Details for: BCHE

Gene ID: 590

Symbol: BCHE

Ensembl ID: ENSG00000114200

Description: butyrylcholinesterase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 59.8863
    Cell Significance Index: -24.6700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 54.2444
    Cell Significance Index: -25.6100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.9381
    Cell Significance Index: -21.9000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.2898
    Cell Significance Index: 114.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4893
    Cell Significance Index: 83.5700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1200
    Cell Significance Index: 27.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8963
    Cell Significance Index: 321.4800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.6774
    Cell Significance Index: 9.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6592
    Cell Significance Index: 40.5200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5427
    Cell Significance Index: 5.9000
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.4138
    Cell Significance Index: 3.8400
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.2468
    Cell Significance Index: 2.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2041
    Cell Significance Index: 40.5100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1787
    Cell Significance Index: 3.7400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0771
    Cell Significance Index: 1.8500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0715
    Cell Significance Index: 49.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0283
    Cell Significance Index: 17.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0075
    Cell Significance Index: 3.3200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0019
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0071
    Cell Significance Index: -13.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0071
    Cell Significance Index: -10.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0075
    Cell Significance Index: -5.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0209
    Cell Significance Index: -38.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0301
    Cell Significance Index: -40.9900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0329
    Cell Significance Index: -24.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0377
    Cell Significance Index: -23.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0388
    Cell Significance Index: -29.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0411
    Cell Significance Index: -23.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0603
    Cell Significance Index: -32.9500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0619
    Cell Significance Index: -7.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0650
    Cell Significance Index: -13.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0757
    Cell Significance Index: -34.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0774
    Cell Significance Index: -15.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0916
    Cell Significance Index: -26.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1072
    Cell Significance Index: -19.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1219
    Cell Significance Index: -20.8200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1470
    Cell Significance Index: -2.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1475
    Cell Significance Index: -10.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1615
    Cell Significance Index: -23.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1662
    Cell Significance Index: -20.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1958
    Cell Significance Index: -25.2900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2161
    Cell Significance Index: -24.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2225
    Cell Significance Index: -25.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2261
    Cell Significance Index: -31.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2387
    Cell Significance Index: -16.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2434
    Cell Significance Index: -24.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2566
    Cell Significance Index: -7.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2632
    Cell Significance Index: -30.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2644
    Cell Significance Index: -27.5300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2945
    Cell Significance Index: -7.5700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3130
    Cell Significance Index: -24.7900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.3201
    Cell Significance Index: -3.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3389
    Cell Significance Index: -25.2600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3561
    Cell Significance Index: -18.5500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4007
    Cell Significance Index: -6.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4225
    Cell Significance Index: -26.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4239
    Cell Significance Index: -32.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4479
    Cell Significance Index: -27.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4836
    Cell Significance Index: -21.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4867
    Cell Significance Index: -22.8800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5094
    Cell Significance Index: -25.7500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5337
    Cell Significance Index: -6.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.5714
    Cell Significance Index: -25.9000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5808
    Cell Significance Index: -11.3400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5810
    Cell Significance Index: -22.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5851
    Cell Significance Index: -30.7200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5955
    Cell Significance Index: -24.4000
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.6258
    Cell Significance Index: -3.9300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6558
    Cell Significance Index: -18.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7288
    Cell Significance Index: -25.3300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.7297
    Cell Significance Index: -4.3300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7337
    Cell Significance Index: -10.8300
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.7361
    Cell Significance Index: -10.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7408
    Cell Significance Index: -38.4800
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.7738
    Cell Significance Index: -4.7400
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.8012
    Cell Significance Index: -6.9300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8104
    Cell Significance Index: -23.8700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.8108
    Cell Significance Index: -20.2200
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.8252
    Cell Significance Index: -7.4600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.8457
    Cell Significance Index: -5.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.8553
    Cell Significance Index: -39.8800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8653
    Cell Significance Index: -27.5600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8692
    Cell Significance Index: -30.4500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9145
    Cell Significance Index: -19.4100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.9156
    Cell Significance Index: -15.6900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9285
    Cell Significance Index: -30.4000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.9556
    Cell Significance Index: -27.2700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9718
    Cell Significance Index: -26.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.9730
    Cell Significance Index: -25.9800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -1.0000
    Cell Significance Index: -16.8200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.0106
    Cell Significance Index: -20.2900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.0377
    Cell Significance Index: -26.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.0586
    Cell Significance Index: -28.8200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.0590
    Cell Significance Index: -26.9800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.0594
    Cell Significance Index: -26.4600
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -1.0629
    Cell Significance Index: -12.5300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.0805
    Cell Significance Index: -23.6600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0978
    Cell Significance Index: -40.3000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -1.1144
    Cell Significance Index: -17.6800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.1234
    Cell Significance Index: -35.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Diverse Tissue Expression:** BCHE is expressed in various tissues, including the adrenal gland, neural crest cells, mesothelial cells, kidney proximal convoluted tubule epithelial cells, and neural cells, highlighting its potential role in diverse physiological processes. 2. **Hydrolase Activity:** BCHE exhibits hydrolase activity, specifically hydrolyzing ester bonds, which is crucial for its enzymatic function. 3. **Acetylcholine Catabolism:** BCHE is involved in the catabolism of acetylcholine, a neurotransmitter that plays a vital role in immune regulation and synaptic transmission. 4. **Amyloid-Binding:** BCHE has been shown to bind amyloid-beta, a peptide associated with Alzheimer's disease, suggesting a potential role in amyloid clearance and disease pathogenesis. **Pathways and Functions:** 1. **Acetylcholinesterase Activity:** BCHE's enzymatic activity is crucial for the breakdown of acetylcholine, regulating neurotransmission and synaptic plasticity. 2. **Amyloid-Beta Clearance:** BCHE's binding to amyloid-beta may facilitate its clearance, potentially mitigating Alzheimer's disease pathogenesis. 3. **Cocaine Metabolism:** BCHE is involved in the metabolism of cocaine, a psychoactive substance that can affect immune function and behavior. 4. **Xenobiotic Metabolism:** BCHE's role in xenobiotic metabolism highlights its potential involvement in the detoxification of environmental toxins and other foreign substances. 5. **Neurotransmitter Clearance:** BCHE's function in clearing neurotransmitters, such as acetylcholine, is essential for maintaining synaptic homeostasis and regulating immune responses. **Clinical Significance:** 1. **Alzheimer's Disease:** BCHE's binding to amyloid-beta and potential role in amyloid clearance make it an interesting target for Alzheimer's disease therapy. 2. **Cocaine Addiction:** BCHE's involvement in cocaine metabolism highlights the enzyme's potential as a biomarker for cocaine exposure and addiction. 3. **Neurological Disorders:** BCHE's role in neurotransmitter clearance and synaptic plasticity makes it a potential target for the treatment of neurological disorders, such as Parkinson's disease and multiple sclerosis. 4. **Immune Regulation:** BCHE's involvement in acetylcholine catabolism and amyloid-beta clearance suggests its potential role in regulating immune responses and maintaining immune homeostasis. In conclusion, BCHE is a multifaceted enzyme with diverse functions in various physiological and pathological processes. Further research is necessary to fully elucidate the role of BCHE in immune regulation and disease pathogenesis, but its potential as a therapeutic target and biomarker for various diseases makes it an exciting area of investigation.

Genular Protein ID: 2939782717

Symbol: CHLE_HUMAN

Name: Cholinesterase

UniProtKB Accession Codes:

P06276 A8K7P8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 84 DrugCentral 1 EC 2 EMBL 7 EMDB 2 ESTHER 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 89 PDBsum 89 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3035536

Title: Isolation and characterization of full-length cDNA clones coding for cholinesterase from fetal human tissues.

PubMed ID: 3035536

DOI: 10.1073/pnas.84.11.3555

PubMed ID: 3477799

Title: Brain cDNA clone for human cholinesterase.

PubMed ID: 3477799

DOI: 10.1073/pnas.84.19.6682

PubMed ID: 2322535

Title: Structure of the gene for human butyrylcholinesterase. Evidence for a single copy.

PubMed ID: 2322535

DOI: 10.1021/bi00453a015

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3542989

Title: Complete amino acid sequence of human serum cholinesterase.

PubMed ID: 3542989

DOI: 10.1016/s0021-9258(19)75818-9

PubMed ID: 20946535

Title: Biochemical, molecular and preclinical characterization of a double-virus-reduced human butyrylcholinesterase preparation designed for clinical use.

PubMed ID: 20946535

DOI: 10.1111/j.1423-0410.2010.01415.x

PubMed ID: 3115973

Title: Location of disulfide bonds within the sequence of human serum cholinesterase.

PubMed ID: 3115973

DOI: 10.1016/s0021-9258(18)45149-6

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 18203274

Title: Glycoproteomic characterization of butyrylcholinesterase from human plasma.

PubMed ID: 18203274

DOI: 10.1002/pmic.200700720

PubMed ID: 19542320

Title: Adenovirus-transduced human butyrylcholinesterase in mouse blood functions as a bioscavenger of chemical warfare nerve agents.

PubMed ID: 19542320

DOI: 10.1124/mol.109.055665

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 19452557

Title: The structure of G117H mutant of butyrylcholinesterase: nerve agents scavenger.

PubMed ID: 19452557

DOI: 10.1002/prot.22442

PubMed ID: 22444575

Title: Identification of phosphorylated butyrylcholinesterase in human plasma using immunoaffinity purification and mass spectrometry.

PubMed ID: 22444575

DOI: 10.1016/j.aca.2012.02.023

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25054547

Title: Characterization of a novel BCHE 'silent' allele: point mutation (p.Val204Asp) causes loss of activity and prolonged apnea with suxamethonium.

PubMed ID: 25054547

DOI: 10.1371/journal.pone.0101552

PubMed ID: 12869558

Title: Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products.

PubMed ID: 12869558

DOI: 10.1074/jbc.m210241200

PubMed ID: 15667209

Title: Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging.

PubMed ID: 15667209

DOI: 10.1021/bi048238d

PubMed ID: 17768338

Title: Crystallization and X-ray structure of full-length recombinant human butyrylcholinesterase.

PubMed ID: 17768338

DOI: 10.1107/s1744309107037335

PubMed ID: 17355286

Title: Mechanisms of cholinesterase inhibition by inorganic mercury.

PubMed ID: 17355286

DOI: 10.1111/j.1742-4658.2007.05732.x

PubMed ID: 18975951

Title: Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation.

PubMed ID: 18975951

DOI: 10.1021/ja804941z

PubMed ID: 19368529

Title: Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun.

PubMed ID: 19368529

DOI: 10.1042/bj20090091

PubMed ID: 23679855

Title: Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase.

PubMed ID: 23679855

DOI: 10.1042/bj20130013

PubMed ID: 2915989

Title: Identification of the structural mutation responsible for the dibucaine-resistant (atypical) variant form of human serum cholinesterase.

PubMed ID: 2915989

DOI: 10.1073/pnas.86.3.953

PubMed ID: 1349196

Title: DNA mutations associated with the human butyrylcholinesterase J-variant.

PubMed ID: 1349196

PubMed ID: 1415224

Title: Identification of two different point mutations associated with the fluoride-resistant phenotype for human butyrylcholinesterase.

PubMed ID: 1415224

PubMed ID: 1611188

Title: A variant serum cholinesterase and a confirmed point mutation at Gly-365 to Arg found in a patient with liver cirrhosis.

PubMed ID: 1611188

DOI: 10.2169/internalmedicine.31.357

PubMed ID: 1306123

Title: Structural basis of the butyrylcholinesterase H-variant segregating in two Danish families.

PubMed ID: 1306123

DOI: 10.1097/00008571-199210000-00006

PubMed ID: 7634491

Title: Genetic basis of the silent phenotype of serum butyrylcholinesterase in three compound heterozygotes.

PubMed ID: 7634491

DOI: 10.1016/0009-8981(95)06014-1

PubMed ID: 8680411

Title: Mutations of human butyrylcholinesterase gene in a family with hypocholinesterasemia.

PubMed ID: 8680411

DOI: 10.1002/humu.1380060411

PubMed ID: 8554068

Title: Characterization of 12 silent alleles of the human butyrylcholinesterase (BCHE) gene.

PubMed ID: 8554068

PubMed ID: 9543549

Title: Genetic analysis of a Japanese patient with butyrylcholinesterase deficiency.

PubMed ID: 9543549

DOI: 10.1046/j.1469-1809.1997.6160491.x

PubMed ID: 9388484

Title: Human butyrylcholinesterase L330I mutation belongs to a fluoride-resistant gene, by expression in human fetal kidney cells.

PubMed ID: 9388484

DOI: 10.1006/bbrc.1997.7658

PubMed ID: 9191541

Title: Genetic mutations of butyrylcholine esterase identified from phenotypic abnormalities in Japan.

PubMed ID: 9191541

PubMed ID: 9110359

Title: Characterization of an unstable variant (BChE115D) of human butyrylcholinesterase.

PubMed ID: 9110359

DOI: 10.1097/00008571-199702000-00004

PubMed ID: 9694584

Title: Identification of a point mutation associated with a silent phenotype of human serum butyrylcholinesterase - a case of familial cholinesterasemia.

PubMed ID: 9694584

DOI: 10.1016/s0009-8981(98)00058-8

PubMed ID: 10404729

Title: Three point mutations of human butyrylcholinesterase in a Japanese family and the alterations of three-dimensional structure.

PubMed ID: 10404729

DOI: 10.1016/s0009-8981(99)00030-3

PubMed ID: 11928765

Title: Naturally occurring mutation, Asp70His, in human butyrylcholinesterase.

PubMed ID: 11928765

DOI: 10.1258/0004563021901775

PubMed ID: 12881446

Title: Butyrylcholinesterase (BCHE) genotyping for post-succinylcholine apnea in an Australian population.

PubMed ID: 12881446

DOI: 10.1373/49.8.1297

PubMed ID: 15563885

Title: Novel mutations in the BCHE gene in patients with no butyrylcholinesterase activity.

PubMed ID: 15563885

DOI: 10.1016/j.cccn.2004.09.004

PubMed ID: 15781196

Title: Four new mutations in the BCHE gene of human butyrylcholinesterase in a Brazilian blood donor sample.

PubMed ID: 15781196

DOI: 10.1016/j.ymgme.2004.12.005

PubMed ID: 16788378

Title: Naturally occurring mutation Leu307Pro of human butyrylcholinesterase in the Vysya community of India.

PubMed ID: 16788378

DOI: 10.1097/01.fpc.0000197464.37211.77

PubMed ID: 17700357

Title: Expression of three naturally occurring genetic variants (G75R, E90D, I99M) of the BCHE gene of human butyrylcholinesterase.

PubMed ID: 17700357

DOI: 10.1097/01.fpc.0000236333.49422.86

PubMed ID: 18075469

Title: Two novel mutations in the BCHE gene in patients with prolonged duration of action of mivacurium or succinylcholine during anaesthesia.

PubMed ID: 18075469

DOI: 10.1097/fpc.0b013e3282f06646

PubMed ID: 18300943

Title: Five new naturally occurring mutations of the BCHE gene and frequencies of 12 butyrylcholinesterase alleles in a Brazilian population.

PubMed ID: 18300943

DOI: 10.1097/fpc.0b013e3282f5107e

PubMed ID: 25264279

Title: Characterization of a novel butyrylcholinesterase point mutation (p.Ala34Val), 'silent' with mivacurium.

PubMed ID: 25264279

DOI: 10.1016/j.bcp.2014.09.014

Sequence Information:

  • Length: 602
  • Mass: 68418
  • Checksum: C9836409D9057F27
  • Sequence:
    • MHSKVTIICI RFLFWFLLLC MLIGKSHTED DIIIATKNGK VRGMNLTVFG GTVTAFLGIP 
YAQPPLGRLR FKKPQSLTKW SDIWNATKYA NSCCQNIDQS FPGFHGSEMW NPNTDLSEDC 
LYLNVWIPAP KPKNATVLIW IYGGGFQTGT SSLHVYDGKF LARVERVIVV SMNYRVGALG 
FLALPGNPEA PGNMGLFDQQ LALQWVQKNI AAFGGNPKSV TLFGESAGAA SVSLHLLSPG 
SHSLFTRAIL QSGSFNAPWA VTSLYEARNR TLNLAKLTGC SRENETEIIK CLRNKDPQEI 
LLNEAFVVPY GTPLSVNFGP TVDGDFLTDM PDILLELGQF KKTQILVGVN KDEGTAFLVY 
GAPGFSKDNN SIITRKEFQE GLKIFFPGVS EFGKESILFH YTDWVDDQRP ENYREALGDV 
VGDYNFICPA LEFTKKFSEW GNNAFFYYFE HRSSKLPWPE WMGVMHGYEI EFVFGLPLER 
RDNYTKAEEI LSRSIVKRWA NFAKYGNPNE TQNNSTSWPV FKSTEQKYLT LNTESTRIMT 
KLRAQQCRFW TSFFPKVLEM TGNIDEAEWE WKAGFHRWNN YMMDWKNQFN DYTSKKESCV 
GL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.