CCND1 | ENSG00000110092 | NCBI 595

Details for: CCND1

Gene ID: 595

Symbol: CCND1

Ensembl ID: ENSG00000110092

Description: cyclin D1

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic g1/s transition in cancer due to rb1 defects
(R-HSA-9659787)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin d associated events in g1
(R-HSA-69231)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective binding of rb1 mutants to e2f1,(e2f2, e2f3)
(R-HSA-9661069)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Drug-mediated inhibition of cdk4/cdk6 activity
(R-HSA-9754119)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
G1 phase
(R-HSA-69236)
G1/s transition
(R-HSA-69206)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Ptk6 regulates cell cycle
(R-HSA-8849470)
Regulation of runx1 expression and activity
(R-HSA-8934593)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Runx3 regulates p14-arf
(R-HSA-8951936)
Runx3 regulates wnt signaling
(R-HSA-8951430)
Scf(skp2)-mediated degradation of p27/p21
(R-HSA-187577)
Signaling by interleukins
(R-HSA-449147)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by ptk6
(R-HSA-8848021)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by runx2
(R-HSA-8878166)
Transcriptional regulation by runx3
(R-HSA-8878159)
Transcriptional regulation by ventx
(R-HSA-8853884)
Ubiquitin-dependent degradation of cyclin d
(R-HSA-75815)
Bicellular tight junction
(GO:0005923)
Cell division
(GO:0051301)
Centrosome
(GO:0005813)
Cyclin-dependent protein kinase holoenzyme complex
(GO:0000307)
Cyclin-dependent protein serine/threonine kinase activator activity
(GO:0061575)
Cyclin-dependent protein serine/threonine kinase regulator activity
(GO:0016538)
Cyclin d1-cdk4 complex
(GO:0097128)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna damage response
(GO:0006974)
Endoplasmic reticulum unfolded protein response
(GO:0030968)
Enzyme binding
(GO:0019899)
Fat cell differentiation
(GO:0045444)
G1/s transition of mitotic cell cycle
(GO:0000082)
Histone deacetylase binding
(GO:0042826)
Lactation
(GO:0007595)
Liver regeneration
(GO:0097421)
Mammary gland alveolus development
(GO:0060749)
Mammary gland epithelial cell proliferation
(GO:0033598)
Mitotic g1 dna damage checkpoint signaling
(GO:0031571)
Negative regulation of epithelial cell differentiation
(GO:0030857)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuron differentiation
(GO:0030182)
Nuclear membrane
(GO:0031965)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0045737)
Positive regulation of g1/s transition of mitotic cell cycle
(GO:1900087)
Positive regulation of g2/m transition of mitotic cell cycle
(GO:0010971)
Positive regulation of mammary gland epithelial cell proliferation
(GO:0033601)
Positive regulation of protein phosphorylation
(GO:0001934)
Proline-rich region binding
(GO:0070064)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Re-entry into mitotic cell cycle
(GO:0000320)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Response to leptin
(GO:0044321)
Response to uv-a
(GO:0070141)
Response to xenobiotic stimulus
(GO:0009410)
Transcription corepressor activity
(GO:0003714)
Transcription repressor complex
(GO:0017053)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

CCND1_HUMAN

Genular Protein ID: 2371683716

Symbol: CCND1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P24385 Q6LEF0

Database IDs:

Citations:

PubMed ID: 1826542

Title: A novel cyclin encoded by a bcl1-linked candidate oncogene.

PubMed ID: 1826542

DOI: 10.1038/350512a0

PubMed ID: 1833066

Title: Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast.

PubMed ID: 1833066

DOI: 10.1016/0092-8674(91)90042-w

PubMed ID: 1827756

Title: Human D-type cyclin.

PubMed ID: 1827756

DOI: 10.1016/0092-8674(91)90100-d

PubMed ID: 1833629

Title: Characterization of a candidate bcl-1 gene.

PubMed ID: 1833629

DOI: 10.1128/mcb.11.10.4846-4853.1991

PubMed ID: 8204893

Title: Rearrangement of CCND1 (BCL1/PRAD1) 3' untranslated region in mantle-cell lymphomas and t(11q13)-associated leukemias.

PubMed ID: 8204893

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7687458

Title: The PRAD1/cyclin D1 proto-oncogene: genomic organization, 5' DNA sequence, and sequence of a tumor-specific rearrangement breakpoint.

PubMed ID: 7687458

DOI: 10.1002/gcc.2870070205

PubMed ID: 8114739

Title: Identification of G1 kinase activity for cdk6, a novel cyclin D partner.

PubMed ID: 8114739

DOI: 10.1128/mcb.14.3.2077-2086.1994

PubMed ID: 8302605

Title: CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1.

PubMed ID: 8302605

PubMed ID: 8695815

Title: Dysregulation of cyclin D1 by translocation into an IgH gamma switch region in two multiple myeloma cell lines.

PubMed ID: 8695815

PubMed ID: 9106657

Title: New functional activities for the p21 family of CDK inhibitors.

PubMed ID: 9106657

DOI: 10.1101/gad.11.7.847

PubMed ID: 10766840

Title: Ubiquitination of free cyclin D1 is independent of phosphorylation on threonine 286.

PubMed ID: 10766840

DOI: 10.1074/jbc.275.16.12074

PubMed ID: 15241418

Title: Cyclin-dependent kinases regulate the antiproliferative function of Smads.

PubMed ID: 15241418

DOI: 10.1038/nature02650

PubMed ID: 16569215

Title: INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases.

PubMed ID: 16569215

DOI: 10.1042/bj20051669

PubMed ID: 18417529

Title: Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription.

PubMed ID: 18417529

DOI: 10.1677/joe-08-0001

PubMed ID: 19124461

Title: Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest.

PubMed ID: 19124461

DOI: 10.1074/jbc.m808843200

PubMed ID: 19917254

Title: Suppression of cancer cell growth by promoting cyclin D1 degradation.

PubMed ID: 19917254

DOI: 10.1016/j.molcel.2009.10.018

PubMed ID: 19412162

Title: F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage.

PubMed ID: 19412162

DOI: 10.1038/nature08011

PubMed ID: 20399237

Title: TM4SF5 accelerates G1/S phase progression via cytosolic p27Kip1 expression and RhoA activity.

PubMed ID: 20399237

DOI: 10.1016/j.bbamcr.2010.04.001

PubMed ID: 21952639

Title: NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor.

PubMed ID: 21952639

DOI: 10.4161/cc.10.19.17176

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 33854232

Title: AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity.

PubMed ID: 33854232

DOI: 10.1038/s41586-021-03422-5

PubMed ID: 33854235

Title: CRL4AMBRA1 is a master regulator of D-type cyclins.

PubMed ID: 33854235

DOI: 10.1038/s41586-021-03445-y

PubMed ID: 33854239

Title: The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D.

PubMed ID: 33854239

DOI: 10.1038/s41586-021-03474-7

PubMed ID: 19237565

Title: Crystal structure of human CDK4 in complex with a D-type cyclin.

PubMed ID: 19237565

DOI: 10.1073/pnas.0809645106

Sequence Information:

Length: 295
Mass: 33729
Checksum: 3CC00C9905F58D3A
Sequence:

MEHQLLCCEV ETIRRAYPDA NLLNDRVLRA MLKAEETCAP SVSYFKCVQK EVLPSMRKIV 
ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS LEPVKKSRLQ LLGATCMFVA SKMKETIPLT 
AEKLCIYTDN SIRPEELLQM ELLLVNKLKW NLAAMTPHDF IEHFLSKMPE AEENKQIIRK 
HAQTFVALCA TDVKFISNPP SMVAAGSVVA AVQGLNLRSP NNFLSYYRLT RFLSRVIKCD 
PDCLRACQEQ IEALLESSLR QAQQNMDPKA AEEEEEEEEE VDLACTPTDV RDVDI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CCND1

Associated with

Other Information

A novel cyclin encoded by a bcl1-linked candidate oncogene. PubMed ID: 1826542

Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. PubMed ID: 1833066

Human D-type cyclin. PubMed ID: 1827756

Characterization of a candidate bcl-1 gene. PubMed ID: 1833629

Rearrangement of CCND1 (BCL1/PRAD1) 3' untranslated region in mantle-cell lymphomas and t(11q13)-associated leukemias. PubMed ID: 8204893

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The PRAD1/cyclin D1 proto-oncogene: genomic organization, 5' DNA sequence, and sequence of a tumor-specific rearrangement breakpoint. PubMed ID: 7687458

Identification of G1 kinase activity for cdk6, a novel cyclin D partner. PubMed ID: 8114739

CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1. PubMed ID: 8302605

Dysregulation of cyclin D1 by translocation into an IgH gamma switch region in two multiple myeloma cell lines. PubMed ID: 8695815

New functional activities for the p21 family of CDK inhibitors. PubMed ID: 9106657

Ubiquitination of free cyclin D1 is independent of phosphorylation on threonine 286. PubMed ID: 10766840

Cyclin-dependent kinases regulate the antiproliferative function of Smads. PubMed ID: 15241418

INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases. PubMed ID: 16569215

Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription. PubMed ID: 18417529

Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest. PubMed ID: 19124461

Suppression of cancer cell growth by promoting cyclin D1 degradation. PubMed ID: 19917254

F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage. PubMed ID: 19412162

TM4SF5 accelerates G1/S phase progression via cytosolic p27Kip1 expression and RhoA activity. PubMed ID: 20399237

NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor. PubMed ID: 21952639

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity. PubMed ID: 33854232

CRL4AMBRA1 is a master regulator of D-type cyclins. PubMed ID: 33854235

The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D. PubMed ID: 33854239

Crystal structure of human CDK4 in complex with a D-type cyclin. PubMed ID: 19237565