Rsad2 | ENSMUSG00000020641 | NCBI 58185

Details for: Rsad2

Gene ID: 58185

Symbol: Rsad2

Ensembl ID: ENSMUSG00000020641

Description: radical S-adenosyl methionine domain containing 2

Associated with

4 iron, 4 sulfur cluster binding
(GO:0051539)
Catalytic activity
(GO:0003824)
Cd4-positive, alpha-beta t cell activation
(GO:0035710)
Cd4-positive, alpha-beta t cell differentiation
(GO:0043367)
Defense response to virus
(GO:0051607)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Fibrillar center
(GO:0001650)
Golgi apparatus
(GO:0005794)
Immune system process
(GO:0002376)
Innate immune response
(GO:0045087)
Iron-sulfur cluster binding
(GO:0051536)
Lipid droplet
(GO:0005811)
Lyase activity
(GO:0016829)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrion
(GO:0005739)
Negative regulation of protein secretion
(GO:0050709)
Negative regulation of viral genome replication
(GO:0045071)
Ossification
(GO:0001503)
Positive regulation of immune response
(GO:0050778)
Positive regulation of t-helper 2 cell cytokine production
(GO:2000553)
Positive regulation of toll-like receptor 7 signaling pathway
(GO:0034157)
Positive regulation of toll-like receptor 9 signaling pathway
(GO:0034165)
Protein binding
(GO:0005515)
Protein self-association
(GO:0043621)
Regulation of ossification
(GO:0030278)
Response to virus
(GO:0009615)

Other Information

Proteins

RSAD2_MOUSE

Genular Protein ID: 1530387898

Symbol: RSAD2_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8CBB9 Q3U5I6 Q3U5T4 Q3U622 Q3U627 Q3U7I6 Q3U7M1 Q3U8F4 Q3U8U7 Q3U941 Q3U977 Q3U9E1 Q3U9J0 Q3U9J3 Q3UBW6 Q3UC07 Q3UDI0 Q6PEU4 Q8VHM2 Q9JHD4

Database IDs:

Citations:

PubMed ID: 11038379

Title: Vesicular stomatitis virus and pseudorabies virus induce a vig1/cig5 homologue in mouse dendritic cells via different pathways.

PubMed ID: 11038379

DOI: 10.1099/0022-1317-81-11-2675

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11752458

Title: Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus.

PubMed ID: 11752458

DOI: 10.1073/pnas.011593298

PubMed ID: 15890971

Title: The antiviral cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and regulated by proinflammatory agents.

PubMed ID: 15890971

DOI: 10.1161/01.atv.0000170130.85334.38

PubMed ID: 16849320

Title: Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1.

PubMed ID: 16849320

DOI: 10.1074/jbc.m604516200

PubMed ID: 17686841

Title: Identification and characterization of interferon-induced proteins that inhibit alphavirus replication.

PubMed ID: 17686841

DOI: 10.1128/jvi.01282-07

PubMed ID: 19047684

Title: Viperin is required for optimal Th2 responses and T-cell receptor-mediated activation of NF-kappaB and AP-1.

PubMed ID: 19047684

DOI: 10.1182/blood-2008-07-171942

PubMed ID: 19920176

Title: The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic alpha-helix.

PubMed ID: 19920176

DOI: 10.1073/pnas.0911679106

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22177558

Title: Viperin: a multifunctional, interferon-inducible protein that regulates virus replication.

PubMed ID: 22177558

DOI: 10.1016/j.chom.2011.11.004

PubMed ID: 21435586

Title: Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells.

PubMed ID: 21435586

DOI: 10.1016/j.immuni.2011.03.010

PubMed ID: 21880757

Title: The interferon-inducible gene viperin restricts West Nile virus pathogenesis.

PubMed ID: 21880757

DOI: 10.1128/jvi.05519-11

PubMed ID: 36387278

Title: Radical-SAM dependent nucleotide dehydratase (SAND), rectification of the names of an ancient iron-sulfur enzyme using NC-IUBMB recommendations.

PubMed ID: 36387278

DOI: 10.3389/fmolb.2022.1032220

PubMed ID: 28607080

Title: Structural studies of viperin, an antiviral radical SAM enzyme.

PubMed ID: 28607080

DOI: 10.1073/pnas.1705402114

Sequence Information:

Length: 362
Mass: 41524
Checksum: F56F0BBEC9F20E50
Sequence:

MGMLVPTALA ARLLSLFQQQ LGSLWSGLAI LFCWLRIALG WLDPGKEQPQ VRGEPEDTQE 
TQEDGNSTQP TTPVSVNYHF TRQCNYKCGF CFHTAKTSFV LPLEEAKRGL LLLKQAGLEK 
INFSGGEPFL QDRGEYLGKL VRFCKEELAL PSVSIVSNGS LIRERWFKDY GEYLDILAIS 
CDSFDEQVNA LIGRGQGKKN HVENLQKLRR WCRDYKVAFK INSVINRFNV DEDMNEHIKA 
LSPVRWKVFQ CLLIEGENSG EDALREAERF LISNEEFETF LERHKEVSCL VPESNQKMKD 
SYLILDEYMR FLNCTGGRKD PSKSILDVGV EEAIKFSGFD EKMFLKRGGK YVWSKADLKL 
DW

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rsad2

Associated with

Other Information

Vesicular stomatitis virus and pseudorabies virus induce a vig1/cig5 homologue in mouse dendritic cells via different pathways. PubMed ID: 11038379

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus. PubMed ID: 11752458

The antiviral cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and regulated by proinflammatory agents. PubMed ID: 15890971

Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1. PubMed ID: 16849320

Identification and characterization of interferon-induced proteins that inhibit alphavirus replication. PubMed ID: 17686841

Viperin is required for optimal Th2 responses and T-cell receptor-mediated activation of NF-kappaB and AP-1. PubMed ID: 19047684

The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic alpha-helix. PubMed ID: 19920176

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Viperin: a multifunctional, interferon-inducible protein that regulates virus replication. PubMed ID: 22177558

Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells. PubMed ID: 21435586

The interferon-inducible gene viperin restricts West Nile virus pathogenesis. PubMed ID: 21880757

Radical-SAM dependent nucleotide dehydratase (SAND), rectification of the names of an ancient iron-sulfur enzyme using NC-IUBMB recommendations. PubMed ID: 36387278

Structural studies of viperin, an antiviral radical SAM enzyme. PubMed ID: 28607080