Details for: Ghrl

Gene ID: 59301

Symbol: Ghrl

Ensembl ID: ENSRNOG00000010349

Description: ghrelin and obestatin prepropeptide

Associated with

  • G alpha (q) signalling events
    (R-RNO-416476)
  • Gpcr downstream signalling
    (R-RNO-388396)
  • Metabolism of proteins
    (R-RNO-392499)
  • Peptide hormone metabolism
    (R-RNO-2980736)
  • Signaling by gpcr
    (R-RNO-372790)
  • Synthesis, secretion, and deacylation of ghrelin
    (R-RNO-422085)
  • Actin polymerization or depolymerization
    (GO:0008154)
  • Adult feeding behavior
    (GO:0008343)
  • Axon
    (GO:0030424)
  • Cytoplasm
    (GO:0005737)
  • Decidualization
    (GO:0046697)
  • Dendrite development
    (GO:0016358)
  • Energy homeostasis
    (GO:0097009)
  • Excitatory postsynaptic potential
    (GO:0060079)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Gastric acid secretion
    (GO:0001696)
  • Ghrelin receptor binding
    (GO:0031768)
  • Glutamatergic synapse
    (GO:0098978)
  • G protein-coupled receptor binding
    (GO:0001664)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Growth hormone-releasing hormone activity
    (GO:0016608)
  • Hormone activity
    (GO:0005179)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of circadian sleep/wake cycle, rem sleep
    (GO:0042322)
  • Negative regulation of endothelial cell proliferation
    (GO:0001937)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of insulin secretion
    (GO:0046676)
  • Negative regulation of interleukin-1 beta production
    (GO:0032691)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of locomotion
    (GO:0040013)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Positive regulation of adipose tissue development
    (GO:1904179)
  • Positive regulation of appetite
    (GO:0032100)
  • Positive regulation of bone development
    (GO:1903012)
  • Positive regulation of circadian sleep/wake cycle, non-rem sleep
    (GO:0046010)
  • Positive regulation of cold-induced thermogenesis
    (GO:0120162)
  • Positive regulation of corticotropin secretion
    (GO:0051461)
  • Positive regulation of cortisol secretion
    (GO:0051464)
  • Positive regulation of cytosolic calcium ion concentration
    (GO:0007204)
  • Positive regulation of eating behavior
    (GO:1904000)
  • Positive regulation of feeding behavior
    (GO:2000253)
  • Positive regulation of gastric mucosal blood circulation
    (GO:1904346)
  • Positive regulation of gastro-intestinal system smooth muscle contraction
    (GO:1904306)
  • Positive regulation of growth
    (GO:0045927)
  • Positive regulation of growth hormone secretion
    (GO:0060124)
  • Positive regulation of growth rate
    (GO:0040010)
  • Positive regulation of insulin secretion
    (GO:0032024)
  • Positive regulation of insulin secretion involved in cellular response to glucose stimulus
    (GO:0035774)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of response to food
    (GO:0032097)
  • Positive regulation of small intestinal transit
    (GO:0120058)
  • Positive regulation of small intestine smooth muscle contraction
    (GO:1904349)
  • Positive regulation of sprouting angiogenesis
    (GO:1903672)
  • Positive regulation of synapse assembly
    (GO:0051965)
  • Positive regulation of vascular endothelial cell proliferation
    (GO:1905564)
  • Postsynapse
    (GO:0098794)
  • Postsynaptic modulation of chemical synaptic transmission
    (GO:0099170)
  • Protein tyrosine kinase activator activity
    (GO:0030296)
  • Regulation of cell population proliferation
    (GO:0042127)
  • Regulation of gastric motility
    (GO:1905333)
  • Regulation of postsynapse organization
    (GO:0099175)
  • Regulation of response to food
    (GO:0032095)
  • Regulation of transmission of nerve impulse
    (GO:0051969)
  • Response to electrical stimulus
    (GO:0051602)
  • Response to estrogen
    (GO:0043627)
  • Response to hormone
    (GO:0009725)
  • Response to nutrient levels
    (GO:0031667)
  • Schaffer collateral - ca1 synapse
    (GO:0098685)
  • Signal transduction
    (GO:0007165)
  • Synapse assembly
    (GO:0007416)

Other Information

Genular Protein ID: 2758879393

Symbol: GHRL_RAT

Name: Appetite-regulating hormone

UniProtKB Accession Codes:

Q9QYH7 Q9ET69

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 CTD 1 EMBL 2 Ensembl 3 GO 63 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 Reactome 2 RefSeq 1 SAM 1 SMR 1 STRING 1 TreeFam 1 UCSC 1 UniProtKB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 10604470

Title: Ghrelin is a growth-hormone-releasing acylated peptide from stomach.

PubMed ID: 10604470

DOI: 10.1038/45230

PubMed ID: 10801861

Title: Purification and characterization of rat des-Gln14-ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor.

PubMed ID: 10801861

DOI: 10.1074/jbc.m002784200

PubMed ID: 16284174

Title: Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake.

PubMed ID: 16284174

DOI: 10.1126/science.1117255

PubMed ID: 11162448

Title: Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue.

PubMed ID: 11162448

DOI: 10.1006/bbrc.2000.4039

PubMed ID: 11549267

Title: Structure-activity relationship of ghrelin: pharmacological study of ghrelin peptides.

PubMed ID: 11549267

DOI: 10.1006/bbrc.2001.5553

PubMed ID: 11306336

Title: Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor.

PubMed ID: 11306336

DOI: 10.1016/s1043-2760(00)00362-3

PubMed ID: 17289961

Title: Comment on 'Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake'.

PubMed ID: 17289961

DOI: 10.1126/science.1135047

Sequence Information:

  • Length: 117
  • Mass: 13176
  • Checksum: 8857546FE51A7691
  • Sequence:
    • MVSSATICSL LLLSMLWMDM AMAGSSFLSP EHQKAQQRKE SKKPPAKLQP RALEGWLHPE 
DRGQAEEAEE ELEIRFNAPF DVGIKLSGAQ YQQHGRALGK FLQDILWEEV KEAPANK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.