Details for: Hpx

Gene ID: 58917

Symbol: Hpx

Ensembl ID: ENSRNOG00000018257

Description: hemopexin

Associated with

  • Binding and uptake of ligands by scavenger receptors
    (R-RNO-2173782)
  • Scavenging of heme from plasma
    (R-RNO-2168880)
  • Vesicle-mediated transport
    (R-RNO-5653656)
  • Extracellular space
    (GO:0005615)
  • Heme metabolic process
    (GO:0042168)
  • Heme transmembrane transporter activity
    (GO:0015232)
  • Heme transport
    (GO:0015886)
  • Hemoglobin metabolic process
    (GO:0020027)
  • Intracellular iron ion homeostasis
    (GO:0006879)
  • Metal ion binding
    (GO:0046872)
  • Positive regulation of humoral immune response mediated by circulating immunoglobulin
    (GO:0002925)
  • Positive regulation of immunoglobulin production
    (GO:0002639)
  • Positive regulation of response to type ii interferon
    (GO:0060332)
  • Positive regulation of type ii interferon-mediated signaling pathway
    (GO:0060335)
  • Positive regulation of tyrosine phosphorylation of stat protein
    (GO:0042531)
  • Regulation of protein metabolic process
    (GO:0051246)
  • Type ii interferon-mediated signaling pathway
    (GO:0060333)

Other Information

Genular Protein ID: 2090512437

Symbol: HEMO_RAT

Name: Hemopexin

UniProtKB Accession Codes:

P20059 Q5BKB4

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 CDD 1 CTD 1 ChEBI 8 ChEMBL 1 EMBL 3 Ensembl 4 GO 13 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SwissPalm 1 TreeFam 1 UCSC 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 1988069

Title: Rat hemopexin. Molecular cloning, primary structural characterization, and analysis of gene expression.

PubMed ID: 1988069

DOI: 10.1021/bi00217a036

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1599480

Title: Identification of an interleukin-6 responsive element and characterization of the proximal promoter region of the rat hemopexin gene.

PubMed ID: 1599480

DOI: 10.1016/s0006-291x(05)81002-2

PubMed ID: 3421961

Title: N-terminal amino acid sequences of the hemopexins from chicken, rat and rabbit.

PubMed ID: 3421961

DOI: 10.1016/s0006-291x(88)80540-0

PubMed ID: 1587840

Title: Hemopexin is synthesized in peripheral nerves but not in central nervous system and accumulates after axotomy.

PubMed ID: 1587840

DOI: 10.1016/s0021-9258(19)50058-8

Sequence Information:

  • Length: 460
  • Mass: 51351
  • Checksum: 508963FEE0E31D92
  • Sequence:
    • MARTVVALNI LVLLGLCWSL AVANPLPAAH ETVAKGENGT KPDSDVIEHC SDAWSFDATT 
MDHNGTMLFF KGEFVWRGHS GIRELISERW KNPVTSVDAA FRGPDSVFLI KEDKVWVYPP 
EKKENGYPKL FQEEFPGIPY PPDAAVECHR GECQSEGVLF FQGNRKWFWD FATRTQKERS 
WPAVGNCTAA LRWLERYYCF QGNKFLRFNP VTGEVPPRYP LDARDYFISC PGRGHGKLRN 
GTAHGNSTHP MHSRCNADPG LSALLSDHRG ATYAFSGSHY WRLDSSRDGW HSWPIAHHWP 
QGPSAVDAAF SWDEKVYLIQ GTQVYVFLTK GGNNLVSGYP KRLEKELGSP PGISLDTIDA 
AFSCPGSSKL YVTSGRRLWW LDLKSGAQAT WAELSWPHEK VDGALCLEKS LGPYSCSSNG 
PNLFFIHGPN LYCYSSIDKL NAAKSLPQPQ KVNSILGCSQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.