JAM2 | ENSG00000154721 | NCBI 58494

Details for: JAM2

Gene ID: 58494

Symbol: JAM2

Ensembl ID: ENSG00000154721

Description: junctional adhesion molecule 2

Associated with

Cell surface interactions at the vascular wall
(R-HSA-202733)
Extracellular matrix organization
(R-HSA-1474244)
Hemostasis
(R-HSA-109582)
Integrin cell surface interactions
(R-HSA-216083)
Bicellular tight junction
(GO:0005923)
Cell-cell adhesion
(GO:0098609)
Cell-cell contact zone
(GO:0044291)
Cell surface
(GO:0009986)
Cellular extravasation
(GO:0045123)
Hematopoietic stem cell migration to bone marrow
(GO:0097241)
Integrin binding
(GO:0005178)
Leukocyte cell-cell adhesion
(GO:0007159)
Leukocyte tethering or rolling
(GO:0050901)
Lymphocyte aggregation
(GO:0071593)
Maintenance of blood-brain barrier
(GO:0035633)
Myoblast fusion
(GO:0007520)
Negative regulation of myelination
(GO:0031642)
Plasma membrane
(GO:0005886)
Positive regulation of lymphocyte migration
(GO:2000403)
Protein binding
(GO:0005515)
Protein complex involved in cell adhesion
(GO:0098636)
Somatodendritic compartment
(GO:0036477)
Spermatid development
(GO:0007286)
Tight junction
(GO:0070160)

Other Information

Proteins

Junctional adhesion molecule B

Genular Protein ID: 1291334109

Symbol: JAM2_HUMAN

Name: Junctional adhesion molecule B

UniProtKB Accession Codes:

P57087 B2R6T9 B4DGT9 Q6UXG6 Q6YNC1

Database IDs:

Citations:

PubMed ID: 10779521

Title: Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells.

PubMed ID: 10779521

DOI: 10.1074/jbc.m003189200

PubMed ID: 10945976

Title: A novel protein with homology to the junctional adhesion molecule: Characterization of leukocyte interactions.

PubMed ID: 10945976

DOI: 10.1074/jbc.m002718200

PubMed ID: 12036298

Title: Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis.

PubMed ID: 12036298

DOI: 10.1006/geno.2002.6782

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 11590146

Title: Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor.

PubMed ID: 11590146

DOI: 10.1074/jbc.m105972200

PubMed ID: 12239159

Title: Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration.

PubMed ID: 12239159

DOI: 10.1182/blood-2001-11-0098

PubMed ID: 12070135

Title: JAM2 interacts with alpha4beta1. Facilitation by JAM3.

PubMed ID: 12070135

DOI: 10.1074/jbc.c200331200

PubMed ID: 11823489

Title: Vascular endothelial-junctional adhesion molecule (VE-JAM)/JAM 2 interacts with T, NK, and dendritic cells through JAM 3.

PubMed ID: 11823489

DOI: 10.4049/jimmunol.168.4.1618

PubMed ID: 12810109

Title: Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.

PubMed ID: 12810109

DOI: 10.1016/s1471-4906(03)00117-0

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 24357068

Title: Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells.

PubMed ID: 24357068

DOI: 10.1002/stem.1624

PubMed ID: 32142645

Title: Bi-allelic JAM2 Variants Lead to Early-Onset Recessive Primary Familial Brain Calcification.

PubMed ID: 32142645

DOI: 10.1016/j.ajhg.2020.02.007

PubMed ID: 31851307

Title: Biallelic loss-of-function mutations in JAM2 cause primary familial brain calcification.

PubMed ID: 31851307

DOI: 10.1093/brain/awz392

Sequence Information:

Length: 298
Mass: 33207
Checksum: CA78E518E22DCAEE
Sequence:

MARRSRHRLL LLLLRYLVVA LGYHKAYGFS APKDQQVVTA VEYQEAILAC KTPKKTVSSR 
LEWKKLGRSV SFVYYQQTLQ GDFKNRAEMI DFNIRIKNVT RSDAGKYRCE VSAPSEQGQN 
LEEDTVTLEV LVAPAVPSCE VPSSALSGTV VELRCQDKEG NPAPEYTWFK DGIRLLENPR 
LGSQSTNSSY TMNTKTGTLQ FNTVSKLDTG EYSCEARNSV GYRRCPGKRM QVDDLNISGI 
IAAVVVVALV ISVCGLGVCY AQRKGYFSKE TSFQKSNSSS KATTMSENDF KHTKSFII

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: JAM2

Associated with

Other Information

Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells. PubMed ID: 10779521

A novel protein with homology to the junctional adhesion molecule: Characterization of leukocyte interactions. PubMed ID: 10945976

Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis. PubMed ID: 12036298

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of human chromosome 21. PubMed ID: 10830953

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor. PubMed ID: 11590146

Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration. PubMed ID: 12239159

JAM2 interacts with alpha4beta1. Facilitation by JAM3. PubMed ID: 12070135

Vascular endothelial-junctional adhesion molecule (VE-JAM)/JAM 2 interacts with T, NK, and dendritic cells through JAM 3. PubMed ID: 11823489

Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. PubMed ID: 12810109

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. PubMed ID: 16335952

Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells. PubMed ID: 24357068

Bi-allelic JAM2 Variants Lead to Early-Onset Recessive Primary Familial Brain Calcification. PubMed ID: 32142645

Biallelic loss-of-function mutations in JAM2 cause primary familial brain calcification. PubMed ID: 31851307