Ncstn | ENSMUSG00000003458 | NCBI 59287

Details for: Ncstn

Gene ID: 59287

Symbol: Ncstn

Ensembl ID: ENSMUSG00000003458

Description: nicastrin

Associated with

Axon guidance
(R-MMU-422475)
Cell death signalling via nrage, nrif and nade
(R-MMU-204998)
Death receptor signaling
(R-MMU-73887)
Developmental biology
(R-MMU-1266738)
Eph-ephrin mediated repulsion of cells
(R-MMU-3928665)
Eph-ephrin signaling
(R-MMU-2682334)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Nervous system development
(R-MMU-9675108)
Neutrophil degranulation
(R-MMU-6798695)
Noncanonical activation of notch3
(R-MMU-9017802)
Notch3 activation and transmission of signal to the nucleus
(R-MMU-9013507)
Nrif signals cell death from the nucleus
(R-MMU-205043)
Nuclear signaling by erbb4
(R-MMU-1251985)
P75 ntr receptor-mediated signalling
(R-MMU-193704)
Regulated proteolysis of p75ntr
(R-MMU-193692)
Signaling by erbb4
(R-MMU-1236394)
Signaling by notch
(R-MMU-157118)
Signaling by notch3
(R-MMU-9012852)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Adult behavior
(GO:0030534)
Amyloid-beta formation
(GO:0034205)
Amyloid-beta metabolic process
(GO:0050435)
Amyloid precursor protein biosynthetic process
(GO:0042983)
Amyloid precursor protein catabolic process
(GO:0042987)
Amyloid precursor protein metabolic process
(GO:0042982)
Aspartic endopeptidase activity, intramembrane cleaving
(GO:0042500)
Atpase binding
(GO:0051117)
Cellular response to calcium ion
(GO:0071277)
Central nervous system myelination
(GO:0022010)
Cytoplasmic vesicle
(GO:0031410)
Dopamine receptor signaling pathway
(GO:0007212)
Early endosome
(GO:0005769)
Endopeptidase activity
(GO:0004175)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Epithelial cell proliferation
(GO:0050673)
Gamma-secretase complex
(GO:0070765)
Glutamate receptor signaling pathway
(GO:0007215)
Golgi apparatus
(GO:0005794)
Golgi membrane
(GO:0000139)
Growth factor receptor binding
(GO:0070851)
Learning or memory
(GO:0007611)
Lysosomal membrane
(GO:0005765)
Lysosome
(GO:0005764)
Membrane
(GO:0016020)
Membrane protein ectodomain proteolysis
(GO:0006509)
Membrane protein intracellular domain proteolysis
(GO:0031293)
Myeloid cell homeostasis
(GO:0002262)
Neuron apoptotic process
(GO:0051402)
Notch receptor processing
(GO:0007220)
Notch signaling pathway
(GO:0007219)
Peptidase activity
(GO:0008233)
Plasma membrane
(GO:0005886)
Positive regulation of amyloid precursor protein biosynthetic process
(GO:0042986)
Positive regulation of catalytic activity
(GO:0043085)
Positive regulation of endopeptidase activity
(GO:0010950)
Presynaptic membrane
(GO:0042734)
Protein-containing complex
(GO:0032991)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein processing
(GO:0016485)
Regulation of long-term synaptic potentiation
(GO:1900271)
Sarcolemma
(GO:0042383)
Short-term synaptic potentiation
(GO:1990926)
Synaptic membrane
(GO:0097060)
Synaptic vesicle
(GO:0008021)
T cell proliferation
(GO:0042098)

Other Information

Proteins

Nicastrin

Genular Protein ID: 786107846

Symbol: NICA_MOUSE

Name: Nicastrin

UniProtKB Accession Codes:

P57716 E9QLZ6 Q8VE20

Database IDs:

Citations:

PubMed ID: 10993067

Title: Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing.

PubMed ID: 10993067

DOI: 10.1038/35024009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12716934

Title: Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals.

PubMed ID: 12716934

DOI: 10.1523/jneurosci.23-08-03272.2003

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 708
Mass: 78492
Checksum: 32B57BB478FEB0AC
Sequence:

MATTRGGSGP DPGSRGLLLL SFSVVLAGLC GGNSVERKIY IPLNKTAPCV RLLNATHQIG 
CQSSISGDTG VIHVVEKEED LKWVLTDGPN PPYMVLLEGK LFTRDVMEKL KGTTSRIAGL 
AVTLAKPNST SSFSPSVQCP NDGFGIYSNS YGPEFAHCKK TLWNELGNGL AYEDFSFPIF 
LLEDENETKV IKQCYQDHNL GQNGSAPSFP LCAMQLFSHM HAVISTATCM RRSFIQSTFS 
INPEIVCDPL SDYNVWSMLK PINTSVGLEP DVRVVVAATR LDSRSFFWNV APGAESAVAS 
FVTQLAAAEA LHKAPDVTTL SRNVMFVFFQ GETFDYIGSS RMVYDMENGK FPVRLENIDS 
FVELGQVALR TSLDLWMHTD PMSQKNESVK NQVEDLLATL EKSGAGVPEV VLRRLAQSQA 
LPPSSLQRFL RARNISGVVL ADHSGSFHNR YYQSIYDTAE NINVTYPEWQ SPEEDLNFVT 
DTAKALANVA TVLARALYEL AGGTNFSSSI QADPQTVTRL LYGFLVRANN SWFQSILKHD 
LRSYLDDRPL QHYIAVSSPT NTTYVVQYAL ANLTGKATNL TREQCQDPSK VPNESKDLYE 
YSWVQGPWNS NRTERLPQCV RSTVRLARAL SPAFELSQWS STEYSTWAES RWKDIQARIF 
LIASKELEFI TLIVGFSTLV FSLIVTYCIN AKADVLFVAP REPGAVSY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ncstn

Associated with

Other Information

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. PubMed ID: 10993067

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals. PubMed ID: 12716934

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. PubMed ID: 19349973