Details for: BCHE

Gene ID: 590

Symbol: BCHE

Ensembl ID: ENSG00000114200

Description: butyrylcholinesterase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.06
    Marker Score: 36544.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.98
    Marker Score: 2117
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.97
    Marker Score: 631
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.93
    Marker Score: 1820
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.73
    Marker Score: 3571
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.7
    Marker Score: 1065
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168704
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.43
    Marker Score: 690
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.38
    Marker Score: 1703
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.17
    Marker Score: 1285
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.14
    Marker Score: 4215
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.13
    Marker Score: 391
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.11
    Marker Score: 4283
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.09
    Marker Score: 14374
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.07
    Marker Score: 430
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.07
    Marker Score: 643
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.05
    Marker Score: 664.5
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251778
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.03
    Marker Score: 4463
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71798
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48021.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.98
    Marker Score: 2002
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.95
    Marker Score: 1801
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.95
    Marker Score: 6077
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.93
    Marker Score: 452
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5298
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.89
    Marker Score: 2334
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5278
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.87
    Marker Score: 4658
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.87
    Marker Score: 213
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 611
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 704
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1251
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.71
    Marker Score: 1450.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.71
    Marker Score: 4633
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.71
    Marker Score: 335
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.7
    Marker Score: 973
  • Cell Name: fibrocyte (CL0000135)
    Fold Change: 0.7
    Marker Score: 215
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.68
    Marker Score: 455
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.66
    Marker Score: 1021
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.64
    Marker Score: 287
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.63
    Marker Score: 2073
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 411
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.62
    Marker Score: 9630.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.6
    Marker Score: 3580
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.59
    Marker Score: 144
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.59
    Marker Score: 554
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.59
    Marker Score: 146
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.57
    Marker Score: 614
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.57
    Marker Score: 246
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.56
    Marker Score: 426
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.56
    Marker Score: 184
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.53
    Marker Score: 282
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.53
    Marker Score: 651
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.53
    Marker Score: 1261
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.52
    Marker Score: 195
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.5
    Marker Score: 486
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.49
    Marker Score: 199
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.48
    Marker Score: 268
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.48
    Marker Score: 235
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.44
    Marker Score: 115
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.44
    Marker Score: 209
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.44
    Marker Score: 513
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.43
    Marker Score: 271
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.42
    Marker Score: 997
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.41
    Marker Score: 976
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.41
    Marker Score: 666
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.4
    Marker Score: 272
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.4
    Marker Score: 138
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.4
    Marker Score: 235
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.37
    Marker Score: 84
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.36
    Marker Score: 439
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.36
    Marker Score: 81
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.36
    Marker Score: 89
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.36
    Marker Score: 256
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.36
    Marker Score: 162
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.35
    Marker Score: 232
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.35
    Marker Score: 12893
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.35
    Marker Score: 374
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.35
    Marker Score: 13174
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.34
    Marker Score: 119
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.34
    Marker Score: 1209
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.34
    Marker Score: 127
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.34
    Marker Score: 1309
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.33
    Marker Score: 325.5
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.33
    Marker Score: 190
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.33
    Marker Score: 110
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.32
    Marker Score: 74
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.32
    Marker Score: 319
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.32
    Marker Score: 354
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.31
    Marker Score: 391
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.31
    Marker Score: 187
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.31
    Marker Score: 587

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Other Information

**Key characteristics:** - BCHE is a glycoprotein with a molecular weight of approximately 150 kDa. - It is found in both soluble and membrane-bound forms. - It is expressed in high levels in the central nervous system, particularly in the brain and spinal cord. - BCHE is a key enzyme in the synthesis of acetylcholine, which is a neurotransmitter involved in a variety of physiological processes, including muscle contraction, memory, and learning. **Pathways and functions:** - BCHE is involved in the regulation of inflammation. It is expressed in inflammatory cells, such as macrophages and neutrophils, and it is thought to play a role in the production of inflammatory cytokines. - BCHE is also involved in cell migration. It is expressed in endothelial cells and other cell types that are migrating through the blood-brain barrier. - BCHE is involved in the metabolism of lipids and proteins. It is expressed in liver cells and is involved in the synthesis of choline esters, which are precursors for the synthesis of acetylcholine. - BCHE is involved in the clearance of neurotransmitters from the synaptic cleft. It is expressed in neurons and is thought to play a role in the regulation of synaptic plasticity. **Clinical significance:** - Mutations in BCHE genes have been linked to a number of human diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. - BCHE inhibitors are being investigated as potential treatments for these diseases. **Additional notes:** - BCHE is a highly regulated enzyme. Its activity is typically low in healthy individuals, but it is elevated in individuals with neurodegenerative diseases. - BCHE is a multifunctional enzyme that can perform a variety of different reactions. - It is a key enzyme in the synthesis of acetylcholine, which is a neurotransmitter involved in a variety of physiological processes, including muscle contraction, memory, and learning.

Genular Protein ID: 2939782717

Symbol: CHLE_HUMAN

Name: Cholinesterase

UniProtKB Accession Codes:

P06276 A8K7P8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 83 DrugCentral 1 EC 2 EMBL 7 EMDB 2 EPD 1 ESTHER 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 97 PDBsum 89 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3035536

Title: Isolation and characterization of full-length cDNA clones coding for cholinesterase from fetal human tissues.

PubMed ID: 3035536

DOI: 10.1073/pnas.84.11.3555

PubMed ID: 3477799

Title: Brain cDNA clone for human cholinesterase.

PubMed ID: 3477799

DOI: 10.1073/pnas.84.19.6682

PubMed ID: 2322535

Title: Structure of the gene for human butyrylcholinesterase. Evidence for a single copy.

PubMed ID: 2322535

DOI: 10.1021/bi00453a015

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3542989

Title: Complete amino acid sequence of human serum cholinesterase.

PubMed ID: 3542989

DOI: 10.1016/s0021-9258(19)75818-9

PubMed ID: 20946535

Title: Biochemical, molecular and preclinical characterization of a double-virus-reduced human butyrylcholinesterase preparation designed for clinical use.

PubMed ID: 20946535

DOI: 10.1111/j.1423-0410.2010.01415.x

PubMed ID: 3115973

Title: Location of disulfide bonds within the sequence of human serum cholinesterase.

PubMed ID: 3115973

DOI: 10.1016/s0021-9258(18)45149-6

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 18203274

Title: Glycoproteomic characterization of butyrylcholinesterase from human plasma.

PubMed ID: 18203274

DOI: 10.1002/pmic.200700720

PubMed ID: 19542320

Title: Adenovirus-transduced human butyrylcholinesterase in mouse blood functions as a bioscavenger of chemical warfare nerve agents.

PubMed ID: 19542320

DOI: 10.1124/mol.109.055665

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 19452557

Title: The structure of G117H mutant of butyrylcholinesterase: nerve agents scavenger.

PubMed ID: 19452557

DOI: 10.1002/prot.22442

PubMed ID: 22444575

Title: Identification of phosphorylated butyrylcholinesterase in human plasma using immunoaffinity purification and mass spectrometry.

PubMed ID: 22444575

DOI: 10.1016/j.aca.2012.02.023

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25054547

Title: Characterization of a novel BCHE 'silent' allele: point mutation (p.Val204Asp) causes loss of activity and prolonged apnea with suxamethonium.

PubMed ID: 25054547

DOI: 10.1371/journal.pone.0101552

PubMed ID: 12869558

Title: Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products.

PubMed ID: 12869558

DOI: 10.1074/jbc.m210241200

PubMed ID: 15667209

Title: Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging.

PubMed ID: 15667209

DOI: 10.1021/bi048238d

PubMed ID: 17768338

Title: Crystallization and X-ray structure of full-length recombinant human butyrylcholinesterase.

PubMed ID: 17768338

DOI: 10.1107/s1744309107037335

PubMed ID: 17355286

Title: Mechanisms of cholinesterase inhibition by inorganic mercury.

PubMed ID: 17355286

DOI: 10.1111/j.1742-4658.2007.05732.x

PubMed ID: 18975951

Title: Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation.

PubMed ID: 18975951

DOI: 10.1021/ja804941z

PubMed ID: 19368529

Title: Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun.

PubMed ID: 19368529

DOI: 10.1042/bj20090091

PubMed ID: 23679855

Title: Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase.

PubMed ID: 23679855

DOI: 10.1042/bj20130013

PubMed ID: 2915989

Title: Identification of the structural mutation responsible for the dibucaine-resistant (atypical) variant form of human serum cholinesterase.

PubMed ID: 2915989

DOI: 10.1073/pnas.86.3.953

PubMed ID: 1349196

Title: DNA mutations associated with the human butyrylcholinesterase J-variant.

PubMed ID: 1349196

PubMed ID: 1415224

Title: Identification of two different point mutations associated with the fluoride-resistant phenotype for human butyrylcholinesterase.

PubMed ID: 1415224

PubMed ID: 1611188

Title: A variant serum cholinesterase and a confirmed point mutation at Gly-365 to Arg found in a patient with liver cirrhosis.

PubMed ID: 1611188

DOI: 10.2169/internalmedicine.31.357

PubMed ID: 1306123

Title: Structural basis of the butyrylcholinesterase H-variant segregating in two Danish families.

PubMed ID: 1306123

DOI: 10.1097/00008571-199210000-00006

PubMed ID: 7634491

Title: Genetic basis of the silent phenotype of serum butyrylcholinesterase in three compound heterozygotes.

PubMed ID: 7634491

DOI: 10.1016/0009-8981(95)06014-1

PubMed ID: 8680411

Title: Mutations of human butyrylcholinesterase gene in a family with hypocholinesterasemia.

PubMed ID: 8680411

DOI: 10.1002/humu.1380060411

PubMed ID: 8554068

Title: Characterization of 12 silent alleles of the human butyrylcholinesterase (BCHE) gene.

PubMed ID: 8554068

PubMed ID: 9543549

Title: Genetic analysis of a Japanese patient with butyrylcholinesterase deficiency.

PubMed ID: 9543549

DOI: 10.1046/j.1469-1809.1997.6160491.x

PubMed ID: 9388484

Title: Human butyrylcholinesterase L330I mutation belongs to a fluoride-resistant gene, by expression in human fetal kidney cells.

PubMed ID: 9388484

DOI: 10.1006/bbrc.1997.7658

PubMed ID: 9191541

Title: Genetic mutations of butyrylcholine esterase identified from phenotypic abnormalities in Japan.

PubMed ID: 9191541

PubMed ID: 9110359

Title: Characterization of an unstable variant (BChE115D) of human butyrylcholinesterase.

PubMed ID: 9110359

DOI: 10.1097/00008571-199702000-00004

PubMed ID: 9694584

Title: Identification of a point mutation associated with a silent phenotype of human serum butyrylcholinesterase - a case of familial cholinesterasemia.

PubMed ID: 9694584

DOI: 10.1016/s0009-8981(98)00058-8

PubMed ID: 10404729

Title: Three point mutations of human butyrylcholinesterase in a Japanese family and the alterations of three-dimensional structure.

PubMed ID: 10404729

DOI: 10.1016/s0009-8981(99)00030-3

PubMed ID: 11928765

Title: Naturally occurring mutation, Asp70His, in human butyrylcholinesterase.

PubMed ID: 11928765

DOI: 10.1258/0004563021901775

PubMed ID: 12881446

Title: Butyrylcholinesterase (BCHE) genotyping for post-succinylcholine apnea in an Australian population.

PubMed ID: 12881446

DOI: 10.1373/49.8.1297

PubMed ID: 15563885

Title: Novel mutations in the BCHE gene in patients with no butyrylcholinesterase activity.

PubMed ID: 15563885

DOI: 10.1016/j.cccn.2004.09.004

PubMed ID: 15781196

Title: Four new mutations in the BCHE gene of human butyrylcholinesterase in a Brazilian blood donor sample.

PubMed ID: 15781196

DOI: 10.1016/j.ymgme.2004.12.005

PubMed ID: 16788378

Title: Naturally occurring mutation Leu307Pro of human butyrylcholinesterase in the Vysya community of India.

PubMed ID: 16788378

DOI: 10.1097/01.fpc.0000197464.37211.77

PubMed ID: 17700357

Title: Expression of three naturally occurring genetic variants (G75R, E90D, I99M) of the BCHE gene of human butyrylcholinesterase.

PubMed ID: 17700357

DOI: 10.1097/01.fpc.0000236333.49422.86

PubMed ID: 18075469

Title: Two novel mutations in the BCHE gene in patients with prolonged duration of action of mivacurium or succinylcholine during anaesthesia.

PubMed ID: 18075469

DOI: 10.1097/fpc.0b013e3282f06646

PubMed ID: 18300943

Title: Five new naturally occurring mutations of the BCHE gene and frequencies of 12 butyrylcholinesterase alleles in a Brazilian population.

PubMed ID: 18300943

DOI: 10.1097/fpc.0b013e3282f5107e

PubMed ID: 25264279

Title: Characterization of a novel butyrylcholinesterase point mutation (p.Ala34Val), 'silent' with mivacurium.

PubMed ID: 25264279

DOI: 10.1016/j.bcp.2014.09.014

Sequence Information:

  • Length: 602
  • Mass: 68418
  • Checksum: C9836409D9057F27
  • Sequence:
    • MHSKVTIICI RFLFWFLLLC MLIGKSHTED DIIIATKNGK VRGMNLTVFG GTVTAFLGIP 
YAQPPLGRLR FKKPQSLTKW SDIWNATKYA NSCCQNIDQS FPGFHGSEMW NPNTDLSEDC 
LYLNVWIPAP KPKNATVLIW IYGGGFQTGT SSLHVYDGKF LARVERVIVV SMNYRVGALG 
FLALPGNPEA PGNMGLFDQQ LALQWVQKNI AAFGGNPKSV TLFGESAGAA SVSLHLLSPG 
SHSLFTRAIL QSGSFNAPWA VTSLYEARNR TLNLAKLTGC SRENETEIIK CLRNKDPQEI 
LLNEAFVVPY GTPLSVNFGP TVDGDFLTDM PDILLELGQF KKTQILVGVN KDEGTAFLVY 
GAPGFSKDNN SIITRKEFQE GLKIFFPGVS EFGKESILFH YTDWVDDQRP ENYREALGDV 
VGDYNFICPA LEFTKKFSEW GNNAFFYYFE HRSSKLPWPE WMGVMHGYEI EFVFGLPLER 
RDNYTKAEEI LSRSIVKRWA NFAKYGNPNE TQNNSTSWPV FKSTEQKYLT LNTESTRIMT 
KLRAQQCRFW TSFFPKVLEM TGNIDEAEWE WKAGFHRWNN YMMDWKNQFN DYTSKKESCV 
GL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.