Stk4 | ENSMUSG00000018209 | NCBI 58231

Details for: Stk4

Gene ID: 58231

Symbol: Stk4

Ensembl ID: ENSMUSG00000018209

Description: serine/threonine kinase 4

Associated with

Signaling by hippo
(R-MMU-2028269)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Branching involved in blood vessel morphogenesis
(GO:0001569)
Canonical wnt signaling pathway
(GO:0060070)
Cell differentiation involved in embryonic placenta development
(GO:0060706)
Cell morphogenesis
(GO:0000902)
Cell population proliferation
(GO:0008283)
Central nervous system development
(GO:0007417)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endocardium development
(GO:0003157)
Epithelial cell proliferation
(GO:0050673)
Extrinsic apoptotic signaling pathway via death domain receptors
(GO:0008625)
Hepatocyte apoptotic process
(GO:0097284)
Hippo signaling
(GO:0035329)
Identical protein binding
(GO:0042802)
Intracellular signal transduction
(GO:0035556)
Keratinocyte differentiation
(GO:0030216)
Kinase activity
(GO:0016301)
Magnesium ion binding
(GO:0000287)
Metal ion binding
(GO:0046872)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of organ growth
(GO:0046621)
Neural tube formation
(GO:0001841)
Nuclear body
(GO:0016604)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Organ growth
(GO:0035265)
Peptidyl-serine phosphorylation
(GO:0018105)
Phosphorylation
(GO:0016310)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
(GO:1902043)
Positive regulation of fat cell differentiation
(GO:0045600)
Positive regulation of hepatocyte apoptotic process
(GO:1903945)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of protein binding
(GO:0032092)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of substrate-dependent cell migration, cell attachment to substrate
(GO:1904237)
Positive regulation of vascular associated smooth muscle cell apoptotic process
(GO:1905461)
Primitive hemopoiesis
(GO:0060215)
Protein-containing complex
(GO:0032991)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein import into nucleus
(GO:0006606)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein stabilization
(GO:0050821)
Protein tetramerization
(GO:0051262)
Regulation of cell differentiation involved in embryonic placenta development
(GO:0060800)
Regulation of mapk cascade
(GO:0043408)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Signal transduction
(GO:0007165)
Transferase activity
(GO:0016740)

Other Information

Proteins

Serine/threonine-protein kinase 4

Genular Protein ID: 632013610

Symbol: STK4_MOUSE

Name: Serine/threonine-protein kinase 4

UniProtKB Accession Codes:

Q9JI11

Database IDs:

Citations:

PubMed ID: 11278283

Title: MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation.

PubMed ID: 11278283

DOI: 10.1074/jbc.m005109200

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15345747

Title: Phosphoproteomic analysis of the developing mouse brain.

PubMed ID: 15345747

DOI: 10.1074/mcp.m400085-mcp200

PubMed ID: 17947660

Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.

PubMed ID: 17947660

DOI: 10.4049/jimmunol.179.9.5864

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20080689

Title: Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver.

PubMed ID: 20080689

DOI: 10.1073/pnas.0911427107

PubMed ID: 28087714

Title: DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.

PubMed ID: 28087714

DOI: 10.1101/gad.284539.116

Sequence Information:

Length: 487
Mass: 55541
Checksum: A21E9519AD209C40
Sequence:

METVQLRNPP RRQLKKLDED SLTKQPEEVF DVLEKLGEGS YGSVYKAIHK ETGQIVAIKQ 
VPVESDLQEI IKEISIMQQC DSPHVVKYYG SYFKNTDLWI VMEYCGAGSV SDIIRLRNKT 
LTEDEIATIL QSTLKGLEYL HFMRKIHRDI KAGNILLNTE GHAKLADFGV AGQLTDTMAK 
RNTVIGTPFW MAPEVIQEIG YNCVADIWSL GITAIEMAEG KPPYADIHPM RAIFMIPTNP 
PPTFRKPELW SDNFMDFVKQ CLVKSPEQRA TATQLLQHPF VKSAKGVSIL RDLINEAMDV 
KLKRQEAQQR EVDQDDEENS EEDEMDSGTM VRAAGDEMGT VRVASTMSGG ANTMIEHGDT 
LPSQLGTMVI NTEDEEEEGT MKRRDETMQP AKPSFLEYFE QKEKENQINS FGKNVSGSLK 
NSSDWKIPQD GDYEFLKSWT VEDLQKRLLA LDPMMEQEME EIRQKYRSKR QPILDAIEAK 
KRRQQNF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Stk4

Associated with

Other Information

MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation. PubMed ID: 11278283

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Phosphoproteomic analysis of the developing mouse brain. PubMed ID: 15345747

Quantitative time-resolved phosphoproteomic analysis of mast cell signaling. PubMed ID: 17947660

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. PubMed ID: 20080689

DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2. PubMed ID: 28087714