Details for: BAX

Gene ID: 581

Symbol: BAX

Ensembl ID: ENSG00000087088

Description: BCL2 associated X, apoptosis regulator

Associated with

Other Information

Genular Protein ID: 1293566266

Symbol: BAX_HUMAN

Name: Apoptosis regulator BAX

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8358790

Title: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.

PubMed ID: 8358790

DOI: 10.1016/0092-8674(93)90509-o

PubMed ID: 7607685

Title: Mapping of the human BAX gene to chromosome 19q13.3-q13.4 and isolation of a novel alternatively spliced transcript, BAX delta.

PubMed ID: 7607685

DOI: 10.1016/0888-7543(95)80180-t

PubMed ID: 9920818

Title: Identification and characterization of baxepsilon, a novel bax variant missing the BH2 and the transmembrane domains.

PubMed ID: 9920818

DOI: 10.1006/bbrc.1998.0130

PubMed ID: 10772918

Title: Characterization of Bax-sigma, a cell death-inducing isoform of Bax.

PubMed ID: 10772918

DOI: 10.1006/bbrc.2000.2537

PubMed ID: 11912183

Title: The expression of a new variant of the pro-apoptotic molecule Bax, Baxpsi, is correlated with an increased survival of glioblastoma multiforme patients.

PubMed ID: 11912183

DOI: 10.1093/hmg/11.6.675

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7475270

Title: Bax mutations in cell lines derived from hematological malignancies.

PubMed ID: 7475270

PubMed ID: 8521816

Title: A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.

PubMed ID: 8521816

DOI: 10.1002/j.1460-2075.1995.tb00246.x

PubMed ID: 10228148

Title: Conformation of the Bax C-terminus regulates subcellular location and cell death.

PubMed ID: 10228148

DOI: 10.1093/emboj/18.9.2330

PubMed ID: 11060313

Title: MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains.

PubMed ID: 11060313

DOI: 10.1074/jbc.m008955200

PubMed ID: 11259440

Title: Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax.

PubMed ID: 11259440

DOI: 10.1074/jbc.m101527200

PubMed ID: 11462023

Title: E1B 19K blocks Bax oligomerization and tumor necrosis factor alpha-mediated apoptosis.

PubMed ID: 11462023

DOI: 10.1128/jvi.75.16.7506-7516.2001

PubMed ID: 12732850

Title: Humanin peptide suppresses apoptosis by interfering with Bax activation.

PubMed ID: 12732850

DOI: 10.1038/nature01627

PubMed ID: 15071501

Title: JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins.

PubMed ID: 15071501

DOI: 10.1038/sj.emboj.7600194

PubMed ID: 15004034

Title: Apoptosis repressor with caspase recruitment domain protects against cell death by interfering with Bax activation.

PubMed ID: 15004034

DOI: 10.1074/jbc.m400695200

PubMed ID: 15004026

Title: An anti-apoptotic viral protein that recruits Bax to mitochondria.

PubMed ID: 15004026

DOI: 10.1074/jbc.m308408200

PubMed ID: 16113678

Title: Clusterin inhibits apoptosis by interacting with activated Bax.

PubMed ID: 16113678

DOI: 10.1038/ncb1291

PubMed ID: 16199525

Title: MAP-1 is a mitochondrial effector of Bax.

PubMed ID: 16199525

DOI: 10.1073/pnas.0503524102

PubMed ID: 16964429

Title: Sequence analysis shows that Lifeguard belongs to a new evolutionarily conserved cytoprotective family.

PubMed ID: 16964429

PubMed ID: 16509771

Title: IAN family critically regulates survival and development of T lymphocytes.

PubMed ID: 16509771

DOI: 10.1371/journal.pbio.0040103

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20300062

Title: IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation.

PubMed ID: 20300062

DOI: 10.1038/emboj.2010.39

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21458670

Title: Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol.

PubMed ID: 21458670

DOI: 10.1016/j.cell.2011.02.034

PubMed ID: 23235460

Title: The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist.

PubMed ID: 23235460

DOI: 10.1038/cddis.2012.178

PubMed ID: 23055042

Title: Human Bop is a novel BH3-only member of the Bcl-2 protein family.

PubMed ID: 23055042

DOI: 10.1007/s13238-012-2069-7

PubMed ID: 25609812

Title: Tom70 mediates Sendai virus-induced apoptosis on mitochondria.

PubMed ID: 25609812

DOI: 10.1128/jvi.02959-14

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27558414

Title: Enterovirus 71 2B induces cell apoptosis by directly inducing the conformational activation of the proapoptotic protein Bax.

PubMed ID: 27558414

DOI: 10.1128/jvi.01499-16

PubMed ID: 29531808

Title: PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetero-oligomerization through interaction with Bid in human colon cancer.

PubMed ID: 29531808

DOI: 10.1038/s41420-017-0006-5

PubMed ID: 31690630

Title: Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization.

PubMed ID: 31690630

DOI: 10.1074/jbc.ra119.011297

PubMed ID: 36361894

Title: Deubiquitinating Enzyme USP12 Regulates the Pro-Apoptosis Protein Bax.

PubMed ID: 36361894

DOI: 10.3390/ijms232113107

PubMed ID: 11106734

Title: Structure of Bax: coregulation of dimer formation and intracellular localization.

PubMed ID: 11106734

DOI: 10.1016/s0092-8674(00)00167-7

PubMed ID: 16946732

Title: Elucidation of some Bax conformational changes through crystallization of an antibody-peptide complex.

PubMed ID: 16946732

DOI: 10.1038/sj.cdd.4402025

PubMed ID: 18948948

Title: BAX activation is initiated at a novel interaction site.

PubMed ID: 18948948

DOI: 10.1038/nature07396

PubMed ID: 21199865

Title: Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis.

PubMed ID: 21199865

DOI: 10.1074/jbc.m110.161281

PubMed ID: 9531611

Title: Hematopoietic malignancies demonstrate loss-of-function mutations of BAX.

PubMed ID: 9531611

Sequence Information:

  • Length: 192
  • Mass: 21184
  • Checksum: 6C0CDB0A7DEE4994
  • Sequence:
  • MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV PQDASTKKLS 
    ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF SDGNFNWGRV VALFYFASKL 
    VLKALCTKVP ELIRTIMGWT LDFLRERLLG WIQDQGGWDG LLSYFGTPTW QTVTIFVAGV 
    LTASLTIWKK MG

Genular Protein ID: 4225522848

Symbol: Q5ZPJ0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 36
  • Mass: 4231
  • Checksum: F6F31103D577759A
  • Sequence:
  • EQPRGGVSSR IEQGEWGGRH PSWPWTRCLR MRPPRS

Genular Protein ID: 3794058840

Symbol: Q5ZPJ1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 112
  • Mass: 12608
  • Checksum: 4CD21BC9AEA1258B
  • Sequence:
  • MIAAVDTDSP REVFFRVAAD MFSDGNFNWG RVVALFYFAS KLVLKALCTK VPELIRTIMG 
    WTLDFLRERL LGWIQDQGGW VRLLKPPHPH HRALTTAPAP PSLPPATPLG PW

Genular Protein ID: 3086669915

Symbol: I6LPK7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 140
  • Mass: 15923
  • Checksum: 99F1FB1E7F41A5B4
  • Sequence:
  • MIAAVDTDSP REVFFRVAAD MFSDGNFNWG RVVALFYFAS KLVLKALCTK VPELIRTIMG 
    WTLDFLRERL LGWIQDQGGW VRLLKPPHPH HRALTTAPAP PSLPPATPLG PWAFWSRSQW 
    CPLPIFRSSD VVYNAFSLRV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.