Tgfb1 | ENSRNOG00000020652 | NCBI 59086

Details for: Tgfb1

Gene ID: 59086

Symbol: Tgfb1

Ensembl ID: ENSRNOG00000020652

Description: transforming growth factor, beta 1

Associated with

Cell surface interactions at the vascular wall
(R-RNO-202733)
Downregulation of tgf-beta receptor signaling
(R-RNO-2173788)
Elastic fibre formation
(R-RNO-1566948)
Extracellular matrix organization
(R-RNO-1474244)
Gene expression (transcription)
(R-RNO-74160)
Generic transcription pathway
(R-RNO-212436)
Hemostasis
(R-RNO-109582)
Molecules associated with elastic fibres
(R-RNO-2129379)
Non-integrin membrane-ecm interactions
(R-RNO-3000171)
Platelet activation, signaling and aggregation
(R-RNO-76002)
Platelet degranulation
(R-RNO-114608)
Regulation of runx3 expression and activity
(R-RNO-8941858)
Response to elevated platelet cytosolic ca2+
(R-RNO-76005)
Rna polymerase ii transcription
(R-RNO-73857)
Runx3 regulates cdkn1a transcription
(R-RNO-8941855)
Runx3 regulates p14-arf
(R-RNO-8951936)
Signaling by tgf-beta receptor complex
(R-RNO-170834)
Signaling by tgfb family members
(R-RNO-9006936)
Signal transduction
(R-RNO-162582)
Syndecan interactions
(R-RNO-3000170)
Tgf-beta receptor signaling activates smads
(R-RNO-2173789)
Tgf-beta receptor signaling in emt (epithelial to mesenchymal transition)
(R-RNO-2173791)
Transcriptional regulation by runx3
(R-RNO-8878159)
Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
(GO:0002460)
Antigen binding
(GO:0003823)
Aortic valve morphogenesis
(GO:0003180)
Apoptotic process
(GO:0006915)
Atp biosynthetic process
(GO:0006754)
Cell activation
(GO:0001775)
Cell morphogenesis
(GO:0000902)
Cell population proliferation
(GO:0008283)
Chondrocyte differentiation
(GO:0002062)
Columnar/cuboidal epithelial cell maturation
(GO:0002069)
Cytokine activity
(GO:0005125)
Deubiquitinase activator activity
(GO:0035800)
Endoderm development
(GO:0007492)
Enzyme binding
(GO:0019899)
Epithelial to mesenchymal transition
(GO:0001837)
Female pregnancy
(GO:0007565)
Gene expression
(GO:0010467)
Germ cell migration
(GO:0008354)
Growth factor activity
(GO:0008083)
Heart development
(GO:0007507)
Heart valve morphogenesis
(GO:0003179)
Hematopoietic progenitor cell differentiation
(GO:0002244)
Hyaluronan catabolic process
(GO:0030214)
Identical protein binding
(GO:0042802)
Inflammatory response
(GO:0006954)
Intracellular calcium ion homeostasis
(GO:0006874)
Morphogenesis of a branching structure
(GO:0001763)
Negative regulation of cell-cell adhesion
(GO:0022408)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of macrophage cytokine production
(GO:0010936)
Negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
(GO:0002859)
Negative regulation of neuroblast proliferation
(GO:0007406)
Negative regulation of ossification
(GO:0030279)
Negative regulation of protein phosphorylation
(GO:0001933)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neural tube closure
(GO:0001843)
Neural tube development
(GO:0021915)
Notch signaling pathway
(GO:0007219)
Oligodendrocyte development
(GO:0014003)
Osteoclast differentiation
(GO:0030316)
Phosphate-containing compound metabolic process
(GO:0006796)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Positive regulation of fibroblast migration
(GO:0010763)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of microglia differentiation
(GO:0014008)
Protein-containing complex binding
(GO:0044877)
Protein export from nucleus
(GO:0006611)
Protein serine/threonine kinase activator activity
(GO:0043539)
Regulation of cell growth
(GO:0001558)
Regulation of gene expression
(GO:0010468)
Regulation of sodium ion transport
(GO:0002028)
Regulation of striated muscle tissue development
(GO:0016202)
Regulation of transforming growth factor beta receptor signaling pathway
(GO:0017015)
Response to glucose
(GO:0009749)
Response to hypoxia
(GO:0001666)
Response to organic cyclic compound
(GO:0014070)
Response to organic substance
(GO:0010033)
Response to wounding
(GO:0009611)
Response to xenobiotic stimulus
(GO:0009410)
Salivary gland morphogenesis
(GO:0007435)
Sprouting angiogenesis
(GO:0002040)
T cell differentiation
(GO:0030217)
Tolerance induction to self antigen
(GO:0002513)
Transforming growth factor beta receptor binding
(GO:0005160)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Type iii transforming growth factor beta receptor binding
(GO:0034714)
Type ii transforming growth factor beta receptor binding
(GO:0005114)
Type i transforming growth factor beta receptor binding
(GO:0034713)
Ureteric bud development
(GO:0001657)
Vasculogenesis
(GO:0001570)

Other Information

Proteins

Transforming growth factor beta-1 proprotein

Genular Protein ID: 3854722220

Symbol: TGFB1_RAT

Name: Transforming growth factor beta-1 proprotein

UniProtKB Accession Codes:

P17246 Q53YM8

Database IDs:

Citations:

PubMed ID: 2349108

Title: cDNA cloning by PCR of rat transforming growth factor beta-1.

PubMed ID: 2349108

DOI: 10.1093/nar/18.10.3059

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2070682

Title: The effects of TGF-beta on bone.

PubMed ID: 2070682

PubMed ID: 11907708

Title: The first stage of transforming growth factor beta1 activation is release of the large latent complex from the extracellular matrix of growth plate chondrocytes by matrix vesicle stromelysin-1 (MMP-3).

PubMed ID: 11907708

DOI: 10.1007/s002230010032

PubMed ID: 26858265

Title: Plakophilin-2 loss promotes TGF-beta1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes.

PubMed ID: 26858265

DOI: 10.1083/jcb.201507018

Sequence Information:

Length: 390
Mass: 44329
Checksum: 5E21108ED50D853C
Sequence:

MPPSGLRLLP LLLPLPWLLV LTPGRPAAGL STCKTIDMEL VKRKRIEAIR GQILSKLRLA 
SPPSQGEVPP GPLPEAVLAL YNSTRDRVAG ESADPEPEPE ADYYAKEVTR VLMVDRNNAI 
YDKTKDITHS IYMFFNTSDI REAVPEPPLL SRAELRLQRF KSTVEQHVEL YQKYSNNSWR 
YLGNRLLTPT DTPEWLSFDV TGVVRQWLNQ GDGIQGFRFS AHCSCDSKDN VLHVEINGIS 
PKRRGDLGTI HDMNRPFLLL MATPLERAQH LHSSRHRRAL DTNYCFSSTE KNCCVRQLYI 
DFRKDLGWKW IHEPKGYHAN FCLGPCPYIW SLDTQYSKVL ALYNQHNPGA SASPCCVPQA 
LEPLPIVYYV GRKPKVEQLS NMIVRSCKCS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tgfb1

Associated with

Other Information

cDNA cloning by PCR of rat transforming growth factor beta-1. PubMed ID: 2349108

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The effects of TGF-beta on bone. PubMed ID: 2070682