Jph2 | ENSMUSG00000017817 | NCBI 59091

Details for: Jph2

Gene ID: 59091

Symbol: Jph2

Ensembl ID: ENSMUSG00000017817

Description: junctophilin 2

Associated with

Calcium ion homeostasis
(GO:0055074)
Core promoter sequence-specific dna binding
(GO:0001046)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Junctional membrane complex
(GO:0030314)
Membrane
(GO:0016020)
Multicellular organism development
(GO:0007275)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleus
(GO:0005634)
Phosphatidic acid binding
(GO:0070300)
Phosphatidylinositol-3,4,5-trisphosphate binding
(GO:0005547)
Phosphatidylinositol-3,5-bisphosphate binding
(GO:0080025)
Phosphatidylinositol-3-phosphate binding
(GO:0032266)
Phosphatidylinositol-4,5-bisphosphate binding
(GO:0005546)
Phosphatidylinositol-4-phosphate binding
(GO:0070273)
Phosphatidylinositol-5-phosphate binding
(GO:0010314)
Phosphatidylserine binding
(GO:0001786)
Plasma membrane
(GO:0005886)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of ryanodine-sensitive calcium-release channel activity
(GO:0060316)
Protein binding
(GO:0005515)
Regulation of cardiac muscle tissue development
(GO:0055024)
Sarcoplasmic reticulum
(GO:0016529)
Z disc
(GO:0030018)

Other Information

Proteins

JPH2_MOUSE

Genular Protein ID: 3772163274

Symbol: JPH2_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9ET78 Q3U077 Q9ET79

Database IDs:

Citations:

PubMed ID: 10949023

Title: Junctophilins: a novel family of junctional membrane complex proteins.

PubMed ID: 10949023

DOI: 10.1016/s1097-2765(00)00003-4

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 19095005

Title: New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.

PubMed ID: 19095005

DOI: 10.1016/j.pharmthera.2008.11.004

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21339484

Title: Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice.

PubMed ID: 21339484

DOI: 10.1161/circulationaha.110.006437

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 26063807

Title: Molecular determinants of Calpain-dependent cleavage of Junctophilin-2 protein in cardiomyocytes.

PubMed ID: 26063807

DOI: 10.1074/jbc.m115.652396

PubMed ID: 28393127

Title: Novel junctophilin-2 mutation A405S is associated with basal septal hypertrophy and diastolic dysfunction.

PubMed ID: 28393127

DOI: 10.1016/j.jacbts.2016.11.004

PubMed ID: 30409805

Title: E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator.

PubMed ID: 30409805

DOI: 10.1126/science.aan3303

Sequence Information:

Length: 696
Mass: 74692
Checksum: 346BA284E076A7FB
Sequence:

MSGGRFDFDD GGAYCGGWEG GKAHGHGLCT GPKGQGEYSG SWNFGFEVAG VYTWPSGNTF 
EGYWSQGKRH GLGIETKGRW LYKGEWTHGF KGRYGIRQST NSGAKYEGTW NNGLQDGYGT 
ETYADGGTYQ GQFTNGMRHG YGVRQSVPYG MAVVVRSPLR TSLSSLRSEH SNGTVAPDSP 
AADGPMLPSP PVPRGGFALT LLATAEAARP QGLFTRGTLL GRLRRSESRT SLGSQRSRLS 
FLKSELSSGA SDAASTGSLA EGAEGPDDAA APFDADIDAT TTETYMGEWK NDKRSGFGVS 
ERSSGLRYEG EWLDNLRHGY GRTTLPDGHR EEGKYRHNVL VKGTKRRVLP LKSSKVRQKV 
EHGVEGAQRA AAIARQKAEI AASRTSHAKA KAEAAEQAAL AANQESNIAR TLAKELAPDF 
YQPGPEYQKR RLLQEILENS ESLLEPPERG LGTGLPERPR ESPQLHERET PQPEGGPPSP 
AGTPPQPKRP RPGASKDGLL SPGSWNGEPG GEGSRPATPS DGAGRRSPAR PASEHMAIEA 
LQPPPAPSQE PEVAMYRGYH SYAVRTGPPE PPPLEDEQEP EPEPEPEVRR SDSAPPSPVS 
ATVPEEEPPA PRSPVPAKQA TLEPKPIVPK AEPKAKARKT EARGLSKAGA KKKGRKEVAQ 
AKEAEVEVEE VPNTVLICMV ILLNIGLAIL FVHLLT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Jph2

Associated with

Other Information

Junctophilins: a novel family of junctional membrane complex proteins. PubMed ID: 10949023

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes. PubMed ID: 19095005

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice. PubMed ID: 21339484

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

Molecular determinants of Calpain-dependent cleavage of Junctophilin-2 protein in cardiomyocytes. PubMed ID: 26063807

Novel junctophilin-2 mutation A405S is associated with basal septal hypertrophy and diastolic dysfunction. PubMed ID: 28393127

E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator. PubMed ID: 30409805