Details for: IL22RA1

Gene ID: 58985

Symbol: IL22RA1

Ensembl ID: ENSG00000142677

Description: interleukin 22 receptor subunit alpha 1

Associated with

Other Information

Genular Protein ID: 1594373359

Symbol: I22R1_HUMAN

Name: Interleukin-22 receptor subunit alpha-1

UniProtKB Accession Codes:

Q8N6P7 A8K839 B2R9Y9 Q9HB22

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10875937

Title: Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R.

PubMed ID: 10875937

DOI: 10.1074/jbc.m005304200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11035029

Title: Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes.

PubMed ID: 11035029

DOI: 10.1074/jbc.m007837200

PubMed ID: 11564763

Title: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types.

PubMed ID: 11564763

DOI: 10.4049/jimmunol.167.7.3545

PubMed ID: 12407026

Title: IL-22, in contrast to IL-10, does not induce Ig production, due to absence of a functional IL-22 receptor on activated human B cells.

PubMed ID: 12407026

DOI: 10.1093/intimm/dxf096

PubMed ID: 11706020

Title: Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2.

PubMed ID: 11706020

DOI: 10.1074/jbc.m106043200

PubMed ID: 12351624

Title: Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions.

PubMed ID: 12351624

DOI: 10.1074/jbc.m205114200

PubMed ID: 12941841

Title: Melanoma differentiation-associated gene 7/interleukin (IL)-24 is a novel ligand that regulates angiogenesis via the IL-22 receptor.

PubMed ID: 12941841

PubMed ID: 15308104

Title: IL-22 increases the innate immunity of tissues.

PubMed ID: 15308104

DOI: 10.1016/j.immuni.2004.07.007

PubMed ID: 15120653

Title: Temporal associations between interleukin 22 and the extracellular domains of IL-22R and IL-10R2.

PubMed ID: 15120653

DOI: 10.1016/j.intimp.2004.01.010

PubMed ID: 17204547

Title: IL-22-mediated liver cell regeneration is abrogated by SOCS-1/3 overexpression in vitro.

PubMed ID: 17204547

DOI: 10.1152/ajpgi.00239.2006

PubMed ID: 17900301

Title: A role for T cell-derived interleukin 22 in psoriatic skin inflammation.

PubMed ID: 17900301

DOI: 10.1111/j.1365-2249.2007.03511.x

PubMed ID: 17906500

Title: Chronic rhinosinusitis with nasal polyps is associated with decreased expression of mucosal interleukin 22 receptor.

PubMed ID: 17906500

DOI: 10.1097/mlg.0b013e31811edd4f

PubMed ID: 17828272

Title: Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation.

PubMed ID: 17828272

DOI: 10.1038/nm1651

PubMed ID: 18061474

Title: The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy.

PubMed ID: 18061474

DOI: 10.1016/j.cyto.2007.10.004

PubMed ID: 26171402

Title: The Human IL-22 Receptor Is Regulated through the Action of the Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial Growth Suppressor.

PubMed ID: 26171402

DOI: 10.1155/2015/912713

PubMed ID: 18675809

Title: Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism.

PubMed ID: 18675809

DOI: 10.1016/j.febslet.2008.07.046

Sequence Information:

  • Length: 574
  • Mass: 63077
  • Checksum: D46CC71D496F3420
  • Sequence:
    • MRTLLTILTV GSLAAHAPED PSDLLQHVKF QSSNFENILT WDSGPEGTPD TVYSIEYKTY 
GERDWVAKKG CQRITRKSCN LTVETGNLTE LYYARVTAVS AGGRSATKMT DRFSSLQHTT 
LKPPDVTCIS KVRSIQMIVH PTPTPIRAGD GHRLTLEDIF HDLFYHLELQ VNRTYQMHLG 
GKQREYEFFG LTPDTEFLGT IMICVPTWAK ESAPYMCRVK TLPDRTWTYS FSGAFLFSMG 
FLVAVLCYLS YRYVTKPPAP PNSLNVQRVL TFQPLRFIQE HVLIPVFDLS GPSSLAQPVQ 
YSQIRVSGPR EPAGAPQRHS LSEITYLGQP DISILQPSNV PPPQILSPLS YAPNAAPEVG 
PPSYAPQVTP EAQFPFYAPQ AISKVQPSSY APQATPDSWP PSYGVCMEGS GKDSPTGTLS 
SPKHLRPKGQ LQKEPPAGSC MLGGLSLQEV TSLAMEESQE AKSLHQPLGI CTDRTSDPNV 
LHSGEEGTPQ YLKGQLPLLS SVQIEGHPMS LPLQPPSRPC SPSDQGPSPW GLLESLVCPK 
DEAKSPAPET SDLEQPTELD SLFRGLALTV QWES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.