NLRC4 | ENSG00000091106 | NCBI 58484

Details for: NLRC4

Gene ID: 58484

Symbol: NLRC4

Ensembl ID: ENSG00000091106

Description: NLR family CARD domain containing 4

Associated with

Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Inflammasomes
(R-HSA-622312)
Innate immune system
(R-HSA-168249)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Rna polymerase ii transcription
(R-HSA-73857)
The ipaf inflammasome
(R-HSA-844623)
Tp53 regulates transcription of caspase activators and caspases
(R-HSA-6803207)
Tp53 regulates transcription of cell death genes
(R-HSA-5633008)
Transcriptional regulation by tp53
(R-HSA-3700989)
Activation of cysteine-type endopeptidase activity
(GO:0097202)
Activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)
Activation of innate immune response
(GO:0002218)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Canonical inflammasome complex
(GO:0061702)
Caspase binding
(GO:0089720)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to bacterium
(GO:0042742)
Detection of bacterium
(GO:0016045)
Endopeptidase activator activity
(GO:0061133)
Icosanoid biosynthetic process
(GO:0046456)
Identical protein binding
(GO:0042802)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Intracellular membrane-bounded organelle
(GO:0043231)
Ipaf inflammasome complex
(GO:0072557)
Magnesium ion binding
(GO:0000287)
Pattern recognition receptor signaling pathway
(GO:0002221)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of protein processing
(GO:0010954)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein homooligomerization
(GO:0051260)
Pyroptosis
(GO:0070269)

Other Information

Proteins

NLR family CARD domain-containing protein 4

Genular Protein ID: 4059991602

Symbol: NLRC4_HUMAN

Name: NLR family CARD domain-containing protein 4

UniProtKB Accession Codes:

Q9NPP4 A8K9F8 B2RBQ3 B3KTF0 D6W580 Q96J81 Q96J82 Q96J83

Database IDs:

Citations:

PubMed ID: 11374873

Title: Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis.

PubMed ID: 11374873

DOI: 10.1006/bbrc.2001.4928

PubMed ID: 11472070

Title: CLAN, a novel human CED-4-like gene.

PubMed ID: 11472070

DOI: 10.1006/geno.2001.6579

PubMed ID: 11390368

Title: Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1.

PubMed ID: 11390368

DOI: 10.1074/jbc.c100250200

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15107016

Title: Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses.

PubMed ID: 15107016

DOI: 10.1042/bj20031506

PubMed ID: 22801494

Title: Novel role of PKR in inflammasome activation and HMGB1 release.

PubMed ID: 22801494

DOI: 10.1038/nature11290

PubMed ID: 33420028

Title: Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8.

PubMed ID: 33420028

DOI: 10.1038/s41467-020-20319-5

PubMed ID: 25385754

Title: An inherited mutation in NLRC4 causes autoinflammation in human and mice.

PubMed ID: 25385754

DOI: 10.1084/jem.20141091

PubMed ID: 25217960

Title: Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation.

PubMed ID: 25217960

DOI: 10.1038/ng.3066

PubMed ID: 25217959

Title: An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome.

PubMed ID: 25217959

DOI: 10.1038/ng.3089

Sequence Information:

Length: 1024
Mass: 116159
Checksum: 49378DBB54938E0F
Sequence:

MNFIKDNSRA LIQRMGMTVI KQITDDLFVW NVLNREEVNI ICCEKVEQDA ARGIIHMILK 
KGSESCNLFL KSLKEWNYPL FQDLNGQSLF HQTSEGDLDD LAQDLKDLYH TPSFLNFYPL 
GEDIDIIFNL KSTFTEPVLW RKDQHHHRVE QLTLNGLLQA LQSPCIIEGE SGKGKSTLLQ 
RIAMLWGSGK CKALTKFKFV FFLRLSRAQG GLFETLCDQL LDIPGTIRKQ TFMAMLLKLR 
QRVLFLLDGY NEFKPQNCPE IEALIKENHR FKNMVIVTTT TECLRHIRQF GALTAEVGDM 
TEDSAQALIR EVLIKELAEG LLLQIQKSRC LRNLMKTPLF VVITCAIQMG ESEFHSHTQT 
TLFHTFYDLL IQKNKHKHKG VAASDFIRSL DHCGDLALEG VFSHKFDFEL QDVSSVNEDV 
LLTTGLLCKY TAQRFKPKYK FFHKSFQEYT AGRRLSSLLT SHEPEEVTKG NGYLQKMVSI 
SDITSTYSSL LRYTCGSSVE ATRAVMKHLA AVYQHGCLLG LSIAKRPLWR QESLQSVKNT 
TEQEILKAIN INSFVECGIH LYQESTSKSA LSQEFEAFFQ GKSLYINSGN IPDYLFDFFE 
HLPNCASALD FIKLDFYGGA MASWEKAAED TGGIHMEEAP ETYIPSRAVS LFFNWKQEFR 
TLEVTLRDFS KLNKQDIRYL GKIFSSATSL RLQIKRCAGV AGSLSLVLST CKNIYSLMVE 
ASPLTIEDER HITSVTNLKT LSIHDLQNQR LPGGLTDSLG NLKNLTKLIM DNIKMNEEDA 
IKLAEGLKNL KKMCLFHLTH LSDIGEGMDY IVKSLSSEPC DLEEIQLVSC CLSANAVKIL 
AQNLHNLVKL SILDLSENYL EKDGNEALHE LIDRMNVLEQ LTALMLPWGC DVQGSLSSLL 
KHLEEVPQLV KLGLKNWRLT DTEIRILGAF FGKNPLKNFQ QLNLAGNRVS SDGWLAFMGV 
FENLKQLVFF DFSTKEFLPD PALVRKLSQV LSKLTFLQEA RLVGWQFDDD DLSVITGAFK 
LVTA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NLRC4

Associated with

Other Information

Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis. PubMed ID: 11374873

CLAN, a novel human CED-4-like gene. PubMed ID: 11472070

Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1. PubMed ID: 11390368

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses. PubMed ID: 15107016

Novel role of PKR in inflammasome activation and HMGB1 release. PubMed ID: 22801494

Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8. PubMed ID: 33420028

An inherited mutation in NLRC4 causes autoinflammation in human and mice. PubMed ID: 25385754

Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation. PubMed ID: 25217960

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome. PubMed ID: 25217959