Details for: Rabggta

Gene ID: 58983

Symbol: Rabggta

Ensembl ID: ENSRNOG00000030483

Description: Rab geranylgeranyltransferase subunit alpha

Associated with

Other Information

Genular Protein ID: 1395216515

Symbol: PGTA_RAT

Name: Geranylgeranyl transferase type-2 subunit alpha

UniProtKB Accession Codes:

Q08602

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BindingDB 1 BioGRID 1 CTD 1 ChEBI 4 ChEMBL 1 ComplexPortal 1 DIP 1 EC 2 EMBL 3 EvolutionaryTrace 1 GO 6 Gene3D 3 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 25 PDBsum 21 PIR 1 PRO 1 PROSITE 1 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 Reactome 2 RefSeq 3 Rhea 3 SMR 1 STRING 1 SUPFAM 3 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 jPOST 1

Citations:

PubMed ID: 8505342

Title: cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase.

PubMed ID: 8505342

DOI: 10.1016/s0021-9258(19)50329-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11675392

Title: Phosphoisoprenoids modulate association of Rab geranylgeranyltransferase with REP-1.

PubMed ID: 11675392

DOI: 10.1074/jbc.m108241200

PubMed ID: 10745007

Title: Crystal structure of Rab geranylgeranyltransferase at 2.0 A resolution.

PubMed ID: 10745007

DOI: 10.1016/s0969-2126(00)00102-7

PubMed ID: 12620235

Title: Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase.

PubMed ID: 12620235

DOI: 10.1016/s1097-2765(03)00044-3

PubMed ID: 18399557

Title: Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex.

PubMed ID: 18399557

DOI: 10.1002/anie.200705795

PubMed ID: 18756270

Title: Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation.

PubMed ID: 18756270

DOI: 10.1038/emboj.2008.164

PubMed ID: 19894725

Title: Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors.

PubMed ID: 19894725

DOI: 10.1021/jm901117d

PubMed ID: 21520375

Title: Structure-guided development of selective RabGGTase inhibitors.

PubMed ID: 21520375

DOI: 10.1002/anie.201101210

PubMed ID: 22963166

Title: Development of selective, potent RabGGTase inhibitors.

PubMed ID: 22963166

DOI: 10.1021/jm300624s

Sequence Information:

  • Length: 567
  • Mass: 64904
  • Checksum: 1F9D235F973EABD5
  • Sequence:
    • MHGRLKVKTS EEQAEAKRLE REQKLKLYQS ATQAVFQKRQ AGELDESVLE LTSQILGANP 
DFATLWNCRR EVLQHLETEK SPEESAALVK AELGFLESCL RVNPKSYGTW HHRCWLLSRL 
PEPNWARELE LCARFLEADE RNFHCWDYRR FVAAQAAVAP AEELAFTDSL ITRNFSNYSS 
WHYRSCLLPQ LHPQPDSGPQ GRLPENVLLK ELELVQNAFF TDPNDQSAWF YHRWLLGRAE 
PHDVLCCVHV SREEACLSVC FSRPLTVGSR MGTLLLMVDE APLSVEWRTP DGRNRPSHVW 
LCDLPAASLN DQLPQHTFRV IWTGSDSQKE CVLLKDRPEC WCRDSATDEQ LFRCELSVEK 
STVLQSELES CKELQELEPE NKWCLLTIIL LMRALDPLLY EKETLQYFST LKAVDPMRAA 
YLDDLRSKFL LENSVLKMEY ADVRVLHLAH KDLTVLCHLE QLLLVTHLDL SHNRLRALPP 
ALAALRCLEV LQASDNALEN VDGVANLPRL QELLLCNNRL QQSAAIQPLV SCPRLVLLNL 
QGNSLCQEEG IQERLAEMLP SVSSILT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.