Details for: BCL2

Gene ID: 596

Symbol: BCL2

Ensembl ID: ENSG00000171791

Description: BCL2 apoptosis regulator

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 287.5048
    Cell Significance Index: -44.7200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 168.9774
    Cell Significance Index: -42.8600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 97.4959
    Cell Significance Index: -46.0300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 91.6823
    Cell Significance Index: -47.1600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.2462
    Cell Significance Index: -44.6900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.4137
    Cell Significance Index: -43.9700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.0724
    Cell Significance Index: -28.6100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.2483
    Cell Significance Index: -37.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.4545
    Cell Significance Index: -45.2000
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 9.9927
    Cell Significance Index: 43.5000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 8.7777
    Cell Significance Index: 110.5300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 6.9057
    Cell Significance Index: 61.3000
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 6.3456
    Cell Significance Index: 39.1500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 4.4803
    Cell Significance Index: 62.6500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.3686
    Cell Significance Index: 26.8900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.1970
    Cell Significance Index: 42.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.1536
    Cell Significance Index: 120.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.8156
    Cell Significance Index: 179.6100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.7502
    Cell Significance Index: 26.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6012
    Cell Significance Index: 321.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4130
    Cell Significance Index: 506.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1050
    Cell Significance Index: 84.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.0095
    Cell Significance Index: 25.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9520
    Cell Significance Index: 61.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9153
    Cell Significance Index: 148.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9000
    Cell Significance Index: 97.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.8926
    Cell Significance Index: 19.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6601
    Cell Significance Index: 39.6300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6448
    Cell Significance Index: 446.0000
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.5829
    Cell Significance Index: 5.8800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.5233
    Cell Significance Index: 805.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3607
    Cell Significance Index: 665.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3298
    Cell Significance Index: 22.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3258
    Cell Significance Index: 613.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2798
    Cell Significance Index: 380.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2784
    Cell Significance Index: 17.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2750
    Cell Significance Index: 174.6400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2111
    Cell Significance Index: 5.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1602
    Cell Significance Index: 10.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1500
    Cell Significance Index: 3.7500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1443
    Cell Significance Index: 130.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1380
    Cell Significance Index: 61.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0902
    Cell Significance Index: 11.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0646
    Cell Significance Index: 1.8600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0627
    Cell Significance Index: 0.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0490
    Cell Significance Index: 2.2200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0369
    Cell Significance Index: 0.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0346
    Cell Significance Index: 6.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0233
    Cell Significance Index: 10.5700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0175
    Cell Significance Index: 3.3300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0159
    Cell Significance Index: 2.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0141
    Cell Significance Index: 1.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0026
    Cell Significance Index: 0.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0051
    Cell Significance Index: -0.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0138
    Cell Significance Index: -10.1500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0200
    Cell Significance Index: -0.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0333
    Cell Significance Index: -18.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0425
    Cell Significance Index: -0.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0650
    Cell Significance Index: -49.2100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0689
    Cell Significance Index: -51.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0785
    Cell Significance Index: -15.5700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0825
    Cell Significance Index: -2.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0861
    Cell Significance Index: -53.7500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0923
    Cell Significance Index: -52.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1042
    Cell Significance Index: -10.6400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1271
    Cell Significance Index: -18.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1391
    Cell Significance Index: -40.0100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1810
    Cell Significance Index: -3.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2014
    Cell Significance Index: -26.0200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2133
    Cell Significance Index: -27.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2156
    Cell Significance Index: -6.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2296
    Cell Significance Index: -6.2500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2346
    Cell Significance Index: -5.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2499
    Cell Significance Index: -52.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2835
    Cell Significance Index: -20.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2892
    Cell Significance Index: -49.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2946
    Cell Significance Index: -30.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2981
    Cell Significance Index: -34.1500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3046
    Cell Significance Index: -35.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4029
    Cell Significance Index: -20.9300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4047
    Cell Significance Index: -47.1600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4484
    Cell Significance Index: -10.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4731
    Cell Significance Index: -12.4400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5022
    Cell Significance Index: -14.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5057
    Cell Significance Index: -40.0500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5350
    Cell Significance Index: -12.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5725
    Cell Significance Index: -25.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6014
    Cell Significance Index: -20.9000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6515
    Cell Significance Index: -39.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6738
    Cell Significance Index: -22.0600
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.7299
    Cell Significance Index: -5.5800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7849
    Cell Significance Index: -19.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7952
    Cell Significance Index: -41.7500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.7989
    Cell Significance Index: -17.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8093
    Cell Significance Index: -51.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8123
    Cell Significance Index: -25.8700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.8296
    Cell Significance Index: -11.8800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.8380
    Cell Significance Index: -16.5700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8878
    Cell Significance Index: -33.6200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.9175
    Cell Significance Index: -18.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The BCL2 gene is a non-coding gene that encodes a protein belonging to the BCL-2 family. The BCL2 protein is a member of the BCL-2 homology-2 (BH2) domain-only family, which is characterized by the presence of three BH2 domains. The BCL2 protein can interact with other BCL-2 family members, either to promote or inhibit apoptosis. The BCL2 protein can also interact with other proteins, such as BAX and BAK, to regulate mitochondrial outer membrane permeabilization and cytochrome c release. **Pathways and Functions** The BCL2 gene is involved in several signaling pathways, including: 1. **Apoptosis**: BCL2 is a key regulator of apoptosis, and its anti-apoptotic function can be modulated by interactions with pro-apoptotic members of the BCL-2 family. 2. **Mitochondrial function**: BCL2 can regulate mitochondrial outer membrane permeabilization and cytochrome c release, which is essential for apoptosis. 3. **Cell growth and proliferation**: BCL2 can regulate cell growth and proliferation by interacting with other proteins, such as PI3K and AKT. 4. **Immune responses**: BCL2 can regulate immune responses by interacting with other proteins, such as NF-κB and IRF3. **Functions** The BCL2 gene has several functions, including: 1. **Apoptosis regulation**: BCL2 regulates apoptosis by interacting with pro-apoptotic members of the BCL-2 family. 2. **Cell survival**: BCL2 promotes cell survival by inhibiting apoptosis. 3. **Mitochondrial function**: BCL2 regulates mitochondrial outer membrane permeabilization and cytochrome c release. 4. **Immune responses**: BCL2 regulates immune responses by interacting with other proteins. **Clinical Significance** The BCL2 gene has been implicated in several diseases, including: 1. **Cancer**: Overexpression of BCL2 is associated with various types of cancer, including lymphoma, leukemia, and breast cancer. 2. **Neurodegenerative diseases**: BCL2 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Immune disorders**: BCL2 has been implicated in immune disorders, such as autoimmune diseases and immunodeficiency disorders. 4. **Infectious diseases**: BCL2 has been implicated in infectious diseases, such as HIV and tuberculosis. In conclusion, the BCL2 gene is a crucial regulator of cell survival, apoptosis, and various cellular processes. Its dysregulation has been implicated in several diseases, including cancer, neurodegenerative diseases, and immune disorders. Further research is needed to fully understand the functions and clinical significance of the BCL2 gene.

Genular Protein ID: 2331516547

Symbol: BCL2_HUMAN

Name: Apoptosis regulator Bcl-2

UniProtKB Accession Codes:

P10415 C9JHD5 P10416 Q13842 Q16197

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 5 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 14 DrugCentral 1 ELM 1 EMBL 10 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 100 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 40 PDBsum 40 PIR 2 PRINTS 2 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 8 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3523487

Title: Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.

PubMed ID: 3523487

DOI: 10.1073/pnas.83.14.5214

PubMed ID: 1508712

Title: Isolation and characterization of the chicken bcl-2 gene: expression in a variety of tissues including lymphoid and neuronal organs in adult and embryo.

PubMed ID: 1508712

DOI: 10.1093/nar/20.16.4187

PubMed ID: 2875799

Title: Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation.

PubMed ID: 2875799

DOI: 10.1016/0092-8674(86)90362-4

PubMed ID: 2834197

Title: Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma.

PubMed ID: 2834197

DOI: 10.1002/j.1460-2075.1988.tb02791.x

PubMed ID: 3285301

Title: Consequences of the t(14;18) chromosomal translocation in follicular lymphoma: deregulated expression of a chimeric and mutated BCL-2 gene.

PubMed ID: 3285301

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1339299

Title: Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas.

PubMed ID: 1339299

PubMed ID: 2250705

Title: Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death.

PubMed ID: 2250705

DOI: 10.1038/348334a0

PubMed ID: 8183370

Title: BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

PubMed ID: 8183370

DOI: 10.1038/369321a0

PubMed ID: 9305631

Title: BAG-1 modulates the chaperone activity of Hsp70/Hsc70.

PubMed ID: 9305631

DOI: 10.1093/emboj/16.16.4887

PubMed ID: 9395403

Title: Conversion of Bcl-2 to a Bax-like death effector by caspases.

PubMed ID: 9395403

DOI: 10.1126/science.278.5345.1966

PubMed ID: 8668206

Title: The p53-binding protein 53BP2 also interacts with Bcl2 and impedes cell cycle progression at G2/M.

PubMed ID: 8668206

DOI: 10.1128/mcb.16.7.3884

PubMed ID: 11368354

Title: Phosphorylation of Bcl2 and regulation of apoptosis.

PubMed ID: 11368354

DOI: 10.1038/sj.leu.2402090

PubMed ID: 10567572

Title: BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

PubMed ID: 10567572

DOI: 10.1128/mcb.19.12.8469

PubMed ID: 11463391

Title: PUMA induces the rapid apoptosis of colorectal cancer cells.

PubMed ID: 11463391

DOI: 10.1016/s1097-2765(01)00213-1

PubMed ID: 12901880

Title: BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis.

PubMed ID: 12901880

DOI: 10.1016/s0006-291x(03)01387-1

PubMed ID: 15733859

Title: The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38).

PubMed ID: 15733859

DOI: 10.1016/j.febslet.2005.01.053

PubMed ID: 15849194

Title: p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association.

PubMed ID: 15849194

DOI: 10.1074/jbc.m413374200

PubMed ID: 15547950

Title: BMRP is a Bcl-2 binding protein that induces apoptosis.

PubMed ID: 15547950

DOI: 10.1002/jcb.20292

PubMed ID: 17090549

Title: Bcl-2 localized at the nuclear compartment induces apoptosis after transient overexpression.

PubMed ID: 17090549

DOI: 10.1074/jbc.m606181200

PubMed ID: 17418785

Title: Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1.

PubMed ID: 17418785

DOI: 10.1016/j.cell.2007.01.045

PubMed ID: 18570871

Title: JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy.

PubMed ID: 18570871

DOI: 10.1016/j.molcel.2008.06.001

PubMed ID: 19706769

Title: Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2.

PubMed ID: 19706769

DOI: 10.1158/0008-5472.can-09-0128

PubMed ID: 19228691

Title: Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect.

PubMed ID: 19228691

DOI: 10.1074/jbc.m808750200

PubMed ID: 20849813

Title: Prolyl hydroxylase 3 interacts with Bcl-2 to regulate doxorubicin-induced apoptosis in H9c2 cells.

PubMed ID: 20849813

DOI: 10.1016/j.bbrc.2010.09.037

PubMed ID: 21358617

Title: Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy.

PubMed ID: 21358617

DOI: 10.1038/emboj.2011.49

PubMed ID: 20889974

Title: Parkin mono-ubiquitinates Bcl-2 and regulates autophagy.

PubMed ID: 20889974

DOI: 10.1074/jbc.m110.101469

PubMed ID: 23055042

Title: Human Bop is a novel BH3-only member of the Bcl-2 protein family.

PubMed ID: 23055042

DOI: 10.1007/s13238-012-2069-7

PubMed ID: 23822101

Title: Mitochondrion-associated protein LRPPRC suppresses the initiation of basal levels of autophagy via enhancing Bcl-2 stability.

PubMed ID: 23822101

DOI: 10.1042/bj20130306

PubMed ID: 23431138

Title: Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma.

PubMed ID: 23431138

DOI: 10.1073/pnas.1217271110

PubMed ID: 25609812

Title: Tom70 mediates Sendai virus-induced apoptosis on mitochondria.

PubMed ID: 25609812

DOI: 10.1128/jvi.02959-14

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29020630

Title: Degradation of Bcl-2 by XIAP and ARTS Promotes Apoptosis.

PubMed ID: 29020630

DOI: 10.1016/j.celrep.2017.09.052

PubMed ID: 31206022

Title: BAP31 regulates mitochondrial function via interaction with Tom40 within ER-mitochondria contact sites.

PubMed ID: 31206022

DOI: 10.1126/sciadv.aaw1386

PubMed ID: 11248023

Title: Solution structure of the antiapoptotic protein bcl-2.

PubMed ID: 11248023

DOI: 10.1073/pnas.041619798

PubMed ID: 15902208

Title: An inhibitor of Bcl-2 family proteins induces regression of solid tumours.

PubMed ID: 15902208

DOI: 10.1038/nature03579

PubMed ID: 17256834

Title: Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.

PubMed ID: 17256834

DOI: 10.1021/jm061152t

Sequence Information:

  • Length: 239
  • Mass: 26266
  • Checksum: 3C49F2B714DC9CCB
  • Sequence:
    • MAHAGRTGYD NREIVMKYIH YKLSQRGYEW DAGDVGAAPP GAAPAPGIFS SQPGHTPHPA 
ASRDPVARTS PLQTPAAPGA AAGPALSPVP PVVHLTLRQA GDDFSRRYRR DFAEMSSQLH 
LTPFTARGRF ATVVEELFRD GVNWGRIVAF FEFGGVMCVE SVNREMSPLV DNIALWMTEY 
LNRHLHTWIQ DNGGWDAFVE LYGPSMRPLF DFSWLSLKTL LSLALVGACI TLGAYLGHK

Genular Protein ID: 3186728609

Symbol: A0A7I2V3S7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A7I2V3S7

Database IDs:

ARBA 16 AlphaFoldDB 1 Bgee 1 CDD 1 CTD 1 DisGeNET 1 EMBL 2 Ensembl 2 GO 8 Gene3D 1 GeneTree 1 HGNC 1 InterPro 9 NCBI Taxonomy 1 PANTHER 2 PRINTS 2 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

Sequence Information:

  • Length: 198
  • Mass: 21876
  • Checksum: DFBC5C863EB02AF7
  • Sequence:
    • MAHAGRTGYD NREIVMKYIH YKLSQRGYEW DAGDVGAAPP GAAPAPGIFS SQPGHTPHPA 
ASRDPVARTS PLQTPAAPGA AAGPALSPVP PVVHLTLRQA GDDFSRRYRR DFAEMSSQLH 
LTPFTARGRF ATVVEELFRD GVNWGRIVAF FEFGGVMCVE SVNREMSPLV DNIALWMTEY 
LNRHLHTWIQ DNGGWLYM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.