Details for: ACE2
Associated with
Other Information
Genular Protein ID: 3301727693
Symbol: ACE2_HUMAN
Name: Angiotensin-converting enzyme 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10969042
Title: A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9.
PubMed ID: 10969042
PubMed ID: 10924499
Title: A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase.
PubMed ID: 10924499
PubMed ID: 15231706
Title: The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis.
PubMed ID: 15231706
DOI: 10.1210/en.2004-0443
PubMed ID: 15937940
Title: Identification of an alternative 5'-untranslated exon and new polymorphisms of angiotensin-converting enzyme 2 gene: lack of association with SARS in the Vietnamese population.
PubMed ID: 15937940
DOI: 10.1002/ajmg.a.30779
PubMed ID: 33077916
Title: Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor.
PubMed ID: 33077916
PubMed ID: 12975309
Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
PubMed ID: 12975309
DOI: 10.1101/gr.1293003
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15276642
Title: Interaction of ACE2 and integrin beta1 in failing human heart.
PubMed ID: 15276642
PubMed ID: 12459472
Title: Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme.
PubMed ID: 12459472
PubMed ID: 12358520
Title: Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors.
PubMed ID: 12358520
DOI: 10.1021/ja0277226
PubMed ID: 11815627
Title: Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase.
PubMed ID: 11815627
PubMed ID: 14504186
Title: Increased angiotensin-(1-7)-forming activity in failing human heart ventricles: evidence for upregulation of the angiotensin-converting enzyme Homologue ACE2.
PubMed ID: 14504186
PubMed ID: 14647384
Title: Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.
PubMed ID: 14647384
DOI: 10.1038/nature02145
PubMed ID: 15151696
Title: ACE2 gene expression is up-regulated in the human failing heart.
PubMed ID: 15151696
PubMed ID: 15141377
Title: Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis.
PubMed ID: 15141377
DOI: 10.1002/path.1570
PubMed ID: 15452268
Title: Efficient replication of severe acute respiratory syndrome coronavirus in mouse cells is limited by murine angiotensin-converting enzyme 2.
PubMed ID: 15452268
PubMed ID: 15084671
PubMed ID: 15671045
Title: Myocardial infarction increases ACE2 expression in rat and humans.
PubMed ID: 15671045
PubMed ID: 15791205
Title: Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2.
PubMed ID: 15791205
PubMed ID: 15983030
Title: Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2).
PubMed ID: 15983030
PubMed ID: 15897467
Title: Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry.
PubMed ID: 15897467
PubMed ID: 16008552
Title: Identification of critical active-site residues in angiotensin-converting enzyme-2 (ACE2) by site-directed mutagenesis.
PubMed ID: 16008552
PubMed ID: 19021774
Title: Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed mutagenesis.
PubMed ID: 19021774
PubMed ID: 18424768
Title: A protein complex in the brush-border membrane explains a Hartnup disorder allele.
PubMed ID: 18424768
DOI: 10.1096/fj.08-107300
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 19185582
Title: Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with hartnup mutations.
PubMed ID: 19185582
PubMed ID: 21563828
Title: Angiotensin-converting enzyme 2 ectodomain shedding cleavage-site identification: determinants and constraints.
PubMed ID: 21563828
DOI: 10.1021/bi200525y
PubMed ID: 21068237
Title: A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry.
PubMed ID: 21068237
DOI: 10.1128/jvi.02062-10
PubMed ID: 24227843
Title: TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein.
PubMed ID: 24227843
DOI: 10.1128/jvi.02202-13
PubMed ID: 27217402
Title: Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System.
PubMed ID: 27217402
PubMed ID: 28293165
Title: [Pyr1]Apelin-13(1-12) Is a Biologically Active ACE2 Metabolite of the Endogenous Cardiovascular Peptide [Pyr1]Apelin-13.
PubMed ID: 28293165
PubMed ID: 32142651
Title: SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor.
PubMed ID: 32142651
PubMed ID: 32075877
Title: Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
PubMed ID: 32075877
PubMed ID: 32155444
Title: Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein.
PubMed ID: 32155444
PubMed ID: 32413319
Title: SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.
PubMed ID: 32413319
PubMed ID: 32425701
Title: Cigarette smoke exposure and inflammatory signaling increase the expression of the SARS-CoV-2 receptor ACE2 in the respiratory tract.
PubMed ID: 32425701
PubMed ID: 32170560
Title: Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection.
PubMed ID: 32170560
PubMed ID: 33102950
Title: The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection.
PubMed ID: 33102950
PubMed ID: 32333915
Title: Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2.
PubMed ID: 32333915
PubMed ID: 32715618
Title: The protein expression profile of ACE2 in human tissues.
PubMed ID: 32715618
PubMed ID: 32221306
Title: Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV.
PubMed ID: 32221306
PubMed ID: 32327758
Title: SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.
PubMed ID: 32327758
PubMed ID: 32358202
Title: SARS-CoV-2 productively infects human gut enterocytes.
PubMed ID: 32358202
PubMed ID: 33000221
Title: Neuropilin-1 as a new potential SARS-CoV-2 infection mediator implicated in the neurologic features and central nervous system involvement of COVID-19.
PubMed ID: 33000221
PubMed ID: 32753553
Title: Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2.
PubMed ID: 32753553
PubMed ID: 33082294
Title: Neuropilin-1 is a host factor for SARS-CoV-2 infection.
PubMed ID: 33082294
PubMed ID: 32404436
Title: TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes.
PubMed ID: 32404436
PubMed ID: 33713620
Title: Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system.
PubMed ID: 33713620
PubMed ID: 34189428
Title: ACE2 interaction with cytoplasmic PDZ protein enhances SARS-CoV-2 invasion.
PubMed ID: 34189428
PubMed ID: 33432067
Title: No evidence for basigin/CD147 as a direct SARS-CoV-2 spike binding receptor.
PubMed ID: 33432067
PubMed ID: 33432184
Title: A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection.
PubMed ID: 33432184
PubMed ID: 33436497
Title: Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications.
PubMed ID: 33436497
PubMed ID: 33436498
Title: Cytoplasmic short linear motifs in ACE2 and integrin beta3 link SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagy.
PubMed ID: 33436498
PubMed ID: 36228039
Title: LRRC15 inhibits SARS-CoV-2 cellular entry in trans.
PubMed ID: 36228039
PubMed ID: 36735681
Title: LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein.
PubMed ID: 36735681
PubMed ID: 36757924
Title: Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs.
PubMed ID: 36757924
PubMed ID: 14754895
Title: ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis.
PubMed ID: 14754895
PubMed ID: 16166518
Title: Structure of SARS coronavirus spike receptor-binding domain complexed with receptor.
PubMed ID: 16166518
PubMed ID: 19901337
Title: Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor.
PubMed ID: 19901337
PubMed ID: 30102747
Title: Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2.
PubMed ID: 30102747
PubMed ID: 30356097
Title: Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis.
PubMed ID: 30356097
PubMed ID: 32225176
Title: Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor.
PubMed ID: 32225176
PubMed ID: 32225175
Title: Structural basis of receptor recognition by SARS-CoV-2.
PubMed ID: 32225175
PubMed ID: 32132184
Title: Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2.
PubMed ID: 32132184
PubMed ID: 33133145
Title: Analysis of the Spectrum of ACE2 Variation Suggests a Possible Influence of Rare and Common Variants on Susceptibility to COVID-19 and Severity of Outcome.
PubMed ID: 33133145
PubMed ID: 32558308
Title: Genetic variability of human angiotensin-converting enzyme 2 (hACE2) among various ethnic populations.
PubMed ID: 32558308
DOI: 10.1002/mgg3.1344
Sequence Information:
- Length: 805
- Mass: 92463
- Checksum: 8EE6EB0A931550E8
- Sequence:
MSSSSWLLLS LVAVTAAQST IEEQAKTFLD KFNHEAEDLF YQSSLASWNY NTNITEENVQ NMNNAGDKWS AFLKEQSTLA QMYPLQEIQN LTVKLQLQAL QQNGSSVLSE DKSKRLNTIL NTMSTIYSTG KVCNPDNPQE CLLLEPGLNE IMANSLDYNE RLWAWESWRS EVGKQLRPLY EEYVVLKNEM ARANHYEDYG DYWRGDYEVN GVDGYDYSRG QLIEDVEHTF EEIKPLYEHL HAYVRAKLMN AYPSYISPIG CLPAHLLGDM WGRFWTNLYS LTVPFGQKPN IDVTDAMVDQ AWDAQRIFKE AEKFFVSVGL PNMTQGFWEN SMLTDPGNVQ KAVCHPTAWD LGKGDFRILM CTKVTMDDFL TAHHEMGHIQ YDMAYAAQPF LLRNGANEGF HEAVGEIMSL SAATPKHLKS IGLLSPDFQE DNETEINFLL KQALTIVGTL PFTYMLEKWR WMVFKGEIPK DQWMKKWWEM KREIVGVVEP VPHDETYCDP ASLFHVSNDY SFIRYYTRTL YQFQFQEALC QAAKHEGPLH KCDISNSTEA GQKLFNMLRL GKSEPWTLAL ENVVGAKNMN VRPLLNYFEP LFTWLKDQNK NSFVGWSTDW SPYADQSIKV RISLKSALGD KAYEWNDNEM YLFRSSVAYA MRQYFLKVKN QMILFGEEDV RVANLKPRIS FNFFVTAPKN VSDIIPRTEV EKAIRMSRSR INDAFRLNDN SLEFLGIQPT LGPPNQPPVS IWLIVFGVVM GVIVVGIVIL IFTGIRDRKK KNKARSGENP YASIDISKGE NNPGFQNTDD VQTSF
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.