Erbb4 | ENSRNOG00000014248 | NCBI 59323

Details for: Erbb4

Gene ID: 59323

Symbol: Erbb4

Ensembl ID: ENSRNOG00000014248

Description: erb-b2 receptor tyrosine kinase 4

Associated with

Atp binding
(GO:0005524)
Basal plasma membrane
(GO:0009925)
Basolateral plasma membrane
(GO:0016323)
Cardiac muscle tissue regeneration
(GO:0061026)
Caveola
(GO:0005901)
Cell fate commitment
(GO:0045165)
Cell migration
(GO:0016477)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to epidermal growth factor stimulus
(GO:0071364)
Central nervous system morphogenesis
(GO:0021551)
Dendrite
(GO:0030425)
Embryonic pattern specification
(GO:0009880)
Epidermal growth factor receptor activity
(GO:0005006)
Epidermal growth factor receptor binding
(GO:0005154)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Erbb2-erbb4 signaling pathway
(GO:0038135)
Erbb4 signaling pathway
(GO:0038130)
Erbb4-erbb4 signaling pathway
(GO:0038138)
Erbb signaling pathway
(GO:0038127)
Establishment of planar polarity involved in nephron morphogenesis
(GO:0072046)
Gaba-ergic synapse
(GO:0098982)
Gaba receptor binding
(GO:0050811)
Glutamatergic synapse
(GO:0098978)
Heart development
(GO:0007507)
Inhibitory synapse
(GO:0060077)
Lactation
(GO:0007595)
Mammary gland alveolus development
(GO:0060749)
Mammary gland development
(GO:0030879)
Mammary gland epithelial cell differentiation
(GO:0060644)
Mitochondrial fragmentation involved in apoptotic process
(GO:0043653)
Mitochondrion
(GO:0005739)
Multicellular organism development
(GO:0007275)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of muscle cell apoptotic process
(GO:0010656)
Negative regulation of neuron migration
(GO:2001223)
Nervous system development
(GO:0007399)
Neural crest cell migration
(GO:0001755)
Neuregulin receptor activity
(GO:0038131)
Neurogenesis
(GO:0022008)
Neuromuscular junction
(GO:0031594)
Neuronal cell body
(GO:0043025)
Neurotransmitter receptor localization to postsynaptic specialization membrane
(GO:0099645)
Nucleus
(GO:0005634)
Olfactory bulb interneuron differentiation
(GO:0021889)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cardiac muscle cell proliferation
(GO:0060045)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of glucose import
(GO:0046326)
Positive regulation of kinase activity
(GO:0033674)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of phospholipid biosynthetic process
(GO:0071073)
Positive regulation of protein localization to cell surface
(GO:2000010)
Positive regulation of receptor signaling pathway via jak-stat
(GO:0046427)
Positive regulation of synaptic transmission, gabaergic
(GO:0032230)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Postsynaptic density membrane
(GO:0098839)
Postsynaptic membrane
(GO:0045211)
Presynaptic membrane
(GO:0042734)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein tyrosine kinase activity
(GO:0004713)
Receptor complex
(GO:0043235)
Receptor signaling pathway via jak-stat
(GO:0007259)
Regulation of cell migration
(GO:0030334)
Regulation of cell population proliferation
(GO:0042127)
Response to hydrogen peroxide
(GO:0042542)
Response to progesterone
(GO:0032570)
Response to xenobiotic stimulus
(GO:0009410)
Signal transduction
(GO:0007165)
Surfactant homeostasis
(GO:0043129)
Synapse assembly
(GO:0007416)
Synapse maturation
(GO:0060074)
Telencephalon development
(GO:0021537)
Transcription cis-regulatory region binding
(GO:0000976)
Transmembrane receptor protein tyrosine kinase activity
(GO:0004714)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)

Other Information

Proteins

Receptor tyrosine-protein kinase erbB-4

Genular Protein ID: 761581649

Symbol: ERBB4_RAT

Name: Receptor tyrosine-protein kinase erbB-4

UniProtKB Accession Codes:

Q62956 Q6UA28 Q6UA29 Q9Z2N7

Database IDs:

Citations:

PubMed ID: 9553078

Title: Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes.

PubMed ID: 9553078

DOI: 10.1074/jbc.273.17.10261

PubMed ID: 15355992

Title: ErbB4 expression in neural progenitor cells (ST14A) is necessary to mediate neuregulin-1-beta1-induced migration.

PubMed ID: 15355992

DOI: 10.1074/jbc.m408374200

PubMed ID: 2025425

Title: An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system.

PubMed ID: 2025425

DOI: 10.1016/0896-6273(91)90167-x

PubMed ID: 9030624

Title: Expression of neuregulins and their putative receptors, ErbB2 and ErbB3, is induced during Wallerian degeneration.

PubMed ID: 9030624

DOI: 10.1523/jneurosci.17-05-01642.1997

PubMed ID: 10839362

Title: Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses.

PubMed ID: 10839362

DOI: 10.1016/s0896-6273(00)81176-9

PubMed ID: 14654373

Title: Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt.

PubMed ID: 14654373

DOI: 10.1016/j.yjmcc.2003.09.012

PubMed ID: 12716924

Title: Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts.

PubMed ID: 12716924

DOI: 10.1523/jneurosci.23-08-03164.2003

PubMed ID: 17250808

Title: Stimulated ErbB4 internalization is necessary for neuregulin signaling in neurons.

PubMed ID: 17250808

DOI: 10.1016/j.bbrc.2007.01.009

PubMed ID: 17521571

Title: The neuregulin-1 receptor erbB4 controls glutamatergic synapse maturation and plasticity.

PubMed ID: 17521571

DOI: 10.1016/j.neuron.2007.03.028

Sequence Information:

Length: 1308
Mass: 146958
Checksum: D944BB0996A08B41
Sequence:

MKLATGLWVW GSLLVAARTV QPSASQSVCA GTENKLSSLS DLEQQYRALR KYYENCEVVM 
GNLEITSIEH NRDLSFLRSI REVTGYVLVA LNQFRYLPLE NLRIIRGTKL YEDRYALAIF 
LNYRKDGNFG LQELGLKNLT EILNGGVYVD QNKFLCYADT IHWQDIVRNP WPSNMTLVST 
IGSSGCGRCH KSCTGRCWGP TENHCQTLTR TVCAEQCDGR CYGPYVSDCC HRECAGGCSG 
PKDTDCFACM NFNDSGACVT QCPQTFVYNP TTFQLEHNFN AKYTYGAFCV KKCPHNFVVD 
SSSCVRACPS SKMEVEENGI KMCKPCTDIC PKACDGIGTG SLMSAQTVDS SNIDKFINCT 
KINGNLIFLV TGIHGDPYNA IDAIDPEKLN VFRTVREITG FLNIQTWPPN MTDFSVFSNL 
VTIGGRVLYS GLSLLILKQQ GITSLQFQSL KEISAGNIYI TDNSNLCYYH TINWTTLFST 
VNQRIVIRDN RRAENCTAEG MVCNHLCSND GCWGPGPDQC LSCRRFSRGK ICIESCNLYD 
GEFREFENGS ICVECDSQCE KMEDGLLTCH GPGPDNCTKC SHFKDGPNCV EKCPDVLQGA 
NSFIFKYADQ DRECHPCHPN CTQGCNGPTS HDCIYYPWTG HSTLPQHART PLIAAGVIGG 
LFILVIMALT FAVYVRRKSI KKKRALRRFL ETELVEPLTP SGTAPNQAQL RILKETELKR 
VKVLGSGAFG TVYKGIWVPE GETVKIPVAI KILNETTGPK ANVEFMDEAL IMASVDHPHL 
VRLLGVCLSP TIQLVTQLMP HGCLLEYVHE HKDNIGSQLL LNWCVQIAKG MMYLEERRLV 
HRDLAARNVL VKSPNHVKIT DFGLARLLEG DEKEYNADGG KMPIKWMALE CIHYRKFTHQ 
SDVWSYGVTI WELMTFGGKP YDGIPTREIP DLLEKGERLP QPPICTIDVY IVMVKCWMID 
ADSRPKFKEL AAEFSRMARD PQRYLVIQGD DRMKLPSPND SKFFQNLLDE EDLEDMMDAE 
EYLVPQAFNI PPPIYTSRTR IDSNRSEIGH SPPPAYTPMS GSQFVYQDGG FATQQGMPMP 
YTATTSTIPE APVAQGATAE MFDDSCCNGT LRKPVVPHVQ EDSSTQRYSA DPTVFAPERN 
PRAELDEEGY MTPMHDKPKQ EYLNPVEENP FVSRRKNGDL QALDNPEYHS ASSGPPKAED 
EYVNEPLYLN TFTNALGNAE YMKNSLLSVP EKAKKAFDNP DYWNHSLPPR STLQHPDYLQ 
EYSTKYFYKQ NGRIRPIVAE NPEYLSEFSL KPGTMLPPPP YRHRNTVV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Erbb4

Associated with

Other Information

Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes. PubMed ID: 9553078

ErbB4 expression in neural progenitor cells (ST14A) is necessary to mediate neuregulin-1-beta1-induced migration. PubMed ID: 15355992

An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system. PubMed ID: 2025425

Expression of neuregulins and their putative receptors, ErbB2 and ErbB3, is induced during Wallerian degeneration. PubMed ID: 9030624

Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. PubMed ID: 10839362

Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt. PubMed ID: 14654373

Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts. PubMed ID: 12716924

Stimulated ErbB4 internalization is necessary for neuregulin signaling in neurons. PubMed ID: 17250808

The neuregulin-1 receptor erbB4 controls glutamatergic synapse maturation and plasticity. PubMed ID: 17521571