RHOU | ENSG00000116574 | NCBI 58480

Details for: RHOU

Gene ID: 58480

Symbol: RHOU

Ensembl ID: ENSG00000116574

Description: ras homolog family member U

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Immune system
(R-HSA-168256)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Rho gtpase cycle
(R-HSA-9012999)
Rhou gtpase cycle
(R-HSA-9013420)
Signaling by interleukins
(R-HSA-449147)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Actin filament organization
(GO:0007015)
Cdc42 protein signal transduction
(GO:0032488)
Cell projection
(GO:0042995)
Cytoskeleton organization
(GO:0007010)
Cytosol
(GO:0005829)
Endocytosis
(GO:0006897)
Endosome membrane
(GO:0010008)
Establishment or maintenance of cell polarity
(GO:0007163)
Focal adhesion
(GO:0005925)
G1/s transition of mitotic cell cycle
(GO:0000082)
Golgi membrane
(GO:0000139)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Guanyl-nucleotide exchange factor activity
(GO:0005085)
Metal ion binding
(GO:0046872)
Plasma membrane
(GO:0005886)
Podosome
(GO:0002102)
Positive regulation of protein targeting to mitochondrion
(GO:1903955)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Rac protein signal transduction
(GO:0016601)
Regulation of cell shape
(GO:0008360)
Regulation of small gtpase mediated signal transduction
(GO:0051056)

Other Information

Proteins

Rho-related GTP-binding protein RhoU

Genular Protein ID: 3152474490

Symbol: RHOU_HUMAN

Name: Rho-related GTP-binding protein RhoU

UniProtKB Accession Codes:

Q7L0Q8 B1AKN1 Q59FE9 Q8TDQ2

Database IDs:

Citations:

PubMed ID: 11459829

Title: Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1.

PubMed ID: 11459829

DOI: 10.1101/gad.894301

PubMed ID: 11894124

Title: Expression of WRCH1 in human cancer and down-regulation of WRCH1 by beta-estradiol in MCF-7 cells.

PubMed ID: 11894124

PubMed ID: 14731133

Title: Novel human, mouse and Xenopus genes encoding a member of the RAS superfamily of low-molecular-weight GTP-binding proteins and its downregulation in W/WV mouse jejunum.

PubMed ID: 14731133

DOI: 10.1111/j.1440-1746.2004.03298.x

PubMed ID: 16751668

Title: Scan of human genome reveals no new loci under ancient balancing selection.

PubMed ID: 16751668

DOI: 10.1534/genetics.106.055715

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16046391

Title: Transforming activity of the Rho family GTPase, Wrch-1, a Wnt-regulated Cdc42 homolog, is dependent on a novel carboxyl-terminal palmitoylation motif.

PubMed ID: 16046391

DOI: 10.1074/jbc.m507362200

PubMed ID: 16472646

Title: Biochemical analyses of the Wrch atypical Rho family GTPases.

PubMed ID: 16472646

DOI: 10.1016/s0076-6879(06)06002-2

PubMed ID: 17620058

Title: Identification of a bipartite focal adhesion localization signal in RhoU/Wrch-1, a Rho family GTPase that regulates cell adhesion and migration.

PubMed ID: 17620058

DOI: 10.1042/bc20070058

PubMed ID: 18086875

Title: The atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics.

PubMed ID: 18086875

DOI: 10.1128/mcb.00201-07

PubMed ID: 21834987

Title: Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration.

PubMed ID: 21834987

DOI: 10.1186/1741-7007-9-54

PubMed ID: 21565175

Title: ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion.

PubMed ID: 21565175

DOI: 10.1016/j.bbrc.2011.04.116

Sequence Information:

Length: 258
Mass: 28218
Checksum: D90059DE82288B97
Sequence:

MPPQQGDPAF PDRCEAPPVP PRRERGGRGG RGPGEPGGRG RAGGAEGRGV KCVLVGDGAV 
GKTSLVVSYT TNGYPTEYIP TAFDNFSAVV SVDGRPVRLQ LCDTAGQDEF DKLRPLCYTN 
TDIFLLCFSV VSPSSFQNVS EKWVPEIRCH CPKAPIILVG TQSDLREDVK VLIELDKCKE 
KPVPEEAAKL CAEEIKAASY IECSALTQKN LKEVFDAAIV AGIQYSDTQQ QPKKSKSRTP 
DKMKNLSKSW WKKYCCFV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RHOU

Associated with

Other Information

Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. PubMed ID: 11459829

Expression of WRCH1 in human cancer and down-regulation of WRCH1 by beta-estradiol in MCF-7 cells. PubMed ID: 11894124

Novel human, mouse and Xenopus genes encoding a member of the RAS superfamily of low-molecular-weight GTP-binding proteins and its downregulation in W/WV mouse jejunum. PubMed ID: 14731133

Scan of human genome reveals no new loci under ancient balancing selection. PubMed ID: 16751668

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Transforming activity of the Rho family GTPase, Wrch-1, a Wnt-regulated Cdc42 homolog, is dependent on a novel carboxyl-terminal palmitoylation motif. PubMed ID: 16046391

Biochemical analyses of the Wrch atypical Rho family GTPases. PubMed ID: 16472646

Identification of a bipartite focal adhesion localization signal in RhoU/Wrch-1, a Rho family GTPase that regulates cell adhesion and migration. PubMed ID: 17620058

The atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics. PubMed ID: 18086875

Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. PubMed ID: 21834987

ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion. PubMed ID: 21565175