Details for: BCAT1

Gene ID: 586

Symbol: BCAT1

Ensembl ID: ENSG00000060982

Description: branched chain amino acid transaminase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 3.24
    Marker Score: 2796
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.98
    Marker Score: 4172
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.79
    Marker Score: 3640
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.77
    Marker Score: 18231
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.75
    Marker Score: 7273
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.69
    Marker Score: 25322
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.69
    Marker Score: 62449
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.66
    Marker Score: 33060
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.65
    Marker Score: 15503
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.62
    Marker Score: 7486
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.61
    Marker Score: 61287
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.59
    Marker Score: 12162
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.57
    Marker Score: 6051
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.51
    Marker Score: 6156.5
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168233
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.44
    Marker Score: 49980
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4
    Marker Score: 86028
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.33
    Marker Score: 2051
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.3
    Marker Score: 12363
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.3
    Marker Score: 418
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.29
    Marker Score: 878
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.28
    Marker Score: 12876
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.28
    Marker Score: 1375
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.25
    Marker Score: 2993.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.23
    Marker Score: 3355
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.23
    Marker Score: 678
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.23
    Marker Score: 13841
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.21
    Marker Score: 1296
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.2
    Marker Score: 915
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.19
    Marker Score: 864
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.18
    Marker Score: 1193
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.18
    Marker Score: 4636
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.17
    Marker Score: 828
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.16
    Marker Score: 5024
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.16
    Marker Score: 475
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.11
    Marker Score: 1339
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.1
    Marker Score: 1263
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.1
    Marker Score: 548
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.08
    Marker Score: 376.5
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.07
    Marker Score: 568
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.06
    Marker Score: 618
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.06
    Marker Score: 301
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.06
    Marker Score: 9094
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.05
    Marker Score: 990
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.05
    Marker Score: 586
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.03
    Marker Score: 843
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.02
    Marker Score: 1447
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.02
    Marker Score: 696
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.02
    Marker Score: 199
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.01
    Marker Score: 1243
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1
    Marker Score: 6531
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71773
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47997
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.98
    Marker Score: 6383
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.97
    Marker Score: 584
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.97
    Marker Score: 223
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.97
    Marker Score: 544
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.96
    Marker Score: 15423
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.95
    Marker Score: 32172
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.93
    Marker Score: 500
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5248
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.92
    Marker Score: 456
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.91
    Marker Score: 574
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2731
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.9
    Marker Score: 379
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5274
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.87
    Marker Score: 5272
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.85
    Marker Score: 539
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.84
    Marker Score: 11119
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.84
    Marker Score: 878
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.83
    Marker Score: 12952
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.82
    Marker Score: 8348
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.82
    Marker Score: 4943
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.81
    Marker Score: 427
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.79
    Marker Score: 195
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.78
    Marker Score: 283
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 597.5
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.78
    Marker Score: 3249
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.77
    Marker Score: 2095
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1249
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.76
    Marker Score: 812
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 697
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.76
    Marker Score: 244
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.76
    Marker Score: 1833
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.75
    Marker Score: 1956
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.75
    Marker Score: 425
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.75
    Marker Score: 562
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.74
    Marker Score: 3902
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1182
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.73
    Marker Score: 1793.5
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.72
    Marker Score: 801
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.72
    Marker Score: 352
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.71
    Marker Score: 713
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.71
    Marker Score: 225.5
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.71
    Marker Score: 465
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.69
    Marker Score: 976
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176

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Other Information

**Key characteristics:** - The BCAT1 gene is located on chromosome 19p13.2. - It is a large gene with a length of approximately 11.5 kilobases. - BCAT1 has 13 exons and 12 introns. - It is expressed in a variety of cell types, including taste receptor cells, pancreatic acinar cells, immature innate lymphoid cells, dopaminergic neurons, chandelier pvalb GABAergic cortical interneurons, lamp5 GABAergic cortical interneurons, pvalb GABAergic cortical interneurons, sst GABAergic cortical interneurons, and near-projecting glutamatergic cortical neurons. **Pathways and functions:** - BCAT1 is involved in the branched-chain amino acid biosynthetic process and the branched-chain amino acid catabolism. - It is also involved in the cytosol, G1/s transition of the mitotic cell cycle, L-isoleucine transaminase activity, L-leucine:2-oxoglutarate aminotransferase activity, L-leucine transaminase activity, L-valine transaminase activity, and leucine biosynthetic process. **Clinical significance:** - Mutations in the BCAT1 gene have been linked to several human diseases, including autism, schizophrenia, and intellectual disability. - BCAT1 is a potential therapeutic target for these diseases, as it is involved in the biosynthesis of branched-chain amino acids, which are essential for the proper functioning of neurons.

Genular Protein ID: 1594714121

Symbol: BCAT1_HUMAN

Name: Branched-chain-amino-acid aminotransferase, cytosolic

UniProtKB Accession Codes:

P54687 B3KY27 B7Z2M5 B7Z5L0 F5H5E4 Q68DQ7 Q96MY9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 7 EC 4 EMBL 9 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 15 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 Rhea 3 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8692959

Title: ECA39, a conserved gene regulated by c-Myc in mice, is involved in G1/S cell cycle regulation in yeast.

PubMed ID: 8692959

DOI: 10.1073/pnas.93.14.7143

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 16141215

Title: Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin.

PubMed ID: 16141215

DOI: 10.1074/jbc.m506486200

PubMed ID: 16143519

Title: The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases.

PubMed ID: 16143519

DOI: 10.1016/j.bmcl.2005.07.058

Sequence Information:

  • Length: 386
  • Mass: 42966
  • Checksum: A43535303A702512
  • Sequence:
    • MKDCSNGCSA ECTGEGGSKE VVGTFKAKDL IVTPATILKE KPDPNNLVFG TVFTDHMLTV 
EWSSEFGWEK PHIKPLQNLS LHPGSSALHY AVELFEGLKA FRGVDNKIRL FQPNLNMDRM 
YRSAVRATLP VFDKEELLEC IQQLVKLDQE WVPYSTSASL YIRPTFIGTE PSLGVKKPTK 
ALLFVLLSPV GPYFSSGTFN PVSLWANPKY VRAWKGGTGD CKMGGNYGSS LFAQCEAVDN 
GCQQVLWLYG EDHQITEVGT MNLFLYWINE DGEEELATPP LDGIILPGVT RRCILDLAHQ 
WGEFKVSERY LTMDDLTTAL EGNRVREMFG SGTACVVCPV SDILYKGETI HIPTMENGPK 
LASRILSKLT DIQYGREESD WTIVLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.