Gene CCND1 - ENSG00000110092 | NCBI Gene ID: 595

Details for: CCND1

Gene ID: 595

Symbol: CCND1

Ensembl ID: ENSG00000110092

Description: cyclin D1

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic g1/s transition in cancer due to rb1 defects
(R-HSA-9659787)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin d associated events in g1
(R-HSA-69231)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective binding of rb1 mutants to e2f1,(e2f2, e2f3)
(R-HSA-9661069)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Drug-mediated inhibition of cdk4/cdk6 activity
(R-HSA-9754119)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
G1 phase
(R-HSA-69236)
G1/s transition
(R-HSA-69206)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Ptk6 regulates cell cycle
(R-HSA-8849470)
Regulation of runx1 expression and activity
(R-HSA-8934593)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Runx3 regulates p14-arf
(R-HSA-8951936)
Runx3 regulates wnt signaling
(R-HSA-8951430)
Scf(skp2)-mediated degradation of p27/p21
(R-HSA-187577)
Signaling by interleukins
(R-HSA-449147)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by ptk6
(R-HSA-8848021)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by runx2
(R-HSA-8878166)
Transcriptional regulation by runx3
(R-HSA-8878159)
Transcriptional regulation by ventx
(R-HSA-8853884)
Ubiquitin-dependent degradation of cyclin d
(R-HSA-75815)
Bicellular tight junction
(GO:0005923)
Cell division
(GO:0051301)
Centrosome
(GO:0005813)
Cyclin-dependent protein kinase holoenzyme complex
(GO:0000307)
Cyclin-dependent protein serine/threonine kinase activator activity
(GO:0061575)
Cyclin-dependent protein serine/threonine kinase regulator activity
(GO:0016538)
Cyclin d1-cdk4 complex
(GO:0097128)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna damage response
(GO:0006974)
Endoplasmic reticulum unfolded protein response
(GO:0030968)
Enzyme binding
(GO:0019899)
Fat cell differentiation
(GO:0045444)
G1/s transition of mitotic cell cycle
(GO:0000082)
Histone deacetylase binding
(GO:0042826)
Lactation
(GO:0007595)
Liver regeneration
(GO:0097421)
Mammary gland alveolus development
(GO:0060749)
Mammary gland epithelial cell proliferation
(GO:0033598)
Mitotic g1 dna damage checkpoint signaling
(GO:0031571)
Negative regulation of epithelial cell differentiation
(GO:0030857)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuron differentiation
(GO:0030182)
Nuclear membrane
(GO:0031965)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0045737)
Positive regulation of g1/s transition of mitotic cell cycle
(GO:1900087)
Positive regulation of g2/m transition of mitotic cell cycle
(GO:0010971)
Positive regulation of mammary gland epithelial cell proliferation
(GO:0033601)
Positive regulation of protein phosphorylation
(GO:0001934)
Proline-rich region binding
(GO:0070064)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Re-entry into mitotic cell cycle
(GO:0000320)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Response to leptin
(GO:0044321)
Response to uv-a
(GO:0070141)
Response to xenobiotic stimulus
(GO:0009410)
Transcription corepressor activity
(GO:0003714)
Transcription repressor complex
(GO:0017053)
Wnt signaling pathway
(GO:0016055)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: chromaffin cell (CL0000166)
Fold Change: 6
Marker Score: 8448
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 2.51
Marker Score: 15995
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.44
Marker Score: 1926
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 2.24
Marker Score: 8288
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 2.23
Marker Score: 2320
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 2.21
Marker Score: 16431.5
Cell Name: neural cell (CL0002319)
Fold Change: 2.2
Marker Score: 1061
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.1
Marker Score: 72837
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 2.06
Marker Score: 10811
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 2
Marker Score: 1701
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 1.91
Marker Score: 2301
Cell Name: secretory cell (CL0000151)
Fold Change: 1.89
Marker Score: 3443
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.86
Marker Score: 16070
Cell Name: hepatoblast (CL0005026)
Fold Change: 1.85
Marker Score: 6053
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.85
Marker Score: 2717.5
Cell Name: basal cell (CL0000646)
Fold Change: 1.75
Marker Score: 2259
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.75
Marker Score: 1849
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.74
Marker Score: 4241
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 1.73
Marker Score: 13518
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.73
Marker Score: 2834.5
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.73
Marker Score: 499
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.72
Marker Score: 1813
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.72
Marker Score: 1150
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.71
Marker Score: 15028
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 1.67
Marker Score: 4247
Cell Name: neural crest cell (CL0011012)
Fold Change: 1.64
Marker Score: 1753
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 1.63
Marker Score: 518
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.62
Marker Score: 1484
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 1.62
Marker Score: 2338.5
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1.6
Marker Score: 1003
Cell Name: club cell (CL0000158)
Fold Change: 1.57
Marker Score: 1829
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.55
Marker Score: 3524
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 1.55
Marker Score: 585
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 1.53
Marker Score: 755
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.51
Marker Score: 1828
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 1.51
Marker Score: 364.5
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.47
Marker Score: 9570
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 1.44
Marker Score: 1024
Cell Name: pneumocyte (CL0000322)
Fold Change: 1.44
Marker Score: 2311
Cell Name: kidney cell (CL1000497)
Fold Change: 1.44
Marker Score: 958
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1.43
Marker Score: 1350
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.43
Marker Score: 3824.5
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.42
Marker Score: 3337
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 1.41
Marker Score: 5871
Cell Name: germ cell (CL0000586)
Fold Change: 1.4
Marker Score: 2450
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.39
Marker Score: 469
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.35
Marker Score: 1268
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.35
Marker Score: 741
Cell Name: stem cell (CL0000034)
Fold Change: 1.34
Marker Score: 3179
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.32
Marker Score: 5078
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.3
Marker Score: 540
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1.29
Marker Score: 1772
Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.29
Marker Score: 1113
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.28
Marker Score: 1416
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.26
Marker Score: 696
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.25
Marker Score: 294
Cell Name: epithelial cell (CL0000066)
Fold Change: 1.25
Marker Score: 1991
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.25
Marker Score: 1188.5
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 1.22
Marker Score: 460
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.22
Marker Score: 2781
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 1.22
Marker Score: 1308
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 1.21
Marker Score: 309
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.21
Marker Score: 564
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 1.18
Marker Score: 266
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.17
Marker Score: 603.5
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 1.15
Marker Score: 399
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.15
Marker Score: 18025
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.15
Marker Score: 784
Cell Name: lung secretory cell (CL1000272)
Fold Change: 1.14
Marker Score: 1016
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 1.13
Marker Score: 1403
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.11
Marker Score: 649
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.11
Marker Score: 319
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 1.1
Marker Score: 273
Cell Name: osteoclast (CL0000092)
Fold Change: 1.09
Marker Score: 542
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 1.09
Marker Score: 488
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 1.09
Marker Score: 273
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 1.08
Marker Score: 9423
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.06
Marker Score: 2680
Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 1.06
Marker Score: 247
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 1.05
Marker Score: 427
Cell Name: keratinocyte (CL0000312)
Fold Change: 1.04
Marker Score: 871
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.04
Marker Score: 264
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.03
Marker Score: 712
Cell Name: microglial cell (CL0000129)
Fold Change: 1.02
Marker Score: 1861
Cell Name: Mueller cell (CL0000636)
Fold Change: 1.01
Marker Score: 1406
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71735.5
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47961
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1
Marker Score: 2025
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1
Marker Score: 582
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.98
Marker Score: 981
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30398
Cell Name: acinar cell (CL0000622)
Fold Change: 0.97
Marker Score: 685
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.97
Marker Score: 1169
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.97
Marker Score: 603
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.97
Marker Score: 3427
Cell Name: lactocyte (CL0002325)
Fold Change: 0.96
Marker Score: 15434
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.96
Marker Score: 194
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 495
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.95
Marker Score: 3283
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 449

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**Key characteristics:** * CCND1 is a proto-oncogene, meaning that it is initially transcribed but is not expressed. * It is induced by various growth factors and cytokines, including EGF and PDGF. * It is a key regulator of the G1/S transition, a critical phase in the cell cycle that determines whether cells will divide or stop dividing. * Mutations in the CCND1 gene have been linked to various human cancers. **Pathways and functions:** * CCND1 is a key regulator of the cell cycle. It is involved in the regulation of cell cycle progression, cell cycle arrest, and apoptosis. * In the G1 phase, CCND1 promotes cell cycle progression by inhibiting the expression of cyclin-dependent kinase inhibitors (CDKIs). * In the G1/S transition, CCND1 is phosphorylated by cyclin-dependent kinase 1 (CDK1) and degraded, which leads to the release of transcription factors that promote DNA synthesis. * CCND1 also regulates the expression of various genes involved in cell cycle regulation. **Clinical significance:** * Mutations in the CCND1 gene have been linked to various human cancers, including breast cancer, lung cancer, and colon cancer. * Targeting CCND1 has been explored as a therapeutic strategy for cancer, but it has not been successful due to the drug resistance of cancer cells. * Research is ongoing to develop novel therapeutic strategies that target CCND1 and overcome drug resistance.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

CCND1_HUMAN

Genular Protein ID: 2371683716

Symbol: CCND1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P24385 Q6LEF0

Database IDs:

Citations:

PubMed ID: 1826542

Title: A novel cyclin encoded by a bcl1-linked candidate oncogene.

PubMed ID: 1826542

DOI: 10.1038/350512a0

PubMed ID: 1833066

Title: Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast.

PubMed ID: 1833066

DOI: 10.1016/0092-8674(91)90042-w

PubMed ID: 1827756

Title: Human D-type cyclin.

PubMed ID: 1827756

DOI: 10.1016/0092-8674(91)90100-d

PubMed ID: 1833629

Title: Characterization of a candidate bcl-1 gene.

PubMed ID: 1833629

DOI: 10.1128/mcb.11.10.4846-4853.1991

PubMed ID: 8204893

Title: Rearrangement of CCND1 (BCL1/PRAD1) 3' untranslated region in mantle-cell lymphomas and t(11q13)-associated leukemias.

PubMed ID: 8204893

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7687458

Title: The PRAD1/cyclin D1 proto-oncogene: genomic organization, 5' DNA sequence, and sequence of a tumor-specific rearrangement breakpoint.

PubMed ID: 7687458

DOI: 10.1002/gcc.2870070205

PubMed ID: 8114739

Title: Identification of G1 kinase activity for cdk6, a novel cyclin D partner.

PubMed ID: 8114739

DOI: 10.1128/mcb.14.3.2077-2086.1994

PubMed ID: 8302605

Title: CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1.

PubMed ID: 8302605

PubMed ID: 8695815

Title: Dysregulation of cyclin D1 by translocation into an IgH gamma switch region in two multiple myeloma cell lines.

PubMed ID: 8695815

PubMed ID: 9106657

Title: New functional activities for the p21 family of CDK inhibitors.

PubMed ID: 9106657

DOI: 10.1101/gad.11.7.847

PubMed ID: 10766840

Title: Ubiquitination of free cyclin D1 is independent of phosphorylation on threonine 286.

PubMed ID: 10766840

DOI: 10.1074/jbc.275.16.12074

PubMed ID: 15241418

Title: Cyclin-dependent kinases regulate the antiproliferative function of Smads.

PubMed ID: 15241418

DOI: 10.1038/nature02650

PubMed ID: 16569215

Title: INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases.

PubMed ID: 16569215

DOI: 10.1042/bj20051669

PubMed ID: 18417529

Title: Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription.

PubMed ID: 18417529

DOI: 10.1677/joe-08-0001

PubMed ID: 19124461

Title: Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest.

PubMed ID: 19124461

DOI: 10.1074/jbc.m808843200

PubMed ID: 19917254

Title: Suppression of cancer cell growth by promoting cyclin D1 degradation.

PubMed ID: 19917254

DOI: 10.1016/j.molcel.2009.10.018

PubMed ID: 19412162

Title: F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage.

PubMed ID: 19412162

DOI: 10.1038/nature08011

PubMed ID: 20399237

Title: TM4SF5 accelerates G1/S phase progression via cytosolic p27Kip1 expression and RhoA activity.

PubMed ID: 20399237

DOI: 10.1016/j.bbamcr.2010.04.001

PubMed ID: 21952639

Title: NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor.

PubMed ID: 21952639

DOI: 10.4161/cc.10.19.17176

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 33854232

Title: AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity.

PubMed ID: 33854232

DOI: 10.1038/s41586-021-03422-5

PubMed ID: 33854235

Title: CRL4AMBRA1 is a master regulator of D-type cyclins.

PubMed ID: 33854235

DOI: 10.1038/s41586-021-03445-y

PubMed ID: 33854239

Title: The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D.

PubMed ID: 33854239

DOI: 10.1038/s41586-021-03474-7

PubMed ID: 19237565

Title: Crystal structure of human CDK4 in complex with a D-type cyclin.

PubMed ID: 19237565

DOI: 10.1073/pnas.0809645106

Sequence Information:

Length: 295
Mass: 33729
Checksum: 3CC00C9905F58D3A
Sequence:

MEHQLLCCEV ETIRRAYPDA NLLNDRVLRA MLKAEETCAP SVSYFKCVQK EVLPSMRKIV 
ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS LEPVKKSRLQ LLGATCMFVA SKMKETIPLT 
AEKLCIYTDN SIRPEELLQM ELLLVNKLKW NLAAMTPHDF IEHFLSKMPE AEENKQIIRK 
HAQTFVALCA TDVKFISNPP SMVAAGSVVA AVQGLNLRSP NNFLSYYRLT RFLSRVIKCD 
PDCLRACQEQ IEALLESSLR QAQQNMDPKA AEEEEEEEEE VDLACTPTDV RDVDI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CCND1

Associated with

Cells (max top 100)

Other Information

A novel cyclin encoded by a bcl1-linked candidate oncogene. PubMed ID: 1826542

Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. PubMed ID: 1833066

Human D-type cyclin. PubMed ID: 1827756

Characterization of a candidate bcl-1 gene. PubMed ID: 1833629

Rearrangement of CCND1 (BCL1/PRAD1) 3' untranslated region in mantle-cell lymphomas and t(11q13)-associated leukemias. PubMed ID: 8204893

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The PRAD1/cyclin D1 proto-oncogene: genomic organization, 5' DNA sequence, and sequence of a tumor-specific rearrangement breakpoint. PubMed ID: 7687458

Identification of G1 kinase activity for cdk6, a novel cyclin D partner. PubMed ID: 8114739

CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1. PubMed ID: 8302605

Dysregulation of cyclin D1 by translocation into an IgH gamma switch region in two multiple myeloma cell lines. PubMed ID: 8695815

New functional activities for the p21 family of CDK inhibitors. PubMed ID: 9106657

Ubiquitination of free cyclin D1 is independent of phosphorylation on threonine 286. PubMed ID: 10766840

Cyclin-dependent kinases regulate the antiproliferative function of Smads. PubMed ID: 15241418

INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases. PubMed ID: 16569215

Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription. PubMed ID: 18417529

Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest. PubMed ID: 19124461

Suppression of cancer cell growth by promoting cyclin D1 degradation. PubMed ID: 19917254

F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage. PubMed ID: 19412162

TM4SF5 accelerates G1/S phase progression via cytosolic p27Kip1 expression and RhoA activity. PubMed ID: 20399237

NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor. PubMed ID: 21952639

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity. PubMed ID: 33854232

CRL4AMBRA1 is a master regulator of D-type cyclins. PubMed ID: 33854235

The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D. PubMed ID: 33854239

Crystal structure of human CDK4 in complex with a D-type cyclin. PubMed ID: 19237565