Rnf8 | ENSMUSG00000090083 | NCBI 58230

Details for: Rnf8

Gene ID: 58230

Symbol: Rnf8

Ensembl ID: ENSMUSG00000090083

Description: ring finger protein 8

Associated with

Cell cycle checkpoints
(R-MMU-69620)
Dna double-strand break repair
(R-MMU-5693532)
Dna double strand break response
(R-MMU-5693606)
G2/m checkpoints
(R-MMU-69481)
G2/m dna damage checkpoint
(R-MMU-69473)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-MMU-5693567)
Homology directed repair
(R-MMU-5693538)
Nonhomologous end-joining (nhej)
(R-MMU-5693571)
Processing of dna double-strand break ends
(R-MMU-5693607)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-MMU-5693565)
Cell cycle
(GO:0007049)
Cell division
(GO:0051301)
Chromatin binding
(GO:0003682)
Chromatin organization
(GO:0006325)
Chromosome
(GO:0005694)
Chromosome, telomeric region
(GO:0000781)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna damage response
(GO:0006974)
Dna repair
(GO:0006281)
Dna repair-dependent chromatin remodeling
(GO:0140861)
Double-strand break repair
(GO:0006302)
Double-strand break repair via nonhomologous end joining
(GO:0006303)
Epigenetic regulation of gene expression
(GO:0040029)
Histone binding
(GO:0042393)
Identical protein binding
(GO:0042802)
Isotype switching
(GO:0045190)
Metal ion binding
(GO:0046872)
Negative regulation of transcription elongation by rna polymerase ii
(GO:0034244)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna repair
(GO:0045739)
Protein autoubiquitination
(GO:0051865)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein k48-linked ubiquitination
(GO:0070936)
Protein k63-linked ubiquitination
(GO:0070534)
Protein ubiquitination
(GO:0016567)
Response to ionizing radiation
(GO:0010212)
Signal transduction in response to dna damage
(GO:0042770)
Site of double-strand break
(GO:0035861)
Sperm dna condensation
(GO:0035092)
Transferase activity
(GO:0016740)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin ligase complex
(GO:0000151)
Ubiquitin protein ligase activity
(GO:0061630)
Ubiquitin protein ligase binding
(GO:0031625)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

ActA-interacting protein 37

Genular Protein ID: 2330447167

Symbol: RNF8_MOUSE

Name: ActA-interacting protein 37

UniProtKB Accession Codes:

Q8VC56 Q4FJV7 Q9JK13

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11207567

Title: LaXp180, a mammalian ActA-binding protein, identified with the yeast two-hybrid system co-localizes with intracellular Listeria monocytogenes.

PubMed ID: 11207567

DOI: 10.1046/j.1462-5822.2000.00034.x

PubMed ID: 20153262

Title: RNF8-dependent histone modifications regulate nucleosome removal during spermatogenesis.

PubMed ID: 20153262

DOI: 10.1016/j.devcel.2010.01.010

PubMed ID: 20080757

Title: The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination.

PubMed ID: 20080757

DOI: 10.1073/pnas.0913790107

PubMed ID: 21706008

Title: Chfr and RNF8 synergistically regulate ATM activation.

PubMed ID: 21706008

DOI: 10.1038/nsmb.2078

PubMed ID: 21857671

Title: DNA-damage response and repair activities at uncapped telomeres depend on RNF8.

PubMed ID: 21857671

DOI: 10.1038/ncb2326

PubMed ID: 22101936

Title: The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection.

PubMed ID: 22101936

DOI: 10.1038/nsmb.2172

PubMed ID: 22266820

Title: The E3 ligase RNF8 regulates KU80 removal and NHEJ repair.

PubMed ID: 22266820

DOI: 10.1038/nsmb.2211

PubMed ID: 24953653

Title: GPS2/KDM4A pioneering activity regulates promoter-specific recruitment of PPARgamma.

PubMed ID: 24953653

DOI: 10.1016/j.celrep.2014.05.041

PubMed ID: 28552346

Title: Ubiquitination-deficient mutations in human Piwi cause male infertility by impairing histone-to-protamine exchange during spermiogenesis.

PubMed ID: 28552346

DOI: 10.1016/j.cell.2017.04.034

Sequence Information:

Length: 488
Mass: 55517
Checksum: 428242204EBC44A1
Sequence:

MGEPDPLVSG QLAARRSWCL RRLGMDCEWL QLEAGTEVTI GRGLSVTYQL ISKVCPLMIS 
RSHCVLKQNP EGQWTIMDNK SLNGVWLNRE RLAPLQGYCI RKGDHIQLGV PLESRETAEY 
EYEVIEEDWE SLAPCLAPKN DQRMEKHKGS RTKRKFSSPG LENLPAEGSS DLRCPLANVA 
SKPIEPEKLH GKGDASSQSL GCLCPGLTSL KASERAAGPH ACSALPKVLE LSCPKKQKAC 
RPSASQNSLE LFKVTMSRML KLKTQMQEKQ IAVLNVKRQT RKGSSKKIVR MEKELRNLQS 
QLYAEQAQQQ ARVEQLEKTF QEEAHYLQGL EKEQGECDLK QQLVQALQEH QALMEELNCS 
KKDFEKIIQA KNKELEQTKE EKDKVQAQKE EVLSHMNDLL ENELQCIICS EYFIEAVTLN 
CAHSFCSFCI NEWMKRKVEC PICRKDIESR TNSLVLDNCI SKMVDNLSSD VKERRSVLIR 
ERRAKRLS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rnf8

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

LaXp180, a mammalian ActA-binding protein, identified with the yeast two-hybrid system co-localizes with intracellular Listeria monocytogenes. PubMed ID: 11207567

RNF8-dependent histone modifications regulate nucleosome removal during spermatogenesis. PubMed ID: 20153262

The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination. PubMed ID: 20080757

Chfr and RNF8 synergistically regulate ATM activation. PubMed ID: 21706008

DNA-damage response and repair activities at uncapped telomeres depend on RNF8. PubMed ID: 21857671

The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection. PubMed ID: 22101936

The E3 ligase RNF8 regulates KU80 removal and NHEJ repair. PubMed ID: 22266820

GPS2/KDM4A pioneering activity regulates promoter-specific recruitment of PPARgamma. PubMed ID: 24953653

Ubiquitination-deficient mutations in human Piwi cause male infertility by impairing histone-to-protamine exchange during spermiogenesis. PubMed ID: 28552346