BCL2A1 | ENSG00000140379 | NCBI 597

Details for: BCL2A1

Gene ID: 597

Symbol: BCL2A1

Ensembl ID: ENSG00000140379

Description: BCL2 related protein A1

Associated with

Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Nuclear events stimulated by alk signaling in cancer
(R-HSA-9725371)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
Channel activity
(GO:0015267)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Mitochondrial fusion
(GO:0008053)
Mitochondrial outer membrane
(GO:0005741)
Negative regulation of apoptotic process
(GO:0043066)
Positive regulation of apoptotic process
(GO:0043065)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Release of cytochrome c from mitochondria
(GO:0001836)
Transmembrane transport
(GO:0055085)

Other Information

Proteins

Bcl-2-related protein A1

Genular Protein ID: 3460079940

Symbol: B2LA1_HUMAN

Name: Bcl-2-related protein A1

UniProtKB Accession Codes:

Q16548 Q6FGZ4 Q6FH19 Q86W13 Q99524

Database IDs:

Citations:

PubMed ID: 7478596

Title: A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow.

PubMed ID: 7478596

PubMed ID: 8605321

Title: Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells.

PubMed ID: 8605321

PubMed ID: 9050999

Title: GRS, a novel member of the Bcl-2 gene family, is highly expressed in multiple cancer cell lines and in normal leukocytes.

PubMed ID: 9050999

DOI: 10.1038/sj.onc.1200898

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10772918

Title: Characterization of Bax-sigma, a cell death-inducing isoform of Bax.

PubMed ID: 10772918

DOI: 10.1006/bbrc.2000.2537

PubMed ID: 23055042

Title: Human Bop is a novel BH3-only member of the Bcl-2 protein family.

PubMed ID: 23055042

DOI: 10.1007/s13238-012-2069-7

PubMed ID: 34245648

Title: UBQLN4 is an ATM substrate that stabilizes the anti-apoptotic proteins BCL2A1 and BCL2L10 in mesothelioma.

PubMed ID: 34245648

DOI: 10.1002/1878-0261.13058

PubMed ID: 18812174

Title: Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim.

PubMed ID: 18812174

DOI: 10.1016/j.febslet.2008.09.028

Sequence Information:

Length: 175
Mass: 20132
Checksum: 329D98AF2BE07A0D
Sequence:

MTDCEFGYIY RLAQDYLQCV LQIPQPGSGP SKTSRVLQNV AFSVQKEVEK NLKSCLDNVN 
VVSVDTARTL FNQVMEKEFE DGIINWGRIV TIFAFEGILI KKLLRQQIAP DVDTYKEISY 
FVAEFIMNNT GEWIRQNGGW ENGFVKKFEP KSGWMTFLEV TGKICEMLSL LKQYC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BCL2A1

Associated with

Other Information

A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow. PubMed ID: 7478596

Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells. PubMed ID: 8605321

GRS, a novel member of the Bcl-2 gene family, is highly expressed in multiple cancer cell lines and in normal leukocytes. PubMed ID: 9050999

Analysis of the DNA sequence and duplication history of human chromosome 15. PubMed ID: 16572171

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of Bax-sigma, a cell death-inducing isoform of Bax. PubMed ID: 10772918

Human Bop is a novel BH3-only member of the Bcl-2 protein family. PubMed ID: 23055042

UBQLN4 is an ATM substrate that stabilizes the anti-apoptotic proteins BCL2A1 and BCL2L10 in mesothelioma. PubMed ID: 34245648

Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim. PubMed ID: 18812174