Details for: BCAT1

Gene ID: 586

Symbol: BCAT1

Ensembl ID: ENSG00000060982

Description: branched chain amino acid transaminase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 122.2188
    Cell Significance Index: -31.0000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 81.4909
    Cell Significance Index: -33.5700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 57.0324
    Cell Significance Index: -38.2700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.0764
    Cell Significance Index: -29.6700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.3380
    Cell Significance Index: -36.1700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.2297
    Cell Significance Index: -20.2000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 8.0450
    Cell Significance Index: 62.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.9690
    Cell Significance Index: 51.7800
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 1.4099
    Cell Significance Index: 12.4200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2990
    Cell Significance Index: 709.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0503
    Cell Significance Index: 376.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0101
    Cell Significance Index: 202.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.8515
    Cell Significance Index: 145.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8270
    Cell Significance Index: 113.5700
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.6327
    Cell Significance Index: 7.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5548
    Cell Significance Index: 64.6600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4544
    Cell Significance Index: 314.3000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4071
    Cell Significance Index: 26.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3696
    Cell Significance Index: 22.7200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3205
    Cell Significance Index: 12.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2916
    Cell Significance Index: 12.9000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2411
    Cell Significance Index: 5.2800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1689
    Cell Significance Index: 19.9200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1596
    Cell Significance Index: 1.9800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0910
    Cell Significance Index: 10.3900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0713
    Cell Significance Index: 1.7100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0401
    Cell Significance Index: 0.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0067
    Cell Significance Index: 0.1800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0037
    Cell Significance Index: 0.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0031
    Cell Significance Index: 0.2100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0015
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0131
    Cell Significance Index: -24.6700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0163
    Cell Significance Index: -12.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0213
    Cell Significance Index: -39.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0222
    Cell Significance Index: -16.4800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0236
    Cell Significance Index: -36.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0268
    Cell Significance Index: -16.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0295
    Cell Significance Index: -40.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0438
    Cell Significance Index: -27.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0467
    Cell Significance Index: -26.3200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0534
    Cell Significance Index: -0.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0629
    Cell Significance Index: -28.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0663
    Cell Significance Index: -29.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0774
    Cell Significance Index: -15.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0906
    Cell Significance Index: -9.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1024
    Cell Significance Index: -29.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1197
    Cell Significance Index: -25.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1378
    Cell Significance Index: -24.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1850
    Cell Significance Index: -26.8900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2201
    Cell Significance Index: -28.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2285
    Cell Significance Index: -28.0900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2286
    Cell Significance Index: -5.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2311
    Cell Significance Index: -26.4800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2394
    Cell Significance Index: -5.0800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2563
    Cell Significance Index: -4.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2767
    Cell Significance Index: -35.7500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2939
    Cell Significance Index: -7.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3015
    Cell Significance Index: -15.8300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.3259
    Cell Significance Index: -3.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3374
    Cell Significance Index: -35.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3803
    Cell Significance Index: -17.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4089
    Cell Significance Index: -31.3800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4118
    Cell Significance Index: -32.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4443
    Cell Significance Index: -31.4200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4497
    Cell Significance Index: -6.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4799
    Cell Significance Index: -35.7700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4870
    Cell Significance Index: -9.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4874
    Cell Significance Index: -13.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4977
    Cell Significance Index: -27.9300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5048
    Cell Significance Index: -10.1400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5304
    Cell Significance Index: -11.4600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5339
    Cell Significance Index: -10.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5356
    Cell Significance Index: -33.7600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5366
    Cell Significance Index: -27.9500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6044
    Cell Significance Index: -19.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6582
    Cell Significance Index: -34.1900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6741
    Cell Significance Index: -22.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6820
    Cell Significance Index: -32.0600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.7055
    Cell Significance Index: -9.0400
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.7168
    Cell Significance Index: -8.9100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7225
    Cell Significance Index: -25.3100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7493
    Cell Significance Index: -18.6900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.7819
    Cell Significance Index: -9.7500
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.7954
    Cell Significance Index: -13.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.8126
    Cell Significance Index: -17.0100
  • Cell Name: diffuse bipolar 2 cell (CL4033028)
    Fold Change: -0.8223
    Cell Significance Index: -10.1000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8287
    Cell Significance Index: -24.4100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.8301
    Cell Significance Index: -17.3300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.8374
    Cell Significance Index: -9.4600
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -0.8426
    Cell Significance Index: -10.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8477
    Cell Significance Index: -23.6900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8960
    Cell Significance Index: -32.8900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.9018
    Cell Significance Index: -12.9500
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.9246
    Cell Significance Index: -11.9900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.9317
    Cell Significance Index: -32.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.0348
    Cell Significance Index: -36.3600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.0352
    Cell Significance Index: -17.7400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.0399
    Cell Significance Index: -19.2200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -1.0443
    Cell Significance Index: -8.6200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.0478
    Cell Significance Index: -13.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BCAT1 is a cytosolic enzyme that catalyzes the conversion of branched-chain amino acids (leucine, isoleucine, and valine) into their corresponding keto-acids. This reaction is essential for the regulation of amino acid metabolism, as it allows for the generation of energy and the synthesis of various biomolecules. BCAT1 is also involved in the regulation of the G1/s transition of the mitotic cell cycle, suggesting its role in cell proliferation and differentiation. **Pathways and Functions:** BCAT1 is involved in several key pathways, including: 1. **Branched-chain-amino-acid transaminase activity**: BCAT1 catalyzes the conversion of branched-chain amino acids into their corresponding keto-acids, which is essential for amino acid metabolism. 2. **Branched-chain amino acid biosynthetic process**: BCAT1 is involved in the synthesis of branched-chain amino acids, which are essential for protein synthesis and other cellular processes. 3. **Branched-chain amino acid catabolism**: BCAT1 is also involved in the breakdown of branched-chain amino acids, which is essential for energy production and the regulation of amino acid metabolism. 4. **Cytosol**: BCAT1 is localized to the cytosol, where it plays a crucial role in the regulation of amino acid metabolism. 5. **Mitochondrion**: BCAT1 is also localized to the mitochondrion, where it is involved in the regulation of energy production and the synthesis of various biomolecules. **Clinical Significance:** BCAT1 has significant implications for various diseases, including: 1. **Metabolic disorders**: BCAT1 is involved in the regulation of amino acid metabolism, which is essential for the treatment of metabolic disorders, such as hepatic encephalopathy. 2. **Neurological disorders**: BCAT1 is expressed in neurons and is involved in the regulation of amino acid metabolism, which is essential for the treatment of neurological disorders, such as Parkinson's disease. 3. **Cancer**: BCAT1 is overexpressed in various types of cancer, including pancreatic cancer, and is involved in the regulation of amino acid metabolism, which is essential for cancer progression. 4. **Neurodevelopmental disorders**: BCAT1 is involved in the regulation of amino acid metabolism, which is essential for the treatment of neurodevelopmental disorders, such as autism spectrum disorder. In conclusion, BCAT1 is a critical enzyme involved in the regulation of amino acid metabolism, and its dysregulation has significant implications for various diseases. Further research is needed to fully understand the role of BCAT1 in immunological and metabolic processes, and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 1594714121

Symbol: BCAT1_HUMAN

Name: Branched-chain-amino-acid aminotransferase, cytosolic

UniProtKB Accession Codes:

P54687 B3KY27 B7Z2M5 B7Z5L0 F5H5E4 Q68DQ7 Q96MY9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 7 EC 4 EMBL 9 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 15 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 Rhea 3 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8692959

Title: ECA39, a conserved gene regulated by c-Myc in mice, is involved in G1/S cell cycle regulation in yeast.

PubMed ID: 8692959

DOI: 10.1073/pnas.93.14.7143

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 16141215

Title: Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin.

PubMed ID: 16141215

DOI: 10.1074/jbc.m506486200

PubMed ID: 16143519

Title: The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases.

PubMed ID: 16143519

DOI: 10.1016/j.bmcl.2005.07.058

Sequence Information:

  • Length: 386
  • Mass: 42966
  • Checksum: A43535303A702512
  • Sequence:
    • MKDCSNGCSA ECTGEGGSKE VVGTFKAKDL IVTPATILKE KPDPNNLVFG TVFTDHMLTV 
EWSSEFGWEK PHIKPLQNLS LHPGSSALHY AVELFEGLKA FRGVDNKIRL FQPNLNMDRM 
YRSAVRATLP VFDKEELLEC IQQLVKLDQE WVPYSTSASL YIRPTFIGTE PSLGVKKPTK 
ALLFVLLSPV GPYFSSGTFN PVSLWANPKY VRAWKGGTGD CKMGGNYGSS LFAQCEAVDN 
GCQQVLWLYG EDHQITEVGT MNLFLYWINE DGEEELATPP LDGIILPGVT RRCILDLAHQ 
WGEFKVSERY LTMDDLTTAL EGNRVREMFG SGTACVVCPV SDILYKGETI HIPTMENGPK 
LASRILSKLT DIQYGREESD WTIVLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.