Details for: BCL2

Gene ID: 596

Symbol: BCL2

Ensembl ID: ENSG00000171791

Description: BCL2 apoptosis regulator

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 5.66
    Marker Score: 7,048
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 4.51
    Marker Score: 1,648
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 3.88
    Marker Score: 3,851
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 3.54
    Marker Score: 2,904
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 3.05
    Marker Score: 2,008
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.05
    Marker Score: 65,069
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 3.04
    Marker Score: 2,696
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.84
    Marker Score: 1,971
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.7
    Marker Score: 1,507
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.69
    Marker Score: 3,784
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.66
    Marker Score: 3,224
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.4
    Marker Score: 3,229
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.39
    Marker Score: 2,746
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.28
    Marker Score: 34,032
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.26
    Marker Score: 1,193
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.23
    Marker Score: 1,720
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.2
    Marker Score: 16,841
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.12
    Marker Score: 1,834
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 2.11
    Marker Score: 765
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.08
    Marker Score: 751
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.05
    Marker Score: 1,199
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.05
    Marker Score: 1,140
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.98
    Marker Score: 18,633
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.84
    Marker Score: 1,811
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.81
    Marker Score: 617
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.81
    Marker Score: 1,950
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.73
    Marker Score: 968
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.69
    Marker Score: 841
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.68
    Marker Score: 5,971
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.67
    Marker Score: 3,388
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.63
    Marker Score: 14,022
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.62
    Marker Score: 32,252
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.61
    Marker Score: 806
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.61
    Marker Score: 783
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.61
    Marker Score: 3,795
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.61
    Marker Score: 6,739
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.6
    Marker Score: 966
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.57
    Marker Score: 487
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.56
    Marker Score: 501
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.55
    Marker Score: 95,292
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.54
    Marker Score: 450
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.53
    Marker Score: 541
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.48
    Marker Score: 516
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.47
    Marker Score: 2,568
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.46
    Marker Score: 546
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 166,973
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.45
    Marker Score: 55,188
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.44
    Marker Score: 868
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.43
    Marker Score: 435
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.43
    Marker Score: 5,518
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.4
    Marker Score: 1,336
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.39
    Marker Score: 1,304
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.38
    Marker Score: 350
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.36
    Marker Score: 5,839
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.33
    Marker Score: 350
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.32
    Marker Score: 69,718
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.31
    Marker Score: 2,512
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.29
    Marker Score: 13,120
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.29
    Marker Score: 3,093
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.28
    Marker Score: 12,705
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.28
    Marker Score: 20,032
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.26
    Marker Score: 436
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.25
    Marker Score: 825
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.24
    Marker Score: 1,762
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.19
    Marker Score: 871
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.18
    Marker Score: 307
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.17
    Marker Score: 5,404
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.17
    Marker Score: 431
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.16
    Marker Score: 1,953
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.15
    Marker Score: 430
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.12
    Marker Score: 1,210
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.11
    Marker Score: 4,532
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.11
    Marker Score: 10,563
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.11
    Marker Score: 1,186
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.1
    Marker Score: 749
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.09
    Marker Score: 553
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.09
    Marker Score: 3,045
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.08
    Marker Score: 2,271
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.08
    Marker Score: 389
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.07
    Marker Score: 39,565
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.07
    Marker Score: 1,135
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.06
    Marker Score: 1,110
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.05
    Marker Score: 571
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.05
    Marker Score: 10,582
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.05
    Marker Score: 1,130
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.04
    Marker Score: 502
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.02
    Marker Score: 1,237
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.02
    Marker Score: 10,517
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.02
    Marker Score: 1,030
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.01
    Marker Score: 1,096
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1
    Marker Score: 760
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1
    Marker Score: 2,446
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,670
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,895
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.99
    Marker Score: 5,920
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,386
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.98
    Marker Score: 918
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.97
    Marker Score: 1,666
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.97
    Marker Score: 1,029
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.96
    Marker Score: 845

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The BCL2 gene is a non-coding gene that encodes a protein belonging to the BCL-2 family. The BCL2 protein is a member of the BCL-2 homology-2 (BH2) domain-only family, which is characterized by the presence of three BH2 domains. The BCL2 protein can interact with other BCL-2 family members, either to promote or inhibit apoptosis. The BCL2 protein can also interact with other proteins, such as BAX and BAK, to regulate mitochondrial outer membrane permeabilization and cytochrome c release. **Pathways and Functions** The BCL2 gene is involved in several signaling pathways, including: 1. **Apoptosis**: BCL2 is a key regulator of apoptosis, and its anti-apoptotic function can be modulated by interactions with pro-apoptotic members of the BCL-2 family. 2. **Mitochondrial function**: BCL2 can regulate mitochondrial outer membrane permeabilization and cytochrome c release, which is essential for apoptosis. 3. **Cell growth and proliferation**: BCL2 can regulate cell growth and proliferation by interacting with other proteins, such as PI3K and AKT. 4. **Immune responses**: BCL2 can regulate immune responses by interacting with other proteins, such as NF-κB and IRF3. **Functions** The BCL2 gene has several functions, including: 1. **Apoptosis regulation**: BCL2 regulates apoptosis by interacting with pro-apoptotic members of the BCL-2 family. 2. **Cell survival**: BCL2 promotes cell survival by inhibiting apoptosis. 3. **Mitochondrial function**: BCL2 regulates mitochondrial outer membrane permeabilization and cytochrome c release. 4. **Immune responses**: BCL2 regulates immune responses by interacting with other proteins. **Clinical Significance** The BCL2 gene has been implicated in several diseases, including: 1. **Cancer**: Overexpression of BCL2 is associated with various types of cancer, including lymphoma, leukemia, and breast cancer. 2. **Neurodegenerative diseases**: BCL2 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Immune disorders**: BCL2 has been implicated in immune disorders, such as autoimmune diseases and immunodeficiency disorders. 4. **Infectious diseases**: BCL2 has been implicated in infectious diseases, such as HIV and tuberculosis. In conclusion, the BCL2 gene is a crucial regulator of cell survival, apoptosis, and various cellular processes. Its dysregulation has been implicated in several diseases, including cancer, neurodegenerative diseases, and immune disorders. Further research is needed to fully understand the functions and clinical significance of the BCL2 gene.

Genular Protein ID: 2331516547

Symbol: BCL2_HUMAN

Name: Apoptosis regulator Bcl-2

UniProtKB Accession Codes:

P10415 C9JHD5 P10416 Q13842 Q16197

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 5 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 14 DrugCentral 1 ELM 1 EMBL 10 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 100 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 34 PDBsum 32 PIR 2 PRINTS 2 PRO 1 PROSITE 6 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 7 RefSeq 2 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3523487

Title: Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.

PubMed ID: 3523487

DOI: 10.1073/pnas.83.14.5214

PubMed ID: 1508712

Title: Isolation and characterization of the chicken bcl-2 gene: expression in a variety of tissues including lymphoid and neuronal organs in adult and embryo.

PubMed ID: 1508712

DOI: 10.1093/nar/20.16.4187

PubMed ID: 2875799

Title: Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation.

PubMed ID: 2875799

DOI: 10.1016/0092-8674(86)90362-4

PubMed ID: 2834197

Title: Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma.

PubMed ID: 2834197

DOI: 10.1002/j.1460-2075.1988.tb02791.x

PubMed ID: 3285301

Title: Consequences of the t(14;18) chromosomal translocation in follicular lymphoma: deregulated expression of a chimeric and mutated BCL-2 gene.

PubMed ID: 3285301

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1339299

Title: Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas.

PubMed ID: 1339299

PubMed ID: 2250705

Title: Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death.

PubMed ID: 2250705

DOI: 10.1038/348334a0

PubMed ID: 8183370

Title: BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

PubMed ID: 8183370

DOI: 10.1038/369321a0

PubMed ID: 9305631

Title: BAG-1 modulates the chaperone activity of Hsp70/Hsc70.

PubMed ID: 9305631

DOI: 10.1093/emboj/16.16.4887

PubMed ID: 9395403

Title: Conversion of Bcl-2 to a Bax-like death effector by caspases.

PubMed ID: 9395403

DOI: 10.1126/science.278.5345.1966

PubMed ID: 8668206

Title: The p53-binding protein 53BP2 also interacts with Bcl2 and impedes cell cycle progression at G2/M.

PubMed ID: 8668206

DOI: 10.1128/mcb.16.7.3884

PubMed ID: 11368354

Title: Phosphorylation of Bcl2 and regulation of apoptosis.

PubMed ID: 11368354

DOI: 10.1038/sj.leu.2402090

PubMed ID: 10567572

Title: BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

PubMed ID: 10567572

DOI: 10.1128/mcb.19.12.8469

PubMed ID: 11463391

Title: PUMA induces the rapid apoptosis of colorectal cancer cells.

PubMed ID: 11463391

DOI: 10.1016/s1097-2765(01)00213-1

PubMed ID: 12901880

Title: BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis.

PubMed ID: 12901880

DOI: 10.1016/s0006-291x(03)01387-1

PubMed ID: 15733859

Title: The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38).

PubMed ID: 15733859

DOI: 10.1016/j.febslet.2005.01.053

PubMed ID: 15849194

Title: p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association.

PubMed ID: 15849194

DOI: 10.1074/jbc.m413374200

PubMed ID: 15547950

Title: BMRP is a Bcl-2 binding protein that induces apoptosis.

PubMed ID: 15547950

DOI: 10.1002/jcb.20292

PubMed ID: 17090549

Title: Bcl-2 localized at the nuclear compartment induces apoptosis after transient overexpression.

PubMed ID: 17090549

DOI: 10.1074/jbc.m606181200

PubMed ID: 17418785

Title: Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1.

PubMed ID: 17418785

DOI: 10.1016/j.cell.2007.01.045

PubMed ID: 18570871

Title: JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy.

PubMed ID: 18570871

DOI: 10.1016/j.molcel.2008.06.001

PubMed ID: 19706769

Title: Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2.

PubMed ID: 19706769

DOI: 10.1158/0008-5472.can-09-0128

PubMed ID: 19228691

Title: Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect.

PubMed ID: 19228691

DOI: 10.1074/jbc.m808750200

PubMed ID: 20849813

Title: Prolyl hydroxylase 3 interacts with Bcl-2 to regulate doxorubicin-induced apoptosis in H9c2 cells.

PubMed ID: 20849813

DOI: 10.1016/j.bbrc.2010.09.037

PubMed ID: 21358617

Title: Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy.

PubMed ID: 21358617

DOI: 10.1038/emboj.2011.49

PubMed ID: 20889974

Title: Parkin mono-ubiquitinates Bcl-2 and regulates autophagy.

PubMed ID: 20889974

DOI: 10.1074/jbc.m110.101469

PubMed ID: 23055042

Title: Human Bop is a novel BH3-only member of the Bcl-2 protein family.

PubMed ID: 23055042

DOI: 10.1007/s13238-012-2069-7

PubMed ID: 23431138

Title: Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma.

PubMed ID: 23431138

DOI: 10.1073/pnas.1217271110

PubMed ID: 25609812

Title: Tom70 mediates Sendai virus-induced apoptosis on mitochondria.

PubMed ID: 25609812

DOI: 10.1128/jvi.02959-14

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29020630

Title: Degradation of Bcl-2 by XIAP and ARTS Promotes Apoptosis.

PubMed ID: 29020630

DOI: 10.1016/j.celrep.2017.09.052

PubMed ID: 31206022

Title: BAP31 regulates mitochondrial function via interaction with Tom40 within ER-mitochondria contact sites.

PubMed ID: 31206022

DOI: 10.1126/sciadv.aaw1386

PubMed ID: 11248023

Title: Solution structure of the antiapoptotic protein bcl-2.

PubMed ID: 11248023

DOI: 10.1073/pnas.041619798

PubMed ID: 15902208

Title: An inhibitor of Bcl-2 family proteins induces regression of solid tumours.

PubMed ID: 15902208

DOI: 10.1038/nature03579

PubMed ID: 17256834

Title: Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.

PubMed ID: 17256834

DOI: 10.1021/jm061152t

Sequence Information:

  • Length: 239
  • Mass: 26266
  • Checksum: 3C49F2B714DC9CCB
  • Sequence:
    • MAHAGRTGYD NREIVMKYIH YKLSQRGYEW DAGDVGAAPP GAAPAPGIFS SQPGHTPHPA 
ASRDPVARTS PLQTPAAPGA AAGPALSPVP PVVHLTLRQA GDDFSRRYRR DFAEMSSQLH 
LTPFTARGRF ATVVEELFRD GVNWGRIVAF FEFGGVMCVE SVNREMSPLV DNIALWMTEY 
LNRHLHTWIQ DNGGWDAFVE LYGPSMRPLF DFSWLSLKTL LSLALVGACI TLGAYLGHK

Genular Protein ID: 3186728609

Symbol: A0A7I2V3S7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A7I2V3S7

Database IDs:

ARBA 16 AlphaFoldDB 1 Bgee 1 CDD 1 CTD 1 EMBL 2 EPD 1 Ensembl 2 GO 8 Gene3D 1 GeneTree 1 HGNC 1 InterPro 9 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PRINTS 2 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 Proteomes 2 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 1

Citations:

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

Sequence Information:

  • Length: 198
  • Mass: 21876
  • Checksum: DFBC5C863EB02AF7
  • Sequence:
    • MAHAGRTGYD NREIVMKYIH YKLSQRGYEW DAGDVGAAPP GAAPAPGIFS SQPGHTPHPA 
ASRDPVARTS PLQTPAAPGA AAGPALSPVP PVVHLTLRQA GDDFSRRYRR DFAEMSSQLH 
LTPFTARGRF ATVVEELFRD GVNWGRIVAF FEFGGVMCVE SVNREMSPLV DNIALWMTEY 
LNRHLHTWIQ DNGGWLYM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.