Details for: Crbn

Gene ID: 58799

Symbol: Crbn

Ensembl ID: ENSMUSG00000005362

Description: cereblon

Associated with

  • Cul4a-ring e3 ubiquitin ligase complex
    (GO:0031464)
  • Cytoplasm
    (GO:0005737)
  • Locomotory exploration behavior
    (GO:0035641)
  • Membrane
    (GO:0016020)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of large conductance calcium-activated potassium channel activity
    (GO:1902607)
  • Negative regulation of monoatomic ion transmembrane transport
    (GO:0034766)
  • Negative regulation of protein-containing complex assembly
    (GO:0031333)
  • Nucleus
    (GO:0005634)
  • Perinuclear region of cytoplasm
    (GO:0048471)
  • Positive regulation of protein-containing complex assembly
    (GO:0031334)
  • Positive regulation of wnt signaling pathway
    (GO:0030177)
  • Proteasome-mediated ubiquitin-dependent protein catabolic process
    (GO:0043161)
  • Protein ubiquitination
    (GO:0016567)
  • Transmembrane transporter binding
    (GO:0044325)

Other Information

Genular Protein ID: 3222521968

Symbol: CRBN_MOUSE

Name: Protein cereblon

UniProtKB Accession Codes:

Q8C7D2 Q3TVC2 Q5RJV6 Q6IS49 Q80XJ1 Q8BP45 Q8C6B7 Q9JKR4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 CCDS 2 CDD 1 CTD 1 ChEBI 7 ChiTaRS 1 DNASU 1 EMBL 8 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 15 Gene3D 3 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 5 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 7 PRO 1 PROSITE 2 PROSITE-ProRule 2 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 2 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20131966

Title: Temporal and spatial mouse brain expression of cereblon, an ionic channel regulator involved in human intelligence.

PubMed ID: 20131966

DOI: 10.3109/01677060903567849

PubMed ID: 21995942

Title: Behavioral characterization of cereblon forebrain-specific conditional null mice: a model for human non-syndromic intellectual disability.

PubMed ID: 21995942

DOI: 10.1016/j.bbr.2011.09.039

PubMed ID: 29530986

Title: Cereblon Maintains Synaptic and Cognitive Function by Regulating BK Channel.

PubMed ID: 29530986

DOI: 10.1523/jneurosci.2081-17.2018

PubMed ID: 25108355

Title: Structure of the human cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs.

PubMed ID: 25108355

DOI: 10.1038/nsmb.2874

Sequence Information:

  • Length: 445
  • Mass: 50880
  • Checksum: D66C2C3D50366E27
  • Sequence:
    • MAGEGDQQDA AHNMGNHLPL LPADSEDEDD EIEMEVEDQD SKEARKPNII NFDTSLPTSH 
TYLGADMEEF HGRTLHDDDS CQVIPVLPEV LMILIPGQTL PLQLSHPQEV SMVRNLIQKD 
RTFAVLAYSN VQEREAQFGT TAEIYAYREE QEFGIEVVKV KAIGRQRFKV LELRTQSDGI 
QQAKVQILPE CVLPSTMSAV QLESLNKCQV FPSKPISWED QYSCKWWQKY QKRKFHCANL 
TSWPRWLYSL YDAETLMDRI KKQLREWDEN LKDDSLPENP IDFSYRVAAC LPIDDVLRIQ 
LLKIGSAIQR LRCELDIMNK CTSLCCKQCQ ETEITTKNEI FSLSLCGPMA AYVNPHGYVH 
ETLTVYKASN LNLIGRPSTV HSWFPGYAWT IAQCKICASH IGWKFTATKK DMSPQKFWGL 
TRSALLPTIP ETEDEISPDK VILCL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.