Details for: Carm1

Gene ID: 59035

Symbol: Carm1

Ensembl ID: ENSMUSG00000032185

Description: coactivator-associated arginine methyltransferase 1

Associated with

Other Information

Genular Protein ID: 157142914

Symbol: CARM1_MOUSE

Name: Histone-arginine methyltransferase CARM1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10381882

Title: Regulation of transcription by a protein methyltransferase.

PubMed ID: 10381882

DOI: 10.1126/science.284.5423.2174

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 11341840

Title: Methylation of histone H3 by coactivator-associated arginine methyltransferase 1.

PubMed ID: 11341840

DOI: 10.1021/bi002631b

PubMed ID: 11747826

Title: Hormone-dependent, CARM1-directed, arginine-specific methylation of histone H3 on a steroid-regulated promoter.

PubMed ID: 11747826

DOI: 10.1016/s0960-9822(01)00600-5

PubMed ID: 11701890

Title: A transcriptional switch mediated by cofactor methylation.

PubMed ID: 11701890

DOI: 10.1126/science.1065961

PubMed ID: 12498683

Title: Crosstalk between CARM1 methylation and CBP acetylation on histone H3.

PubMed ID: 12498683

DOI: 10.1016/s0960-9822(02)01387-8

PubMed ID: 11751582

Title: Methylation at arginine 17 of histone H3 is linked to gene activation.

PubMed ID: 11751582

DOI: 10.1093/embo-reports/kvf013

PubMed ID: 11850402

Title: PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays.

PubMed ID: 11850402

DOI: 10.1093/embo-reports/kvf052

PubMed ID: 11713257

Title: The coactivator-associated arginine methyltransferase is necessary for muscle differentiation: CARM1 coactivates myocyte enhancer factor-2.

PubMed ID: 11713257

DOI: 10.1074/jbc.m109835200

PubMed ID: 11983685

Title: Synergistic coactivator function by coactivator-associated arginine methyltransferase (CARM) 1 and beta-catenin with two different classes of DNA-binding transcriptional activators.

PubMed ID: 11983685

DOI: 10.1074/jbc.m110865200

PubMed ID: 12237300

Title: Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase.

PubMed ID: 12237300

DOI: 10.1074/jbc.m206187200

PubMed ID: 12351636

Title: Requirement for multiple domains of the protein arginine methyltransferase CARM1 in its transcriptional coactivator function.

PubMed ID: 12351636

DOI: 10.1074/jbc.m207623200

PubMed ID: 11997499

Title: Synergy among nuclear receptor coactivators: selective requirement for protein methyltransferase and acetyltransferase activities.

PubMed ID: 11997499

DOI: 10.1128/mcb.22.11.3621-3632.2002

PubMed ID: 12756295

Title: Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice.

PubMed ID: 12756295

DOI: 10.1073/pnas.1232272100

PubMed ID: 15186775

Title: Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53.

PubMed ID: 15186775

DOI: 10.1016/j.cell.2004.05.009

PubMed ID: 15339660

Title: Histone deimination antagonizes arginine methylation.

PubMed ID: 15339660

DOI: 10.1016/j.cell.2004.08.020

PubMed ID: 14966289

Title: Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity.

PubMed ID: 14966289

DOI: 10.1128/mcb.24.5.2103-2117.2004

PubMed ID: 15616592

Title: Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression.

PubMed ID: 15616592

DOI: 10.1038/sj.emboj.7600500

PubMed ID: 16508003

Title: CARM1 regulates proliferation of PC12 cells by methylating HuD.

PubMed ID: 16508003

DOI: 10.1128/mcb.26.6.2273-2285.2006

PubMed ID: 16322096

Title: Transcriptional intermediary factor 1alpha mediates physical interaction and functional synergy between the coactivator-associated arginine methyltransferase 1 and glucocorticoid receptor-interacting protein 1 nuclear receptor coactivators.

PubMed ID: 16322096

DOI: 10.1210/me.2005-0393

PubMed ID: 17218272

Title: The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing.

PubMed ID: 17218272

DOI: 10.1016/j.molcel.2006.11.019

PubMed ID: 18188184

Title: CARM1 promotes adipocyte differentiation by coactivating PPARgamma.

PubMed ID: 18188184

DOI: 10.1038/sj.embor.7401151

PubMed ID: 19843527

Title: Biochemical control of CARM1 enzymatic activity by phosphorylation.

PubMed ID: 19843527

DOI: 10.1074/jbc.m109.065524

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 19897492

Title: Enzymatic activity is required for the in vivo functions of CARM1.

PubMed ID: 19897492

DOI: 10.1074/jbc.m109.035865

PubMed ID: 21138967

Title: Automethylation of CARM1 allows coupling of transcription and mRNA splicing.

PubMed ID: 21138967

DOI: 10.1093/nar/gkq1246

PubMed ID: 30366907

Title: A C9orf72-CARM1 axis regulates lipid metabolism under glucose starvation-induced nutrient stress.

PubMed ID: 30366907

DOI: 10.1101/gad.315564.118

PubMed ID: 17882261

Title: Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase.

PubMed ID: 17882261

DOI: 10.1038/sj.emboj.7601856

Sequence Information:

  • Length: 608
  • Mass: 65854
  • Checksum: C621F2AA9FBA2DA3
  • Sequence:
  • MAAAAATAVG PGAGSAGVAG PGGAGPCATV SVFPGARLLT IGDANGEIQR HAEQQALRLE 
    VRAGPDAAGI ALYSHEDVCV FKCSVSRETE CSRVGRQSFI ITLGCNSVLI QFATPHDFCS 
    FYNILKTCRG HTLERSVFSE RTEESSAVQY FQFYGYLSQQ QNMMQDYVRT GTYQRAILQN 
    HTDFKDKIVL DVGCGSGILS FFAAQAGARK IYAVEASTMA QHAEVLVKSN NLTDRIVVIP 
    GKVEEVSLPE QVDIIISEPM GYMLFNERML ESYLHAKKYL KPSGNMFPTI GDVHLAPFTD 
    EQLYMEQFTK ANFWYQPSFH GVDLSALRGA AVDEYFRQPV VDTFDIRILM AKSVKYTVNF 
    LEAKEGDLHR IEIPFKFHML HSGLVHGLAF WFDVAFIGSI MTVWLSTAPT EPLTHWYQVR 
    CLFQSPLFAK AGDTLSGTCL LIANKRQSYD ISIVAQVDQT GSKSSNLLDL KNPFFRYTGT 
    TPSPPPGSHY TSPSENMWNT GSTYNLSSGV AVAGMPTAYD LSSVIAGGSS VGHNNLIPLA 
    NTGIVNHTHS RMGSIMSTGI VQGSSGAQGG GGSSSAHYAV NNQFTMGGPA ISMASPMSIP 
    TNTMHYGS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.