Details for: Pmaip1

Gene ID: 58801

Symbol: Pmaip1

Ensembl ID: ENSMUSG00000024521

Description: phorbol-12-myristate-13-acetate-induced protein 1

Associated with

  • Activation of bh3-only proteins
    (R-MMU-114452)
  • Activation of noxa and translocation to mitochondria
    (R-MMU-111448)
  • Apoptosis
    (R-MMU-109581)
  • Bh3-only proteins associate with and inactivate anti-apoptotic bcl-2 members
    (R-MMU-111453)
  • Intrinsic pathway for apoptosis
    (R-MMU-109606)
  • Programmed cell death
    (R-MMU-5357801)
  • Activation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0006919)
  • Apoptotic process
    (GO:0006915)
  • Bcl-2 family protein complex
    (GO:0097136)
  • Cellular response to glucose starvation
    (GO:0042149)
  • Cytosol
    (GO:0005829)
  • Defense response to virus
    (GO:0051607)
  • Dna damage response
    (GO:0006974)
  • Fibroblast apoptotic process
    (GO:0044346)
  • Intrinsic apoptotic signaling pathway
    (GO:0097193)
  • Intrinsic apoptotic signaling pathway by p53 class mediator
    (GO:0072332)
  • Intrinsic apoptotic signaling pathway in response to dna damage
    (GO:0008630)
  • Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
    (GO:0042771)
  • Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
    (GO:0070059)
  • Mitochondrion
    (GO:0005739)
  • Negative regulation of fibroblast proliferation
    (GO:0048147)
  • Negative regulation of mitochondrial membrane potential
    (GO:0010917)
  • Nucleus
    (GO:0005634)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043280)
  • Positive regulation of dna damage response, signal transduction by p53 class mediator
    (GO:0043517)
  • Positive regulation of establishment of protein localization to mitochondrion
    (GO:1903749)
  • Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
    (GO:1902043)
  • Positive regulation of fibroblast apoptotic process
    (GO:2000271)
  • Positive regulation of glucose metabolic process
    (GO:0010907)
  • Positive regulation of intrinsic apoptotic signaling pathway
    (GO:2001244)
  • Positive regulation of neuron apoptotic process
    (GO:0043525)
  • Positive regulation of release of cytochrome c from mitochondria
    (GO:0090200)
  • Proteasomal protein catabolic process
    (GO:0010498)
  • Protein binding
    (GO:0005515)
  • Reactive oxygen species metabolic process
    (GO:0072593)
  • Regulation of apoptotic process
    (GO:0042981)
  • Regulation of mitochondrial membrane permeability
    (GO:0046902)
  • Release of cytochrome c from mitochondria
    (GO:0001836)
  • Response to dsrna
    (GO:0043331)
  • Response to uv
    (GO:0009411)
  • Response to x-ray
    (GO:0010165)
  • T cell homeostasis
    (GO:0043029)

Other Information

Genular Protein ID: 2643824178

Symbol: APR_MOUSE

Name: Phorbol-12-myristate-13-acetate-induced protein 1

UniProtKB Accession Codes:

Q9JM54

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisProt 1 ELM 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 34 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MGI 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PRO 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 10807576

Title: Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis.

PubMed ID: 10807576

DOI: 10.1126/science.288.5468.1053

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15901672

Title: Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

PubMed ID: 15901672

DOI: 10.1101/gad.1304105

PubMed ID: 15694340

Title: Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.

PubMed ID: 15694340

DOI: 10.1016/j.molcel.2004.12.030

PubMed ID: 16822983

Title: BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death.

PubMed ID: 16822983

DOI: 10.1523/jneurosci.0196-06.2006

PubMed ID: 17389404

Title: Structural insights into the degradation of Mcl-1 induced by BH3 domains.

PubMed ID: 17389404

DOI: 10.1073/pnas.0701297104

Sequence Information:

  • Length: 103
  • Mass: 11566
  • Checksum: 9B9A5B04D5535E30
  • Sequence:
    • MPGRKARRNA PVNPTRAELP PEFAAQLRKI GDKVYCTWSA PDITVVLAQM PGKSQKSRMR 
SPSPTRVPAD LKDECAQLRR IGDKVNLRQK LLNLISKLFN LVT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.