Details for: BCAT2

Gene ID: 587

Symbol: BCAT2

Ensembl ID: ENSG00000105552

Description: branched chain amino acid transaminase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.82
    Marker Score: 38809
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.81
    Marker Score: 18219
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.77
    Marker Score: 2603.5
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.53
    Marker Score: 2675
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 168043
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.35
    Marker Score: 744
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.31
    Marker Score: 1393
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.3
    Marker Score: 3072
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.27
    Marker Score: 834
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.24
    Marker Score: 4876
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.17
    Marker Score: 1040
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.16
    Marker Score: 6902
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.15
    Marker Score: 674
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.11
    Marker Score: 325
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.11
    Marker Score: 17309
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.1
    Marker Score: 2330
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.1
    Marker Score: 10351
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.09
    Marker Score: 1753
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.08
    Marker Score: 732
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.06
    Marker Score: 444
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.06
    Marker Score: 2208
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.05
    Marker Score: 1132
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.04
    Marker Score: 696
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.02
    Marker Score: 4285
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.02
    Marker Score: 2770
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.01
    Marker Score: 1349
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.01
    Marker Score: 9618
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1
    Marker Score: 1545
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1
    Marker Score: 706
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71714
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47938
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.99
    Marker Score: 6467
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.99
    Marker Score: 60933
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.99
    Marker Score: 8510
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.99
    Marker Score: 1042
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30394
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.98
    Marker Score: 1558
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.98
    Marker Score: 844
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.97
    Marker Score: 266
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.96
    Marker Score: 400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2399
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.92
    Marker Score: 309
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5240
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.91
    Marker Score: 1018
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2706.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.9
    Marker Score: 1459
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.9
    Marker Score: 2812
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.89
    Marker Score: 2115
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.88
    Marker Score: 5611
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.85
    Marker Score: 3300
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.85
    Marker Score: 802
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.84
    Marker Score: 337
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.83
    Marker Score: 720
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.82
    Marker Score: 1364
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.82
    Marker Score: 1391
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.81
    Marker Score: 1657
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.81
    Marker Score: 8398
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.81
    Marker Score: 3310
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.8
    Marker Score: 828
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.8
    Marker Score: 1305
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 316
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.78
    Marker Score: 899.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 589.5
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.77
    Marker Score: 150
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.76
    Marker Score: 5836
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.75
    Marker Score: 1707
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.74
    Marker Score: 188
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.73
    Marker Score: 380
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.73
    Marker Score: 5461
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.73
    Marker Score: 304
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.73
    Marker Score: 171
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.73
    Marker Score: 27608
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.72
    Marker Score: 11622
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.72
    Marker Score: 10744
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.72
    Marker Score: 866
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2991.5
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.71
    Marker Score: 6108
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.71
    Marker Score: 4252
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.7
    Marker Score: 351
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.7
    Marker Score: 528
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7
    Marker Score: 701
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.7
    Marker Score: 172
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.7
    Marker Score: 548
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.69
    Marker Score: 241
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.68
    Marker Score: 233
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.68
    Marker Score: 206
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.68
    Marker Score: 13533.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 620
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.67
    Marker Score: 970
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.67
    Marker Score: 4314.5
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.67
    Marker Score: 211
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.67
    Marker Score: 24548
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.66
    Marker Score: 832

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Other Information

**Key characteristics:** * BCAT2 is a transmembrane protein that is localized to the plasma membrane. * It is a member of the branched-chain amino acid transaminase family of enzymes. * BCAT2 is responsible for the transamination of L-isoleucine to L-valine and the transamination of L-valine to L-leucine. **Pathways and functions:** * BCAT2 is involved in the biosynthesis of BCAAs from L-isoleucine and L-valine. * It is also involved in the catabolism of BCAAs, including the production of pyruvate and the generation of acetyl-CoA. * BCAT2 is a key regulator of the leucine catabolic pathway, which is involved in the metabolism of amino acids. **Clinical significance:** Mutations in BCAT2 have been linked to several human diseases, including leucineuria and hypoglycemia. BCAT2 is a potential therapeutic target for these diseases. **Additional notes:** * BCAT2 is a highly conserved protein, with a similar sequence in mice and humans. * It is a chaperone protein that helps to fold other proteins involved in the leucine catabolic pathway. * BCAT2 is a relatively new protein, with most of the human sequence being encoded by a single gene.

Genular Protein ID: 386928016

Symbol: BCAT2_HUMAN

Name: N/A

UniProtKB Accession Codes:

O15382 B2RB87 O00269 Q96KG1 Q9BTB6 Q9BUU6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 7 EC 3 EMBL 8 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 41 PDBsum 29 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 3 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9165094

Title: Cloning of the rat and human mitochondrial branched chain aminotransferases (BCATm).

PubMed ID: 9165094

DOI: 10.1016/s0167-4838(97)00044-7

PubMed ID: 11170829

Title: Molecular cloning and characterization of placental tissue protein 18 (PP18a)/human mitochondrial branched-chain aminotransferase (BCATm) and its novel alternatively spliced PP18b variant.

PubMed ID: 11170829

DOI: 10.1053/plac.2000.0603

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8702755

Title: Two yeast homologs of ECA39, a target for c-Myc regulation, code for cytosolic and mitochondrial branched-chain amino acid aminotransferases.

PubMed ID: 8702755

DOI: 10.1074/jbc.271.34.20242

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25653144

Title: Hypervalinemia and hyperleucine-isoleucinemia caused by mutations in the branched-chain-amino-acid aminotransferase gene.

PubMed ID: 25653144

DOI: 10.1007/s10545-015-9814-z

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 11264579

Title: The structure of human mitochondrial branched-chain aminotransferase.

PubMed ID: 11264579

DOI: 10.1107/s0907444901001925

PubMed ID: 12269802

Title: Crystal structures of human mitochondrial branched chain aminotransferase reaction intermediates: ketimine and pyridoxamine phosphate forms.

PubMed ID: 12269802

DOI: 10.1021/bi020221c

PubMed ID: 16141215

Title: Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin.

PubMed ID: 16141215

DOI: 10.1074/jbc.m506486200

PubMed ID: 17050531

Title: Human mitochondrial branched chain aminotransferase isozyme: structural role of the CXXC center in catalysis.

PubMed ID: 17050531

DOI: 10.1074/jbc.m607552200

Sequence Information:

  • Length: 392
  • Mass: 44288
  • Checksum: EC07047264B190DA
  • Sequence:
    • MAAAALGQIW ARKLLSVPWL LCGPRRYASS SFKAADLQLE MTQKPHKKPG PGEPLVFGKT 
FTDHMLMVEW NDKGWGQPRI QPFQNLTLHP ASSSLHYSLQ LFEGMKAFKG KDQQVRLFRP 
WLNMDRMLRS AMRLCLPSFD KLELLECIRR LIEVDKDWVP DAAGTSLYVR PVLIGNEPSL 
GVSQPTRALL FVILCPVGAY FPGGSVTPVS LLADPAFIRA WVGGVGNYKL GGNYGPTVLV 
QQEALKRGCE QVLWLYGPDH QLTEVGTMNI FVYWTHEDGV LELVTPPLNG VILPGVVRQS 
LLDMAQTWGE FRVVERTITM KQLLRALEEG RVREVFGSGT ACQVCPVHRI LYKDRNLHIP 
TMENGPELIL RFQKELKEIQ YGIRAHEWMF PV

Genular Protein ID: 256333818

Symbol: B3KSI3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KSI3

Database IDs:

ARBA 16 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 13 ChiTaRS 1 DNASU 1 EC 3 EMBL 3 EPD 1 Ensembl 3 GO 5 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 7 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PROSITE 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 3 RuleBase 3 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 352
  • Mass: 39916
  • Checksum: 2BF282313ABEC40A
  • Sequence:
    • MTQKPHKKPG PGEPLVFGKT FTDHMLMVEW NDKGWGQPRI QPFQNLTLHP ASSSLHYSLQ 
LFEGMKAFKG KDQQVRLFRP WLNMDRMLRS AMRLCLPSFD KLELLECIRR LIEVDKDWVP 
DAAGTSLYVR PVLIGNEPSL GVSQPTRALL FVILCPVGAY FPGGSVTPVS LLADPAFIRA 
WVGGVGNYKL GGNYGPTVLV QQEALKRGCE QVLWLYGPDH QLTEVGTMNI FVYWTHEDGV 
LELVTPPLNG VILPGVVRQS LLDMAQTWGE FRVVERTITM KQLLRALEEG RVREVFGSGT 
ACQVCPVHRI LYKDRNLHIP TMENGPELIL RFQKELKEIQ YGIRAHEWMF PV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.