Kmo | ENSRNOG00000003709 | NCBI 59113

Details for: Kmo

Gene ID: 59113

Symbol: Kmo

Ensembl ID: ENSRNOG00000003709

Description: kynurenine 3-monooxygenase

Associated with

Metabolism
(R-RNO-1430728)
Metabolism of amino acids and derivatives
(R-RNO-71291)
Tryptophan catabolism
(R-RNO-71240)
'de novo' nad biosynthetic process from tryptophan
(GO:0034354)
Anthranilate metabolic process
(GO:0043420)
Cellular response to interleukin-1
(GO:0071347)
Cellular response to lipopolysaccharide
(GO:0071222)
Extracellular space
(GO:0005615)
Fad binding
(GO:0071949)
Flavin adenine dinucleotide binding
(GO:0050660)
Kynurenic acid biosynthetic process
(GO:0034276)
Kynurenine 3-monooxygenase activity
(GO:0004502)
Kynurenine metabolic process
(GO:0070189)
L-kynurenine metabolic process
(GO:0097052)
Membrane
(GO:0016020)
Mitochondrial outer membrane
(GO:0005741)
Monooxygenase activity
(GO:0004497)
Nad(p)h oxidase h2o2-forming activity
(GO:0016174)
Nad metabolic process
(GO:0019674)
Positive regulation of glutamate secretion
(GO:0014049)
Positive regulation of glutamate secretion, neurotransmission
(GO:1903296)
Quinolinate biosynthetic process
(GO:0019805)
Response to lipopolysaccharide
(GO:0032496)
Response to salt stress
(GO:0009651)
Tryptophan catabolic process
(GO:0006569)

Other Information

Proteins

KMO_RAT

Genular Protein ID: 1180648912

Symbol: KMO_RAT

Name: N/A

UniProtKB Accession Codes:

O88867

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1332540

Title: A radiometric assay for kynurenine 3-hydroxylase based on the release of 3H2O during hydroxylation of L-[3,5-3H]kynurenine.

PubMed ID: 1332540

DOI: 10.1016/0003-2697(92)90432-7

PubMed ID: 12402501

Title: Endogenous kynurenines as targets for drug discovery and development.

PubMed ID: 12402501

DOI: 10.1038/nrd870

PubMed ID: 26752518

Title: Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis.

PubMed ID: 26752518

DOI: 10.1038/nm.4020

PubMed ID: 28398044

Title: Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.

PubMed ID: 28398044

DOI: 10.1021/acs.jmedchem.7b00055

Sequence Information:

Length: 478
Mass: 54353
Checksum: 72E775D1C05CFFAB
Sequence:

MASSDTEGKR VVVIGGGLVG ALNACFLAKR NFQVDVYEAR EDIRVANFMR GRSINLALSY 
RGRQALKAVG LEDQIVSKGV PMKARMIHSL SGKKSAIPYG NKSQYILSIS REKLNKDLLT 
AVESYPNAKV HFGHKLSKCC PEEGILTMLG PNKVPRDITC DLIVGCDGAY STVRAHLMKK 
PRFDYSQQYI PHGYMELTIP PKNGEYAMEP NCLHIWPRNA FMMIALPNMD KSFTCTLFMS 
FEEFEKLPTH SDVLDFFQKN FPDAIPLMGE QALMRDFFLL PAQPMISVKC SPFHLKSRCV 
LMGDAAHAIV PFFGQGMNAG FEDCLVFDEL MDKFNNDLSV CLPEFSRFRI PDDHAISDLS 
MYNYIEMRAH VNSRWFLFQR LLDKFLHALM PSTFIPLYTM VAFTRIRYHE AVLRWHWQKK 
VINRGLFVLG SLVAIGSAYI LVHHLSPRPL ELLRSAWTGT SGHWNRSADI SPRVPWSH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Kmo

Associated with

Other Information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A radiometric assay for kynurenine 3-hydroxylase based on the release of 3H2O during hydroxylation of L-[3,5-3H]kynurenine. PubMed ID: 1332540

Endogenous kynurenines as targets for drug discovery and development. PubMed ID: 12402501