Gene BCL2L1 - ENSG00000171552 | NCBI Gene ID: 598

Details for: BCL2L1

Gene ID: 598

Symbol: BCL2L1

Ensembl ID: ENSG00000171552

Description: BCL2 like 1

Associated with

Apoptosis
(R-HSA-109581)
Bh3-only proteins associate with and inactivate anti-apoptotic bcl-2 members
(R-HSA-111453)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Flt3 signaling in disease
(R-HSA-9682385)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Inflammasomes
(R-HSA-622312)
Innate immune system
(R-HSA-168249)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Nfe2l2 regulating tumorigenic genes
(R-HSA-9818030)
Nuclear events mediated by nfe2l2
(R-HSA-9759194)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Programmed cell death
(R-HSA-5357801)
Raf/map kinase cascade
(R-HSA-5673001)
Ras processing
(R-HSA-9648002)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-1-mediated effects on programmed cell death
(R-HSA-9692913)
Sars-cov infections
(R-HSA-9679506)
Signaling by flt3 itd and tkd mutants
(R-HSA-9703648)
Signaling by interleukins
(R-HSA-449147)
Signal transduction
(R-HSA-162582)
Stat5 activation downstream of flt3 itd mutants
(R-HSA-9702518)
The nlrp1 inflammasome
(R-HSA-844455)
Viral infection pathways
(R-HSA-9824446)
Apoptotic mitochondrial changes
(GO:0008637)
Apoptotic process in bone marrow cell
(GO:0071839)
Bcl-2 family protein complex
(GO:0097136)
Bh3 domain binding
(GO:0051434)
Cellular response to alkaloid
(GO:0071312)
Cellular response to amino acid stimulus
(GO:0071230)
Cellular response to gamma radiation
(GO:0071480)
Centrosome
(GO:0005813)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to virus
(GO:0051607)
Dendritic cell apoptotic process
(GO:0097048)
Dendritic cell proliferation
(GO:0044565)
Ectopic germ cell programmed cell death
(GO:0035234)
Endocytosis
(GO:0006897)
Endoplasmic reticulum
(GO:0005783)
Epithelial cell proliferation
(GO:0050673)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Fertilization
(GO:0009566)
Germ cell development
(GO:0007281)
Hepatocyte apoptotic process
(GO:0097284)
Identical protein binding
(GO:0042802)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
In utero embryonic development
(GO:0001701)
Male gonad development
(GO:0008584)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial matrix
(GO:0005759)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrion
(GO:0005739)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of dendritic cell apoptotic process
(GO:2000669)
Negative regulation of developmental process
(GO:0051093)
Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
(GO:1902236)
Negative regulation of execution phase of apoptosis
(GO:1900118)
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
(GO:2001240)
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
(GO:1902042)
Negative regulation of intrinsic apoptotic signaling pathway
(GO:2001243)
Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage
(GO:1902230)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of protein localization to plasma membrane
(GO:1903077)
Negative regulation of release of cytochrome c from mitochondria
(GO:0090201)
Negative regulation of reproductive process
(GO:2000242)
Neuron apoptotic process
(GO:0051402)
Nuclear membrane
(GO:0031965)
Ovarian follicle development
(GO:0001541)
Positive regulation of mononuclear cell proliferation
(GO:0032946)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Regulation of cytokinesis
(GO:0032465)
Regulation of growth
(GO:0040008)
Regulation of mitochondrial membrane permeability
(GO:0046902)
Regulation of mitochondrial membrane potential
(GO:0051881)
Release of cytochrome c from mitochondria
(GO:0001836)
Response to cycloheximide
(GO:0046898)
Response to cytokine
(GO:0034097)
Spermatogenesis
(GO:0007283)
Synaptic vesicle membrane
(GO:0030672)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.9
Marker Score: 1133
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.85
Marker Score: 2130
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 1.8
Marker Score: 1357
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 1.79
Marker Score: 15524.5
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.76
Marker Score: 1868
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 1.68
Marker Score: 2437
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.66
Marker Score: 1128
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.63
Marker Score: 1753
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.6
Marker Score: 501
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.59
Marker Score: 1255
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.58
Marker Score: 3732
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 1.55
Marker Score: 648
Cell Name: lactocyte (CL0002325)
Fold Change: 1.54
Marker Score: 24765
Cell Name: germ cell (CL0000586)
Fold Change: 1.5
Marker Score: 2622
Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.5
Marker Score: 2013
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.49
Marker Score: 1424
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.49
Marker Score: 6185
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 1.49
Marker Score: 707
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 1.46
Marker Score: 2773
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.45
Marker Score: 843
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.42
Marker Score: 1571
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.42
Marker Score: 3001
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 1.42
Marker Score: 1712
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.37
Marker Score: 1423
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.36
Marker Score: 29048
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.34
Marker Score: 49548
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.34
Marker Score: 82136
Cell Name: promyelocyte (CL0000836)
Fold Change: 1.33
Marker Score: 656
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.33
Marker Score: 2550
Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.31
Marker Score: 488.5
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.29
Marker Score: 13279
Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.28
Marker Score: 411
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.27
Marker Score: 1284
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.26
Marker Score: 19794
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.26
Marker Score: 365
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.25
Marker Score: 43265.5
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 1.25
Marker Score: 2988
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.24
Marker Score: 5185.5
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.23
Marker Score: 1793
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.23
Marker Score: 10589
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.23
Marker Score: 24373
Cell Name: lung goblet cell (CL1000143)
Fold Change: 1.22
Marker Score: 352
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.22
Marker Score: 1720
Cell Name: neuron (CL0000540)
Fold Change: 1.21
Marker Score: 4913
Cell Name: ependymal cell (CL0000065)
Fold Change: 1.2
Marker Score: 420
Cell Name: club cell (CL0000158)
Fold Change: 1.17
Marker Score: 1367
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.16
Marker Score: 695
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.14
Marker Score: 1765
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.14
Marker Score: 10848
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 1.14
Marker Score: 360
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.13
Marker Score: 3082.5
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 1.12
Marker Score: 450
Cell Name: secretory cell (CL0000151)
Fold Change: 1.11
Marker Score: 2035
Cell Name: pneumocyte (CL0000322)
Fold Change: 1.11
Marker Score: 1791
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.11
Marker Score: 1640
Cell Name: ciliated cell (CL0000064)
Fold Change: 1.1
Marker Score: 3778
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.1
Marker Score: 2232
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 1.1
Marker Score: 2787
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.09
Marker Score: 507
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.09
Marker Score: 527
Cell Name: thymocyte (CL0000893)
Fold Change: 1.08
Marker Score: 1136
Cell Name: late pro-B cell (CL0002048)
Fold Change: 1.08
Marker Score: 1275
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.08
Marker Score: 2719
Cell Name: basal cell (CL0000646)
Fold Change: 1.08
Marker Score: 1391
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.07
Marker Score: 10027
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.06
Marker Score: 3780
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.06
Marker Score: 1286
Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 1.06
Marker Score: 652
Cell Name: podocyte (CL0000653)
Fold Change: 1.06
Marker Score: 392
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.06
Marker Score: 969.5
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.05
Marker Score: 2823
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.05
Marker Score: 6854
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.04
Marker Score: 2367
Cell Name: erythroblast (CL0000765)
Fold Change: 1.03
Marker Score: 640
Cell Name: cardiac neuron (CL0010022)
Fold Change: 1.02
Marker Score: 1266
Cell Name: contractile cell (CL0000183)
Fold Change: 1.01
Marker Score: 549
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 1.01
Marker Score: 418
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.01
Marker Score: 497
Cell Name: hepatoblast (CL0005026)
Fold Change: 1
Marker Score: 3283
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1
Marker Score: 585
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71641
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 1
Marker Score: 524
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47865
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.99
Marker Score: 296
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.99
Marker Score: 492
Cell Name: enterocyte (CL0000584)
Fold Change: 0.99
Marker Score: 4743
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.99
Marker Score: 357
Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.98
Marker Score: 2230
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30379
Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.98
Marker Score: 845
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.97
Marker Score: 2380
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.97
Marker Score: 1721
Cell Name: endocrine cell (CL0000163)
Fold Change: 0.96
Marker Score: 499
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.96
Marker Score: 36584
Cell Name: melanocyte (CL0000148)
Fold Change: 0.96
Marker Score: 390
Cell Name: platelet (CL0000233)
Fold Change: 0.96
Marker Score: 434
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.95
Marker Score: 528
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.95
Marker Score: 852
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.95
Marker Score: 4988
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.95
Marker Score: 24264

Hover over a box to see details here...

**Key characteristics:** * BCL2L1 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed in high levels in cells that are in the process of apoptosis. * BCL2L1 is a key regulator of apoptosis in both normal and cancer cells. * It interacts with other BCL2 family proteins to form a heterodimeric complex that inhibits apoptosis. * BCL2L1 is also a key regulator of cell cycle regulation and proliferation. **Pathways and functions:** * BCL2L1 is involved in the regulation of apoptosis through the mitochondrial pathway. * It binds to the pro-apoptotic protein Bax and prevents it from interacting with Bcl-xL, a pro-apoptotic protein. * This allows Bax to translocate to the mitochondria, where it triggers apoptosis. * BCL2L1 also plays a role in the regulation of cell cycle regulation and proliferation through the PI3K/Akt pathway. * It inhibits the PI3K/Akt pathway by binding to and phosphorylating Phosphatase-dependent kinase-1 (PDK1), a key regulator of the PI3K/Akt pathway. **Clinical significance:** * Mutations in BCL2L1 have been linked to a number of human diseases, including cancer and autoimmune disorders. * BCL2L1 inhibitors are being investigated as a new class of cancer drugs. * Understanding the role of BCL2L1 in apoptosis and cell cycle regulation is important for the development of new therapies for cancer and other diseases that are characterized by uncontrolled cell death.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Bcl-2-like protein 1
Q5TE63_HUMAN

Genular Protein ID: 2822370414

Symbol: B2CL1_HUMAN

Name: Bcl-2-like protein 1

UniProtKB Accession Codes:

Q07817 E1P5L6 Q5CZ89 Q5TE65 Q92976

Database IDs:

Citations:

PubMed ID: 8358789

Title: bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death.

PubMed ID: 8358789

DOI: 10.1016/0092-8674(93)90508-n

PubMed ID: 9675101

Title: Identification of a human cDNA encoding a novel Bcl-x isoform.

PubMed ID: 9675101

DOI: 10.1006/bbrc.1998.8907

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7644501

Title: Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.

PubMed ID: 7644501

DOI: 10.1073/pnas.92.17.7834

PubMed ID: 8596636

Title: Bax-independent inhibition of apoptosis by Bcl-XL.

PubMed ID: 8596636

DOI: 10.1038/379554a0

PubMed ID: 9435230

Title: Modulation of cell death by Bcl-xL through caspase interaction.

PubMed ID: 9435230

DOI: 10.1073/pnas.95.2.554

PubMed ID: 10772918

Title: Characterization of Bax-sigma, a cell death-inducing isoform of Bax.

PubMed ID: 10772918

DOI: 10.1006/bbrc.2000.2537

PubMed ID: 11714801

Title: The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis.

PubMed ID: 11714801

DOI: 10.4049/jimmunol.167.11.6366

PubMed ID: 11463391

Title: PUMA induces the rapid apoptosis of colorectal cancer cells.

PubMed ID: 11463391

DOI: 10.1016/s1097-2765(01)00213-1

PubMed ID: 12011449

Title: Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis.

PubMed ID: 12011449

DOI: 10.1073/pnas.102182299

PubMed ID: 17046835

Title: PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex.

PubMed ID: 17046835

DOI: 10.1074/jbc.m606539200

PubMed ID: 16509771

Title: IAN family critically regulates survival and development of T lymphocytes.

PubMed ID: 16509771

DOI: 10.1371/journal.pbio.0040103

PubMed ID: 17418785

Title: Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1.

PubMed ID: 17418785

DOI: 10.1016/j.cell.2007.01.045

PubMed ID: 19917720

Title: Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis.

PubMed ID: 19917720

DOI: 10.1128/mcb.00882-09

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21840391

Title: Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints.

PubMed ID: 21840391

DOI: 10.1016/j.cellsig.2011.07.017

PubMed ID: 22498477

Title: The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death.

PubMed ID: 22498477

DOI: 10.4161/auto.19084

PubMed ID: 21567405

Title: Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain.

PubMed ID: 21567405

DOI: 10.1002/jcp.22836

PubMed ID: 23055042

Title: Human Bop is a novel BH3-only member of the Bcl-2 protein family.

PubMed ID: 23055042

DOI: 10.1007/s13238-012-2069-7

PubMed ID: 23792689

Title: A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis.

PubMed ID: 23792689

DOI: 10.1038/ncb2791

PubMed ID: 25296756

Title: Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop.

PubMed ID: 25296756

DOI: 10.1074/jbc.m114.567792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27013495

Title: The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis.

PubMed ID: 27013495

DOI: 10.15252/embr.201541392

PubMed ID: 29507230

Title: Transmembrane E3 ligase RNF183 mediates ER stress-induced apoptosis by degrading Bcl-xL.

PubMed ID: 29507230

DOI: 10.1073/pnas.1716439115

PubMed ID: 8692274

Title: X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death.

PubMed ID: 8692274

DOI: 10.1038/381335a0

PubMed ID: 9020082

Title: Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis.

PubMed ID: 9020082

DOI: 10.1126/science.275.5302.983

PubMed ID: 11206074

Title: Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies.

PubMed ID: 11206074

DOI: 10.1110/ps.9.12.2528

PubMed ID: 14534311

Title: Bcl-XL mutations suppress cellular sensitivity to antimycin A.

PubMed ID: 14534311

DOI: 10.1074/jbc.m306021200

PubMed ID: 15902208

Title: An inhibitor of Bcl-2 family proteins induces regression of solid tumours.

PubMed ID: 15902208

DOI: 10.1038/nature03579

PubMed ID: 16368107

Title: BCL-XL dimerization by three-dimensional domain swapping.

PubMed ID: 16368107

DOI: 10.1016/j.jmb.2005.11.032

PubMed ID: 17337444

Title: Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein.

PubMed ID: 17337444

DOI: 10.1074/jbc.m700492200

PubMed ID: 17256834

Title: Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.

PubMed ID: 17256834

DOI: 10.1021/jm061152t

PubMed ID: 21639858

Title: Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL.

PubMed ID: 21639858

DOI: 10.1042/bj20110257

PubMed ID: 23340338

Title: PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.

PubMed ID: 23340338

DOI: 10.1038/nchembio.1166

Sequence Information:

Length: 233
Mass: 26049
Checksum: E09D3CDD851AE9BE
Sequence:

MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA INGNPSWHLA 
DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR YRRAFSDLTS QLHITPGTAY 
QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL CVESVDKEMQ VLVSRIAAWM ATYLNDHLEP 
WIQENGGWDT FVELYGNNAA AESRKGQERF NRWFLTGMTV AGVVLLGSLF SRK

Genular Protein ID: 2281429197

Symbol: Q5TE63_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5TE63

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

Length: 170
Mass: 18894
Checksum: 75D1FC01EC06AD47
Sequence:

MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA INGNPSWHLA 
DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR YRRAFSDLTS QLHITPGTAY 
QSFEQDTFVE LYGNNAAAES RKGQERFNRW FLTGMTVAGV VLLGSLFSRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: BCL2L1

Associated with

Cells (max top 100)

Other Information

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. PubMed ID: 8358789

Identification of a human cDNA encoding a novel Bcl-x isoform. PubMed ID: 9675101

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. PubMed ID: 7644501

Bax-independent inhibition of apoptosis by Bcl-XL. PubMed ID: 8596636

Modulation of cell death by Bcl-xL through caspase interaction. PubMed ID: 9435230

Characterization of Bax-sigma, a cell death-inducing isoform of Bax. PubMed ID: 10772918

The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis. PubMed ID: 11714801

PUMA induces the rapid apoptosis of colorectal cancer cells. PubMed ID: 11463391

Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis. PubMed ID: 12011449

PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex. PubMed ID: 17046835

IAN family critically regulates survival and development of T lymphocytes. PubMed ID: 16509771

Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1. PubMed ID: 17418785

Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis. PubMed ID: 19917720

Initial characterization of the human central proteome. PubMed ID: 21269460

Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints. PubMed ID: 21840391

The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death. PubMed ID: 22498477

Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain. PubMed ID: 21567405

Human Bop is a novel BH3-only member of the Bcl-2 protein family. PubMed ID: 23055042

A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. PubMed ID: 23792689

Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop. PubMed ID: 25296756

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis. PubMed ID: 27013495

Transmembrane E3 ligase RNF183 mediates ER stress-induced apoptosis by degrading Bcl-xL. PubMed ID: 29507230

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. PubMed ID: 8692274

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis. PubMed ID: 9020082

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies. PubMed ID: 11206074

Bcl-XL mutations suppress cellular sensitivity to antimycin A. PubMed ID: 14534311

An inhibitor of Bcl-2 family proteins induces regression of solid tumours. PubMed ID: 15902208

BCL-XL dimerization by three-dimensional domain swapping. PubMed ID: 16368107

Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. PubMed ID: 17337444

Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL. PubMed ID: 17256834

Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL. PubMed ID: 21639858

PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. PubMed ID: 23340338

The sequence of the human genome. PubMed ID: 11181995

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. PubMed ID: 26871637