BCL2L1 | ENSG00000171552 | NCBI 598

Details for: BCL2L1

Gene ID: 598

Symbol: BCL2L1

Ensembl ID: ENSG00000171552

Description: BCL2 like 1

Associated with

Apoptosis
(R-HSA-109581)
Bh3-only proteins associate with and inactivate anti-apoptotic bcl-2 members
(R-HSA-111453)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Flt3 signaling in disease
(R-HSA-9682385)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Inflammasomes
(R-HSA-622312)
Innate immune system
(R-HSA-168249)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Nfe2l2 regulating tumorigenic genes
(R-HSA-9818030)
Nuclear events mediated by nfe2l2
(R-HSA-9759194)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Programmed cell death
(R-HSA-5357801)
Raf/map kinase cascade
(R-HSA-5673001)
Ras processing
(R-HSA-9648002)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-1-mediated effects on programmed cell death
(R-HSA-9692913)
Sars-cov infections
(R-HSA-9679506)
Signaling by flt3 itd and tkd mutants
(R-HSA-9703648)
Signaling by interleukins
(R-HSA-449147)
Signal transduction
(R-HSA-162582)
Stat5 activation downstream of flt3 itd mutants
(R-HSA-9702518)
The nlrp1 inflammasome
(R-HSA-844455)
Viral infection pathways
(R-HSA-9824446)
Apoptotic mitochondrial changes
(GO:0008637)
Apoptotic process in bone marrow cell
(GO:0071839)
Bcl-2 family protein complex
(GO:0097136)
Bh3 domain binding
(GO:0051434)
Cellular response to alkaloid
(GO:0071312)
Cellular response to amino acid stimulus
(GO:0071230)
Cellular response to gamma radiation
(GO:0071480)
Centrosome
(GO:0005813)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to virus
(GO:0051607)
Dendritic cell apoptotic process
(GO:0097048)
Dendritic cell proliferation
(GO:0044565)
Ectopic germ cell programmed cell death
(GO:0035234)
Endocytosis
(GO:0006897)
Endoplasmic reticulum
(GO:0005783)
Epithelial cell proliferation
(GO:0050673)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Fertilization
(GO:0009566)
Germ cell development
(GO:0007281)
Hepatocyte apoptotic process
(GO:0097284)
Identical protein binding
(GO:0042802)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
In utero embryonic development
(GO:0001701)
Male gonad development
(GO:0008584)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial matrix
(GO:0005759)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrion
(GO:0005739)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of dendritic cell apoptotic process
(GO:2000669)
Negative regulation of developmental process
(GO:0051093)
Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
(GO:1902236)
Negative regulation of execution phase of apoptosis
(GO:1900118)
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
(GO:2001240)
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
(GO:1902042)
Negative regulation of intrinsic apoptotic signaling pathway
(GO:2001243)
Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage
(GO:1902230)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of protein localization to plasma membrane
(GO:1903077)
Negative regulation of release of cytochrome c from mitochondria
(GO:0090201)
Negative regulation of reproductive process
(GO:2000242)
Neuron apoptotic process
(GO:0051402)
Nuclear membrane
(GO:0031965)
Ovarian follicle development
(GO:0001541)
Positive regulation of mononuclear cell proliferation
(GO:0032946)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Regulation of cytokinesis
(GO:0032465)
Regulation of growth
(GO:0040008)
Regulation of mitochondrial membrane permeability
(GO:0046902)
Regulation of mitochondrial membrane potential
(GO:0051881)
Release of cytochrome c from mitochondria
(GO:0001836)
Response to cycloheximide
(GO:0046898)
Response to cytokine
(GO:0034097)
Spermatogenesis
(GO:0007283)
Synaptic vesicle membrane
(GO:0030672)

Other Information

Proteins

Bcl-2-like protein 1
Q5TE63_HUMAN

Genular Protein ID: 2822370414

Symbol: B2CL1_HUMAN

Name: Bcl-2-like protein 1

UniProtKB Accession Codes:

Q07817 E1P5L6 Q5CZ89 Q5TE65 Q92976

Database IDs:

Citations:

PubMed ID: 8358789

Title: bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death.

PubMed ID: 8358789

DOI: 10.1016/0092-8674(93)90508-n

PubMed ID: 9675101

Title: Identification of a human cDNA encoding a novel Bcl-x isoform.

PubMed ID: 9675101

DOI: 10.1006/bbrc.1998.8907

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7644501

Title: Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.

PubMed ID: 7644501

DOI: 10.1073/pnas.92.17.7834

PubMed ID: 8596636

Title: Bax-independent inhibition of apoptosis by Bcl-XL.

PubMed ID: 8596636

DOI: 10.1038/379554a0

PubMed ID: 9435230

Title: Modulation of cell death by Bcl-xL through caspase interaction.

PubMed ID: 9435230

DOI: 10.1073/pnas.95.2.554

PubMed ID: 10772918

Title: Characterization of Bax-sigma, a cell death-inducing isoform of Bax.

PubMed ID: 10772918

DOI: 10.1006/bbrc.2000.2537

PubMed ID: 11714801

Title: The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis.

PubMed ID: 11714801

DOI: 10.4049/jimmunol.167.11.6366

PubMed ID: 11463391

Title: PUMA induces the rapid apoptosis of colorectal cancer cells.

PubMed ID: 11463391

DOI: 10.1016/s1097-2765(01)00213-1

PubMed ID: 12011449

Title: Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis.

PubMed ID: 12011449

DOI: 10.1073/pnas.102182299

PubMed ID: 17046835

Title: PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex.

PubMed ID: 17046835

DOI: 10.1074/jbc.m606539200

PubMed ID: 16509771

Title: IAN family critically regulates survival and development of T lymphocytes.

PubMed ID: 16509771

DOI: 10.1371/journal.pbio.0040103

PubMed ID: 17418785

Title: Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1.

PubMed ID: 17418785

DOI: 10.1016/j.cell.2007.01.045

PubMed ID: 19917720

Title: Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis.

PubMed ID: 19917720

DOI: 10.1128/mcb.00882-09

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21840391

Title: Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints.

PubMed ID: 21840391

DOI: 10.1016/j.cellsig.2011.07.017

PubMed ID: 22498477

Title: The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death.

PubMed ID: 22498477

DOI: 10.4161/auto.19084

PubMed ID: 21567405

Title: Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain.

PubMed ID: 21567405

DOI: 10.1002/jcp.22836

PubMed ID: 23055042

Title: Human Bop is a novel BH3-only member of the Bcl-2 protein family.

PubMed ID: 23055042

DOI: 10.1007/s13238-012-2069-7

PubMed ID: 23792689

Title: A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis.

PubMed ID: 23792689

DOI: 10.1038/ncb2791

PubMed ID: 25296756

Title: Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop.

PubMed ID: 25296756

DOI: 10.1074/jbc.m114.567792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27013495

Title: The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis.

PubMed ID: 27013495

DOI: 10.15252/embr.201541392

PubMed ID: 29507230

Title: Transmembrane E3 ligase RNF183 mediates ER stress-induced apoptosis by degrading Bcl-xL.

PubMed ID: 29507230

DOI: 10.1073/pnas.1716439115

PubMed ID: 8692274

Title: X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death.

PubMed ID: 8692274

DOI: 10.1038/381335a0

PubMed ID: 9020082

Title: Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis.

PubMed ID: 9020082

DOI: 10.1126/science.275.5302.983

PubMed ID: 11206074

Title: Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies.

PubMed ID: 11206074

DOI: 10.1110/ps.9.12.2528

PubMed ID: 14534311

Title: Bcl-XL mutations suppress cellular sensitivity to antimycin A.

PubMed ID: 14534311

DOI: 10.1074/jbc.m306021200

PubMed ID: 15902208

Title: An inhibitor of Bcl-2 family proteins induces regression of solid tumours.

PubMed ID: 15902208

DOI: 10.1038/nature03579

PubMed ID: 16368107

Title: BCL-XL dimerization by three-dimensional domain swapping.

PubMed ID: 16368107

DOI: 10.1016/j.jmb.2005.11.032

PubMed ID: 17337444

Title: Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein.

PubMed ID: 17337444

DOI: 10.1074/jbc.m700492200

PubMed ID: 17256834

Title: Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.

PubMed ID: 17256834

DOI: 10.1021/jm061152t

PubMed ID: 21639858

Title: Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL.

PubMed ID: 21639858

DOI: 10.1042/bj20110257

PubMed ID: 23340338

Title: PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.

PubMed ID: 23340338

DOI: 10.1038/nchembio.1166

Sequence Information:

Length: 233
Mass: 26049
Checksum: E09D3CDD851AE9BE
Sequence:

MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA INGNPSWHLA 
DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR YRRAFSDLTS QLHITPGTAY 
QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL CVESVDKEMQ VLVSRIAAWM ATYLNDHLEP 
WIQENGGWDT FVELYGNNAA AESRKGQERF NRWFLTGMTV AGVVLLGSLF SRK

Genular Protein ID: 2281429197

Symbol: Q5TE63_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5TE63

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

Length: 170
Mass: 18894
Checksum: 75D1FC01EC06AD47
Sequence:

MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA INGNPSWHLA 
DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR YRRAFSDLTS QLHITPGTAY 
QSFEQDTFVE LYGNNAAAES RKGQERFNRW FLTGMTVAGV VLLGSLFSRK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BCL2L1

Associated with

Other Information

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. PubMed ID: 8358789

Identification of a human cDNA encoding a novel Bcl-x isoform. PubMed ID: 9675101

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. PubMed ID: 7644501

Bax-independent inhibition of apoptosis by Bcl-XL. PubMed ID: 8596636

Modulation of cell death by Bcl-xL through caspase interaction. PubMed ID: 9435230

Characterization of Bax-sigma, a cell death-inducing isoform of Bax. PubMed ID: 10772918

The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis. PubMed ID: 11714801

PUMA induces the rapid apoptosis of colorectal cancer cells. PubMed ID: 11463391

Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis. PubMed ID: 12011449

PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex. PubMed ID: 17046835

IAN family critically regulates survival and development of T lymphocytes. PubMed ID: 16509771

Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1. PubMed ID: 17418785

Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis. PubMed ID: 19917720

Initial characterization of the human central proteome. PubMed ID: 21269460

Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints. PubMed ID: 21840391

The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death. PubMed ID: 22498477

Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain. PubMed ID: 21567405

Human Bop is a novel BH3-only member of the Bcl-2 protein family. PubMed ID: 23055042

A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. PubMed ID: 23792689

Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop. PubMed ID: 25296756

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis. PubMed ID: 27013495

Transmembrane E3 ligase RNF183 mediates ER stress-induced apoptosis by degrading Bcl-xL. PubMed ID: 29507230

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. PubMed ID: 8692274

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis. PubMed ID: 9020082

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies. PubMed ID: 11206074

Bcl-XL mutations suppress cellular sensitivity to antimycin A. PubMed ID: 14534311

An inhibitor of Bcl-2 family proteins induces regression of solid tumours. PubMed ID: 15902208

BCL-XL dimerization by three-dimensional domain swapping. PubMed ID: 16368107

Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. PubMed ID: 17337444

Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL. PubMed ID: 17256834

Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL. PubMed ID: 21639858

PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. PubMed ID: 23340338

The sequence of the human genome. PubMed ID: 11181995

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. PubMed ID: 26871637