Smpd3 | ENSMUSG00000031906 | NCBI 58994

Details for: Smpd3

Gene ID: 58994

Symbol: Smpd3

Ensembl ID: ENSMUSG00000031906

Description: sphingomyelin phosphodiesterase 3, neutral

Associated with

Death receptor signaling
(R-MMU-73887)
Glycosphingolipid catabolism
(R-MMU-9840310)
Glycosphingolipid metabolism
(R-MMU-1660662)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Sphingolipid metabolism
(R-MMU-428157)
Tnfr1-mediated ceramide production
(R-MMU-5626978)
Tnf signaling
(R-MMU-75893)
Artery smooth muscle contraction
(GO:0014824)
Bmp signaling pathway
(GO:0030509)
Bone development
(GO:0060348)
Bone growth
(GO:0098868)
Bone mineralization
(GO:0030282)
Cartilage development
(GO:0051216)
Cell cycle
(GO:0007049)
Cellular response to hydrogen peroxide
(GO:0070301)
Cellular response to magnesium ion
(GO:0071286)
Cellular response to oxidised low-density lipoprotein particle stimulus
(GO:0140052)
Cellular response to peptide
(GO:1901653)
Cellular response to reactive oxygen species
(GO:0034614)
Cellular response to redox state
(GO:0071461)
Cellular response to tumor necrosis factor
(GO:0071356)
Ceramide metabolic process
(GO:0006672)
Chondrocyte development
(GO:0002063)
Chondrocyte development involved in endochondral bone morphogenesis
(GO:0003433)
Collagen metabolic process
(GO:0032963)
Cytoplasm
(GO:0005737)
Dentinogenesis
(GO:0097187)
Dna biosynthetic process
(GO:0071897)
Dopamine uptake
(GO:0090494)
Endochondral ossification
(GO:0001958)
Extracellular matrix assembly
(GO:0085029)
Extracellular region
(GO:0005576)
G1 to g0 transition
(GO:0070314)
Golgi apparatus
(GO:0005794)
Golgi cis cisterna
(GO:0000137)
Hematopoietic progenitor cell differentiation
(GO:0002244)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Lipid metabolic process
(GO:0006629)
Lung alveolus development
(GO:0048286)
Lung development
(GO:0030324)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Mitotic nuclear division
(GO:0140014)
Multicellular organism development
(GO:0007275)
Multicellular organism growth
(GO:0035264)
Negative regulation of cytosolic calcium ion concentration
(GO:0051481)
Negative regulation of hyaluronan biosynthetic process
(GO:1900126)
Negative regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051898)
Neutral sphingomyelin phosphodiesterase activity
(GO:0061751)
Ossification
(GO:0001503)
Peptide hormone secretion
(GO:0030072)
Phosphatidic acid binding
(GO:0070300)
Phosphatidylserine binding
(GO:0001786)
Phosphoric diester hydrolase activity
(GO:0008081)
Plasma membrane
(GO:0005886)
Platelet-derived growth factor receptor signaling pathway
(GO:0048008)
Polysaccharide transport
(GO:0015774)
Positive regulation of ceramide biosynthetic process
(GO:2000304)
Positive regulation of exosomal secretion
(GO:1903543)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of nitric oxide biosynthetic process
(GO:0045429)
Positive regulation of non-canonical nf-kappab signal transduction
(GO:1901224)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Protein binding
(GO:0005515)
Regulation of cartilage development
(GO:0061035)
Regulation of hyaluronan biosynthetic process
(GO:1900125)
Regulation of leukocyte migration
(GO:0002685)
Regulation of protein phosphorylation
(GO:0001932)
Respiratory system development
(GO:0060541)
Signal transduction
(GO:0007165)
Skeletal system development
(GO:0001501)
Sphingolipid mediated signaling pathway
(GO:0090520)
Sphingolipid metabolic process
(GO:0006665)
Sphingomyelin catabolic process
(GO:0006685)
Sphingomyelin metabolic process
(GO:0006684)
Sphingomyelin phosphodiesterase activity
(GO:0004767)

Other Information

Proteins

Neutral sphingomyelinase 2

Genular Protein ID: 1121273659

Symbol: NSMA2_MOUSE

Name: Neutral sphingomyelinase 2

UniProtKB Accession Codes:

Q9JJY3 Q3UTQ5

Database IDs:

Citations:

PubMed ID: 10823942

Title: Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase.

PubMed ID: 10823942

DOI: 10.1073/pnas.97.11.5895

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12566438

Title: Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism.

PubMed ID: 12566438

DOI: 10.1074/jbc.m212262200

PubMed ID: 15051724

Title: Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells.

PubMed ID: 15051724

DOI: 10.1074/jbc.m313662200

PubMed ID: 15929065

Title: Differential regulation of ceramide in lipid-rich microdomains (rafts): antagonistic role of palmitoyl:protein thioesterase and neutral sphingomyelinase 2.

PubMed ID: 15929065

DOI: 10.1002/jnr.20549

PubMed ID: 16025116

Title: A deletion in the gene encoding sphingomyelin phosphodiesterase 3 (Smpd3) results in osteogenesis and dentinogenesis imperfecta in the mouse.

PubMed ID: 16025116

DOI: 10.1038/ng1603

PubMed ID: 15764706

Title: Neutral sphingomyelinase 2 (smpd3) in the control of postnatal growth and development.

PubMed ID: 15764706

DOI: 10.1073/pnas.0406380102

PubMed ID: 17272284

Title: Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization.

PubMed ID: 17272284

DOI: 10.1074/jbc.m611249200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21550973

Title: Identification of novel anionic phospholipid binding domains in neutral sphingomyelinase 2 with selective binding preference.

PubMed ID: 21550973

DOI: 10.1074/jbc.m110.156471

Sequence Information:

Length: 655
Mass: 71197
Checksum: 6764769EEAB5A168
Sequence:

MVLYTTPFPN SCLSALHAVS WALIFPCYWL VDRLLASFIP TTYEKRQRAD DPCCLQLFCT 
VLFTPVYLAL LVAALPFAFL GFIFWSPLQS ARRPYSYSRL EDKNPAGGAA LLSEWKGTGA 
GKSFCFATAN VCLLPDSLAR LNNVFNTQAR AKEIGQRIRN GAARPQIKIY IDSPTNTSIS 
AASFSSLVSP QGGDGSRAVP GSIKRTASVE YKGDGGRHPS DEAANGPASG EQADGSLEDS 
CIVRIGGEEG GRPQEADDPA AGSQARNGAG GTPKGQTPNH NQRDGDSGSL GSPSASRESL 
VKARAGQDSG GSGEPGANSK LLYKTSVVKK AAARRRRHPD EAFDHEVSAF FPANLDFLCL 
QEVFDKRAAA KLKEQLHGYF EYILYDVGVY GCHGCCNFKC LNSGLFFASR YPVMDVAYHC 
YPNGCSFDAL ASKGALFLKV QVGSTPQDQR IVGYIACTHL HAPPEDSAVR CEQLDLLQDW 
LADFRKSTSS TSTANPEELV VFDVICGDLN FDNCSSDDKL EQQHSLFTRY KDPCRLGPGE 
EKPWAIGTLL DTNGLYDEDV CTPDNLQKVL ESEEGRREYL AFPTSKSPGA GQKGRKDLLK 
GNGRRIDYML HAEEGLCPDW KAEVEEFSFI TQLSGLTDHL PVAMRLMVSA GEEEA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Smpd3

Associated with

Other Information

Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase. PubMed ID: 10823942

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism. PubMed ID: 12566438

Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells. PubMed ID: 15051724

Differential regulation of ceramide in lipid-rich microdomains (rafts): antagonistic role of palmitoyl:protein thioesterase and neutral sphingomyelinase 2. PubMed ID: 15929065

A deletion in the gene encoding sphingomyelin phosphodiesterase 3 (Smpd3) results in osteogenesis and dentinogenesis imperfecta in the mouse. PubMed ID: 16025116

Neutral sphingomyelinase 2 (smpd3) in the control of postnatal growth and development. PubMed ID: 15764706

Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization. PubMed ID: 17272284

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Identification of novel anionic phospholipid binding domains in neutral sphingomyelinase 2 with selective binding preference. PubMed ID: 21550973