Details for: Zbp1

Gene ID: 58203

Symbol: Zbp1

Ensembl ID: ENSMUSG00000027514

Description: Z-DNA binding protein 1

Associated with

Other Information

Genular Protein ID: 2403404248

Symbol: ZBP1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9QY24 Q8VE02 Q9D8B9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 2 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 EMBL 3 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneTree 1 Genevisible 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 10564822

Title: Cloning of DLM-1, a novel gene that is up-regulated in activated macrophages, using RNA differential display.

PubMed ID: 10564822

DOI: 10.1016/s0378-1119(99)00419-9

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17618271

Title: DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.

PubMed ID: 17618271

DOI: 10.1038/nature06013

PubMed ID: 18375758

Title: Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules.

PubMed ID: 18375758

DOI: 10.1073/pnas.0801295105

PubMed ID: 19590578

Title: DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB.

PubMed ID: 19590578

DOI: 10.1038/embor.2009.109

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22423968

Title: DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA.

PubMed ID: 22423968

DOI: 10.1016/j.chom.2012.01.016

PubMed ID: 31600504

Title: DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA.

PubMed ID: 31600504

DOI: 10.1016/j.chom.2019.09.004

PubMed ID: 23283962

Title: DNA sensing-independent inhibition of herpes simplex virus 1 replication by DAI/ZBP1.

PubMed ID: 23283962

DOI: 10.1128/jvi.02860-12

PubMed ID: 27746097

Title: DAI senses influenza A virus genomic RNA and activates RIPK3-dependent cell death.

PubMed ID: 27746097

DOI: 10.1016/j.chom.2016.09.014

PubMed ID: 27917412

Title: ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways.

PubMed ID: 27917412

DOI: 10.1126/sciimmunol.aag2045

PubMed ID: 27819681

Title: RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation.

PubMed ID: 27819681

DOI: 10.1038/nature20558

PubMed ID: 27819682

Title: RIPK1 inhibits ZBP1-driven necroptosis during development.

PubMed ID: 27819682

DOI: 10.1038/nature20559

PubMed ID: 28716805

Title: Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis.

PubMed ID: 28716805

DOI: 10.15252/embj.201796476

PubMed ID: 28607035

Title: Murine cytomegalovirus IE3-dependent transcription is required for DAI/ZBP1-mediated necroptosis.

PubMed ID: 28607035

DOI: 10.15252/embr.201743947

PubMed ID: 28634194

Title: ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death.

PubMed ID: 28634194

DOI: 10.1084/jem.20170550

PubMed ID: 29073079

Title: Inhibition of DAI-dependent necroptosis by the Z-DNA binding domain of the vaccinia virus innate immune evasion protein, E3.

PubMed ID: 29073079

DOI: 10.1073/pnas.1700999114

PubMed ID: 30050136

Title: Species-independent contribution of ZBP1/DAI/DLM-1-triggered necroptosis in host defense against HSV1.

PubMed ID: 30050136

DOI: 10.1038/s41419-018-0868-3

PubMed ID: 29321274

Title: IRF1 is a transcriptional regulator of ZBP1 promoting NLRP3 inflammasome activation and cell death during influenza virus infection.

PubMed ID: 29321274

DOI: 10.4049/jimmunol.1701538

PubMed ID: 29236673

Title: ZBP1: innate sensor regulating cell death and inflammation.

PubMed ID: 29236673

DOI: 10.1016/j.it.2017.11.002

PubMed ID: 30635240

Title: The nucleotide sensor ZBP1 and kinase RIPK3 induce the enzyme IRG1 to promote an antiviral metabolic state in neurons.

PubMed ID: 30635240

DOI: 10.1016/j.immuni.2018.11.017

PubMed ID: 30498077

Title: Viral M45 and necroptosis-associated proteins form heteromeric amyloid assemblies.

PubMed ID: 30498077

DOI: 10.15252/embr.201846518

PubMed ID: 31358656

Title: ZBP1/DAI Drives RIPK3-Mediated Cell Death Induced by IFNs in the Absence of RIPK1.

PubMed ID: 31358656

DOI: 10.4049/jimmunol.1900216

PubMed ID: 32200799

Title: Influenza virus Z-RNAs induce ZBP1-mediated necroptosis.

PubMed ID: 32200799

DOI: 10.1016/j.cell.2020.02.050

PubMed ID: 31630209

Title: ZBP1 governs the inflammasome-independent IL-1alpha and neutrophil inflammation that play a dual role in anti-influenza virus immunity.

PubMed ID: 31630209

DOI: 10.1093/intimm/dxz070

PubMed ID: 32298652

Title: Caspase-6 is a key regulator of innate immunity, inflammasome activation, and host defense.

PubMed ID: 32298652

DOI: 10.1016/j.cell.2020.03.040

PubMed ID: 32350114

Title: The Zalpha2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development.

PubMed ID: 32350114

DOI: 10.1074/jbc.ra120.013752

PubMed ID: 33109609

Title: ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis).

PubMed ID: 33109609

DOI: 10.1074/jbc.ra120.015924

PubMed ID: 32315377

Title: Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation.

PubMed ID: 32315377

DOI: 10.1084/jem.20191913

PubMed ID: 32296175

Title: Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation.

PubMed ID: 32296175

DOI: 10.1038/s41586-020-2129-8

PubMed ID: 34471287

Title: AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence.

PubMed ID: 34471287

DOI: 10.1038/s41586-021-03875-8

PubMed ID: 33397971

Title: ZBP1 promotes LPS-induced cell death and IL-1beta release via RHIM-mediated interactions with RIPK1.

PubMed ID: 33397971

DOI: 10.1038/s41467-020-20357-z

PubMed ID: 11524677

Title: Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteins.

PubMed ID: 11524677

DOI: 10.1038/nsb0901-761

Sequence Information:

  • Length: 411
  • Mass: 44331
  • Checksum: 6D5F7B526A7DAA40
  • Sequence:
    • MAEAPVDLST GDNLEQKILQ VLSDDGGPVK IGQLVKKCQV PKKTLNQVLY RLKKEDRVSS 
PEPATWSIGG AASGDGAPAI PENSSAQPSL DERILRFLEA NGPHRALHIA KALGMTTAKE 
VNPLLYSMRN KHLLSYDGQT WKIYHSRQEG QDIAHSGVTQ ESPAIICQHN PVNMICQQGA 
NSHISIANSN AIQIGHGNVI VREKACGEPG PRTSHPLPLA WDASAQDMPP VAHGAQYIYM 
DKSLLQQVQL GHHNEMSLVG DAGKHPSYSF SDSPPEVSTT TADPGASFNM QTFEPGPHPE 
GDTVQTVHIK SCFLEDATIG NGNKMTIHLR SKGEVMESGD SEEPKKEDTG TSSEATPPRS 
CQHTPSDSML PTSELRAMAL GDSSPQTTEP VLREHEVQDI ESSQDTGLSK Q

Genular Protein ID: 2320930570

Symbol: A2APF7_MOUSE

Name: N/A

UniProtKB Accession Codes:

A2APF7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 IntAct 1 InterPro 5 MGI 2 MaxQB 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 2 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 jPOST 1

Citations:

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 411
  • Mass: 44271
  • Checksum: 985F7B527F7DA5EA
  • Sequence:
    • MAEAPVDLST GDNLEQKILQ VLSDDGGPVK IGQLVKKCQV PKKTLNQVLY RLKKEDRVSS 
PEPATWSIGG AASGDGAPAI PENSSAQPSL DERILRFLEA NGPHRALHIA KALGMTTAKE 
VNPLLYSMRN KHLLSYDGQT WKIYHSRQEG QDIAHSGVTQ ESPAIICQHN PVNMICQQGA 
NSHISIANSN AIQIGHGNVI VREKACGEPG PRTSHPLPLA WDASAQDMPP VAHGAQYIYM 
DKSLLQQVQL GHHNEMSLVG DAGKHPSYSF SDSPPEVSTT TADPGASFNM QTSEPGPHPE 
GDTVQTVHIK SCFLEDATIG NGNKMTIHLR SKGEVMESGD SEEPKKEDTG TSSEATPPRS 
CQHTPSDSML PTSELRAMAL GDSSPQTTEP VLREHEVQDI ESSQDTGLSK Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.