Details for: BCAT1
Gene ID: 586
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: BCAT1
Ensembl ID: ENSG00000060982
Description: branched chain amino acid transaminase 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 35.27rCSI 48.22%PRS 61.75
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CSI 26.75rCSI 25.75%PRS 53.46
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CSI 26.34rCSI 39.15%PRS 55.3
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CSI 23.31rCSI 30.98%PRS 58.65
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CSI 12.18rCSI 22.8%PRS 42
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CSI 11.62rCSI 19.51%PRS 35.97
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CSI 11.58rCSI 23%PRS 51.21
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CSI 11.52rCSI 16.62%PRS 62.9
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CSI 11.21rCSI 17.83%PRS 45.59
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CSI 10rCSI 9.18%PRS 61.57
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CSI 9.58rCSI 18.08%PRS 63.62
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CSI 9.06rCSI 64.76%PRS 47.33
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CSI 8.78rCSI 68.04%PRS 49.81
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CSI 8.4rCSI 55.77%PRS 50.7
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CSI 8.09rCSI 6.7%PRS 54.68
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CSI 7.47rCSI 8.92%PRS 35.79
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CSI 7.21rCSI 22.54%PRS 39.84
-
CSI 6.91rCSI 26.11%PRS 36.76
-
CSI 6.63rCSI 4.96%PRS 68.47
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CSI 6.13rCSI 36.2%PRS 49.04
-
CSI 5.63rCSI 9.63%PRS 78.24
-
CSI 5.54rCSI 14.44%PRS 52.32
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CSI 5.41rCSI 6.97%PRS 37.01
-
CSI 5.33rCSI 13.54%PRS 48.22
-
CSI 4.67rCSI 3.69%PRS 40.25
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CSI 4.67rCSI 14.6%PRS 37.35
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CSI 4.67rCSI 3.1%PRS 56.68
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CSI 4.63rCSI 8.18%PRS 34.96
-
CSI 4.13rCSI 8.57%PRS 50.39
-
CSI 4rCSI 4.64%PRS 62.21
-
CSI 3.95rCSI 9.38%PRS 57.9
-
CSI 3.83rCSI 4.2%PRS 56.76
-
CSI 3.82rCSI 3.93%PRS 70.98
-
CSI 3.79rCSI 4.34%PRS 74.41
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CSI 3.56rCSI 4.11%PRS 46.97
-
CSI 3.52rCSI 4.88%PRS 55.94
-
CSI 3.52rCSI 3.51%PRS 46.77
-
CSI 3.47rCSI 4.45%PRS 50.79
-
CSI 3.42rCSI 13.92%PRS 48.99
-
CSI 3.36rCSI 4.67%PRS 52.31
-
CSI 3.33rCSI 3.01%PRS 49.92
-
CSI 3.3rCSI 2.86%PRS 57.77
-
CSI 3.29rCSI 4.09%PRS 34.22
-
CSI 3.23rCSI 18.24%PRS 38.62
-
CSI 3.22rCSI 2.6%PRS 54.28
-
CSI 3.11rCSI 7.18%PRS 43.21
-
CSI 3.09rCSI 3.74%PRS 61.49
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CSI 2.99rCSI 4.81%PRS 38.1
-
CSI 2.99rCSI 2.3%PRS 52.61
-
CSI 2.97rCSI 4.53%PRS 49.51
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CSI 2.97rCSI 3.81%PRS 46.97
-
CSI 2.91rCSI 38.06%PRS 70.21
-
CSI 2.89rCSI 4.36%PRS 56.12
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CSI 2.88rCSI 6.58%PRS 52.54
-
CSI 2.8rCSI 2.46%PRS 58.5
-
CSI 2.59rCSI 6.3%PRS 34.74
-
CSI 2.51rCSI 5.52%PRS 57.1
-
CSI 2.47rCSI 3.8%PRS 61.16
-
CSI 2.4rCSI 4.82%PRS 42.43
-
CSI 2.34rCSI 4.74%PRS 33.87
-
CSI 2.25rCSI 2.83%PRS 65.99
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CSI 2.23rCSI 5.36%PRS 61.81
-
CSI 2.22rCSI 2.66%PRS 51.17
-
CSI 2.16rCSI 3.91%PRS 70.99
-
CSI 2.08rCSI 4.66%PRS 71.95
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CSI 1.99rCSI 3.62%PRS 45.79
-
CSI 1.97rCSI 3.05%PRS 61.52
-
CSI 1.91rCSI 4.22%PRS 40.21
-
CSI 1.88rCSI 2.91%PRS 51.06
-
CSI 1.85rCSI 1.53%PRS 51.92
-
CSI 1.85rCSI 2.42%PRS 66.73
-
CSI 1.82rCSI 3%PRS 58.54
-
CSI 1.81rCSI 6.5%PRS 34.64
-
CSI 1.77rCSI 2.19%PRS 48.98
-
CSI 1.75rCSI 2.2%PRS 63.39
-
CSI 1.69rCSI 3.76%PRS 60.42
-
CSI 1.68rCSI 2.66%PRS 54.52
-
CSI 1.66rCSI 4.55%PRS 67.42
-
CSI 1.65rCSI 5.52%PRS 39.54
-
CSI 1.62rCSI 3.22%PRS 71.43
-
CSI 1.61rCSI 7.56%PRS 70.13
-
CSI 1.6rCSI 2.88%PRS 46.25
-
CSI 1.54rCSI 4.04%PRS 73.44
-
CSI 1.52rCSI 36.43%PRS 35.34
-
CSI 1.44rCSI 34.86%PRS 36.32
-
CSI 1.44rCSI 6.77%PRS 48.89
-
CSI 1.34rCSI 2.05%PRS 70.03
-
CSI 1.31rCSI 3.76%PRS 68.66
-
CSI 1.28rCSI 4.16%PRS 54.82
-
CSI 1.26rCSI 4.91%PRS 73.76
-
CSI 1.25rCSI 5.97%PRS 52.66
-
CSI 1.23rCSI 3.52%PRS 66.74
-
CSI 1.16rCSI 4.42%PRS 44.98
-
CSI 1.14rCSI 2.74%PRS 71.66
-
CSI 1.13rCSI 3.01%PRS 65.99
-
CSI 1.13rCSI 8.32%PRS 40.32
-
CSI 1.06rCSI 1.53%PRS 69.36
-
CSI 0.94rCSI 2.24%PRS 41.2
-
CSI 0.94rCSI 6.38%PRS 49.63
-
CSI 0.91rCSI 2.64%PRS 43.45
-
CSI 0.1rCSI 0.8%PRS 67.6%
-
CSI 0.4rCSI 7.2%PRS 44.5%
-
CSI 0.4rCSI 2.2%PRS 63.5%
-
CSI 0.4rCSI 8.3%PRS 45.9%
-
CSI 0.5rCSI 6.5%PRS 44.7%
-
CSI 0.5rCSI 2.6%PRS 76.2%
-
CSI 0.5rCSI 5.9%PRS 78.5%
-
CSI 0.7rCSI 3.0%PRS 73.5%
-
CSI 0.7rCSI 2.3%PRS 43.0%
-
CSI 0.7rCSI 22.1%PRS 74.9%
-
CSI 0.8rCSI 4.6%PRS 37.4%
-
CSI 0.8rCSI 7.2%PRS 40.1%
-
CSI 0.9rCSI 2.9%PRS 40.9%
-
CSI 0.9rCSI 4.9%PRS 67.1%
-
CSI 0.9rCSI 2.6%PRS 43.5%
-
CSI 0.9rCSI 6.4%PRS 49.6%
-
CSI 0.9rCSI 2.2%PRS 41.2%
-
CSI 1.1rCSI 1.5%PRS 69.4%
-
CSI 1.1rCSI 8.3%PRS 40.3%
-
CSI 1.1rCSI 3.0%PRS 66.0%
-
CSI 1.1rCSI 2.7%PRS 71.7%
-
CSI 1.2rCSI 4.4%PRS 45.0%
-
CSI 1.2rCSI 3.5%PRS 66.7%
-
CSI 1.3rCSI 6.0%PRS 52.7%
-
CSI 1.3rCSI 4.9%PRS 73.8%
-
CSI 1.3rCSI 4.2%PRS 54.8%
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CSI 1.3rCSI 3.8%PRS 68.7%
-
CSI 1.3rCSI 2.1%PRS 70.0%
-
CSI 1.4rCSI 6.8%PRS 48.9%
-
CSI 1.4rCSI 34.9%PRS 36.3%
-
CSI 1.5rCSI 36.4%PRS 35.3%
-
CSI 1.5rCSI 4.0%PRS 73.4%
-
CSI 1.6rCSI 2.9%PRS 46.3%
-
CSI 1.6rCSI 7.6%PRS 70.1%
-
CSI 1.6rCSI 3.2%PRS 71.4%
-
CSI 1.7rCSI 5.5%PRS 39.5%
-
CSI 1.7rCSI 4.6%PRS 67.4%
-
CSI 1.7rCSI 2.7%PRS 54.5%
-
CSI 1.7rCSI 3.8%PRS 60.4%
-
CSI 1.8rCSI 2.2%PRS 63.4%
-
CSI 1.8rCSI 2.2%PRS 49.0%
-
CSI 1.8rCSI 6.5%PRS 34.6%
-
CSI 1.8rCSI 3.0%PRS 58.5%
-
CSI 1.9rCSI 2.4%PRS 66.7%
-
CSI 1.9rCSI 1.5%PRS 51.9%
-
CSI 1.9rCSI 2.9%PRS 51.1%
-
CSI 1.9rCSI 4.2%PRS 40.2%
-
CSI 2.0rCSI 3.1%PRS 61.5%
-
CSI 2.0rCSI 3.6%PRS 45.8%
-
CSI 2.1rCSI 4.7%PRS 72.0%
-
CSI 2.2rCSI 3.9%PRS 71.0%
-
CSI 2.2rCSI 2.7%PRS 51.2%
-
CSI 2.2rCSI 5.4%PRS 61.8%
-
CSI 2.3rCSI 2.8%PRS 66.0%
-
CSI 2.3rCSI 4.7%PRS 33.9%
-
CSI 2.4rCSI 4.8%PRS 42.4%
-
CSI 2.5rCSI 3.8%PRS 61.2%
-
CSI 2.5rCSI 5.5%PRS 57.1%
-
CSI 2.6rCSI 6.3%PRS 34.7%
-
CSI 2.8rCSI 2.5%PRS 58.5%
-
CSI 2.9rCSI 6.6%PRS 52.5%
-
CSI 2.9rCSI 4.4%PRS 56.1%
-
CSI 2.9rCSI 38.1%PRS 70.2%
-
CSI 3.0rCSI 3.8%PRS 47.0%
-
CSI 3.0rCSI 4.5%PRS 49.5%
-
CSI 3.0rCSI 2.3%PRS 52.6%
-
CSI 3.0rCSI 4.8%PRS 38.1%
-
CSI 3.1rCSI 3.7%PRS 61.5%
-
CSI 3.1rCSI 7.2%PRS 43.2%
-
CSI 3.2rCSI 2.6%PRS 54.3%
-
CSI 3.2rCSI 18.2%PRS 38.6%
-
CSI 3.3rCSI 4.1%PRS 34.2%
-
CSI 3.3rCSI 2.9%PRS 57.8%
-
CSI 3.3rCSI 3.0%PRS 49.9%
-
CSI 3.4rCSI 4.7%PRS 52.3%
-
CSI 3.4rCSI 13.9%PRS 49.0%
-
CSI 3.5rCSI 4.5%PRS 50.8%
-
CSI 3.5rCSI 3.5%PRS 46.8%
-
CSI 3.5rCSI 4.9%PRS 55.9%
-
CSI 3.6rCSI 4.1%PRS 47.0%
-
CSI 3.8rCSI 4.3%PRS 74.4%
-
CSI 3.8rCSI 3.9%PRS 71.0%
-
CSI 3.8rCSI 4.2%PRS 56.8%
-
CSI 4.0rCSI 9.4%PRS 57.9%
-
CSI 4.0rCSI 4.6%PRS 62.2%
-
CSI 4.1rCSI 8.6%PRS 50.4%
-
CSI 4.6rCSI 8.2%PRS 35.0%
-
CSI 4.7rCSI 3.1%PRS 56.7%
-
CSI 4.7rCSI 14.6%PRS 37.4%
-
CSI 4.7rCSI 3.7%PRS 40.3%
-
CSI 5.3rCSI 13.5%PRS 48.2%
-
CSI 5.4rCSI 7.0%PRS 37.0%
-
CSI 5.5rCSI 14.4%PRS 52.3%
-
CSI 5.6rCSI 9.6%PRS 78.2%
-
CSI 6.1rCSI 36.2%PRS 49.0%
-
CSI 6.6rCSI 5.0%PRS 68.5%
-
CSI 6.9rCSI 26.1%PRS 36.8%
-
CSI 7.2rCSI 22.5%PRS 39.8%
-
CSI 7.5rCSI 8.9%PRS 35.8%
-
CSI 8.1rCSI 6.7%PRS 54.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1594714121
Symbol: BCAT1_HUMAN
Name: Branched-chain-amino-acid aminotransferase, cytosolic
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8692959
Title: ECA39, a conserved gene regulated by c-Myc in mice, is involved in G1/S cell cycle regulation in yeast.
PubMed ID: 8692959
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 16141215
Title: Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin.
PubMed ID: 16141215
PubMed ID: 16143519
Title: The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases.
PubMed ID: 16143519
Sequence Information:
- Length: 386
- Mass: 42966
- Checksum: A43535303A702512
- Sequence:
MKDCSNGCSA ECTGEGGSKE VVGTFKAKDL IVTPATILKE KPDPNNLVFG TVFTDHMLTV EWSSEFGWEK PHIKPLQNLS LHPGSSALHY AVELFEGLKA FRGVDNKIRL FQPNLNMDRM YRSAVRATLP VFDKEELLEC IQQLVKLDQE WVPYSTSASL YIRPTFIGTE PSLGVKKPTK ALLFVLLSPV GPYFSSGTFN PVSLWANPKY VRAWKGGTGD CKMGGNYGSS LFAQCEAVDN GCQQVLWLYG EDHQITEVGT MNLFLYWINE DGEEELATPP LDGIILPGVT RRCILDLAHQ WGEFKVSERY LTMDDLTTAL EGNRVREMFG SGTACVVCPV SDILYKGETI HIPTMENGPK LASRILSKLT DIQYGREESD WTIVLS