Details for: KLHL12

Gene ID: 59349

Symbol: KLHL12

Ensembl ID: ENSG00000117153

Description: kelch like family member 12

Associated with

Other Information

Genular Protein ID: 876378330

Symbol: KLH12_HUMAN

Name: Kelch-like protein 12

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15383316

Title: hDKIR, a human homologue of the Drosophila kelch protein, involved in a ring-like structure.

PubMed ID: 15383316

DOI: 10.1016/j.yexcr.2004.06.023

PubMed ID: 16108817

Title: Identification of specific autoantigens in Sjoegren's syndrome by SEREX.

PubMed ID: 16108817

DOI: 10.1111/j.1365-2567.2005.02197.x

PubMed ID: 16547521

Title: The KLHL12-cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation.

PubMed ID: 16547521

DOI: 10.1038/ncb1381

PubMed ID: 18303015

Title: BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase.

PubMed ID: 18303015

DOI: 10.1074/jbc.m708473200

PubMed ID: 20100572

Title: KLHL12-mediated ubiquitination of the dopamine D4 receptor does not target the receptor for degradation.

PubMed ID: 20100572

DOI: 10.1016/j.cellsig.2010.01.014

PubMed ID: 22358839

Title: Ubiquitin-dependent regulation of COPII coat size and function.

PubMed ID: 22358839

DOI: 10.1038/nature10822

PubMed ID: 27565346

Title: Two distinct types of E3 ligases work in unison to regulate substrate ubiquitylation.

PubMed ID: 27565346

DOI: 10.1016/j.cell.2016.07.027

PubMed ID: 27716508

Title: Regulation of the CUL3 ubiquitin ligase by a calcium-dependent co-adaptor.

PubMed ID: 27716508

DOI: 10.1016/j.cell.2016.09.026

PubMed ID: 30190310

Title: Dimerization quality control ensures neuronal development and survival.

PubMed ID: 30190310

DOI: 10.1126/science.aap8236

PubMed ID: 23349464

Title: Structural basis for Cul3 assembly with the BTB-Kelch family of E3 ubiquitin ligases.

PubMed ID: 23349464

DOI: 10.1074/jbc.m112.437996

Sequence Information:

  • Length: 568
  • Mass: 63277
  • Checksum: 4EB1BC33B6351B5D
  • Sequence:
  • MGGIMAPKDI MTNTHAKSIL NSMNSLRKSN TLCDVTLRVE QKDFPAHRIV LAACSDYFCA 
    MFTSELSEKG KPYVDIQGLT ASTMEILLDF VYTETVHVTV ENVQELLPAA CLLQLKGVKQ 
    ACCEFLESQL DPSNCLGIRD FAETHNCVDL MQAAEVFSQK HFPEVVQHEE FILLSQGEVE 
    KLIKCDEIQV DSEEPVFEAV INWVKHAKKE REESLPNLLQ YVRMPLLTPR YITDVIDAEP 
    FIRCSLQCRD LVDEAKKFHL RPELRSQMQG PRTRARLGAN EVLLVVGGFG SQQSPIDVVE 
    KYDPKTQEWS FLPSITRKRR YVASVSLHDR IYVIGGYDGR SRLSSVECLD YTADEDGVWY 
    SVAPMNVRRG LAGATTLGDM IYVSGGFDGS RRHTSMERYD PNIDQWSMLG DMQTAREGAG 
    LVVASGVIYC LGGYDGLNIL NSVEKYDPHT GHWTNVTPMA TKRSGAGVAL LNDHIYVVGG 
    FDGTAHLSSV EAYNIRTDSW TTVTSMTTPR CYVGATVLRG RLYAIAGYDG NSLLSSIECY 
    DPIIDSWEVV TSMGTQRCDA GVCVLREK

Genular Protein ID: 1014547613

Symbol: Q9H7R2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 204
  • Mass: 22538
  • Checksum: 80CE9BB8EE05AF06
  • Sequence:
  • MQGPRTRARL GANEVLLVVG GFGSQQSPID VVEKYDPKTQ EWSFLPSITR KRRYVASVSL 
    HDRIYVIGGY DGRSRLSSVE CLDYTADEDG VWYSVAPMNV RRGLAGATTL GDMIYVSGGF 
    DGSRRHTSME RYDPNIDQWS MLGDMQTARE GAGLVVASGV IYCLGGYDGL NILNSVEKYD 
    PHTGHWTNVT PMATKRSDMM VIPC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.