Shank3 | ENSRNOG00000052296 | NCBI 59312

Details for: Shank3

Gene ID: 59312

Symbol: Shank3

Ensembl ID: ENSRNOG00000052296

Description: SH3 and multiple ankyrin repeat domains 3

Associated with

Actin binding
(GO:0003779)
Adult behavior
(GO:0030534)
Ampa glutamate receptor clustering
(GO:0097113)
Associative learning
(GO:0008306)
Brain morphogenesis
(GO:0048854)
Ciliary membrane
(GO:0060170)
Cytoplasm
(GO:0005737)
Dendritic spine
(GO:0043197)
Dendritic spine morphogenesis
(GO:0060997)
Embryonic epithelial tube formation
(GO:0001838)
Exploration behavior
(GO:0035640)
Gene expression
(GO:0010467)
Glial cell proliferation
(GO:0014009)
Glutamatergic synapse
(GO:0098978)
G protein-coupled receptor binding
(GO:0001664)
Guanylate kinase-associated protein clustering
(GO:0097117)
Identical protein binding
(GO:0042802)
Ionotropic glutamate receptor binding
(GO:0035255)
Learning
(GO:0007612)
Learning or memory
(GO:0007611)
Locomotion
(GO:0040011)
Locomotory behavior
(GO:0007626)
Locomotory exploration behavior
(GO:0035641)
Long-term synaptic depression
(GO:0060292)
Long-term synaptic potentiation
(GO:0060291)
Maintenance of postsynaptic density structure
(GO:0099562)
Mapk cascade
(GO:0000165)
Memory
(GO:0007613)
Modulation of chemical synaptic transmission
(GO:0050804)
Negative regulation of actin filament bundle assembly
(GO:0032232)
Negative regulation of cell volume
(GO:0045794)
Neural precursor cell proliferation
(GO:0061351)
Neuromuscular process controlling balance
(GO:0050885)
Neuron projection
(GO:0043005)
Neuron spine
(GO:0044309)
Nmda glutamate receptor clustering
(GO:0097114)
Plasma membrane
(GO:0005886)
Plasma membrane bounded cell projection
(GO:0120025)
Positive regulation of dendritic spine development
(GO:0060999)
Positive regulation of excitatory postsynaptic potential
(GO:2000463)
Positive regulation of glutamate receptor signaling pathway
(GO:1900451)
Positive regulation of long-term neuronal synaptic plasticity
(GO:0048170)
Positive regulation of long-term synaptic potentiation
(GO:1900273)
Positive regulation of synapse structural plasticity
(GO:0051835)
Positive regulation of synaptic transmission, glutamatergic
(GO:0051968)
Postsynaptic density
(GO:0014069)
Postsynaptic density, intracellular component
(GO:0099092)
Postsynaptic density assembly
(GO:0097107)
Postsynaptic membrane
(GO:0045211)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein self-association
(GO:0043621)
Regulation of ampa glutamate receptor clustering
(GO:1904717)
Regulation of behavioral fear response
(GO:2000822)
Regulation of dendritic spine morphogenesis
(GO:0061001)
Regulation of grooming behavior
(GO:2000821)
Regulation of long-term synaptic depression
(GO:1900452)
Regulation of long-term synaptic potentiation
(GO:1900271)
Regulation of postsynapse organization
(GO:0099175)
Regulation of synaptic plasticity
(GO:0048167)
Response to interleukin-17
(GO:0097396)
Scaffold protein binding
(GO:0097110)
Sh3 domain binding
(GO:0017124)
Social behavior
(GO:0035176)
Striatal medium spiny neuron differentiation
(GO:0021773)
Structural constituent of postsynaptic density
(GO:0098919)
Synapse assembly
(GO:0007416)
Synapse organization
(GO:0050808)
Synaptic receptor adaptor activity
(GO:0030160)
Vocalization behavior
(GO:0071625)
Vocal learning
(GO:0042297)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

SH3 and multiple ankyrin repeat domains protein 3

Genular Protein ID: 3061982878

Symbol: SHAN3_RAT

Name: SH3 and multiple ankyrin repeat domains protein 3

UniProtKB Accession Codes:

Q9JLU4 Q9WUY7 Q9WV47

Database IDs:

Citations:

PubMed ID: 10527873

Title: Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family.

PubMed ID: 10527873

DOI: 10.1006/bbrc.1999.1489

PubMed ID: 10433268

Title: Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin.

PubMed ID: 10433268

DOI: 10.1016/s0896-6273(00)80809-0

PubMed ID: 10958799

Title: The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family.

PubMed ID: 10958799

DOI: 10.1074/jbc.m006448200

PubMed ID: 10433269

Title: Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins.

PubMed ID: 10433269

DOI: 10.1016/s0896-6273(00)80810-7

PubMed ID: 10806096

Title: The Shank family of scaffold proteins.

PubMed ID: 10806096

DOI: 10.1242/jcs.113.11.1851

PubMed ID: 15014124

Title: Linkage of the actin cytoskeleton to the postsynaptic density via direct interactions of Abp1 with the ProSAP/Shank family.

PubMed ID: 15014124

DOI: 10.1523/jneurosci.5479-03.2004

PubMed ID: 16522626

Title: ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the postsynaptic density that links the spine-associated Rap-Gap (SPAR) to the scaffolding protein ProSAP2/Shank3.

PubMed ID: 16522626

DOI: 10.1074/jbc.m601101200

PubMed ID: 17304222

Title: Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formation.

PubMed ID: 17304222

DOI: 10.1038/sj.emboj.7601569

PubMed ID: 21795692

Title: Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses.

PubMed ID: 21795692

DOI: 10.1074/jbc.m111.258384

PubMed ID: 23100419

Title: Autism-associated mutations in ProSAP2/Shank3 impair synaptic transmission and neurexin-neuroligin-mediated transsynaptic signaling.

PubMed ID: 23100419

DOI: 10.1523/jneurosci.2215-12.2012

PubMed ID: 21606927

Title: SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism.

PubMed ID: 21606927

DOI: 10.1038/mp.2011.57

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 23897824

Title: SHANK3 gene mutations associated with autism facilitate ligand binding to the Shank3 ankyrin repeat region.

PubMed ID: 23897824

DOI: 10.1074/jbc.m112.424747

PubMed ID: 24089484

Title: Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism.

PubMed ID: 24089484

DOI: 10.1523/jneurosci.1175-13.2013

PubMed ID: 16439662

Title: An architectural framework that may lie at the core of the postsynaptic density.

PubMed ID: 16439662

DOI: 10.1126/science.1118995

Sequence Information:

Length: 1740
Mass: 186376
Checksum: A9F486E893EA5AA0
Sequence:

MDGPGASAVV VRVGIPDLQQ TKCLRLDPTA PVWAAKQRVL CALNHSLQDA LNYGLFQPPS 
RGRAGKFLDE ERLLQDYPPN LDTPLPYLEF RYKRRVYAQN LIDDKQFAKL HTKANLKKFM 
DYVQLHSTDK VARLLDKGLD PNFHDPDSGE CPLSLAAQLD NATDLLKVLR NGGAHLDFRT 
RDGLTAVHCA TRQRNAGALT TLLDLGASPD YKDSRGLTPL YHSALGGGDA LCCELLLHDH 
AQLGTTDENG WQEIHQACRF GHVQHLEHLL FYGANMGAQN ASGNTALHIC ALYNQESCAR 
VLLFRGANKD VRNYNSQTAF QVAIIAGNFE LAEVIKTHKD SDVVPFRETP SYAKRRRLAG 
PSGLASPRPL QRSASDINLK GDQPAASPGP TLRSLPHQLL LQRLQEEKDR DRDGEQENDI 
SGPSAGRGGH SKISPSGPGG SGPAPGPGPA SPAPPAPPPR GPKRKLYSAV PGRKFIAVKA 
HSPQGEGEIP LHRGEAVKVL SIGEGGFWEG TVKGRTGWFP ADCVEEVQMR QYDTRHETRE 
DRTKRLFRHY TVGSYDSLTS HSDYVIDDKV AILQKRDHEG FGFVLRGAKA ETPIEEFTPT 
PAFPALQYLE SVDVEGVAWK AGLRTGDFLI EVNGVNVVKV GHKQVVGLIR QGGNRLVMKV 
VSVTRKPEED SARRRAPPPP KRAPSTTLTL RSKSMTAELE ELASIRRRKG EKLDEILAVA 
AEPTLRPDIA DADSRAATVK QRPTSRRITP AEISSLFERQ GLPGPEKLPG SLRKGIPRTK 
SVGEDEKLAS LLEGRFPRST SMQDTVREGR GIPPPPQTAP PPPPAPYYFD SGPPPTFSPP 
PPPPGRAYDT VRSSFKPGLE ARLGAGAAGL YDSGTPLGPL PYPERQKRAR SMIILQDSAP 
EVGDVPRPAP AATPPERPKR RPRPSGPDSP YANLGAFSAS LFAPSKPQRR KSPLVKQLQV 
EDAQERAALA VGSPGPVGGS FAREPSPTHR GPRPGGLDYS SGEGLGLTFG GPSPGPVKER 
RLEERRRSTV FLSVGAIEGS PPSADLPSLQ PSRSIDERLL GTGATTGRDL LLPSPVSALK 
PLVGGPSLGP SGSTFIHPLT GKPLDPSSPL ALALAARERA LASQTPSRSP TPVHSPDADR 
PGPLFVDVQT RDSERGPLAS PAFSPRSPAW IPVPARREAE KPTREERKSP EDKKSMILSV 
LDTSLQRPAG LIVVHATSNG QEPNRLGAEE ERPGTPELAP TPMQAAAVAE PMPSPRAQPP 
GSIPADPGPG QGSSEEEPEL VFAVNLPPAQ LSSSDEETRE ELARIGLVPP PEEFANGILL 
ATPPPGPGPL PTTVPSPASG KPSSELPPAP ESAADSGVEE ADTRSSSDPH LETTSTISTV 
SSMSTLSSES GELTDTHTSF ADGHTFLLEK PPVPPKPKLK SPLGKGPVTF RDPLLKQSSD 
SELMAQQHHA TSTGLTSAAG PARPRYLFQR RSKLWGDPVE SRGLPGPEDD KPTVISELSS 
RLQQLNKDTR SLGEEPVGGL GSLLDPAKKS PIAAARCAVV PSAGWLFSSL GELSTISAQR 
SPGGPGGGAS YSVRPSGRYP VARRAPSPVK PASLERVEGL GAGVGGAGRP FGLTPPTILK 
SSSLSIPHEP KEVRFVVRSV SARSRSPSPS PLPSPSPGSG PSAGPRRPFQ QKPLQLWSKF 
DVGDWLESIH LGEHRDRFED HEIEGAHLPA LTKEDFVELG VTRVGHRMNI ERALRQLDGS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Shank3

Associated with

Other Information

Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family. PubMed ID: 10527873

Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin. PubMed ID: 10433268

The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family. PubMed ID: 10958799

Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. PubMed ID: 10433269

The Shank family of scaffold proteins. PubMed ID: 10806096

Linkage of the actin cytoskeleton to the postsynaptic density via direct interactions of Abp1 with the ProSAP/Shank family. PubMed ID: 15014124

ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the postsynaptic density that links the spine-associated Rap-Gap (SPAR) to the scaffolding protein ProSAP2/Shank3. PubMed ID: 16522626

Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formation. PubMed ID: 17304222

Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. PubMed ID: 21795692

Autism-associated mutations in ProSAP2/Shank3 impair synaptic transmission and neurexin-neuroligin-mediated transsynaptic signaling. PubMed ID: 23100419

SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism. PubMed ID: 21606927

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

SHANK3 gene mutations associated with autism facilitate ligand binding to the Shank3 ankyrin repeat region. PubMed ID: 23897824

Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism. PubMed ID: 24089484

An architectural framework that may lie at the core of the postsynaptic density. PubMed ID: 16439662