Details for: BCL2A1

Gene ID: 597

Symbol: BCL2A1

Ensembl ID: ENSG00000140379

Description: BCL2 related protein A1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 117.0721
    Cell Significance Index: -18.2100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 59.5028
    Cell Significance Index: -15.0900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 50.6453
    Cell Significance Index: -20.5800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 50.1702
    Cell Significance Index: -20.6700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 43.5082
    Cell Significance Index: -22.3800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.4563
    Cell Significance Index: -21.4400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.7369
    Cell Significance Index: -18.1700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.6114
    Cell Significance Index: -20.3900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.4844
    Cell Significance Index: -16.8500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.6870
    Cell Significance Index: -18.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.5847
    Cell Significance Index: 114.6100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.8815
    Cell Significance Index: 71.7400
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 3.3439
    Cell Significance Index: 10.3100
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 2.3906
    Cell Significance Index: 41.0700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.3223
    Cell Significance Index: 35.9300
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 2.0519
    Cell Significance Index: 8.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.2737
    Cell Significance Index: 150.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.1627
    Cell Significance Index: 54.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1383
    Cell Significance Index: 24.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1283
    Cell Significance Index: 214.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9053
    Cell Significance Index: 89.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7981
    Cell Significance Index: 720.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2840
    Cell Significance Index: 46.2000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2205
    Cell Significance Index: 23.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1966
    Cell Significance Index: 10.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1709
    Cell Significance Index: 22.0800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: 0.1627
    Cell Significance Index: 2.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0419
    Cell Significance Index: 26.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0108
    Cell Significance Index: 0.7500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0032
    Cell Significance Index: 2.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0060
    Cell Significance Index: -4.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0064
    Cell Significance Index: -3.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0068
    Cell Significance Index: -0.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0075
    Cell Significance Index: -5.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0078
    Cell Significance Index: -14.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0116
    Cell Significance Index: -21.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0136
    Cell Significance Index: -20.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0137
    Cell Significance Index: -7.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0161
    Cell Significance Index: -21.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0187
    Cell Significance Index: -0.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0292
    Cell Significance Index: -1.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0296
    Cell Significance Index: -21.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0306
    Cell Significance Index: -6.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0332
    Cell Significance Index: -21.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0332
    Cell Significance Index: -14.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0333
    Cell Significance Index: -5.6900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0341
    Cell Significance Index: -1.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0357
    Cell Significance Index: -1.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0465
    Cell Significance Index: -21.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0535
    Cell Significance Index: -15.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0535
    Cell Significance Index: -19.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0647
    Cell Significance Index: -6.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0774
    Cell Significance Index: -8.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0813
    Cell Significance Index: -10.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0847
    Cell Significance Index: -16.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0874
    Cell Significance Index: -17.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0933
    Cell Significance Index: -5.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0996
    Cell Significance Index: -17.9600
  • Cell Name: CD14-positive, CD16-low monocyte (CL0001055)
    Fold Change: -0.0998
    Cell Significance Index: -0.9600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1070
    Cell Significance Index: -14.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1233
    Cell Significance Index: -2.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1392
    Cell Significance Index: -17.1200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1417
    Cell Significance Index: -16.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1442
    Cell Significance Index: -20.9600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1478
    Cell Significance Index: -3.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1499
    Cell Significance Index: -4.8000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1658
    Cell Significance Index: -3.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1673
    Cell Significance Index: -19.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1764
    Cell Significance Index: -18.3700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1831
    Cell Significance Index: -7.9600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1834
    Cell Significance Index: -4.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2050
    Cell Significance Index: -5.7300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2269
    Cell Significance Index: -16.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2391
    Cell Significance Index: -12.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2482
    Cell Significance Index: -18.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2595
    Cell Significance Index: -19.9100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2653
    Cell Significance Index: -3.8800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2747
    Cell Significance Index: -21.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2967
    Cell Significance Index: -19.9500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2970
    Cell Significance Index: -17.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3007
    Cell Significance Index: -14.0200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.3072
    Cell Significance Index: -2.8600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3202
    Cell Significance Index: -6.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3221
    Cell Significance Index: -20.7800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3250
    Cell Significance Index: -2.6500
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.3420
    Cell Significance Index: -2.9900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3467
    Cell Significance Index: -21.8500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3568
    Cell Significance Index: -6.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3674
    Cell Significance Index: -9.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3676
    Cell Significance Index: -20.6300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3906
    Cell Significance Index: -20.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4268
    Cell Significance Index: -18.8800
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.4290
    Cell Significance Index: -3.4800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4597
    Cell Significance Index: -11.1400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4620
    Cell Significance Index: -16.9600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.4949
    Cell Significance Index: -4.3600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4965
    Cell Significance Index: -5.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4981
    Cell Significance Index: -18.8600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5178
    Cell Significance Index: -18.1400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5194
    Cell Significance Index: -13.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** BCL2A1 is a member of the BCL2 family of proteins, which are characterized by their ability to interact with other BCL2 family members to regulate apoptosis. BCL2A1 is specifically expressed in immune cells, where it plays a crucial role in regulating the extrinsic and intrinsic apoptotic pathways. The protein has been shown to interact with other BCL2 family members, such as BCL2 and BAX, to regulate apoptosis. BCL2A1 also has a role in regulating mitochondrial function, including the release of cytochrome c from mitochondria, which is a key event in the intrinsic apoptotic pathway. **Pathways and Functions** BCL2A1 is involved in several key pathways that regulate apoptosis, including: 1. **Extrinsic Apoptotic Signaling Pathway**: BCL2A1 interacts with death receptors, such as Fas and TNFR1, to regulate apoptosis. When death receptors are activated, they trigger a signaling cascade that ultimately leads to the activation of caspases, which execute the apoptotic program. 2. **Intrinsic Apoptotic Signaling Pathway**: BCL2A1 regulates the intrinsic apoptotic pathway by interacting with mitochondrial proteins, such as BAX and BAK, to regulate the release of cytochrome c from mitochondria. This event triggers a downstream signaling cascade that ultimately leads to the activation of caspases. 3. **Mitochondrial Fusion**: BCL2A1 has been shown to regulate mitochondrial fusion, which is an essential process for maintaining mitochondrial function and integrity. 4. **Protein Binding and Homodimerization**: BCL2A1 interacts with other BCL2 family members to regulate protein binding and homodimerization, which are critical processes for regulating apoptosis. **Clinical Significance** Dysregulation of BCL2A1 has been implicated in various diseases, including: 1. **Cancer**: BCL2A1 has been shown to be overexpressed in certain types of cancer, including leukemia and lymphoma. This overexpression can lead to resistance to chemotherapy and radiation therapy. 2. **Autoimmune Disorders**: BCL2A1 has been implicated in the pathogenesis of autoimmune disorders, such as rheumatoid arthritis and lupus. Dysregulation of BCL2A1 can lead to the activation of autoreactive T cells and the production of autoantibodies. 3. **Inflammatory Disorders**: BCL2A1 has been shown to play a role in regulating inflammation, including the production of pro-inflammatory cytokines and the activation of immune cells. In conclusion, BCL2A1 is a critical regulator of apoptosis and immune cell function. Dysregulation of BCL2A1 has been implicated in various diseases, including cancer, autoimmune disorders, and inflammatory disorders. Further research is needed to fully understand the role of BCL2A1 in human disease and to develop therapeutic strategies to target this gene.

Genular Protein ID: 3460079940

Symbol: B2LA1_HUMAN

Name: Bcl-2-related protein A1

UniProtKB Accession Codes:

Q16548 Q6FGZ4 Q6FH19 Q86W13 Q99524

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 15 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7478596

Title: A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow.

PubMed ID: 7478596

PubMed ID: 8605321

Title: Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells.

PubMed ID: 8605321

PubMed ID: 9050999

Title: GRS, a novel member of the Bcl-2 gene family, is highly expressed in multiple cancer cell lines and in normal leukocytes.

PubMed ID: 9050999

DOI: 10.1038/sj.onc.1200898

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10772918

Title: Characterization of Bax-sigma, a cell death-inducing isoform of Bax.

PubMed ID: 10772918

DOI: 10.1006/bbrc.2000.2537

PubMed ID: 23055042

Title: Human Bop is a novel BH3-only member of the Bcl-2 protein family.

PubMed ID: 23055042

DOI: 10.1007/s13238-012-2069-7

PubMed ID: 34245648

Title: UBQLN4 is an ATM substrate that stabilizes the anti-apoptotic proteins BCL2A1 and BCL2L10 in mesothelioma.

PubMed ID: 34245648

DOI: 10.1002/1878-0261.13058

PubMed ID: 18812174

Title: Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim.

PubMed ID: 18812174

DOI: 10.1016/j.febslet.2008.09.028

Sequence Information:

  • Length: 175
  • Mass: 20132
  • Checksum: 329D98AF2BE07A0D
  • Sequence:
    • MTDCEFGYIY RLAQDYLQCV LQIPQPGSGP SKTSRVLQNV AFSVQKEVEK NLKSCLDNVN 
VVSVDTARTL FNQVMEKEFE DGIINWGRIV TIFAFEGILI KKLLRQQIAP DVDTYKEISY 
FVAEFIMNNT GEWIRQNGGW ENGFVKKFEP KSGWMTFLEV TGKICEMLSL LKQYC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.