Details for: OVOL2

Gene ID: 58495

Symbol: OVOL2

Ensembl ID: ENSG00000125850

Description: ovo like zinc finger 2

Associated with

  • Angiogenesis
    (GO:0001525)
  • Cell population proliferation
    (GO:0008283)
  • Chromatin binding
    (GO:0003682)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dorsal/ventral pattern formation
    (GO:0009953)
  • Embryonic digestive tract morphogenesis
    (GO:0048557)
  • Endocardium formation
    (GO:0060214)
  • Epidermal cell differentiation
    (GO:0009913)
  • Heart looping
    (GO:0001947)
  • Heart trabecula formation
    (GO:0060347)
  • Labyrinthine layer blood vessel development
    (GO:0060716)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of epithelial to mesenchymal transition
    (GO:0010719)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of smad protein signal transduction
    (GO:0060392)
  • Negative regulation of stem cell proliferation
    (GO:2000647)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of transforming growth factor beta receptor signaling pathway
    (GO:0030512)
  • Neural crest cell migration
    (GO:0001755)
  • Neural fold formation
    (GO:0001842)
  • Nucleus
    (GO:0005634)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of keratinocyte differentiation
    (GO:0045618)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of keratinocyte proliferation
    (GO:0010837)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Other Information

Genular Protein ID: 583445981

Symbol: OVOL2_HUMAN

Name: Zinc finger protein 339

UniProtKB Accession Codes:

Q9BRP0 Q5T8B4 Q9BX22 Q9HA54 Q9Y4M0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 1 GO 33 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12213202

Title: Ovol2, a mammalian homolog of Drosophila ovo: gene structure, chromosomal mapping, and aberrant expression in blind-sterile mice.

PubMed ID: 12213202

DOI: 10.1006/geno.2002.6831

PubMed ID: 19700410

Title: Ovol2 suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing c-Myc and Notch1.

PubMed ID: 19700410

DOI: 10.1074/jbc.m109.008847

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 26749309

Title: Autosomal-dominant corneal endothelial dystrophies CHED1 and PPCD1 are allelic disorders caused by non-coding mutations in the promoter of OVOL2.

PubMed ID: 26749309

DOI: 10.1016/j.ajhg.2015.11.018

Sequence Information:

  • Length: 275
  • Mass: 30438
  • Checksum: 3563EC44510E04AB
  • Sequence:
    • MPKVFLVKRR SLGVSVRSWD ELPDEKRADT YIPVGLGRLL HDPPEDCRSD GGSSSGSGSS 
SAGEPGGAES SSSPHAPESE TPEPGDAEGP DGHLATKQRP VARSKIKFTT GTCSDSVVHS 
CDLCGKGFRL QRMLNRHLKC HNQVKRHLCT FCGKGFNDTF DLKRHVRTHT GIRPYKCNVC 
NKAFTQRCSL ESHLKKIHGV QQQYAYKQRR DKLYVCEDCG YTGPTQEDLY LHVNSAHPGS 
SFLKKTSKKL AALLQGKLTS AHQENTSLSE EEERK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.