Details for: BAX

Gene ID: 581

Symbol: BAX

Ensembl ID: ENSG00000087088

Description: BCL2 associated X, apoptosis regulator

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.56
    Marker Score: 7072
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.49
    Marker Score: 24636
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.36
    Marker Score: 60461.5
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.35
    Marker Score: 15002
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.2
    Marker Score: 123117
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.15
    Marker Score: 2597
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.13
    Marker Score: 4141
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.11
    Marker Score: 73056
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.03
    Marker Score: 5912.5
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.02
    Marker Score: 27172
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.02
    Marker Score: 9677
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.99
    Marker Score: 20201
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.98
    Marker Score: 3542.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.95
    Marker Score: 1073
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.94
    Marker Score: 2753
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.94
    Marker Score: 2216
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.89
    Marker Score: 5291
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.89
    Marker Score: 770
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.88
    Marker Score: 5911
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.83
    Marker Score: 1331
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.81
    Marker Score: 7425.5
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.81
    Marker Score: 3827
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.78
    Marker Score: 1783
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.78
    Marker Score: 551.5
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.78
    Marker Score: 10807
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.78
    Marker Score: 767
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.78
    Marker Score: 2617
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.78
    Marker Score: 4217
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.75
    Marker Score: 2573
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.75
    Marker Score: 1533
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.74
    Marker Score: 2804
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.74
    Marker Score: 4208
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.74
    Marker Score: 1049
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.73
    Marker Score: 722
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.72
    Marker Score: 860
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.7
    Marker Score: 977
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.69
    Marker Score: 4392
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.69
    Marker Score: 1660
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.68
    Marker Score: 2929
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.68
    Marker Score: 1687
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.67
    Marker Score: 10674
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.67
    Marker Score: 1564
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.67
    Marker Score: 1571
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.67
    Marker Score: 590
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.67
    Marker Score: 6546.5
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.65
    Marker Score: 5214
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.64
    Marker Score: 960
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.63
    Marker Score: 3705
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.63
    Marker Score: 1374
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.63
    Marker Score: 4062
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.62
    Marker Score: 2037
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.61
    Marker Score: 2768
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.61
    Marker Score: 3357.5
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.6
    Marker Score: 3910
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.59
    Marker Score: 1493.5
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.59
    Marker Score: 1678
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.58
    Marker Score: 6796
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.57
    Marker Score: 1051
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.56
    Marker Score: 5540
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.55
    Marker Score: 2642
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.55
    Marker Score: 1122.5
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.54
    Marker Score: 1027
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.54
    Marker Score: 369
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.54
    Marker Score: 1167
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.54
    Marker Score: 4574
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.54
    Marker Score: 1206
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.53
    Marker Score: 1838.5
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.53
    Marker Score: 528
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.53
    Marker Score: 2501.5
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.52
    Marker Score: 2090
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.51
    Marker Score: 5607
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.51
    Marker Score: 1540
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.51
    Marker Score: 1235
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.51
    Marker Score: 1639
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.5
    Marker Score: 1572
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.5
    Marker Score: 1665
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.5
    Marker Score: 733
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.49
    Marker Score: 16774.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.48
    Marker Score: 6398
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.48
    Marker Score: 556.5
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.47
    Marker Score: 4008.5
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.47
    Marker Score: 2269
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.47
    Marker Score: 472
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.47
    Marker Score: 1013
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.46
    Marker Score: 1618
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.46
    Marker Score: 857
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.46
    Marker Score: 2316
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.46
    Marker Score: 2009
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.45
    Marker Score: 1698
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.44
    Marker Score: 12443
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.44
    Marker Score: 164982
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.44
    Marker Score: 8523
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.43
    Marker Score: 500
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.42
    Marker Score: 1180
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.42
    Marker Score: 973
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.42
    Marker Score: 643.5
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.41
    Marker Score: 526
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.4
    Marker Score: 426
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.4
    Marker Score: 1573
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.4
    Marker Score: 368

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Other Information

**Key characteristics:** * BAX is a transmembrane protein with a conserved structure that includes an extracellular domain and a cytoplasmic domain. * The cytoplasmic domain of BAX is responsible for its pro-apoptotic activity. * BAX can interact with other proteins, such as BCL1 and BCL2, which are other members of the BCL family of proteins. * BAX is a key regulator of the mitochondrial pathway of apoptosis. **Pathways and functions:** * BAX is primarily a pro-apoptotic protein, but it can also act as an anti-apoptotic protein under certain conditions. * In the absence of anti-apoptotic signals, BAX translocates to the mitochondria and promotes the release of cytochrome c, a key initiator of the mitochondrial pathway of apoptosis. * BAX also regulates the expression of genes involved in cell cycle regulation and apoptosis. **Clinical significance:** * Mutations in the BAX gene have been linked to a variety of human cancers, including breast cancer, lung cancer, and leukemia. * Targeting BAX has been investigated as a therapeutic strategy for cancer, but it has not been successful due to the protein's role in both normal and cancer cells. * However, recent research has shown that targeting BAX in cancer cells can be effective. **Additional information:** * BAX is a member of the BCL family of proteins, which are a group of proteins that are involved in apoptosis. * BAX is a key regulator of the mitochondrial pathway of apoptosis. * BAX is a highly conserved protein that is found in all eukaryotic cells.

Genular Protein ID: 1293566266

Symbol: BAX_HUMAN

Name: Apoptosis regulator BAX

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8358790

Title: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.

PubMed ID: 8358790

DOI: 10.1016/0092-8674(93)90509-o

PubMed ID: 7607685

Title: Mapping of the human BAX gene to chromosome 19q13.3-q13.4 and isolation of a novel alternatively spliced transcript, BAX delta.

PubMed ID: 7607685

DOI: 10.1016/0888-7543(95)80180-t

PubMed ID: 9920818

Title: Identification and characterization of baxepsilon, a novel bax variant missing the BH2 and the transmembrane domains.

PubMed ID: 9920818

DOI: 10.1006/bbrc.1998.0130

PubMed ID: 10772918

Title: Characterization of Bax-sigma, a cell death-inducing isoform of Bax.

PubMed ID: 10772918

DOI: 10.1006/bbrc.2000.2537

PubMed ID: 11912183

Title: The expression of a new variant of the pro-apoptotic molecule Bax, Baxpsi, is correlated with an increased survival of glioblastoma multiforme patients.

PubMed ID: 11912183

DOI: 10.1093/hmg/11.6.675

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7475270

Title: Bax mutations in cell lines derived from hematological malignancies.

PubMed ID: 7475270

PubMed ID: 8521816

Title: A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.

PubMed ID: 8521816

DOI: 10.1002/j.1460-2075.1995.tb00246.x

PubMed ID: 10228148

Title: Conformation of the Bax C-terminus regulates subcellular location and cell death.

PubMed ID: 10228148

DOI: 10.1093/emboj/18.9.2330

PubMed ID: 11060313

Title: MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains.

PubMed ID: 11060313

DOI: 10.1074/jbc.m008955200

PubMed ID: 11259440

Title: Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax.

PubMed ID: 11259440

DOI: 10.1074/jbc.m101527200

PubMed ID: 11462023

Title: E1B 19K blocks Bax oligomerization and tumor necrosis factor alpha-mediated apoptosis.

PubMed ID: 11462023

DOI: 10.1128/jvi.75.16.7506-7516.2001

PubMed ID: 12732850

Title: Humanin peptide suppresses apoptosis by interfering with Bax activation.

PubMed ID: 12732850

DOI: 10.1038/nature01627

PubMed ID: 15071501

Title: JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins.

PubMed ID: 15071501

DOI: 10.1038/sj.emboj.7600194

PubMed ID: 15004034

Title: Apoptosis repressor with caspase recruitment domain protects against cell death by interfering with Bax activation.

PubMed ID: 15004034

DOI: 10.1074/jbc.m400695200

PubMed ID: 15004026

Title: An anti-apoptotic viral protein that recruits Bax to mitochondria.

PubMed ID: 15004026

DOI: 10.1074/jbc.m308408200

PubMed ID: 16113678

Title: Clusterin inhibits apoptosis by interacting with activated Bax.

PubMed ID: 16113678

DOI: 10.1038/ncb1291

PubMed ID: 16199525

Title: MAP-1 is a mitochondrial effector of Bax.

PubMed ID: 16199525

DOI: 10.1073/pnas.0503524102

PubMed ID: 16964429

Title: Sequence analysis shows that Lifeguard belongs to a new evolutionarily conserved cytoprotective family.

PubMed ID: 16964429

PubMed ID: 16509771

Title: IAN family critically regulates survival and development of T lymphocytes.

PubMed ID: 16509771

DOI: 10.1371/journal.pbio.0040103

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20300062

Title: IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation.

PubMed ID: 20300062

DOI: 10.1038/emboj.2010.39

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21458670

Title: Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol.

PubMed ID: 21458670

DOI: 10.1016/j.cell.2011.02.034

PubMed ID: 23235460

Title: The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist.

PubMed ID: 23235460

DOI: 10.1038/cddis.2012.178

PubMed ID: 23055042

Title: Human Bop is a novel BH3-only member of the Bcl-2 protein family.

PubMed ID: 23055042

DOI: 10.1007/s13238-012-2069-7

PubMed ID: 25609812

Title: Tom70 mediates Sendai virus-induced apoptosis on mitochondria.

PubMed ID: 25609812

DOI: 10.1128/jvi.02959-14

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27558414

Title: Enterovirus 71 2B induces cell apoptosis by directly inducing the conformational activation of the proapoptotic protein Bax.

PubMed ID: 27558414

DOI: 10.1128/jvi.01499-16

PubMed ID: 29531808

Title: PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetero-oligomerization through interaction with Bid in human colon cancer.

PubMed ID: 29531808

DOI: 10.1038/s41420-017-0006-5

PubMed ID: 31690630

Title: Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization.

PubMed ID: 31690630

DOI: 10.1074/jbc.ra119.011297

PubMed ID: 36361894

Title: Deubiquitinating Enzyme USP12 Regulates the Pro-Apoptosis Protein Bax.

PubMed ID: 36361894

DOI: 10.3390/ijms232113107

PubMed ID: 11106734

Title: Structure of Bax: coregulation of dimer formation and intracellular localization.

PubMed ID: 11106734

DOI: 10.1016/s0092-8674(00)00167-7

PubMed ID: 16946732

Title: Elucidation of some Bax conformational changes through crystallization of an antibody-peptide complex.

PubMed ID: 16946732

DOI: 10.1038/sj.cdd.4402025

PubMed ID: 18948948

Title: BAX activation is initiated at a novel interaction site.

PubMed ID: 18948948

DOI: 10.1038/nature07396

PubMed ID: 21199865

Title: Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis.

PubMed ID: 21199865

DOI: 10.1074/jbc.m110.161281

PubMed ID: 9531611

Title: Hematopoietic malignancies demonstrate loss-of-function mutations of BAX.

PubMed ID: 9531611

Sequence Information:

  • Length: 192
  • Mass: 21184
  • Checksum: 6C0CDB0A7DEE4994
  • Sequence:
  • MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV PQDASTKKLS 
    ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF SDGNFNWGRV VALFYFASKL 
    VLKALCTKVP ELIRTIMGWT LDFLRERLLG WIQDQGGWDG LLSYFGTPTW QTVTIFVAGV 
    LTASLTIWKK MG

Genular Protein ID: 4225522848

Symbol: Q5ZPJ0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 36
  • Mass: 4231
  • Checksum: F6F31103D577759A
  • Sequence:
  • EQPRGGVSSR IEQGEWGGRH PSWPWTRCLR MRPPRS

Genular Protein ID: 3794058840

Symbol: Q5ZPJ1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 112
  • Mass: 12608
  • Checksum: 4CD21BC9AEA1258B
  • Sequence:
  • MIAAVDTDSP REVFFRVAAD MFSDGNFNWG RVVALFYFAS KLVLKALCTK VPELIRTIMG 
    WTLDFLRERL LGWIQDQGGW VRLLKPPHPH HRALTTAPAP PSLPPATPLG PW

Genular Protein ID: 3086669915

Symbol: I6LPK7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 140
  • Mass: 15923
  • Checksum: 99F1FB1E7F41A5B4
  • Sequence:
  • MIAAVDTDSP REVFFRVAAD MFSDGNFNWG RVVALFYFAS KLVLKALCTK VPELIRTIMG 
    WTLDFLRERL LGWIQDQGGW VRLLKPPHPH HRALTTAPAP PSLPPATPLG PWAFWSRSQW 
    CPLPIFRSSD VVYNAFSLRV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.