Details for: Nr4a3

Gene ID: 58853

Symbol: Nr4a3

Ensembl ID: ENSRNOG00000005964

Description: nuclear receptor subfamily 4, group A, member 3

Associated with

  • Gene expression (transcription)
    (R-RNO-74160)
  • Generic transcription pathway
    (R-RNO-212436)
  • Nuclear receptor transcription pathway
    (R-RNO-383280)
  • Rna polymerase ii transcription
    (R-RNO-73857)
  • Adult behavior
    (GO:0030534)
  • Animal organ regeneration
    (GO:0031100)
  • Axon guidance
    (GO:0007411)
  • Camp response element binding
    (GO:0035497)
  • Cellular respiration
    (GO:0045333)
  • Cellular response to catecholamine stimulus
    (GO:0071870)
  • Cellular response to corticotropin-releasing hormone stimulus
    (GO:0071376)
  • Cellular response to leptin stimulus
    (GO:0044320)
  • Common myeloid progenitor cell proliferation
    (GO:0035726)
  • Dendritic cell apoptotic process
    (GO:0097048)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Energy homeostasis
    (GO:0097009)
  • Fat cell differentiation
    (GO:0045444)
  • Gastrulation
    (GO:0007369)
  • Hippocampus development
    (GO:0021766)
  • Histone acetyltransferase binding
    (GO:0035035)
  • Inner ear morphogenesis
    (GO:0042472)
  • Intracellular receptor signaling pathway
    (GO:0030522)
  • Intracellular signal transduction
    (GO:0035556)
  • Mast cell degranulation
    (GO:0043303)
  • Mesoderm formation
    (GO:0001707)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Negative regulation of smooth muscle cell apoptotic process
    (GO:0034392)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuromuscular process controlling balance
    (GO:0050885)
  • Neuron apoptotic process
    (GO:0051402)
  • Nuclear glucocorticoid receptor binding
    (GO:0035259)
  • Nuclear receptor activity
    (GO:0004879)
  • Nucleus
    (GO:0005634)
  • Platelet-derived growth factor receptor signaling pathway
    (GO:0048008)
  • Positive regulation of cardiac muscle hypertrophy
    (GO:0010613)
  • Positive regulation of cell cycle
    (GO:0045787)
  • Positive regulation of dendritic cell apoptotic process
    (GO:2000670)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of epithelial cell proliferation
    (GO:0050679)
  • Positive regulation of fatty acid oxidation
    (GO:0046321)
  • Positive regulation of feeding behavior
    (GO:2000253)
  • Positive regulation of glucose transmembrane transport
    (GO:0010828)
  • Positive regulation of mast cell activation by fc-epsilon receptor signaling pathway
    (GO:0038097)
  • Positive regulation of mast cell cytokine production
    (GO:0032765)
  • Positive regulation of monocyte aggregation
    (GO:1900625)
  • Positive regulation of smooth muscle cell proliferation
    (GO:0048661)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of vascular associated smooth muscle cell migration
    (GO:1904754)
  • Positive regulation of vascular associated smooth muscle cell proliferation
    (GO:1904707)
  • Protein binding
    (GO:0005515)
  • Protein homodimerization activity
    (GO:0042803)
  • Protein kinase binding
    (GO:0019901)
  • Regulation of smooth muscle cell proliferation
    (GO:0048660)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Regulation of type b pancreatic cell proliferation
    (GO:0061469)
  • Response to hydrogen peroxide
    (GO:0042542)
  • Response to peptide hormone
    (GO:0043434)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Semicircular canal morphogenesis
    (GO:0048752)
  • Sequence-specific dna binding
    (GO:0043565)
  • Smooth muscle cell apoptotic process
    (GO:0034390)
  • Transcription coactivator binding
    (GO:0001223)
  • Transcription regulator complex
    (GO:0005667)
  • Vestibular reflex
    (GO:0060005)
  • Zinc ion binding
    (GO:0008270)

Other Information

Genular Protein ID: 85437977

Symbol: NR4A3_RAT

Name: Nuclear receptor subfamily 4 group A member 3

UniProtKB Accession Codes:

P51179 Q2XPY2 Q63516 Q9QWQ3

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 CDD 1 CTD 1 EMBL 4 Ensembl 4 GO 62 Gene3D 2 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 4 PRO 1 PROSITE 3 PROSITE-ProRule 2 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 Reactome 1 RefSeq 2 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 UCSC 1 UniProtKB 2 eggNOG 1

Citations:

PubMed ID: 7811288

Title: Molecular cloning of a novel thyroid/steroid receptor superfamily gene from cultured rat neuronal cells.

PubMed ID: 7811288

DOI: 10.1006/bbrc.1994.2900

PubMed ID: 7556683

Title: NOR-2 (neuron-derived orphan receptor), a brain zinc finger protein, is highly induced during liver regeneration.

PubMed ID: 7556683

DOI: 10.1016/0014-5793(95)00998-o

PubMed ID: 7914660

Title: Expression of nuclear hormone receptors within the rat hippocampus: identification of novel orphan receptors.

PubMed ID: 7914660

DOI: 10.1016/0169-328x(94)90235-6

PubMed ID: 10523643

Title: Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation.

PubMed ID: 10523643

DOI: 10.1128/mcb.19.11.7549

PubMed ID: 15591535

Title: Protein-protein interactions and transcriptional antagonism between the subfamily of NGFI-B/Nur77 orphan nuclear receptors and glucocorticoid receptor.

PubMed ID: 15591535

DOI: 10.1210/me.2004-0333

PubMed ID: 16945922

Title: The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferation.

PubMed ID: 16945922

DOI: 10.1074/jbc.m603436200

PubMed ID: 19321449

Title: TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77.

PubMed ID: 19321449

DOI: 10.1074/jbc.m809023200

PubMed ID: 24706823

Title: Nkx6.1 regulates islet beta-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors.

PubMed ID: 24706823

DOI: 10.1073/pnas.1320953111

PubMed ID: 25625556

Title: The orphan receptor NOR1 participates in isoprenaline-induced cardiac hypertrophy by regulating PARP-1.

PubMed ID: 25625556

DOI: 10.1111/bph.13091

Sequence Information:

  • Length: 628
  • Mass: 68564
  • Checksum: 9AC285D9A65226D9
  • Sequence:
    • MPCVQAQYSP SPPGSTYATQ TYGSEYTTEI MNPDYAKLTM DLGSTGIMAT ATTSLPSFST 
FMEGYPSSCE LKPSCLYQMP PSGPRPLIKM EEGREHGYHH HHHHHHHHHH HHQQQQPSIP 
PPSGPEDEVL PSTSMYFKQS PPSTPTTPGF PPQAGALWDD ELPSAPGCIA PGPLLDPQMK 
AVPPMAAAAR FPIFFKPSPP HPPAPSPAGG HHLGYDPTAA AALSLPLGAA AAAGSQAAAL 
EGHPYGLPLA KRTATLTFPP LGLTASPTAS SLLGESPSLP SPPNRSSSSG EGTCAVCGDN 
AACQHYGVRT CEGCKGFFKR TVQKNAKYVC LANKNCPVDK RRRNRCQYCR FQKCLSVGMV 
KEVVRTDSLK GRRGRLPSKP KSPLQQEPSQ PSPPSPPICM MNALVRALTD ATPRDLDYSR 
YCPTDQATAG TDAEHVQQFY NLLTASIDVS RSWAEKIPGF TDLPKEDQTL LIESAFLELF 
VLRLSIRSNT AEDKFVFCNG LVLHRLQCLR GFGEWLDSIK DFSLNLQSLN LDIQALACLS 
ALSMITERHG LKEPKRVEEL CNKITSSLKD HQRKGQALEP SEPKVLRALV ELRKICTQGL 
QRIFYLKLED LVSPPSVIDK LFLDTLPF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.