CCND1 | ENSG00000110092 | NCBI 595

Details for: CCND1

Gene ID: 595

Symbol: CCND1

Ensembl ID: ENSG00000110092

Description: cyclin D1

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic g1/s transition in cancer due to rb1 defects
(R-HSA-9659787)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin d associated events in g1
(R-HSA-69231)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective binding of rb1 mutants to e2f1,(e2f2, e2f3)
(R-HSA-9661069)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Drug-mediated inhibition of cdk4/cdk6 activity
(R-HSA-9754119)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
G1 phase
(R-HSA-69236)
G1/s transition
(R-HSA-69206)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Mitf-m-dependent gene expression
(R-HSA-9856651)
Mitf-m-regulated melanocyte development
(R-HSA-9730414)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Ptk6 regulates cell cycle
(R-HSA-8849470)
Regulation of mitf-m-dependent genes involved in cell cycle and proliferation
(R-HSA-9825892)
Regulation of runx1 expression and activity
(R-HSA-8934593)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Runx3 regulates p14-arf
(R-HSA-8951936)
Runx3 regulates wnt signaling
(R-HSA-8951430)
Scf(skp2)-mediated degradation of p27/p21
(R-HSA-187577)
Signaling by interleukins
(R-HSA-449147)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by ptk6
(R-HSA-8848021)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by runx2
(R-HSA-8878166)
Transcriptional regulation by runx3
(R-HSA-8878159)
Transcriptional regulation by ventx
(R-HSA-8853884)
Ubiquitin-dependent degradation of cyclin d
(R-HSA-75815)
Bicellular tight junction
(GO:0005923)
Cell division
(GO:0051301)
Cyclin-dependent protein kinase holoenzyme complex
(GO:0000307)
Cyclin-dependent protein serine/threonine kinase activator activity
(GO:0061575)
Cyclin-dependent protein serine/threonine kinase regulator activity
(GO:0016538)
Cyclin d1-cdk4 complex
(GO:0097128)
Cyclin d1-cdk6 complex
(GO:0097131)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna damage response
(GO:0006974)
Endoplasmic reticulum unfolded protein response
(GO:0030968)
Enzyme binding
(GO:0019899)
Fat cell differentiation
(GO:0045444)
G1/s transition of mitotic cell cycle
(GO:0000082)
Histone deacetylase binding
(GO:0042826)
Lactation
(GO:0007595)
Liver regeneration
(GO:0097421)
Mammary gland alveolus development
(GO:0060749)
Mammary gland epithelial cell proliferation
(GO:0033598)
Microtubule organizing center
(GO:0005815)
Mitotic g1 dna damage checkpoint signaling
(GO:0031571)
Negative regulation of epithelial cell differentiation
(GO:0030857)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuron differentiation
(GO:0030182)
Nuclear membrane
(GO:0031965)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0045737)
Positive regulation of g1/s transition of mitotic cell cycle
(GO:1900087)
Positive regulation of g2/m transition of mitotic cell cycle
(GO:0010971)
Positive regulation of mammary gland epithelial cell proliferation
(GO:0033601)
Positive regulation of protein phosphorylation
(GO:0001934)
Proline-rich region binding
(GO:0070064)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Re-entry into mitotic cell cycle
(GO:0000320)
Response to leptin
(GO:0044321)
Response to uv-a
(GO:0070141)
Response to xenobiotic stimulus
(GO:0009410)
Transcription corepressor activity
(GO:0003714)
Transcription repressor complex
(GO:0017053)
Wnt signaling pathway
(GO:0016055)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 240.3160
Cell Significance Index: -37.3800
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 149.4618
Cell Significance Index: -37.9100
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 83.4815
Cell Significance Index: -34.3900
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 75.7894
Cell Significance Index: -30.7900
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 56.6747
Cell Significance Index: -38.0300
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 32.3543
Cell Significance Index: -30.8900
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 30.4309
Cell Significance Index: -37.5200
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 14.2355
Cell Significance Index: -38.1400
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 10.6757
Cell Significance Index: -32.7900
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 9.5133
Cell Significance Index: -37.5400
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.3433
Cell Significance Index: -18.2600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 5.6671
Cell Significance Index: 77.3200
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 4.8733
Cell Significance Index: 30.1500
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 3.7931
Cell Significance Index: 262.3200
Cell Name: glomerular capillary endothelial cell (CL1001005)
Fold Change: 3.5659
Cell Significance Index: 13.2900
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 3.3676
Cell Significance Index: 50.4600
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 2.9947
Cell Significance Index: 18.4300
Cell Name: kidney cell (CL1000497)
Fold Change: 2.6377
Cell Significance Index: 21.0600
Cell Name: peg cell (CL4033014)
Fold Change: 2.5853
Cell Significance Index: 59.7300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.5530
Cell Significance Index: 69.4900
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2.5272
Cell Significance Index: 131.6400
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 2.4893
Cell Significance Index: 404.8600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 2.4651
Cell Significance Index: 138.3300
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 2.1612
Cell Significance Index: 152.8500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.1412
Cell Significance Index: 263.2900
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.0925
Cell Significance Index: 1142.7700
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.0578
Cell Significance Index: 18.9500
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.0467
Cell Significance Index: 106.3200
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.0467
Cell Significance Index: 904.9000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.8532
Cell Significance Index: 38.7900
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.8356
Cell Significance Index: 199.6600
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.6019
Cell Significance Index: 317.9100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.3077
Cell Significance Index: 235.7400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.1898
Cell Significance Index: 55.9200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.9617
Cell Significance Index: 44.8400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.9411
Cell Significance Index: 70.1400
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.8252
Cell Significance Index: 6.8300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.7081
Cell Significance Index: 15.3400
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5953
Cell Significance Index: 17.1500
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.5918
Cell Significance Index: 16.5400
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.5897
Cell Significance Index: 8.4000
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.5572
Cell Significance Index: 8.6200
Cell Name: lactocyte (CL0002325)
Fold Change: 0.5048
Cell Significance Index: 65.2200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4602
Cell Significance Index: 20.8600
Cell Name: perivascular cell (CL4033054)
Fold Change: 0.3119
Cell Significance Index: 1.4400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3080
Cell Significance Index: 58.6100
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.3050
Cell Significance Index: 3.4700
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.2714
Cell Significance Index: 2.9500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2440
Cell Significance Index: 6.1000
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.2129
Cell Significance Index: 156.0700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1337
Cell Significance Index: 205.8000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1139
Cell Significance Index: 11.2700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0909
Cell Significance Index: 68.8000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0706
Cell Significance Index: 2.4800
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.0662
Cell Significance Index: 0.4000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 0.0576
Cell Significance Index: 4.5600
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0152
Cell Significance Index: 20.6800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0112
Cell Significance Index: -21.0100
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0144
Cell Significance Index: -0.4600
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0179
Cell Significance Index: -0.1900
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0185
Cell Significance Index: -0.3100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0210
Cell Significance Index: -2.1500
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0267
Cell Significance Index: -49.2100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0307
Cell Significance Index: -22.7100
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0327
Cell Significance Index: -0.8800
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0345
Cell Significance Index: -21.5300
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0458
Cell Significance Index: -31.7000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0467
Cell Significance Index: -29.6700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0506
Cell Significance Index: -28.5300
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0566
Cell Significance Index: -6.4900
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0661
Cell Significance Index: -7.5400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0732
Cell Significance Index: -12.5000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0749
Cell Significance Index: -33.9900
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0780
Cell Significance Index: -3.9400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0934
Cell Significance Index: -12.8200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.1062
Cell Significance Index: -38.1000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1306
Cell Significance Index: -37.5700
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1470
Cell Significance Index: -3.1300
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.1484
Cell Significance Index: -1.2100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1544
Cell Significance Index: -17.9900
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1722
Cell Significance Index: -36.2600
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1808
Cell Significance Index: -36.2600
Cell Name: odontoblast (CL0000060)
Fold Change: -0.1821
Cell Significance Index: -23.3400
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.2172
Cell Significance Index: -8.9000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2201
Cell Significance Index: -32.0000
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2577
Cell Significance Index: -19.7800
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2599
Cell Significance Index: -9.0300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.3113
Cell Significance Index: -36.7100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3596
Cell Significance Index: -37.4400
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4815
Cell Significance Index: -25.2800
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.4851
Cell Significance Index: -4.0800
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5068
Cell Significance Index: -31.0700
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.5300
Cell Significance Index: -15.6100
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.5527
Cell Significance Index: -35.6600
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.5805
Cell Significance Index: -36.5900
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -0.5870
Cell Significance Index: -7.5600
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.5941
Cell Significance Index: -39.9500
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.6058
Cell Significance Index: -10.2100
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.6356
Cell Significance Index: -39.0700
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: -0.6673
Cell Significance Index: -4.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** CCND1 is a 32-kilodalton protein that belongs to the cyclin family. It is characterized by its ability to bind to cyclin-dependent kinases (CDKs), specifically CDK4 and CDK6, to regulate the G1/S transition. CCND1 is also known for its role in regulating the cell cycle, particularly in the transition from the G1 phase to the S phase. It is a transcriptional regulator that is involved in various cellular processes, including cell proliferation, differentiation, and survival. **Pathways and Functions** CCND1 is involved in several cellular pathways, including: 1. Cell cycle regulation: CCND1 regulates the transition from the G1 phase to the S phase by binding to CDK4 and CDK6. 2. Cyclin-dependent protein kinase holoenzyme complex: CCND1 is a component of the cyclin-dependent protein kinase holoenzyme complex, which is essential for the progression of cells through the cell cycle. 3. Chromatin modifying enzymes: CCND1 is involved in regulating chromatin modifying enzymes, which are essential for gene expression and cell cycle progression. 4. Immune system: CCND1 is expressed in immune cells and is involved in regulating immune responses, including cytokine signaling and immune cell differentiation. 5. Estrogen-dependent gene expression: CCND1 is a target gene of estrogen receptors, and its expression is regulated by estrogen signaling pathways. **Clinical Significance** CCND1 is a significant biomarker for various cancers, including breast, lung, and colon cancer. Overexpression of CCND1 is associated with poor prognosis, and its expression is often used as a diagnostic marker. CCND1 is also involved in various cellular processes, including cell proliferation, differentiation, and survival, making it a potential target for therapeutic interventions. In addition to its role in cancer, CCND1 is also involved in various other diseases, including: 1. Liver regeneration: CCND1 is involved in regulating liver regeneration and is expressed in liver regenerating cells. 2. Lactation: CCND1 is expressed in mammary gland epithelial cells and is involved in regulating lactation. 3. Fat cell differentiation: CCND1 is involved in regulating fat cell differentiation and is expressed in adipocytes. Overall, CCND1 is a complex protein that plays a critical role in regulating the cell cycle and various cellular processes. Its overexpression is associated with poor prognosis in various cancers, and its expression is often used as a diagnostic marker.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

CCND1_HUMAN

Genular Protein ID: 2371683716

Symbol: CCND1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P24385 Q6LEF0

Database IDs:

Citations:

PubMed ID: 1826542

Title: A novel cyclin encoded by a bcl1-linked candidate oncogene.

PubMed ID: 1826542

DOI: 10.1038/350512a0

PubMed ID: 1833066

Title: Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast.

PubMed ID: 1833066

DOI: 10.1016/0092-8674(91)90042-w

PubMed ID: 1827756

Title: Human D-type cyclin.

PubMed ID: 1827756

DOI: 10.1016/0092-8674(91)90100-d

PubMed ID: 1833629

Title: Characterization of a candidate bcl-1 gene.

PubMed ID: 1833629

DOI: 10.1128/mcb.11.10.4846-4853.1991

PubMed ID: 8204893

Title: Rearrangement of CCND1 (BCL1/PRAD1) 3' untranslated region in mantle-cell lymphomas and t(11q13)-associated leukemias.

PubMed ID: 8204893

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7687458

Title: The PRAD1/cyclin D1 proto-oncogene: genomic organization, 5' DNA sequence, and sequence of a tumor-specific rearrangement breakpoint.

PubMed ID: 7687458

DOI: 10.1002/gcc.2870070205

PubMed ID: 8114739

Title: Identification of G1 kinase activity for cdk6, a novel cyclin D partner.

PubMed ID: 8114739

DOI: 10.1128/mcb.14.3.2077-2086.1994

PubMed ID: 8302605

Title: CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1.

PubMed ID: 8302605

PubMed ID: 8695815

Title: Dysregulation of cyclin D1 by translocation into an IgH gamma switch region in two multiple myeloma cell lines.

PubMed ID: 8695815

PubMed ID: 9106657

Title: New functional activities for the p21 family of CDK inhibitors.

PubMed ID: 9106657

DOI: 10.1101/gad.11.7.847

PubMed ID: 10766840

Title: Ubiquitination of free cyclin D1 is independent of phosphorylation on threonine 286.

PubMed ID: 10766840

DOI: 10.1074/jbc.275.16.12074

PubMed ID: 15241418

Title: Cyclin-dependent kinases regulate the antiproliferative function of Smads.

PubMed ID: 15241418

DOI: 10.1038/nature02650

PubMed ID: 16569215

Title: INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases.

PubMed ID: 16569215

DOI: 10.1042/bj20051669

PubMed ID: 18417529

Title: Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription.

PubMed ID: 18417529

DOI: 10.1677/joe-08-0001

PubMed ID: 19124461

Title: Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest.

PubMed ID: 19124461

DOI: 10.1074/jbc.m808843200

PubMed ID: 19917254

Title: Suppression of cancer cell growth by promoting cyclin D1 degradation.

PubMed ID: 19917254

DOI: 10.1016/j.molcel.2009.10.018

PubMed ID: 19412162

Title: F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage.

PubMed ID: 19412162

DOI: 10.1038/nature08011

PubMed ID: 20399237

Title: TM4SF5 accelerates G1/S phase progression via cytosolic p27Kip1 expression and RhoA activity.

PubMed ID: 20399237

DOI: 10.1016/j.bbamcr.2010.04.001

PubMed ID: 21952639

Title: NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor.

PubMed ID: 21952639

DOI: 10.4161/cc.10.19.17176

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 33854232

Title: AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity.

PubMed ID: 33854232

DOI: 10.1038/s41586-021-03422-5

PubMed ID: 33854235

Title: CRL4AMBRA1 is a master regulator of D-type cyclins.

PubMed ID: 33854235

DOI: 10.1038/s41586-021-03445-y

PubMed ID: 33854239

Title: The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D.

PubMed ID: 33854239

DOI: 10.1038/s41586-021-03474-7

PubMed ID: 19237565

Title: Crystal structure of human CDK4 in complex with a D-type cyclin.

PubMed ID: 19237565

DOI: 10.1073/pnas.0809645106

Sequence Information:

Length: 295
Mass: 33729
Checksum: 3CC00C9905F58D3A
Sequence:

MEHQLLCCEV ETIRRAYPDA NLLNDRVLRA MLKAEETCAP SVSYFKCVQK EVLPSMRKIV 
ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS LEPVKKSRLQ LLGATCMFVA SKMKETIPLT 
AEKLCIYTDN SIRPEELLQM ELLLVNKLKW NLAAMTPHDF IEHFLSKMPE AEENKQIIRK 
HAQTFVALCA TDVKFISNPP SMVAAGSVVA AVQGLNLRSP NNFLSYYRLT RFLSRVIKCD 
PDCLRACQEQ IEALLESSLR QAQQNMDPKA AEEEEEEEEE VDLACTPTDV RDVDI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CCND1

Associated with

Cells (max top 100)

Other Information

A novel cyclin encoded by a bcl1-linked candidate oncogene. PubMed ID: 1826542

Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. PubMed ID: 1833066

Human D-type cyclin. PubMed ID: 1827756

Characterization of a candidate bcl-1 gene. PubMed ID: 1833629

Rearrangement of CCND1 (BCL1/PRAD1) 3' untranslated region in mantle-cell lymphomas and t(11q13)-associated leukemias. PubMed ID: 8204893

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The PRAD1/cyclin D1 proto-oncogene: genomic organization, 5' DNA sequence, and sequence of a tumor-specific rearrangement breakpoint. PubMed ID: 7687458

Identification of G1 kinase activity for cdk6, a novel cyclin D partner. PubMed ID: 8114739

CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1. PubMed ID: 8302605

Dysregulation of cyclin D1 by translocation into an IgH gamma switch region in two multiple myeloma cell lines. PubMed ID: 8695815

New functional activities for the p21 family of CDK inhibitors. PubMed ID: 9106657

Ubiquitination of free cyclin D1 is independent of phosphorylation on threonine 286. PubMed ID: 10766840

Cyclin-dependent kinases regulate the antiproliferative function of Smads. PubMed ID: 15241418

INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases. PubMed ID: 16569215

Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription. PubMed ID: 18417529

Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest. PubMed ID: 19124461

Suppression of cancer cell growth by promoting cyclin D1 degradation. PubMed ID: 19917254

F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage. PubMed ID: 19412162

TM4SF5 accelerates G1/S phase progression via cytosolic p27Kip1 expression and RhoA activity. PubMed ID: 20399237

NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor. PubMed ID: 21952639

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity. PubMed ID: 33854232

CRL4AMBRA1 is a master regulator of D-type cyclins. PubMed ID: 33854235

The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D. PubMed ID: 33854239

Crystal structure of human CDK4 in complex with a D-type cyclin. PubMed ID: 19237565