Details for: casp8

Gene ID: 58022

Symbol: casp8

Ensembl ID: ENSDARG00000058325

Description: caspase 8, apoptosis-related cysteine peptidase

Associated with

  • Activation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0006919)
  • Apoptotic process
    (GO:0006915)
  • Cd95 death-inducing signaling complex
    (GO:0031265)
  • Cysteine-type endopeptidase activity
    (GO:0004197)
  • Cysteine-type endopeptidase activity involved in apoptotic signaling pathway
    (GO:0097199)
  • Cysteine-type peptidase activity
    (GO:0008234)
  • Cytoplasm
    (GO:0005737)
  • Death effector domain binding
    (GO:0035877)
  • Induction by virus of host apoptotic process
    (GO:0019051)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of neuron apoptotic process
    (GO:0043525)
  • Proteolysis
    (GO:0006508)
  • Regulation of apoptotic process
    (GO:0042981)
  • Regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043281)

Other Information

Genular Protein ID: 2905787808

Symbol: Q66I19_DANRE

Name: N/A

UniProtKB Accession Codes:

Q66I19

Database IDs:

ARBA 2 CDD 3 CTD 1 EMBL 2 GO 6 Gene3D 2 InterPro 8 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 7 PeptideAtlas 1 Pfam 2 Proteomes 2 RefSeq 2 RuleBase 1 SAM 1 SMART 2 SUPFAM 2 ZFIN 2

Citations:

PubMed ID: 16888647

Title: Delineation of the cell-extrinsic apoptosis pathway in the zebrafish.

PubMed ID: 16888647

DOI: 10.1038/sj.cdd.4402015

PubMed ID: 16456712

Title: Thioacetamide induced liver damage in zebrafish embryo as a disease model for steatohepatitis.

PubMed ID: 16456712

PubMed ID: 17459614

Title: Conserved function of caspase-8 in apoptosis during bony fish evolution.

PubMed ID: 17459614

DOI: 10.1016/j.gene.2007.03.010

PubMed ID: 18510930

Title: Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.

PubMed ID: 18510930

DOI: 10.1016/j.cell.2008.03.037

PubMed ID: 19032987

Title: Prolactin functions as a survival factor during zebrafish embryogenesis.

PubMed ID: 19032987

PubMed ID: 23594743

Title: The zebrafish reference genome sequence and its relationship to the human genome.

PubMed ID: 23594743

DOI: 10.1038/nature12111

PubMed ID: 30277848

Title: Nux Vomica Exposure Triggered Liver Injury and Metabolic Disturbance in Zebrafish Larvae.

PubMed ID: 30277848

PubMed ID: 30290360

Title: Microcystin-LR exposure induced nephrotoxicity by triggering apoptosis in female zebrafish.

PubMed ID: 30290360

PubMed ID: 30928664

Title: Excessive inflammation impairs heart regeneration in zebrafish breakdance mutant after cryoinjury.

PubMed ID: 30928664

PubMed ID: 30308910

Title: Macrolides induce severe cardiotoxicity and developmental toxicity in zebrafish embryos.

PubMed ID: 30308910

PubMed ID: 30399559

Title: Trimethyltin chloride induces reactive oxygen species-mediated apoptosis in retinal cells during zebrafish eye development.

PubMed ID: 30399559

Sequence Information:

  • Length: 476
  • Mass: 54963
  • Checksum: 2EA22110F14C1E01
  • Sequence:
    • MDPQIFHEID ENLTSGDVDQ LKFLCLDFIP KRRLESVTDA KDLILRLDEQ GLLEDELLFP 
ELLITIGRID LLEILKKSKE EVERNLLRCD NSRKGVSAYR KMLLKISEDM TEENFRAAKF 
LLDLPRAKLG RSTSFLDALI EMEKQQRLGP DNLDELYRIL EKCDKQLAVM IERFRNQSHR 
DQEQGGRLPL EEVFLNNPVS ETMERERRRN SSAGTITTDA ETPLNPNEYY ILTQRPLGYC 
LIINNYNFLK STNLLKRTGT DMDKDRLAKL FSRMHFQIEV RNDLEAWAIK DEIKQFANRN 
HASMGAFVCC ILSHGEKGTV LGTDGKPVEI REVTLPFAGC RTLASKPKLF FIQACQGDEN 
QAGVWTSDGR EDAPEEDEKY EEDAGIIVLR KIPIEADFLI GMATVEHYLS YRHTKEGSIF 
IQELCKKMEE LCPKKEDMLS ILTKVNFEVS KRILKGYKQM PEPRYTLTKK LVLPID

Genular Protein ID: 4053692764

Symbol: A0A8M2BD46_DANRE

Name: N/A

UniProtKB Accession Codes:

A0A8M2BD46

Database IDs:

ARBA 2 CDD 3 CTD 1 GO 4 Gene3D 2 InterPro 8 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 7 PeptideAtlas 1 Pfam 2 Proteomes 2 RefSeq 2 RuleBase 1 SMART 2 SUPFAM 2 ZFIN 2

Citations:

PubMed ID: 23594743

Title: The zebrafish reference genome sequence and its relationship to the human genome.

PubMed ID: 23594743

DOI: 10.1038/nature12111

Sequence Information:

  • Length: 477
  • Mass: 55036
  • Checksum: AB00734E434A947B
  • Sequence:
    • MDPQIFHEID ENLTSGDVDQ LKFLCLDFIP KRRLESVTDA KDLILRLDEQ GLLEDELLFP 
ELLITIGRID LLEILKKSKE EVKRNLLRCD NSRKGVSAYR KMLLKISEDM TEENFRAAKF 
LLDLPRAKLG RSTSFLDTLI EMEKQQRLGP DNLDELYRIL EKCDKQLAVM IERFRNQSHR 
DQEQVGGRLP LEEVFLNNPV SETMERERRR NSSAGTITTD AETPLNPNEY YILTQRPLGY 
CLIINNYNFL KSTNLLKRTG TDMDKDRLAK LFSRMHFQIE VRSDLEAWAI KDEIKQFANK 
NHASMGAFVC CILSHGEKGT VLGTDGKPVE IREVTLPFAG CRTLASKPKL FFIQACQGDE 
NQAGVWTSDG REDAPEEDEK YEEDAGIIVL RKIPIEADFL IGMATVEHYL SYRHTKEGSI 
FIQELCKKME ELCPKKEDML SILTKVNFEV SKRILKGYKQ MPEPRYTLTK KLVLPID

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.