Dact1 | ENSMUSG00000044548 | NCBI 59036

Details for: Dact1

Gene ID: 59036

Symbol: Dact1

Ensembl ID: ENSMUSG00000044548

Description: dishevelled-binding antagonist of beta-catenin 1

Associated with

Degradation of dvl
(R-MMU-4641258)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Beta-catenin binding
(GO:0008013)
Beta-catenin destruction complex
(GO:0030877)
Canonical wnt signaling pathway
(GO:0060070)
Cytoplasm
(GO:0005737)
Delta-catenin binding
(GO:0070097)
Dendrite morphogenesis
(GO:0048813)
Embryonic hindgut morphogenesis
(GO:0048619)
Embryonic morphogenesis
(GO:0048598)
Gastrulation with mouth forming second
(GO:0001702)
Glutamatergic synapse
(GO:0098978)
Histone deacetylase binding
(GO:0042826)
Multicellular organism development
(GO:0007275)
Negative regulation of beta-catenin-tcf complex assembly
(GO:1904864)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of g1/s transition of mitotic cell cycle
(GO:2000134)
Negative regulation of jnk cascade
(GO:0046329)
Negative regulation of protein binding
(GO:0032091)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of wnt signaling pathway
(GO:0030178)
Nervous system development
(GO:0007399)
Neural tube development
(GO:0021915)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of fat cell differentiation
(GO:0045600)
Positive regulation of protein binding
(GO:0032092)
Positive regulation of protein catabolic process
(GO:0045732)
Positive regulation of wnt signaling pathway
(GO:0030177)
Postsynapse
(GO:0098794)
Protein binding
(GO:0005515)
Protein kinase a binding
(GO:0051018)
Protein kinase c binding
(GO:0005080)
Regulation of canonical wnt signaling pathway
(GO:0060828)
Regulation of nodal signaling pathway
(GO:1900107)
Regulation of postsynapse organization
(GO:0099175)
Regulation of protein stability
(GO:0031647)
Regulation of wnt signaling pathway, planar cell polarity pathway
(GO:2000095)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Synapse
(GO:0045202)
Synapse organization
(GO:0050808)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

Dapper homolog 1
D3Z5V0_MOUSE

Genular Protein ID: 2774253158

Symbol: DACT1_MOUSE

Name: Dapper homolog 1

UniProtKB Accession Codes:

Q8R4A3 Q80VG9 Q8BP49 Q9JK89

Database IDs:

Citations:

PubMed ID: 11970895

Title: Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation.

PubMed ID: 11970895

DOI: 10.1016/s1534-5807(02)00140-5

PubMed ID: 16278878

Title: Vertebrate homologues of Frodo are dynamically expressed during embryonic development in tissues undergoing extensive morphogenetic movements.

PubMed ID: 16278878

DOI: 10.1002/dvdy.20609

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 14636582

Title: Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled.

PubMed ID: 14636582

DOI: 10.1016/s1097-2765(03)00427-1

PubMed ID: 16881060

Title: Three Dact gene family members are expressed during embryonic development and in the adult brains of mice.

PubMed ID: 16881060

DOI: 10.1002/dvdy.20917

PubMed ID: 17197390

Title: The evolutionally conserved activity of Dapper2 in antagonizing TGF-beta signaling.

PubMed ID: 17197390

DOI: 10.1096/fj.06-6246com

PubMed ID: 19073771

Title: Dact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt/beta-catenin signaling network.

PubMed ID: 19073771

DOI: 10.2337/db08-1180

PubMed ID: 19701191

Title: Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak.

PubMed ID: 19701191

DOI: 10.1038/ng.435

PubMed ID: 20145239

Title: Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled activity and leads to posterior malformation in mice.

PubMed ID: 20145239

DOI: 10.1074/jbc.m109.085381

PubMed ID: 21718540

Title: All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases.

PubMed ID: 21718540

DOI: 10.1186/1471-2091-12-33

PubMed ID: 20335472

Title: Dact1 is a postsynaptic protein required for dendrite, spine, and excitatory synapse development in the mouse forebrain.

PubMed ID: 20335472

DOI: 10.1523/jneurosci.0354-10.2010

Sequence Information:

Length: 778
Mass: 84306
Checksum: 31EAD7E9BBA77DE7
Sequence:

MKPDAAREPE PLSPGRGAEA EGRWRERGEA DTERQRTRER QEATLAGLAE LGYLRQRQEL 
LVRGALRCSG TVGTVAPRSG ELRGDAAQRS RLEEKFLEEN ILLLRRQLNC LRRRDAGLLN 
QLQELDKQIS DLRLDVEKTS EEHLETDSRP SSGFYELSDG ASGSLSNSSN SVFSECLSSC 
HSSTCFCSPL EAALTISDGC PKSADVNPKY QCDLVSKNGN DVYRYPSPLH AVAVQSPMFL 
LCLTGNTLRE EEGLGSHASD ICIGSELNAT KTDNSLPSPS SLWSASHPAS SKKMDGYILS 
LVQKKTHPVR TNKPRTSVNA DPTKGLLRNG SVCVRAPSGV PPGSSVNFKN TKQMCLPAGG 
ITSLENGPFS PPKQRSKDSK TDQLESKRLA LPESCSAGAA MEPQSKHVPK AAKAASQELT 
RCQAGLGESM KESNQASAVS PKTSPGRGPV APAESKALQL PKKMSQKNSL QAVPALDRPA 
LDFKSEGSSQ SLEEGHLVKA QFIPGQQAAA RPHRAHRNPG VARSATLKAR GQAAMEHGLP 
TVREKPRAAG KKCRFPDDSD TNKKFRKTSA KGRRSGGLQD AGLPGRALGT GGHRAGSRAH 
AHGREPVVAK PKHKRTDYRR WKSSAEVSYE EALRRARRAR REHGAAYRVA VALPYASPYA 
YVPSDSEYSA ECESLFHSTV VDTSEDEQSN YTTNCFGDSE SSVSEGDFVG ESTTTSDSEE 
SGGLIWSQFV QTLPIQTVTA PDLHTRPTKT FVKIKASHNL KKKILRFRSG SLKLMTTV

Genular Protein ID: 2471698364

Symbol: D3Z5V0_MOUSE

Name: N/A

UniProtKB Accession Codes:

D3Z5V0

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 815
Mass: 88114
Checksum: BED60B58D1014269
Sequence:

MKPDAAREPE PLSPGRGAEA EGRWRERGEA DTERQRTRER QEATLAGLAE LGYLRQRQEL 
LVRGALRCSG TVGTVAPRSG ELRGDAAQRS RLEEKFLEEN ILLLRRQLNC LRRRDAGLLN 
QLQELDKQIS DLRLDVEKTS EEHLETDSRP SSGFYELSDG ASGSLSNSSN SVFSECLSSC 
HSSTCFCSPL EAALTISDGC PKSADLIGWL ECKGGPCEDQ ASGTVCSSPS TPQFNSLDVI 
ADVNPKYQCD LVSKNGNDVY RYPSPLHAVA VQSPMFLLCL TGNTLREEEG LGSHASDICI 
GSELNATKTD NSLPSPSSLW SASHPASSKK MDGYILSLVQ KKTHPVRTNK PRTSVNADPT 
KGLLRNGSVC VRAPSGVPPG SSVNFKNTKQ MCLPAGGITS LENGPFSPPK QRSKDSKTDQ 
LESKRLALPE SCSAGAAMEP QSKHVPKAAK AASQELTRCQ AGLGESMKES NQASAVSPKT 
SPGRGPVAPA ESKALQLPKK MSQKNSLQAV PALDRPALDF KSEGSSQSLE EGHLVKAQFI 
PGQQAAARPH RAHRNPGVAR SATLKARGQA AMEHGLPTVR EKPRAAGKKC RFPDDSDTNK 
KFRKTSAKGR RSGGLQDAGL PGRALGTGGH RAGSRAHAHG REPVVAKPKH KRTDYRRWKS 
SAEVSYEEAL RRARRARREH GAAYRVAVAL PYASPYAYVP SDSEYSAECE SLFHSTVVDT 
SEDEQSNYTT NCFGDSESSV SEGDFVGEST TTSDSEESGG LIWSQFVQTL PIQTVTAPDL 
HTRPTKTFVK IKASHNLKKK ILRFRSGSLK LMTTV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Dact1

Associated with

Other Information

Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation. PubMed ID: 11970895

Vertebrate homologues of Frodo are dynamically expressed during embryonic development in tissues undergoing extensive morphogenetic movements. PubMed ID: 16278878

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. PubMed ID: 14636582

Three Dact gene family members are expressed during embryonic development and in the adult brains of mice. PubMed ID: 16881060

The evolutionally conserved activity of Dapper2 in antagonizing TGF-beta signaling. PubMed ID: 17197390

Dact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt/beta-catenin signaling network. PubMed ID: 19073771

Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak. PubMed ID: 19701191

Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled activity and leads to posterior malformation in mice. PubMed ID: 20145239

All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases. PubMed ID: 21718540

Dact1 is a postsynaptic protein required for dendrite, spine, and excitatory synapse development in the mouse forebrain. PubMed ID: 20335472

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303