 associated RING domain 1

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • conjunctival epithelial cell CL1000432
    CSI 8.01
    rCSI 12.23%
    PRS 77
  • melanocyte CL0000148
    CSI 5.89
    rCSI 4.37%
    PRS 69.69
  • keratinocyte CL0000312
    CSI 4.58
    rCSI 3.84%
    PRS 79.82
  • class switched memory B cell CL0000972
    CSI 3.86
    rCSI 2.88%
    PRS 89.26
  • mature T cell CL0002419
    CSI 3.36
    rCSI 2.61%
    PRS 90.9
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 3.33
    rCSI 4.27%
    PRS 72.85
  • plasmacytoid dendritic cell, human CL0001058
    CSI 3.03
    rCSI 2.11%
    PRS 79.88
  • glioblast CL0000030
    CSI 3.02
    rCSI 4.82%
    PRS 68.2
  • neural crest cell CL0011012
    CSI 2.73
    rCSI 2.16%
    PRS 64.58
  • stem cell CL0000034
    CSI 2.66
    rCSI 2.57%
    PRS 69.22
  • cerebral cortex endothelial cell CL1001602
    CSI 2.65
    rCSI 4.59%
    PRS 67.64
  • epithelial cell of lower respiratory tract CL0002632
    CSI 2.64
    rCSI 2.04%
    PRS 80.24
  • large pre-B-II cell CL0000957
    CSI 2.62
    rCSI 7.49%
    PRS 83.18
  • placental villous trophoblast CL2000060
    CSI 2.6
    rCSI 4.01%
    PRS 75.69
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 2.58
    rCSI 2.53%
    PRS 90.04
  • respiratory suprabasal cell CL4033048
    CSI 2.54
    rCSI 3.26%
    PRS 80.26
  • astrocyte of the cerebral cortex CL0002605
    CSI 2.53
    rCSI 5.67%
    PRS 58.85
  • mesenchymal cell CL0008019
    CSI 2.53
    rCSI 6.42%
    PRS 70
  • precursor B cell CL0000817
    CSI 2.51
    rCSI 2.2%
    PRS 84.18
  • granulocyte monocyte progenitor cell CL0000557
    CSI 2.51
    rCSI 2.17%
    PRS 80.77
  • pro-B cell CL0000826
    CSI 2.37
    rCSI 1.96%
    PRS 78.95
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 2.17
    rCSI 5.86%
    PRS 82.06
  • enteric smooth muscle cell CL0002504
    CSI 2.14
    rCSI 3.06%
    PRS 77.74
  • small intestine goblet cell CL1000495
    CSI 2.13
    rCSI 4.68%
    PRS 82.67
  • BEST4+ enteroycte CL4030026
    CSI 2.12
    rCSI 2.64%
    PRS 77.91
  • rod bipolar cell CL0000751
    CSI 2.11
    rCSI 3.79%
    PRS 69.78
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 2
    rCSI 1.81%
    PRS 74.46
  • early lymphoid progenitor CL0000936
    CSI 1.97
    rCSI 1.73%
    PRS 81.71
  • fraction A pre-pro B cell CL0002045
    CSI 1.93
    rCSI 2.21%
    PRS 88.23
  • intrahepatic cholangiocyte CL0002538
    CSI 1.91
    rCSI 4.57%
    PRS 81.77
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 1.88
    rCSI 7.11%
    PRS 58.56
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.81
    rCSI 3.2%
    PRS 57.3
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 1.77
    rCSI 2.04%
    PRS 68.74
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 1.73
    rCSI 2.15%
    PRS 56.04
  • promyelocyte CL0000836
    CSI 1.72
    rCSI 2.48%
    PRS 83.26
  • radial glial cell CL0000681
    CSI 1.68
    rCSI 2.34%
    PRS 75.25
  • respiratory basal cell CL0002633
    CSI 1.67
    rCSI 1.73%
    PRS 81.25
  • fallopian tube secretory epithelial cell CL4030006
    CSI 1.65
    rCSI 1.59%
    PRS 75.89
  • lung neuroendocrine cell CL1000223
    CSI 1.63
    rCSI 2.41%
    PRS 81.07
  • stromal cell CL0000499
    CSI 1.62
    rCSI 4.56%
    PRS 71.71
  • common dendritic progenitor CL0001029
    CSI 1.62
    rCSI 2.03%
    PRS 85.73
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 1.6
    rCSI 1.24%
    PRS 78.94
  • microcirculation associated smooth muscle cell CL0008035
    CSI 1.56
    rCSI 4.52%
    PRS 76.38
  • late pro-B cell CL0002048
    CSI 1.56
    rCSI 3.9%
    PRS 91.48
  • dendritic cell, human CL0001056
    CSI 1.54
    rCSI 2.37%
    PRS 85.33
  • common myeloid progenitor CL0000049
    CSI 1.51
    rCSI 1.22%
    PRS 78.79
  • lung secretory cell CL1000272
    CSI 1.41
    rCSI 3.49%
    PRS 76.07
  • basal cell of epidermis CL0002187
    CSI 1.33
    rCSI 2.36%
    PRS 46.37
  • VIP GABAergic cortical interneuron CL4023016
    CSI 1.31
    rCSI 1.57%
    PRS 58.05
  • Schwann cell CL0002573
    CSI 1.29
    rCSI 3.67%
    PRS 72.87
  • basal cell of prostate epithelium CL0002341
    CSI 1.29
    rCSI 3.72%
    PRS 83.93
  • promonocyte CL0000559
    CSI 1.28
    rCSI 2.2%
    PRS 83.36
  • basal cell CL0000646
    CSI 1.28
    rCSI 1.71%
    PRS 75.57
  • neural progenitor cell CL0011020
    CSI 1.26
    rCSI 5.54%
    PRS 65.16
  • corneal epithelial cell CL0000575
    CSI 1.25
    rCSI 3.57%
    PRS 84.51
  • lung ciliated cell CL1000271
    CSI 1.12
    rCSI 1.29%
    PRS 68.32
  • suprabasal keratinocyte CL4033013
    CSI 1.09
    rCSI 1.78%
    PRS 43.51
  • parietal epithelial cell CL1000452
    CSI 1.03
    rCSI 2.74%
    PRS 67.93
  • kidney connecting tubule epithelial cell CL1000768
    CSI 0.96
    rCSI 2.44%
    PRS 66.72
  • paneth cell of epithelium of small intestine CL1000343
    CSI 0.81
    rCSI 2.28%
    PRS 84.62
  • transit amplifying cell of small intestine CL0009012
    CSI 0.76
    rCSI 3.33%
    PRS 85.7
  • germinal center B cell CL0000844
    CSI 0.74
    rCSI 2.21%
    PRS 87.51
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 0.73
    rCSI 1.78%
    PRS 56.18
  • L6b glutamatergic cortical neuron CL4023038
    CSI 0.66
    rCSI 2.05%
    PRS 59.86
  • blood vessel smooth muscle cell CL0019018
    CSI 0.61
    rCSI 4.95%
    PRS 70.17
  • myelocyte CL0002193
    CSI 0.48
    rCSI 3.16%
    PRS 91.96

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [BARD1](/details-gene/580) (BRCA1 associated RING domain 1) is a protein-coding gene located on chromosome 2q35. It encodes a crucial tumor suppressor protein that forms a heterodimer with the BRCA1 protein. This complex functions as an E3 ubiquitin ligase, playing a central role in the cellular response to DNA damage, particularly in the repair of DNA double-strand breaks through homologous recombination ([Link](https://doi.org/10.1038/ng1296-430), [Link](https://doi.org/10.1074/jbc.274.9.5659)). Its functions are integral to maintaining genomic stability, regulating the cell cycle, and controlling apoptosis. Germline mutations in [BARD1](/details-gene/580) are associated with an increased predisposition to various cancers, including breast and ovarian cancers ([601593](https://omim.org/entry/601593)). Expression data indicates its significance across a broad range of cell types, with particularly high relevance in epithelial cells, melanocytes, and various immune and progenitor cell populations, underscoring its fundamental role in cellular homeostasis. ## Cellular Roles and Expression Landscape The expression profile of [BARD1](/details-gene/580) highlights its importance in cells that are highly proliferative or frequently exposed to genotoxic stress. **Overall**, the gene shows the highest significance in [conjunctival epithelial cell](/details-cell/CL1000432) (CSI: 8.01), suggesting a critical protective function at this environmental interface. High significance is also observed in other epithelial lineages and pigment-producing cells, such as [melanocyte](/details-cell/CL0000148) (CSI: 5.89) and [keratinocyte](/details-cell/CL0000312) (CSI: 4.58), which are constantly exposed to UV radiation and require robust DNA repair mechanisms. Furthermore, [BARD1](/details-gene/580) is a significant gene in the immune system, with notable CSI scores in [class switched memory B cell](/details-cell/CL0000972) (CSI: 3.86), [mature T cell](/details-cell/CL0002419) (CSI: 3.36), and [plasmacytoid dendritic cell, human](/details-cell/CL0001058) (CSI: 3.03). This pattern is consistent with its role in maintaining genomic integrity during the programmed DNA breaks and rapid clonal expansion inherent to adaptive immune responses. The gene's relevance in progenitor and developing cells is evidenced by its expression in [neuroblast (sensu Vertebrata)](/details-cell/CL0000031) (CSI: 3.33), [glioblast](/details-cell/CL0000030) (CSI: 3.02), [neural crest cell](/details-cell/CL0011012) (CSI: 2.73), and [stem cell](/details-cell/CL0000034) (CSI: 2.66). This widespread importance in precursor populations underscores its fundamental role in cell cycle checkpoints and safeguarding the genome of dividing cells. ## Pathways and Molecular Function The primary molecular function of [BARD1](/details-gene/580) is mediated through its stable interaction with BRCA1, forming the BRCA1/BARD1 heterodimeric E3 ubiquitin ligase complex ([GO:0031436](https://www.ebi.ac.uk/QuickGO/term/GO:0031436)). This complex exhibits [ubiquitin-protein transferase activity](/details-gene/GO:0004842) and is known to assemble unconventional polyubiquitin chains via K6 of ubiquitin, a critical step in signaling at sites of DNA damage ([Link](https://doi.org/10.1074/jbc.c300249200), [Link](https://doi.org/10.1093/hmg/ddh095)). Functionally, [BARD1](/details-gene/580) is integral to a network of processes dedicated to genome maintenance. It is a key component of the [DNA damage response](/details-gene/GO:0006974), specifically the [DNA repair](/details-gene/GO:0006281) pathway of [homologous recombination](/details-gene/GO:0035825). This is extensively detailed in Reactome, where [BARD1](/details-gene/580) is implicated in the [DNA double strand break response](/details-gene/R-HSA-5693606) and [Hdr through homologous recombination (hrr)](/details-gene/R-HSA-5685942). Loss of BARD1 function leads to defective DNA repair, a state linked to cancer predisposition ([R-HSA-9699150](https://reactome.org/content/detail/R-HSA-9699150)). Beyond direct repair, [BARD1](/details-gene/580) is also involved in the [regulation of cell cycle](/details-gene/GO:0051726), particularly at [G2/M checkpoints](/details-gene/R-HSA-69481), preventing the propagation of cells with damaged DNA. It also participates in the regulation of apoptosis, with roles in both [positive regulation of apoptotic process](/details-gene/GO:0043065) and [negative regulation of apoptotic process](/details-gene/GO:0043066), suggesting it helps determine cell fate following genotoxic stress. ## Research Directions The widespread importance of [BARD1](/details-gene/580) in genome integrity is well-established, but its cell-type-specific roles and the therapeutic implications of its dysfunction warrant further investigation. ### Proposed Hypotheses 1. Given its high significance in multiple lymphocyte populations ([class switched memory B cell](/details-cell/CL0000972), [mature T cell](/details-cell/CL0002419)), [BARD1](/details-gene/580) may have a specialized role in safeguarding the genome during the programmed DNA cleavage and proliferation associated with V(D)J recombination and somatic hypermutation. Hypofunctional [BARD1](/details-gene/580) variants could therefore increase the risk of lymphoid malignancies by permitting the survival of cells with oncogenic translocations. 2. The exceptionally high CSI value of [BARD1](/details-gene/580) in [conjunctival epithelial cell](/details-cell/CL1000432) suggests it is not merely a housekeeping gene but a key component of the ocular surface's first line of defense against environmental mutagens like UV radiation. Its function in these cells may extend beyond canonical DNA repair to include modulation of inflammation or regulation of cellular turnover to eliminate damaged cells. ### Key Experiments To test the second hypothesis regarding the specialized role of [BARD1](/details-gene/580) in the conjunctiva, an experimental approach could involve using a 3D organotypic culture of human conjunctival epithelial cells. After using siRNA or CRISPR-Cas9 to knock down [BARD1](/details-gene/580) expression, these cultures would be exposed to a controlled dose of UVB radiation. Key endpoints would include: * Quantification of DNA double-strand breaks via immunofluorescence for γH2AX foci. * Assessment of cell cycle arrest and apoptosis using flow cytometry. * Analysis of the inflammatory secretome (e.g., IL-6, IL-8, TNF-α) by multiplex immunoassay to determine if BARD1 loss dysregulates the local inflammatory response to damage. This would help elucidate whether [BARD1](/details-gene/580) primarily acts in DNA repair or has a broader role in managing the cellular stress response in this unique tissue. ### Therapeutic Potential As a tumor suppressor, [BARD1](/details-gene/580) itself is not a target for inhibition. Instead, its functional status is a critical biomarker. Tumors with loss-of-function mutations in [BARD1](/details-gene/580) are deficient in homologous recombination repair, rendering them highly sensitive to PARP (poly-ADP ribose polymerase) inhibitors through the mechanism of synthetic lethality. Therefore, screening for [BARD1](/details-gene/580) mutations can guide patient selection for PARP inhibitor therapies. Additionally, certain oncogenic splice isoforms of [BARD1](/details-gene/580) have been reported in gynecological cancers ([Link](https://doi.org/10.1158/0008-5472.CAN-07-2370)), which may represent novel therapeutic targets for isoform-specific inhibitors or RNA-based therapeutics.

Genular Protein ID: 775548544

Symbol: BARD1_HUMAN

Name: BRCA1-associated RING domain protein 1

UniProtKB Accession Codes:

Q99728 F6MDH7 F6MDH8 F6MDH9 O43574 Q53SS5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 15 EMDB 7 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 36 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 20 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8944023

Title: Identification of a RING protein that can interact in vivo with the BRCA1 gene product.

PubMed ID: 8944023

DOI: 10.1038/ng1296-430

PubMed ID: 9425226

Title: Mutations in the BRCA1-associated RING domain (BARD1) gene in primary breast, ovarian and uterine cancers.

PubMed ID: 9425226

DOI: 10.1093/hmg/7.2.195

PubMed ID: 18089818

Title: Oncogenic BARD1 isoforms expressed in gynecological cancers.

PubMed ID: 18089818

DOI: 10.1158/0008-5472.can-07-2370

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10026184

Title: Mapping the functional domains of BRCA1. Interaction of the ring finger domains of BRCA1 and BARD1.

PubMed ID: 10026184

DOI: 10.1074/jbc.274.9.5659

PubMed ID: 10477523

Title: Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50.

PubMed ID: 10477523

DOI: 10.1126/science.285.5433.1576

PubMed ID: 12890688

Title: The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin.

PubMed ID: 12890688

DOI: 10.1074/jbc.c300249200

PubMed ID: 14976165

Title: BRCA1:BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair.

PubMed ID: 14976165

DOI: 10.1093/hmg/ddh095

PubMed ID: 17643122

Title: CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response.

PubMed ID: 17643122

DOI: 10.1038/nsmb1277

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19261749

Title: NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control.

PubMed ID: 19261749

DOI: 10.1101/gad.1770309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20351172

Title: The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function.

PubMed ID: 20351172

DOI: 10.1128/mcb.01056-09

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 11573085

Title: Structure of a BRCA1-BARD1 heterodimeric RING-RING complex.

PubMed ID: 11573085

DOI: 10.1038/nsb1001-833

PubMed ID: 17550235

Title: Crystal structure of the BARD1 BRCT domains.

PubMed ID: 17550235

DOI: 10.1021/bi700323t

PubMed ID: 18842000

Title: The BARD1 C-terminal domain structure and interactions with polyadenylation factor CstF-50.

PubMed ID: 18842000

DOI: 10.1021/bi801115g

PubMed ID: 18480049

Title: Crystal structure of the BARD1 ankyrin repeat domain and its functional consequences.

PubMed ID: 18480049

DOI: 10.1074/jbc.m802333200

Sequence Information:

  • Length: 777
  • Mass: 86648
  • Checksum: 95E2D904046B5646
  • Sequence:
    • MPDNRQPRNR QPRIRSGNEP RSAPAMEPDG RGAWAHSRAA LDRLEKLLRC SRCTNILREP 
VCLGGCEHIF CSNCVSDCIG TGCPVCYTPA WIQDLKINRQ LDSMIQLCSK LRNLLHDNEL 
SDLKEDKPRK SLFNDAGNKK NSIKMWFSPR SKKVRYVVSK ASVQTQPAIK KDASAQQDSY 
EFVSPSPPAD VSERAKKASA RSGKKQKKKT LAEINQKWNL EAEKEDGEFD SKEESKQKLV 
SFCSQPSVIS SPQINGEIDL LASGSLTESE CFGSLTEVSL PLAEQIESPD TKSRNEVVTP 
EKVCKNYLTS KKSLPLENNG KRGHHNRLSS PISKRCRTSI LSTSGDFVKQ TVPSENIPLP 
ECSSPPSCKR KVGGTSGRKN SNMSDEFISL SPGTPPSTLS SSSYRRVMSS PSAMKLLPNM 
AVKRNHRGET LLHIASIKGD IPSVEYLLQN GSDPNVKDHA GWTPLHEACN HGHLKVVELL 
LQHKALVNTT GYQNDSPLHD AAKNGHVDIV KLLLSYGASR NAVNIFGLRP VDYTDDESMK 
SLLLLPEKNE SSSASHCSVM NTGQRRDGPL VLIGSGLSSE QQKMLSELAV ILKAKKYTEF 
DSTVTHVVVP GDAVQSTLKC MLGILNGCWI LKFEWVKACL RRKVCEQEEK YEIPEGPRRS 
RLNREQLLPK LFDGCYFYLW GTFKHHPKDN LIKLVTAGGG QILSRKPKPD SDVTQTINTV 
AYHARPDSDQ RFCTQYIIYE DLCNYHPERV RQGKVWKAPS SWFIDCVMSF ELLPLDS

Genular Protein ID: 2632898752

Symbol: A0A087WZ19_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WZ19

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 2 GeneTree 1 HGNC 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 264
  • Mass: 30365
  • Checksum: DBCFE6853FCDC056
  • Sequence:
    • MPDNRQPRNR QPRIRSGNEP RSAPAMEPDG RGAWAHSRAA LDRLEKLLRC SRCTNILREP 
VCLGGCEHIF CSNCVSDCIG TGCPVCYTPA WIQDLKINRQ LDSMIQLCSK LRNLLHDNEL 
SGVKACLRRK VCEQEEKYEI PEGPRRSRLN REQLLPKLFD GCYFYLWGTF KHHPKDNLIK 
LVTAGGGQIL SRKPKPDSDV TQTINTVAYH ARPDSDQRFC TQYIIYEDLC NYHPERVRQG 
KVWKAPSSWF IDCVMSFELL PLDS

Genular Protein ID: 592413994

Symbol: F6MDI1_HUMAN

Name: N/A

UniProtKB Accession Codes:

F6MDI1

Database IDs:

ARBA 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 18089818

Title: Oncogenic BARD1 isoforms expressed in gynecological cancers.

PubMed ID: 18089818

DOI: 10.1158/0008-5472.CAN-07-2370

PubMed ID: 17556008

Title: Identification of BARD1 splice-isoforms involved in human trophoblast invasion.

PubMed ID: 17556008

DOI: 10.1016/j.biocel.2007.04.018

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 307
  • Mass: 35058
  • Checksum: 2FC7AF807CD518E3
  • Sequence:
    • MPDNRQPRNR QPRIRSGNEP RSAPAMEPDG RGAWAHSRAA LDRLEKLLRC SRCNIFGLRP 
VDYTDDESMK SLLLLPEKNE SSSASHCSVM NTGQRRDGPL VLIGSGLSSE QQKMLSELAV 
ILKAKKYTEF DSTVTHVVVP GDAVQSTLKC MLGILNGCWI LKFEWVKACL RRKVCEQEEK 
YEIPEGPRRS RLNREQLLPK LFDGCYFYLW GTFKHHPKDN LIKLVTAGGG QILSRKPKPD 
SDVTQTINTV AYHARPDSDQ RFCTQYIIYE DLCNYHPERV RQGKVWKAPS SWFIDCVMSF 
ELLPLDS

Genular Protein ID: 1035215371

Symbol: A0AVN2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0AVN2

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 3 IntAct 1 InterPro 8 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 7 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 2 SAM 1 SMART 2 SUPFAM 3

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 777
  • Mass: 86601
  • Checksum: 108C857D8D4818CE
  • Sequence:
    • MPDNRQPRNR QPRIRSGNEP RSASAMEPDG RGAWAHSRAA LDRLEKLLRC SRCTNILREP 
VCLGGCEHIF CSNCVSDCIG TGCPVCYTPA WIQDLKINRQ LDSMIQLCSK LRNLLHDNEL 
SDLKEDKPRK SLFNDAGNKK NSIKMWFSPR SKKVRYVVSK ASVQTQPAIK KDASAQQDSY 
EFVSPSPPAD VSERAKKASA RSGKKQKKKT LAEINQKWNL EAEKEDGEFD SKEESKQKLV 
SFCSQPSVIS SPQINGEIDL LASGSLTESE CFGSLTEVSL PLAEQIESPD TKSRNEVVTP 
EKVCKNYLTS KKSLPLENNG KRGHHNRLSS PISKRCRTSI LSTSGDFVKQ TVPSENIPLP 
ECSSPPSCKR KVGGTSGSKN SNMSDEFISL SPGTPPSTLS SSSYRRVMSS PSAMKLLPNM 
AVKRNHRGET LLHIASIKGD IPSVEYLLQN GSDPNVKDHA GWTPLHEACN HGHLKVVELL 
LQHKALVNTT GYQNDSPLHD AAKNGHMDIV KLLLSYGASR NAVNIFGLRP VDYTDDESMK 
SLLLLPEKNE SSSASHCSVM NTGQRRDGPL VLIGSGLSSE QQKMLSELAV ILKAKKYTEF 
DSTVTHVVVP GDAVQSTLKC MLGILNGCWI LKFEWVKACL RRKVCEQEEK YEIPEGPRRS 
RLNREQLLPK LFDGCYFYLW GTFKHHPKDN LIKLVTAGGG QILSRKPKPD SDVTQTINTV 
AYHARPDSDQ RFCTQYIIYE DLCNYHPERV RQGKVWKAPS SWFIDCVMSF ELLPLDS

Genular Protein ID: 1227380321

Symbol: C9IYG1_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9IYG1

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 326
  • Mass: 37132
  • Checksum: CFE9D72C593F2E3C
  • Sequence:
    • MPDNRQPRNR QPRIRSGNEP RSAPAMEPDG RGAWAHSRAA LDRLEKLLRC SRCTNILREP 
VCLGGCEHIF CSNIFGLRPV DYTDDESMKS LLLLPEKNES SSASHCSVMN TGQRRDGPLV 
LIGSGLSSEQ QKMLSELAVI LKAKKYTEFD STVTHVVVPG DAVQSTLKCM LGILNGCWIL 
KFEWVKACLR RKVCEQEEKY EIPEGPRRSR LNREQLLPKL FDGCYFYLWG TFKHHPKDNL 
IKLVTAGGGQ ILSRKPKPDS DVTQTINTVA YHARPDSDQR FCTQYIIYED LCNYHPERVR 
QGKVWKAPSS WFIDCVMSFE LLPLDS

Genular Protein ID: 4043846987

Symbol: F6MDI0_HUMAN

Name: N/A

UniProtKB Accession Codes:

F6MDI0

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 2 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 1 SUPFAM 2

Citations:

PubMed ID: 18089818

Title: Oncogenic BARD1 isoforms expressed in gynecological cancers.

PubMed ID: 18089818

DOI: 10.1158/0008-5472.CAN-07-2370

PubMed ID: 17556008

Title: Identification of BARD1 splice-isoforms involved in human trophoblast invasion.

PubMed ID: 17556008

DOI: 10.1016/j.biocel.2007.04.018

Sequence Information:

  • Length: 326
  • Mass: 37122
  • Checksum: 725F94B43488BDCC
  • Sequence:
    • MPDNRQPRNR QPRIRSGNEP RSASAMEPDG RGAWAHSRAA LDRLEKLLRC SRCTNILREP 
VCLGGCEHIF CSNIFGLRPV DYTDDESMKS LLLLPEKNES SSASHCSVMN TGQRRDGPLV 
LIGSGLSSEQ QKMLSELAVI LKAKKYTEFD STVTHVVVPG DAVQSTLKCM LGILNGCWIL 
KFEWVKACLR RKVCEQEEKY EIPEGPRRSR LNREQLLPKL FDGCYFYLWG TFKHHPKDNL 
IKLVTAGGGQ ILSRKPKPDS DVTQTINTVA YHARPDSDQR FCTQYIIYED LCNYHPERVR 
QGKVWKAPSS WFIDCVMSFE LLPLDS

Genular Protein ID: 3077981172

Symbol: F6MDI2_HUMAN

Name: N/A

UniProtKB Accession Codes:

F6MDI2

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 2 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 2

Citations:

PubMed ID: 18089818

Title: Oncogenic BARD1 isoforms expressed in gynecological cancers.

PubMed ID: 18089818

DOI: 10.1158/0008-5472.CAN-07-2370

PubMed ID: 17556008

Title: Identification of BARD1 splice-isoforms involved in human trophoblast invasion.

PubMed ID: 17556008

DOI: 10.1016/j.biocel.2007.04.018

Sequence Information:

  • Length: 255
  • Mass: 29332
  • Checksum: 90C3189F2F9A520F
  • Sequence:
    • MPDNRQPRNR QPRIRSGNEP RSASAMEPDG RGAWAHSRAA LDRLEKLLRC SRCTNILREP 
VCLGGCEHIF CSNCVSDCIG TGCPVCYTPA WIQDLKINRQ LDSMIQLCSK LRNLLHDNEL 
SGVKACLRRK VCEQEEKYEI PEGPRRSRLN REQLLPKLFD GCYFYLWGTF KHHPKDNLIK 
LVTAGGGQIL SRKPKPDSDV TQTINTVAYH ARPDSDQRFC TQYIIYEDLC NYHPERVRQG 
KVWKAPSSWF ILSLN