Details for: BCL2

Gene ID: 596

Symbol: BCL2

Ensembl ID: ENSG00000171791

Description: BCL2 apoptosis regulator

Associated with

Other Information

Genular Protein ID: 2331516547

Symbol: BCL2_HUMAN

Name: Apoptosis regulator Bcl-2

UniProtKB Accession Codes:

P10415 C9JHD5 P10416 Q13842 Q16197

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 5 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 14 DrugCentral 1 ELM 1 EMBL 10 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 100 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 34 PDBsum 32 PIR 2 PRINTS 2 PRO 1 PROSITE 6 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 7 RefSeq 2 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3523487

Title: Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.

PubMed ID: 3523487

DOI: 10.1073/pnas.83.14.5214

PubMed ID: 1508712

Title: Isolation and characterization of the chicken bcl-2 gene: expression in a variety of tissues including lymphoid and neuronal organs in adult and embryo.

PubMed ID: 1508712

DOI: 10.1093/nar/20.16.4187

PubMed ID: 2875799

Title: Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation.

PubMed ID: 2875799

DOI: 10.1016/0092-8674(86)90362-4

PubMed ID: 2834197

Title: Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma.

PubMed ID: 2834197

DOI: 10.1002/j.1460-2075.1988.tb02791.x

PubMed ID: 3285301

Title: Consequences of the t(14;18) chromosomal translocation in follicular lymphoma: deregulated expression of a chimeric and mutated BCL-2 gene.

PubMed ID: 3285301

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1339299

Title: Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas.

PubMed ID: 1339299

PubMed ID: 2250705

Title: Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death.

PubMed ID: 2250705

DOI: 10.1038/348334a0

PubMed ID: 8183370

Title: BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

PubMed ID: 8183370

DOI: 10.1038/369321a0

PubMed ID: 9305631

Title: BAG-1 modulates the chaperone activity of Hsp70/Hsc70.

PubMed ID: 9305631

DOI: 10.1093/emboj/16.16.4887

PubMed ID: 9395403

Title: Conversion of Bcl-2 to a Bax-like death effector by caspases.

PubMed ID: 9395403

DOI: 10.1126/science.278.5345.1966

PubMed ID: 8668206

Title: The p53-binding protein 53BP2 also interacts with Bcl2 and impedes cell cycle progression at G2/M.

PubMed ID: 8668206

DOI: 10.1128/mcb.16.7.3884

PubMed ID: 11368354

Title: Phosphorylation of Bcl2 and regulation of apoptosis.

PubMed ID: 11368354

DOI: 10.1038/sj.leu.2402090

PubMed ID: 10567572

Title: BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

PubMed ID: 10567572

DOI: 10.1128/mcb.19.12.8469

PubMed ID: 11463391

Title: PUMA induces the rapid apoptosis of colorectal cancer cells.

PubMed ID: 11463391

DOI: 10.1016/s1097-2765(01)00213-1

PubMed ID: 12901880

Title: BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis.

PubMed ID: 12901880

DOI: 10.1016/s0006-291x(03)01387-1

PubMed ID: 15733859

Title: The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38).

PubMed ID: 15733859

DOI: 10.1016/j.febslet.2005.01.053

PubMed ID: 15849194

Title: p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association.

PubMed ID: 15849194

DOI: 10.1074/jbc.m413374200

PubMed ID: 15547950

Title: BMRP is a Bcl-2 binding protein that induces apoptosis.

PubMed ID: 15547950

DOI: 10.1002/jcb.20292

PubMed ID: 17090549

Title: Bcl-2 localized at the nuclear compartment induces apoptosis after transient overexpression.

PubMed ID: 17090549

DOI: 10.1074/jbc.m606181200

PubMed ID: 17418785

Title: Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1.

PubMed ID: 17418785

DOI: 10.1016/j.cell.2007.01.045

PubMed ID: 18570871

Title: JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy.

PubMed ID: 18570871

DOI: 10.1016/j.molcel.2008.06.001

PubMed ID: 19706769

Title: Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2.

PubMed ID: 19706769

DOI: 10.1158/0008-5472.can-09-0128

PubMed ID: 19228691

Title: Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect.

PubMed ID: 19228691

DOI: 10.1074/jbc.m808750200

PubMed ID: 20849813

Title: Prolyl hydroxylase 3 interacts with Bcl-2 to regulate doxorubicin-induced apoptosis in H9c2 cells.

PubMed ID: 20849813

DOI: 10.1016/j.bbrc.2010.09.037

PubMed ID: 21358617

Title: Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy.

PubMed ID: 21358617

DOI: 10.1038/emboj.2011.49

PubMed ID: 20889974

Title: Parkin mono-ubiquitinates Bcl-2 and regulates autophagy.

PubMed ID: 20889974

DOI: 10.1074/jbc.m110.101469

PubMed ID: 23055042

Title: Human Bop is a novel BH3-only member of the Bcl-2 protein family.

PubMed ID: 23055042

DOI: 10.1007/s13238-012-2069-7

PubMed ID: 23431138

Title: Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma.

PubMed ID: 23431138

DOI: 10.1073/pnas.1217271110

PubMed ID: 25609812

Title: Tom70 mediates Sendai virus-induced apoptosis on mitochondria.

PubMed ID: 25609812

DOI: 10.1128/jvi.02959-14

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29020630

Title: Degradation of Bcl-2 by XIAP and ARTS Promotes Apoptosis.

PubMed ID: 29020630

DOI: 10.1016/j.celrep.2017.09.052

PubMed ID: 31206022

Title: BAP31 regulates mitochondrial function via interaction with Tom40 within ER-mitochondria contact sites.

PubMed ID: 31206022

DOI: 10.1126/sciadv.aaw1386

PubMed ID: 11248023

Title: Solution structure of the antiapoptotic protein bcl-2.

PubMed ID: 11248023

DOI: 10.1073/pnas.041619798

PubMed ID: 15902208

Title: An inhibitor of Bcl-2 family proteins induces regression of solid tumours.

PubMed ID: 15902208

DOI: 10.1038/nature03579

PubMed ID: 17256834

Title: Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.

PubMed ID: 17256834

DOI: 10.1021/jm061152t

Sequence Information:

  • Length: 239
  • Mass: 26266
  • Checksum: 3C49F2B714DC9CCB
  • Sequence:
    • MAHAGRTGYD NREIVMKYIH YKLSQRGYEW DAGDVGAAPP GAAPAPGIFS SQPGHTPHPA 
ASRDPVARTS PLQTPAAPGA AAGPALSPVP PVVHLTLRQA GDDFSRRYRR DFAEMSSQLH 
LTPFTARGRF ATVVEELFRD GVNWGRIVAF FEFGGVMCVE SVNREMSPLV DNIALWMTEY 
LNRHLHTWIQ DNGGWDAFVE LYGPSMRPLF DFSWLSLKTL LSLALVGACI TLGAYLGHK

Genular Protein ID: 3186728609

Symbol: A0A7I2V3S7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A7I2V3S7

Database IDs:

ARBA 16 AlphaFoldDB 1 Bgee 1 CDD 1 CTD 1 EMBL 2 EPD 1 Ensembl 2 GO 8 Gene3D 1 GeneTree 1 HGNC 1 InterPro 9 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PRINTS 2 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 Proteomes 2 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 1

Citations:

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

Sequence Information:

  • Length: 198
  • Mass: 21876
  • Checksum: DFBC5C863EB02AF7
  • Sequence:
    • MAHAGRTGYD NREIVMKYIH YKLSQRGYEW DAGDVGAAPP GAAPAPGIFS SQPGHTPHPA 
ASRDPVARTS PLQTPAAPGA AAGPALSPVP PVVHLTLRQA GDDFSRRYRR DFAEMSSQLH 
LTPFTARGRF ATVVEELFRD GVNWGRIVAF FEFGGVMCVE SVNREMSPLV DNIALWMTEY 
LNRHLHTWIQ DNGGWLYM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.