Nampt | ENSMUSG00000020572 | NCBI 59027

Details for: Nampt

Gene ID: 59027

Symbol: Nampt

Ensembl ID: ENSMUSG00000020572

Description: nicotinamide phosphoribosyltransferase

Associated with

Metabolism
(R-MMU-1430728)
Metabolism of vitamins and cofactors
(R-MMU-196854)
Metabolism of water-soluble vitamins and cofactors
(R-MMU-196849)
Nicotinamide salvaging
(R-MMU-197264)
Nicotinate metabolism
(R-MMU-196807)
Cell junction
(GO:0030054)
Circadian regulation of gene expression
(GO:0032922)
Circadian rhythm
(GO:0007623)
Cytokine activity
(GO:0005125)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Glycosyltransferase activity
(GO:0016757)
Heterocyclic compound binding
(GO:1901363)
Identical protein binding
(GO:0042802)
Microglial cell activation
(GO:0001774)
Nad biosynthetic process
(GO:0009435)
Negative regulation of autophagy
(GO:0010507)
Negative regulation of cellular senescence
(GO:2000773)
Nicotinamide phosphoribosyltransferase activity
(GO:0047280)
Nuclear speck
(GO:0016607)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Positive regulation of nitric-oxide synthase biosynthetic process
(GO:0051770)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Pyridine nucleotide biosynthetic process
(GO:0019363)
Regulation of lung blood pressure
(GO:0014916)
Rhythmic process
(GO:0048511)
Transferase activity
(GO:0016740)

Other Information

Proteins

Nicotinamide phosphoribosyltransferase

Genular Protein ID: 2653373347

Symbol: NAMPT_MOUSE

Name: Nicotinamide phosphoribosyltransferase

UniProtKB Accession Codes:

Q99KQ4 Q8C3B5 Q9JKM0

Database IDs:

Citations:

PubMed ID: 12555668

Title: Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis.

PubMed ID: 12555668

DOI: 10.1002/1521-4141(200211)32:11<3225::aid-immu3225>3.0.co;2-l

PubMed ID: 15381699

Title: The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells.

PubMed ID: 15381699

DOI: 10.1074/jbc.m408388200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19299583

Title: Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis.

PubMed ID: 19299583

DOI: 10.1126/science.1171641

PubMed ID: 19286518

Title: Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1.

PubMed ID: 19286518

DOI: 10.1126/science.1170803

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 16783377

Title: Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents.

PubMed ID: 16783377

DOI: 10.1038/nsmb1105

PubMed ID: 16783373

Title: Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme.

PubMed ID: 16783373

DOI: 10.1038/nsmb1114

Sequence Information:

Length: 491
Mass: 55447
Checksum: D3E522A1841297E6
Sequence:

MNAAAEAEFN ILLATDSYKV THYKQYPPNT SKVYSYFECR EKKTENSKVR KVKYEETVFY 
GLQYILNKYL KGKVVTKEKI QEAKEVYREH FQDDVFNERG WNYILEKYDG HLPIEVKAVP 
EGSVIPRGNV LFTVENTDPE CYWLTNWIET ILVQSWYPIT VATNSREQKK ILAKYLLETS 
GNLDGLEYKL HDFGYRGVSS QETAGIGASA HLVNFKGTDT VAGIALIKKY YGTKDPVPGY 
SVPAAEHSTI TAWGKDHEKD AFEHIVTQFS SVPVSVVSDS YDIYNACEKI WGEDLRHLIV 
SRSTEAPLII RPDSGNPLDT VLKVLDILGK KFPVTENSKG YKLLPPYLRV IQGDGVDINT 
LQEIVEGMKQ KKWSIENVSF GSGGALLQKL TRDLLNCSFK CSYVVTNGLG VNVFKDPVAD 
PNKRSKKGRL SLHRTPAGNF VTLEEGKGDL EEYGHDLLHT VFKNGKVTKS YSFDEVRKNA 
QLNIEQDVAP H

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nampt

Associated with

Other Information

Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis. PubMed ID: 12555668

The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. PubMed ID: 15381699

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. PubMed ID: 19299583

Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. PubMed ID: 19286518

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents. PubMed ID: 16783377

Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme. PubMed ID: 16783373