Pias4 | ENSMUSG00000004934 | NCBI 59004

Details for: Pias4

Gene ID: 59004

Symbol: Pias4

Ensembl ID: ENSMUSG00000004934

Description: protein inhibitor of activated STAT 4

Associated with

Cell cycle
(R-MMU-1640170)
Cell cycle checkpoints
(R-MMU-69620)
Dna double-strand break repair
(R-MMU-5693532)
Dna double strand break response
(R-MMU-5693606)
Dna repair
(R-MMU-73894)
G2/m checkpoints
(R-MMU-69481)
G2/m dna damage checkpoint
(R-MMU-69473)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-MMU-5693567)
Homology directed repair
(R-MMU-5693538)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Metabolism of proteins
(R-MMU-392499)
Metabolism of steroids
(R-MMU-8957322)
Nonhomologous end-joining (nhej)
(R-MMU-5693571)
Post-translational protein modification
(R-MMU-597592)
Processing of dna double-strand break ends
(R-MMU-5693607)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-MMU-5693565)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of dna damage response and repair proteins
(R-MMU-3108214)
Sumoylation of dna replication proteins
(R-MMU-4615885)
Sumoylation of immune response proteins
(R-MMU-4755510)
Sumoylation of intracellular receptors
(R-MMU-4090294)
Sumoylation of sumoylation proteins
(R-MMU-4085377)
Sumoylation of transcription cofactors
(R-MMU-3899300)
Sumoylation of transcription factors
(R-MMU-3232118)
Sumoylation of ubiquitinylation proteins
(R-MMU-3232142)
Vitamin d (calciferol) metabolism
(R-MMU-196791)
Central nervous system development
(GO:0007417)
Cytoplasm
(GO:0005737)
Dna binding
(GO:0003677)
Hair follicle development
(GO:0001942)
Limb epidermis development
(GO:0060887)
Metal ion binding
(GO:0046872)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of nf-kappab transcription factor activity
(GO:0032088)
Negative regulation of protein localization to chromatin
(GO:0120186)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of tumor necrosis factor-mediated signaling pathway
(GO:0010804)
Nuclear matrix
(GO:0016363)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of double-strand break repair via homologous recombination
(GO:1905168)
Positive regulation of intrinsic apoptotic signaling pathway in response to dna damage
(GO:1902231)
Positive regulation of keratinocyte apoptotic process
(GO:1902174)
Positive regulation of protein sumoylation
(GO:0033235)
Protein binding
(GO:0005515)
Protein sumoylation
(GO:0016925)
Receptor signaling pathway via jak-stat
(GO:0007259)
Regulation of mrna stability
(GO:0043488)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Sumo ligase activity
(GO:0061665)
Sumo transferase activity
(GO:0019789)
Transcription coregulator activity
(GO:0003712)
Transcription corepressor activity
(GO:0003714)
Transferase activity
(GO:0016740)
Transferase complex
(GO:1990234)
Ubiquitin protein ligase binding
(GO:0031625)
Wnt signaling pathway
(GO:0016055)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

E3 SUMO-protein ligase PIAS4

Genular Protein ID: 1348543737

Symbol: PIAS4_MOUSE

Name: E3 SUMO-protein ligase PIAS4

UniProtKB Accession Codes:

Q9JM05 Q8R165

Database IDs:

Citations:

PubMed ID: 10854042

Title: Cloning and analysis of a murine Pias family member, Pias-gamma, in developing skin and neurons.

PubMed ID: 10854042

DOI: 10.1385/jmn:14:1-2:107

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11731474

Title: PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies.

PubMed ID: 11731474

DOI: 10.1101/gad.944801

PubMed ID: 12750312

Title: Modification of GATA-2 transcriptional activity in endothelial cells by the SUMO E3 ligase PIASy.

PubMed ID: 12750312

DOI: 10.1161/01.res.0000076893.70898.36

PubMed ID: 16816390

Title: The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through NFkappaB.

PubMed ID: 16816390

DOI: 10.1074/jbc.m601655200

PubMed ID: 16352559

Title: Interaction of moloney murine leukemia virus capsid with Ubc9 and PIASy mediates SUMO-1 addition required early in infection.

PubMed ID: 16352559

DOI: 10.1128/jvi.80.1.342-352.2006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 507
Mass: 55570
Checksum: A8E5E6E3BAC76426
Sequence:

MAAELVEAKN MVMSFRVSDL QMLLGFVGRS KSGLKHELVT RALQLVQFDC SPELFKKIKE 
LYETRYAKKS AEPGPQAPRP LDPLALHSMP RTPLSGPTVD YPVLYGKYLN GLGRLPTKTL 
KPEVRLVKLP FFNMLDELLK PTELVPQSAE KLQESPCIFA LTPRQVEMIR NSRELQPGVK 
AVQVVLRICY SDTSCPQEDQ YPPNIAVKVN HSYCSVPGYY PSNKPGVEPK RPCRPINLTH 
LMYLSSATNR ITVTWGNYGK SYSVALYLVR QLTSSDLLQR LKTIGVKHPE LCKALVKEKL 
RLDPDSEIAT TGVRVSLICP LVKMRLSVPC RAETCAHLQC FDAVFYLQMN EKKPTWMCPV 
CDKPAAYDQL IIDGLLSKIL SECEGADEIE FLAEGSWRPI RAEKEPSCSP QGPILVLGTS 
DANGLAPASS TPGIGSGLSG PGSAGSGAGA AGSLENGKTG ADVVDLTLDS SSSSEDEDED 
EDDDEDEDEG PRPKRRCPFQ KGLVPAC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pias4

Associated with

Other Information

Cloning and analysis of a murine Pias family member, Pias-gamma, in developing skin and neurons. PubMed ID: 10854042

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies. PubMed ID: 11731474

Modification of GATA-2 transcriptional activity in endothelial cells by the SUMO E3 ligase PIASy. PubMed ID: 12750312

The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through NFkappaB. PubMed ID: 16816390

Interaction of moloney murine leukemia virus capsid with Ubc9 and PIASy mediates SUMO-1 addition required early in infection. PubMed ID: 16352559

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079