Usp14 | ENSMUSG00000047879 | NCBI 59025

Details for: Usp14

Gene ID: 59025

Symbol: Usp14

Ensembl ID: ENSMUSG00000047879

Description: ubiquitin specific peptidase 14

Associated with

Cytokine signaling in immune system
(R-MMU-1280215)
Deubiquitination
(R-MMU-5688426)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interleukin-1 family signaling
(R-MMU-446652)
Interleukin-1 signaling
(R-MMU-9020702)
Metabolism of proteins
(R-MMU-392499)
Myd88 cascade initiated on plasma membrane
(R-MMU-975871)
Myd88 dependent cascade initiated on endosome
(R-MMU-975155)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-MMU-166058)
Post-translational protein modification
(R-MMU-597592)
Regulation of nf-kappa b signaling
(R-MMU-9758274)
Signaling by interleukins
(R-MMU-449147)
Tak1-dependent ikk and nf-kappa-b activation
(R-MMU-445989)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 2 (tlr2) cascade
(R-MMU-181438)
Toll like receptor 3 (tlr3) cascade
(R-MMU-168164)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 5 (tlr5) cascade
(R-MMU-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Toll like receptor 10 (tlr10) cascade
(R-MMU-168142)
Toll like receptor tlr1:tlr2 cascade
(R-MMU-168179)
Toll like receptor tlr6:tlr2 cascade
(R-MMU-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-MMU-975138)
Trif(ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Ub-specific processing proteases
(R-MMU-5689880)
Cell surface
(GO:0009986)
Chemical synaptic transmission
(GO:0007268)
Cysteine-type deubiquitinase activity
(GO:0004843)
Cysteine-type peptidase activity
(GO:0008234)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Deubiquitinase activity
(GO:0101005)
Endopeptidase inhibitor activity
(GO:0004866)
Hydrolase activity
(GO:0016787)
Immune system process
(GO:0002376)
Innate immune response
(GO:0045087)
K63-linked deubiquitinase activity
(GO:0061578)
Membrane
(GO:0016020)
Negative regulation of erad pathway
(GO:1904293)
Negative regulation of ubiquitin-dependent protein catabolic process
(GO:2000059)
Peptidase activity
(GO:0008233)
Plasma membrane
(GO:0005886)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Proteasome binding
(GO:0070628)
Proteasome complex
(GO:0000502)
Protein binding
(GO:0005515)
Protein deubiquitination
(GO:0016579)
Proteolysis
(GO:0006508)
Regulation of chemotaxis
(GO:0050920)
Regulation of proteasomal protein catabolic process
(GO:0061136)
Synapse
(GO:0045202)

Other Information

Proteins

Ubiquitin carboxyl-terminal hydrolase 14
E9PYI8_MOUSE

Genular Protein ID: 4166476378

Symbol: UBP14_MOUSE

Name: Ubiquitin carboxyl-terminal hydrolase 14

UniProtKB Accession Codes:

Q9JMA1 Q543U5 Q923F2 Q9D0L0

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11566882

Title: A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14.

PubMed ID: 11566882

DOI: 10.1093/emboj/20.18.5187

PubMed ID: 16190881

Title: Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice.

PubMed ID: 16190881

DOI: 10.1111/j.1471-4159.2005.03409.x

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19726649

Title: The proteasome-associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions.

PubMed ID: 19726649

DOI: 10.1523/jneurosci.2635-09.2009

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 493
Mass: 56002
Checksum: 4E5F5DCB86057FF9
Sequence:

MPLYSVTVKW GKEKFEGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG GTLKDDDWGN 
IKMKNGMTVL MMGSADALPE EPSAKTVFVE DMTEEQLATA MELPCGLTNL GNTCYMNATV 
QCIRSVPELK DALKRYAGAL RASGEMASAQ YITAALRDLF DSMDKTSSSI PPIILLQFLH 
MAFPQFAEKG EQGQYLQQDA NECWIQMMRV LQQKLEAIED DSGRETDSSS APAVTPSKKK 
SLIDQYFGVE FETTMKCTES EEEEVTKGKE NQLQLSCFIN QEVKYLFTGL KLRLQEEITK 
QSPTLQRNAL YIKSSKISRL PAYLTIQMVR FFYKEKESVN AKVLKDVKFP LMLDVYELCT 
PELQEKMVSF RSKFKDLEDK KVNQQPNAND KNSPPKEIKY EPFSFADDIG SNNCGYYDLQ 
AVLTHQGRSS SSGHYVSWVR RKQDEWIKFD DDKVSIVTPE DILRLSGGGD WHIAYVLLYG 
PRRVEIMEEE SEQ

Genular Protein ID: 517739272

Symbol: E9PYI8_MOUSE

Name: N/A

UniProtKB Accession Codes:

E9PYI8

Database IDs:

Citations:

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 458
Mass: 52319
Checksum: 8845A8D60151AF49
Sequence:

MPLYSVTVKW GKEKFEGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG GTLKDDDWGN 
IKMKNMELPC GLTNLGNTCY MNATVQCIRS VPELKDALKR YAGALRASGE MASAQYITAA 
LRDLFDSMDK TSSSIPPIIL LQFLHMAFPQ FAEKGEQGQY LQQDANECWI QMMRVLQQKL 
EAIEDDSGRE TDSSSAPAVT PSKKKSLIDQ YFGVEFETTM KCTESEEEEV TKGKENQLQL 
SCFINQEVKY LFTGLKLRLQ EEITKQSPTL QRNALYIKSS KISRLPAYLT IQMVRFFYKE 
KESVNAKVLK DVKFPLMLDV YELCTPELQE KMVSFRSKFK DLEDKKVNQQ PNANDKNSPP 
KEIKYEPFSF ADDIGSNNCG YYDLQAVLTH QGRSSSSGHY VSWVRRKQDE WIKFDDDKVS 
IVTPEDILRL SGGGDWHIAY VLLYGPRRVE IMEEESEQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Usp14

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14. PubMed ID: 11566882

Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice. PubMed ID: 16190881

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

The proteasome-associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions. PubMed ID: 19726649

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Database document:

PubMed ID: 16141072

PubMed ID: 15489334

PubMed ID: 11566882

PubMed ID: 16190881

PubMed ID: 17242355

PubMed ID: 19726649

PubMed ID: 21183079

PubMed ID: 17242355

PubMed ID: 19468303

PubMed ID: 21183079