Details for: BAX

Gene ID: 581

Symbol: BAX

Ensembl ID: ENSG00000087088

Description: BCL2 associated X, apoptosis regulator

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 240.1231
    Cell Significance Index: -37.3500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 136.5894
    Cell Significance Index: -34.6500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 122.7583
    Cell Significance Index: -50.5700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 112.5273
    Cell Significance Index: -45.7200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 104.5915
    Cell Significance Index: -49.3800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 98.8364
    Cell Significance Index: -50.8400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 73.6935
    Cell Significance Index: -49.4500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 48.7671
    Cell Significance Index: -46.5600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.1165
    Cell Significance Index: -44.5300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.1970
    Cell Significance Index: -48.1300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.9362
    Cell Significance Index: -33.5900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.6824
    Cell Significance Index: -20.5800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.7023
    Cell Significance Index: -12.4800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.9484
    Cell Significance Index: 115.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.1360
    Cell Significance Index: 1928.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.1308
    Cell Significance Index: 137.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.7835
    Cell Significance Index: 974.0000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.3643
    Cell Significance Index: 25.2200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.2198
    Cell Significance Index: 32.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.2167
    Cell Significance Index: 57.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.1341
    Cell Significance Index: 133.7500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0597
    Cell Significance Index: 63.6200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0321
    Cell Significance Index: 71.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9897
    Cell Significance Index: 178.4200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.9665
    Cell Significance Index: 10.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9496
    Cell Significance Index: 116.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9363
    Cell Significance Index: 48.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8467
    Cell Significance Index: 116.2800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7780
    Cell Significance Index: 20.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6656
    Cell Significance Index: 14.4200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6601
    Cell Significance Index: 15.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6263
    Cell Significance Index: 124.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6187
    Cell Significance Index: 12.9500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.5607
    Cell Significance Index: 4.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5432
    Cell Significance Index: 24.6200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4812
    Cell Significance Index: 212.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4775
    Cell Significance Index: 12.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4513
    Cell Significance Index: 57.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4204
    Cell Significance Index: 21.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3554
    Cell Significance Index: 10.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3260
    Cell Significance Index: 24.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3134
    Cell Significance Index: 40.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3118
    Cell Significance Index: 59.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2987
    Cell Significance Index: 8.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2420
    Cell Significance Index: 23.9400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2397
    Cell Significance Index: 16.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1462
    Cell Significance Index: 29.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0859
    Cell Significance Index: 65.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0826
    Cell Significance Index: 3.8500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0690
    Cell Significance Index: 0.6300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0629
    Cell Significance Index: 0.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0462
    Cell Significance Index: 1.2900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0027
    Cell Significance Index: -1.8800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0117
    Cell Significance Index: -22.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0156
    Cell Significance Index: -1.5900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0233
    Cell Significance Index: -0.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0234
    Cell Significance Index: -43.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0298
    Cell Significance Index: -45.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0390
    Cell Significance Index: -53.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0419
    Cell Significance Index: -30.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0430
    Cell Significance Index: -15.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0495
    Cell Significance Index: -36.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0631
    Cell Significance Index: -40.0900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0764
    Cell Significance Index: -0.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0780
    Cell Significance Index: -44.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0880
    Cell Significance Index: -54.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0958
    Cell Significance Index: -43.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1155
    Cell Significance Index: -4.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1226
    Cell Significance Index: -35.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1301
    Cell Significance Index: -3.7300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1455
    Cell Significance Index: -24.8400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1805
    Cell Significance Index: -4.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2265
    Cell Significance Index: -7.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2354
    Cell Significance Index: -27.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2653
    Cell Significance Index: -55.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3001
    Cell Significance Index: -43.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3092
    Cell Significance Index: -35.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3432
    Cell Significance Index: -7.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3716
    Cell Significance Index: -19.5100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3931
    Cell Significance Index: -5.9700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4047
    Cell Significance Index: -4.4000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4114
    Cell Significance Index: -7.2700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4349
    Cell Significance Index: -27.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4535
    Cell Significance Index: -47.2200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4748
    Cell Significance Index: -7.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5134
    Cell Significance Index: -39.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5167
    Cell Significance Index: -31.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5393
    Cell Significance Index: -18.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5609
    Cell Significance Index: -44.4200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5627
    Cell Significance Index: -5.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6413
    Cell Significance Index: -43.1200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.6445
    Cell Significance Index: -11.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7173
    Cell Significance Index: -40.2500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7201
    Cell Significance Index: -21.2100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.7308
    Cell Significance Index: -10.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8080
    Cell Significance Index: -49.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8524
    Cell Significance Index: -22.8400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9902
    Cell Significance Index: -13.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.0024
    Cell Significance Index: -44.3400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0216
    Cell Significance Index: -26.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The BAX gene is a pro-apoptotic gene that encodes a protein involved in the regulation of apoptosis. The BAX protein is a member of the BCL-2 family of proteins, which are key regulators of apoptosis. The BAX protein is characterized by its ability to oligomerize and form pores in the mitochondrial outer membrane, leading to the release of cytochrome c and other pro-apoptotic factors. The BAX protein also interacts with other BCL-2 family members, such as BCL-2 and BAX itself, to regulate apoptosis. **Pathways and Functions:** The BAX gene is involved in several cellular pathways, including: 1. **Apoptosis:** BAX is a key regulator of apoptosis, which is essential for maintaining tissue homeostasis and eliminating damaged or unwanted cells. 2. **Mitochondrial Function:** BAX regulates mitochondrial function, including mitochondrial membrane potential, calcium ion homeostasis, and mitochondrial fragmentation. 3. **Cellular Homeostasis:** BAX is involved in maintaining cellular homeostasis, including regulating cell proliferation, differentiation, and survival. 4. **Immune Response:** BAX is expressed in immune cells, including T cells, macrophages, and natural killer cells, and plays a role in regulating the immune response. **Clinical Significance:** Dysregulation of the BAX gene has been implicated in various diseases, including: 1. **Cancer:** Mutations in the BAX gene have been associated with cancer, including breast cancer, lung cancer, and colon cancer. 2. **Neurodegenerative Disorders:** BAX has been implicated in neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 3. **Autoimmune Diseases:** BAX has been implicated in autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. 4. **Inflammatory Disorders:** BAX has been implicated in inflammatory disorders, including inflammatory bowel disease and atherosclerosis. In conclusion, the BAX gene is a critical regulator of apoptosis and cellular homeostasis, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the functions and significance of the BAX gene in the context of immune system regulation and disease pathogenesis. **Signaling Pathways:** The BAX gene is involved in several signaling pathways, including: 1. **Apoptosis Signaling Pathway:** BAX regulates the apoptosis signaling pathway, which involves the activation of caspases and the release of cytochrome c from mitochondria. 2. **Mitochondrial Signaling Pathway:** BAX regulates mitochondrial signaling pathways, including the regulation of mitochondrial membrane potential and calcium ion homeostasis. 3. **Cellular Signaling Pathway:** BAX regulates cellular signaling pathways, including the regulation of cell proliferation, differentiation, and survival. **Interactions with Other Proteins:** The BAX protein interacts with other proteins, including: 1. **BCL-2:** BAX interacts with BCL-2 to regulate apoptosis. 2. **BAX:** BAX interacts with itself to regulate apoptosis. 3. **Cytochrome c:** BAX regulates the release of cytochrome c from mitochondria. 4. **Mitochondrial Membrane Potential:** BAX regulates mitochondrial membrane potential. **Regulation of Gene Expression:** The BAX gene is regulated by various transcription factors, including: 1. **TP53:** TP53 regulates the expression of the BAX gene. 2. **RUNX2:** RUNX2 regulates the expression of the BAX gene. 3. **NF-κB:** NF-κB regulates the expression of the BAX gene. In conclusion, the BAX gene is a critical regulator of apoptosis and cellular homeostasis, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the functions and significance of the BAX gene in the context of immune system regulation and disease pathogenesis.

Genular Protein ID: 1293566266

Symbol: BAX_HUMAN

Name: Apoptosis regulator BAX

UniProtKB Accession Codes:

Q07812 A8K4W1 P55269 Q07814 Q07815 Q8WZ49 Q9NR76 Q9NYG7 Q9UCZ6 Q9UCZ7 Q9UQD6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CORUM 1 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EMBL 13 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 100 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 36 PDBsum 36 PIR 5 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 Pumba 1 RNAct 1 Reactome 7 RefSeq 7 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 5 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8358790

Title: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.

PubMed ID: 8358790

DOI: 10.1016/0092-8674(93)90509-o

PubMed ID: 7607685

Title: Mapping of the human BAX gene to chromosome 19q13.3-q13.4 and isolation of a novel alternatively spliced transcript, BAX delta.

PubMed ID: 7607685

DOI: 10.1016/0888-7543(95)80180-t

PubMed ID: 9920818

Title: Identification and characterization of baxepsilon, a novel bax variant missing the BH2 and the transmembrane domains.

PubMed ID: 9920818

DOI: 10.1006/bbrc.1998.0130

PubMed ID: 10772918

Title: Characterization of Bax-sigma, a cell death-inducing isoform of Bax.

PubMed ID: 10772918

DOI: 10.1006/bbrc.2000.2537

PubMed ID: 11912183

Title: The expression of a new variant of the pro-apoptotic molecule Bax, Baxpsi, is correlated with an increased survival of glioblastoma multiforme patients.

PubMed ID: 11912183

DOI: 10.1093/hmg/11.6.675

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7475270

Title: Bax mutations in cell lines derived from hematological malignancies.

PubMed ID: 7475270

PubMed ID: 8521816

Title: A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.

PubMed ID: 8521816

DOI: 10.1002/j.1460-2075.1995.tb00246.x

PubMed ID: 10228148

Title: Conformation of the Bax C-terminus regulates subcellular location and cell death.

PubMed ID: 10228148

DOI: 10.1093/emboj/18.9.2330

PubMed ID: 11060313

Title: MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains.

PubMed ID: 11060313

DOI: 10.1074/jbc.m008955200

PubMed ID: 11259440

Title: Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax.

PubMed ID: 11259440

DOI: 10.1074/jbc.m101527200

PubMed ID: 11462023

Title: E1B 19K blocks Bax oligomerization and tumor necrosis factor alpha-mediated apoptosis.

PubMed ID: 11462023

DOI: 10.1128/jvi.75.16.7506-7516.2001

PubMed ID: 12732850

Title: Humanin peptide suppresses apoptosis by interfering with Bax activation.

PubMed ID: 12732850

DOI: 10.1038/nature01627

PubMed ID: 15071501

Title: JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins.

PubMed ID: 15071501

DOI: 10.1038/sj.emboj.7600194

PubMed ID: 15004034

Title: Apoptosis repressor with caspase recruitment domain protects against cell death by interfering with Bax activation.

PubMed ID: 15004034

DOI: 10.1074/jbc.m400695200

PubMed ID: 15004026

Title: An anti-apoptotic viral protein that recruits Bax to mitochondria.

PubMed ID: 15004026

DOI: 10.1074/jbc.m308408200

PubMed ID: 16113678

Title: Clusterin inhibits apoptosis by interacting with activated Bax.

PubMed ID: 16113678

DOI: 10.1038/ncb1291

PubMed ID: 16199525

Title: MAP-1 is a mitochondrial effector of Bax.

PubMed ID: 16199525

DOI: 10.1073/pnas.0503524102

PubMed ID: 16964429

Title: Sequence analysis shows that Lifeguard belongs to a new evolutionarily conserved cytoprotective family.

PubMed ID: 16964429

PubMed ID: 16509771

Title: IAN family critically regulates survival and development of T lymphocytes.

PubMed ID: 16509771

DOI: 10.1371/journal.pbio.0040103

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20300062

Title: IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation.

PubMed ID: 20300062

DOI: 10.1038/emboj.2010.39

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21458670

Title: Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol.

PubMed ID: 21458670

DOI: 10.1016/j.cell.2011.02.034

PubMed ID: 23235460

Title: The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist.

PubMed ID: 23235460

DOI: 10.1038/cddis.2012.178

PubMed ID: 23055042

Title: Human Bop is a novel BH3-only member of the Bcl-2 protein family.

PubMed ID: 23055042

DOI: 10.1007/s13238-012-2069-7

PubMed ID: 25609812

Title: Tom70 mediates Sendai virus-induced apoptosis on mitochondria.

PubMed ID: 25609812

DOI: 10.1128/jvi.02959-14

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27558414

Title: Enterovirus 71 2B induces cell apoptosis by directly inducing the conformational activation of the proapoptotic protein Bax.

PubMed ID: 27558414

DOI: 10.1128/jvi.01499-16

PubMed ID: 29531808

Title: PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetero-oligomerization through interaction with Bid in human colon cancer.

PubMed ID: 29531808

DOI: 10.1038/s41420-017-0006-5

PubMed ID: 31690630

Title: Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization.

PubMed ID: 31690630

DOI: 10.1074/jbc.ra119.011297

PubMed ID: 36361894

Title: Deubiquitinating Enzyme USP12 Regulates the Pro-Apoptosis Protein Bax.

PubMed ID: 36361894

DOI: 10.3390/ijms232113107

PubMed ID: 11106734

Title: Structure of Bax: coregulation of dimer formation and intracellular localization.

PubMed ID: 11106734

DOI: 10.1016/s0092-8674(00)00167-7

PubMed ID: 16946732

Title: Elucidation of some Bax conformational changes through crystallization of an antibody-peptide complex.

PubMed ID: 16946732

DOI: 10.1038/sj.cdd.4402025

PubMed ID: 18948948

Title: BAX activation is initiated at a novel interaction site.

PubMed ID: 18948948

DOI: 10.1038/nature07396

PubMed ID: 21199865

Title: Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis.

PubMed ID: 21199865

DOI: 10.1074/jbc.m110.161281

PubMed ID: 9531611

Title: Hematopoietic malignancies demonstrate loss-of-function mutations of BAX.

PubMed ID: 9531611

Sequence Information:

  • Length: 192
  • Mass: 21184
  • Checksum: 6C0CDB0A7DEE4994
  • Sequence:
    • MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV PQDASTKKLS 
ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF SDGNFNWGRV VALFYFASKL 
VLKALCTKVP ELIRTIMGWT LDFLRERLLG WIQDQGGWDG LLSYFGTPTW QTVTIFVAGV 
LTASLTIWKK MG

Genular Protein ID: 3086669915

Symbol: I6LPK7_HUMAN

Name: N/A

UniProtKB Accession Codes:

I6LPK7

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 2 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 140
  • Mass: 15923
  • Checksum: 99F1FB1E7F41A5B4
  • Sequence:
    • MIAAVDTDSP REVFFRVAAD MFSDGNFNWG RVVALFYFAS KLVLKALCTK VPELIRTIMG 
WTLDFLRERL LGWIQDQGGW VRLLKPPHPH HRALTTAPAP PSLPPATPLG PWAFWSRSQW 
CPLPIFRSSD VVYNAFSLRV

Genular Protein ID: 4225522848

Symbol: Q5ZPJ0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5ZPJ0

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 NCBI Taxonomy 1 OrthoDB 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 36
  • Mass: 4231
  • Checksum: F6F31103D577759A
  • Sequence:
    • EQPRGGVSSR IEQGEWGGRH PSWPWTRCLR MRPPRS

Genular Protein ID: 3794058840

Symbol: Q5ZPJ1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5ZPJ1

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 9 Gene3D 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 112
  • Mass: 12608
  • Checksum: 4CD21BC9AEA1258B
  • Sequence:
    • MIAAVDTDSP REVFFRVAAD MFSDGNFNWG RVVALFYFAS KLVLKALCTK VPELIRTIMG 
WTLDFLRERL LGWIQDQGGW VRLLKPPHPH HRALTTAPAP PSLPPATPLG PW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.