RRAGD | ENSG00000025039 | NCBI 58528

Details for: RRAGD

Gene ID: 58528

Symbol: RRAGD

Ensembl ID: ENSG00000025039

Description: Ras related GTP binding D

Associated with

Amino acids regulate mtorc1
(R-HSA-9639288)
Autophagy
(R-HSA-9612973)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Energy dependent regulation of mtor by lkb1-ampk
(R-HSA-380972)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Intracellular signaling by second messengers
(R-HSA-9006925)
Macroautophagy
(R-HSA-1632852)
Mtorc1-mediated signalling
(R-HSA-166208)
Mtor signalling
(R-HSA-165159)
Pip3 activates akt signaling
(R-HSA-1257604)
Pten regulation
(R-HSA-6807070)
Regulation of pten gene transcription
(R-HSA-8943724)
Rna polymerase ii transcription
(R-HSA-73857)
Signal transduction
(R-HSA-162582)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by tp53
(R-HSA-3700989)
Cellular response to amino acid stimulus
(GO:0071230)
Cellular response to leucine
(GO:0071233)
Cellular response to leucine starvation
(GO:1990253)
Cellular response to starvation
(GO:0009267)
Centrosome
(GO:0005813)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Gdp binding
(GO:0019003)
Gtpase activity
(GO:0003924)
Gtpase binding
(GO:0051020)
Gtp binding
(GO:0005525)
Gtr1-gtr2 gtpase complex
(GO:1990131)
Intracellular membrane-bounded organelle
(GO:0043231)
Lysosomal membrane
(GO:0005765)
Lysosome
(GO:0005764)
Molecular adaptor activity
(GO:0060090)
Negative regulation of autophagy
(GO:0010507)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of torc1 signaling
(GO:1904263)
Positive regulation of tor signaling
(GO:0032008)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein localization
(GO:0008104)

Other Information

Proteins

Ras-related GTP-binding protein D

Genular Protein ID: 3633786259

Symbol: RRAGD_HUMAN

Name: Ras-related GTP-binding protein D

UniProtKB Accession Codes:

Q9NQL2 A8K184 Q7L8F9 Q9NPG0

Database IDs:

Citations:

PubMed ID: 11073942

Title: Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B.

PubMed ID: 11073942

DOI: 10.1074/jbc.m004389200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14660641

Title: A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D.

PubMed ID: 14660641

DOI: 10.1074/jbc.m305935200

PubMed ID: 18497260

Title: The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.

PubMed ID: 18497260

DOI: 10.1126/science.1157535

PubMed ID: 20381137

Title: Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

PubMed ID: 20381137

DOI: 10.1016/j.cell.2010.02.024

PubMed ID: 22575674

Title: SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling.

PubMed ID: 22575674

DOI: 10.1016/j.molcel.2012.04.007

PubMed ID: 24095279

Title: The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.

PubMed ID: 24095279

DOI: 10.1016/j.molcel.2013.09.016

PubMed ID: 25259925

Title: Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.

PubMed ID: 25259925

DOI: 10.1016/j.cell.2014.08.038

PubMed ID: 25561175

Title: SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.

PubMed ID: 25561175

DOI: 10.1038/nature14107

PubMed ID: 25567906

Title: Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.

PubMed ID: 25567906

DOI: 10.1126/science.1257132

PubMed ID: 32612235

Title: A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dube syndrome.

PubMed ID: 32612235

DOI: 10.1038/s41586-020-2444-0

PubMed ID: 34607910

Title: mTOR-Activating Mutations in RRAGD Are Causative for Kidney Tubulopathy and Cardiomyopathy.

PubMed ID: 34607910

DOI: 10.1681/asn.2021030333

Sequence Information:

Length: 400
Mass: 45588
Checksum: 96FF0854B11AA1BC
Sequence:

MSQVLGKPQP QDEDDAEEEE EEDELVGLAD YGDGPDSSDA DPDSGTEEGV LDFSDPFSTE 
VKPRILLMGL RRSGKSSIQK VVFHKMSPNE TLFLESTNKI CREDVSNSSF VNFQIWDFPG 
QIDFFDPTFD YEMIFRGTGA LIFVIDSQDD YMEALARLHL TVTRAYKVNT DINFEVFIHK 
VDGLSDDHKI ETQRDIHQRA NDDLADAGLE KIHLSFYLTS IYDHSIFEAF SKVVQKLIPQ 
LPTLENLLNI FISNSGIEKA FLFDVVSKIY IATDSTPVDM QTYELCCDMI DVVIDISCIY 
GLKEDGAGTP YDKESTAIIK LNNTTVLYLK EVTKFLALVC FVREESFERK GLIDYNFHCF 
RKAIHEVFEV RMKVVKSRKV QNRLQKKKRA TPNGTPRVLL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RRAGD

Associated with

Other Information

Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. PubMed ID: 11073942

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D. PubMed ID: 14660641

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. PubMed ID: 18497260

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. PubMed ID: 20381137

SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling. PubMed ID: 22575674

The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. PubMed ID: 24095279

Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling. PubMed ID: 25259925

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. PubMed ID: 25561175

Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. PubMed ID: 25567906

A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dube syndrome. PubMed ID: 32612235

mTOR-Activating Mutations in RRAGD Are Causative for Kidney Tubulopathy and Cardiomyopathy. PubMed ID: 34607910