BCL2L1 | ENSG00000171552 | NCBI 598

Details for: BCL2L1

Gene ID: 598

Symbol: BCL2L1

Ensembl ID: ENSG00000171552

Description: BCL2 like 1

Associated with

Apoptosis
(R-HSA-109581)
Bh3-only proteins associate with and inactivate anti-apoptotic bcl-2 members
(R-HSA-111453)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Flt3 signaling in disease
(R-HSA-9682385)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Inflammasomes
(R-HSA-622312)
Innate immune system
(R-HSA-168249)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Nfe2l2 regulating tumorigenic genes
(R-HSA-9818030)
Nuclear events mediated by nfe2l2
(R-HSA-9759194)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Programmed cell death
(R-HSA-5357801)
Raf/map kinase cascade
(R-HSA-5673001)
Ras processing
(R-HSA-9648002)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-1-mediated effects on programmed cell death
(R-HSA-9692913)
Sars-cov infections
(R-HSA-9679506)
Signaling by flt3 itd and tkd mutants
(R-HSA-9703648)
Signaling by interleukins
(R-HSA-449147)
Signal transduction
(R-HSA-162582)
Stat5 activation downstream of flt3 itd mutants
(R-HSA-9702518)
The nlrp1 inflammasome
(R-HSA-844455)
Viral infection pathways
(R-HSA-9824446)
Apoptotic mitochondrial changes
(GO:0008637)
Apoptotic process in bone marrow cell
(GO:0071839)
Bh3 domain binding
(GO:0051434)
Cellular response to alkaloid
(GO:0071312)
Cellular response to amino acid stimulus
(GO:0071230)
Cellular response to gamma radiation
(GO:0071480)
Centrosome
(GO:0005813)
Channel activity
(GO:0015267)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to virus
(GO:0051607)
Dendritic cell apoptotic process
(GO:0097048)
Dendritic cell proliferation
(GO:0044565)
Ectopic germ cell programmed cell death
(GO:0035234)
Endocytosis
(GO:0006897)
Endoplasmic reticulum
(GO:0005783)
Epithelial cell proliferation
(GO:0050673)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Fertilization
(GO:0009566)
Germ cell development
(GO:0007281)
Hepatocyte apoptotic process
(GO:0097284)
Identical protein binding
(GO:0042802)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
In utero embryonic development
(GO:0001701)
Male gonad development
(GO:0008584)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial matrix
(GO:0005759)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrion
(GO:0005739)
Negative regulation of anoikis
(GO:2000811)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of autophagy
(GO:0010507)
Negative regulation of dendritic cell apoptotic process
(GO:2000669)
Negative regulation of developmental process
(GO:0051093)
Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
(GO:1902236)
Negative regulation of execution phase of apoptosis
(GO:1900118)
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
(GO:2001240)
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
(GO:1902042)
Negative regulation of intrinsic apoptotic signaling pathway
(GO:2001243)
Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage
(GO:1902230)
Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
(GO:1901029)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of protein localization to plasma membrane
(GO:1903077)
Negative regulation of release of cytochrome c from mitochondria
(GO:0090201)
Negative regulation of reproductive process
(GO:2000242)
Neuron apoptotic process
(GO:0051402)
Ovarian follicle development
(GO:0001541)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of mononuclear cell proliferation
(GO:0032946)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of cytokinesis
(GO:0032465)
Regulation of growth
(GO:0040008)
Regulation of mitochondrial membrane permeability
(GO:0046902)
Regulation of mitochondrial membrane potential
(GO:0051881)
Release of cytochrome c from mitochondria
(GO:0001836)
Response to cycloheximide
(GO:0046898)
Response to cytokine
(GO:0034097)
Spermatogenesis
(GO:0007283)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 257.0314
Cell Significance Index: -39.9800
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 175.9951
Cell Significance Index: -44.6400
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 98.5761
Cell Significance Index: -46.5400
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 93.4261
Cell Significance Index: -37.9600
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 84.4892
Cell Significance Index: -43.4600
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 39.8798
Cell Significance Index: -38.0800
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 27.8599
Cell Significance Index: -34.3500
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 15.5103
Cell Significance Index: -41.5500
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 13.0492
Cell Significance Index: -40.0800
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 11.9255
Cell Significance Index: -26.1000
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 11.9233
Cell Significance Index: -47.0500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.8143
Cell Significance Index: 360.0500
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.5196
Cell Significance Index: 1372.1300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.1952
Cell Significance Index: 239.7600
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.9609
Cell Significance Index: 13.8200
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.8632
Cell Significance Index: 51.8200
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.8377
Cell Significance Index: 457.5000
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.7900
Cell Significance Index: 7.2800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.7209
Cell Significance Index: 88.6400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.6549
Cell Significance Index: 118.0600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.6462
Cell Significance Index: 17.5900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.5695
Cell Significance Index: 7.7700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.5575
Cell Significance Index: 35.1400
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5000
Cell Significance Index: 14.4100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4760
Cell Significance Index: 47.0900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4153
Cell Significance Index: 79.0300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3749
Cell Significance Index: 134.4700
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3660
Cell Significance Index: 253.1100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3187
Cell Significance Index: 24.4600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2439
Cell Significance Index: 12.6700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2186
Cell Significance Index: 10.1900
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.1801
Cell Significance Index: 13.4300
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.1581
Cell Significance Index: 1.8900
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1258
Cell Significance Index: 20.4600
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1212
Cell Significance Index: 53.5700
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1147
Cell Significance Index: 211.5500
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1133
Cell Significance Index: 213.3500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0971
Cell Significance Index: 4.4000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0649
Cell Significance Index: 99.8900
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0168
Cell Significance Index: 22.8300
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0082
Cell Significance Index: 5.2300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0003
Cell Significance Index: 0.2600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0050
Cell Significance Index: -2.2800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0094
Cell Significance Index: -0.2500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0184
Cell Significance Index: -13.5000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0279
Cell Significance Index: -0.9800
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0349
Cell Significance Index: -4.4700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0366
Cell Significance Index: -27.1400
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0398
Cell Significance Index: -4.0700
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.0491
Cell Significance Index: -0.4000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0523
Cell Significance Index: -8.9300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0588
Cell Significance Index: -8.0700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0674
Cell Significance Index: -1.4600
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0685
Cell Significance Index: -8.8600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0719
Cell Significance Index: -40.5500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0775
Cell Significance Index: -4.0700
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0790
Cell Significance Index: -1.3300
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0852
Cell Significance Index: -53.1900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1021
Cell Significance Index: -12.0500
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1078
Cell Significance Index: -4.7700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1331
Cell Significance Index: -38.3100
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1400
Cell Significance Index: -2.4000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1437
Cell Significance Index: -3.0600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1619
Cell Significance Index: -9.9500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1755
Cell Significance Index: -8.2500
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.1794
Cell Significance Index: -5.2700
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1796
Cell Significance Index: -26.1100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2224
Cell Significance Index: -25.9200
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2261
Cell Significance Index: -8.5600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2409
Cell Significance Index: -50.7400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2441
Cell Significance Index: -27.9700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2448
Cell Significance Index: -16.4600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2452
Cell Significance Index: -13.7600
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2528
Cell Significance Index: -13.1700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2601
Cell Significance Index: -7.2700
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2606
Cell Significance Index: -16.8100
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2784
Cell Significance Index: -6.9600
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.3560
Cell Significance Index: -8.6900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3712
Cell Significance Index: -11.8900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.3846
Cell Significance Index: -27.2000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4034
Cell Significance Index: -31.9500
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4074
Cell Significance Index: -42.4200
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.4371
Cell Significance Index: -12.5300
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.5181
Cell Significance Index: -11.0800
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.5654
Cell Significance Index: -8.3500
Cell Name: photoreceptor cell (CL0000210)
Fold Change: -0.5664
Cell Significance Index: -7.9600
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.7449
Cell Significance Index: -45.6700
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.7462
Cell Significance Index: -25.9300
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.7668
Cell Significance Index: -13.5500
Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: -0.7965
Cell Significance Index: -3.0000
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.8175
Cell Significance Index: -24.0800
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.8278
Cell Significance Index: -12.4800
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.9345
Cell Significance Index: -24.0200
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.9399
Cell Significance Index: -20.5800
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.9733
Cell Significance Index: -31.0000
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.9916
Cell Significance Index: -32.4700
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -1.0036
Cell Significance Index: -28.6400
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.0149
Cell Significance Index: -21.5400
Cell Name: granulosa cell (CL0000501)
Fold Change: -1.0184
Cell Significance Index: -26.7800
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.0218
Cell Significance Index: -37.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** BCL2L1 is a member of the Bcl-2 family of proteins, which are characterized by their ability to regulate apoptosis. The BCL2L1 protein contains two main domains: the BH3-only domain and the BH3-homology domain. The BH3-only domain is responsible for interacting with anti-apoptotic Bcl-2 family members, while the BH3-homology domain interacts with pro-apoptotic Bcl-2 family members. This interaction can either inhibit or promote apoptosis, depending on the context. BCL2L1 is also characterized by its ability to form homodimers and heterodimers with other Bcl-2 family members, which can modulate its pro-apoptotic or anti-apoptotic activity. Additionally, BCL2L1 can interact with other proteins, such as MAPK kinases and NF-κB inhibitors, to regulate signaling pathways that respond to various stimuli. **Pathways and Functions** BCL2L1 is involved in numerous signaling pathways that regulate cell survival, growth, and differentiation. Some of the key pathways and functions of BCL2L1 include: 1. **Apoptosis regulation**: BCL2L1 can either inhibit or promote apoptosis, depending on the context. It can interact with anti-apoptotic Bcl-2 family members to inhibit apoptosis or with pro-apoptotic Bcl-2 family members to promote apoptosis. 2. **Cell growth and differentiation**: BCL2L1 can regulate cell growth and differentiation by interacting with signaling pathways that respond to various stimuli, such as growth factors and cytokines. 3. **Stress response**: BCL2L1 can interact with proteins that respond to cellular stress, such as heat shock proteins and chaperones. 4. **Immune response**: BCL2L1 can regulate immune responses by interacting with signaling pathways that respond to viral infections and other pathogens. 5. **Cytokine signaling**: BCL2L1 can interact with cytokines and growth factors to regulate signaling pathways that respond to various stimuli. **Clinical Significance** BCL2L1 has been implicated in various diseases, including: 1. **Cancer**: BCL2L1 can promote cancer by inhibiting apoptosis and promoting cell growth and differentiation. 2. **Neurodegenerative diseases**: BCL2L1 can interact with signaling pathways that respond to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Infectious diseases**: BCL2L1 can regulate immune responses to viral infections and other pathogens. 4. **Inflammatory diseases**: BCL2L1 can interact with signaling pathways that respond to inflammatory stimuli, such as cytokines and growth factors. Overall, BCL2L1 is a critical component of the Bcl-2 family of proteins that regulate apoptosis and other cellular processes. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target for the treatment of these conditions.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Bcl-2-like protein 1
Q5TE63_HUMAN

Genular Protein ID: 2822370414

Symbol: B2CL1_HUMAN

Name: Bcl-2-like protein 1

UniProtKB Accession Codes:

Q07817 E1P5L6 Q5CZ89 Q5TE65 Q92976

Database IDs:

Citations:

PubMed ID: 8358789

Title: bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death.

PubMed ID: 8358789

DOI: 10.1016/0092-8674(93)90508-n

PubMed ID: 9675101

Title: Identification of a human cDNA encoding a novel Bcl-x isoform.

PubMed ID: 9675101

DOI: 10.1006/bbrc.1998.8907

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7644501

Title: Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.

PubMed ID: 7644501

DOI: 10.1073/pnas.92.17.7834

PubMed ID: 8596636

Title: Bax-independent inhibition of apoptosis by Bcl-XL.

PubMed ID: 8596636

DOI: 10.1038/379554a0

PubMed ID: 9435230

Title: Modulation of cell death by Bcl-xL through caspase interaction.

PubMed ID: 9435230

DOI: 10.1073/pnas.95.2.554

PubMed ID: 10772918

Title: Characterization of Bax-sigma, a cell death-inducing isoform of Bax.

PubMed ID: 10772918

DOI: 10.1006/bbrc.2000.2537

PubMed ID: 11714801

Title: The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis.

PubMed ID: 11714801

DOI: 10.4049/jimmunol.167.11.6366

PubMed ID: 11463391

Title: PUMA induces the rapid apoptosis of colorectal cancer cells.

PubMed ID: 11463391

DOI: 10.1016/s1097-2765(01)00213-1

PubMed ID: 12011449

Title: Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis.

PubMed ID: 12011449

DOI: 10.1073/pnas.102182299

PubMed ID: 17046835

Title: PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex.

PubMed ID: 17046835

DOI: 10.1074/jbc.m606539200

PubMed ID: 16509771

Title: IAN family critically regulates survival and development of T lymphocytes.

PubMed ID: 16509771

DOI: 10.1371/journal.pbio.0040103

PubMed ID: 17418785

Title: Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1.

PubMed ID: 17418785

DOI: 10.1016/j.cell.2007.01.045

PubMed ID: 19917720

Title: Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis.

PubMed ID: 19917720

DOI: 10.1128/mcb.00882-09

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21840391

Title: Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints.

PubMed ID: 21840391

DOI: 10.1016/j.cellsig.2011.07.017

PubMed ID: 22498477

Title: The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death.

PubMed ID: 22498477

DOI: 10.4161/auto.19084

PubMed ID: 21567405

Title: Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain.

PubMed ID: 21567405

DOI: 10.1002/jcp.22836

PubMed ID: 23055042

Title: Human Bop is a novel BH3-only member of the Bcl-2 protein family.

PubMed ID: 23055042

DOI: 10.1007/s13238-012-2069-7

PubMed ID: 23792689

Title: A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis.

PubMed ID: 23792689

DOI: 10.1038/ncb2791

PubMed ID: 25296756

Title: Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop.

PubMed ID: 25296756

DOI: 10.1074/jbc.m114.567792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27013495

Title: The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis.

PubMed ID: 27013495

DOI: 10.15252/embr.201541392

PubMed ID: 29507230

Title: Transmembrane E3 ligase RNF183 mediates ER stress-induced apoptosis by degrading Bcl-xL.

PubMed ID: 29507230

DOI: 10.1073/pnas.1716439115

PubMed ID: 8692274

Title: X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death.

PubMed ID: 8692274

DOI: 10.1038/381335a0

PubMed ID: 9020082

Title: Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis.

PubMed ID: 9020082

DOI: 10.1126/science.275.5302.983

PubMed ID: 11206074

Title: Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies.

PubMed ID: 11206074

DOI: 10.1110/ps.9.12.2528

PubMed ID: 14534311

Title: Bcl-XL mutations suppress cellular sensitivity to antimycin A.

PubMed ID: 14534311

DOI: 10.1074/jbc.m306021200

PubMed ID: 15902208

Title: An inhibitor of Bcl-2 family proteins induces regression of solid tumours.

PubMed ID: 15902208

DOI: 10.1038/nature03579

PubMed ID: 16368107

Title: BCL-XL dimerization by three-dimensional domain swapping.

PubMed ID: 16368107

DOI: 10.1016/j.jmb.2005.11.032

PubMed ID: 17337444

Title: Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein.

PubMed ID: 17337444

DOI: 10.1074/jbc.m700492200

PubMed ID: 17256834

Title: Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.

PubMed ID: 17256834

DOI: 10.1021/jm061152t

PubMed ID: 21639858

Title: Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL.

PubMed ID: 21639858

DOI: 10.1042/bj20110257

PubMed ID: 23340338

Title: PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.

PubMed ID: 23340338

DOI: 10.1038/nchembio.1166

Sequence Information:

Length: 233
Mass: 26049
Checksum: E09D3CDD851AE9BE
Sequence:

MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA INGNPSWHLA 
DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR YRRAFSDLTS QLHITPGTAY 
QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL CVESVDKEMQ VLVSRIAAWM ATYLNDHLEP 
WIQENGGWDT FVELYGNNAA AESRKGQERF NRWFLTGMTV AGVVLLGSLF SRK

Genular Protein ID: 2281429197

Symbol: Q5TE63_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5TE63

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

Length: 170
Mass: 18894
Checksum: 75D1FC01EC06AD47
Sequence:

MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA INGNPSWHLA 
DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR YRRAFSDLTS QLHITPGTAY 
QSFEQDTFVE LYGNNAAAES RKGQERFNRW FLTGMTVAGV VLLGSLFSRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BCL2L1

Associated with

Cells (max top 100)

Other Information

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. PubMed ID: 8358789

Identification of a human cDNA encoding a novel Bcl-x isoform. PubMed ID: 9675101

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. PubMed ID: 7644501

Bax-independent inhibition of apoptosis by Bcl-XL. PubMed ID: 8596636

Modulation of cell death by Bcl-xL through caspase interaction. PubMed ID: 9435230

Characterization of Bax-sigma, a cell death-inducing isoform of Bax. PubMed ID: 10772918

The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis. PubMed ID: 11714801

PUMA induces the rapid apoptosis of colorectal cancer cells. PubMed ID: 11463391

Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis. PubMed ID: 12011449

PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex. PubMed ID: 17046835

IAN family critically regulates survival and development of T lymphocytes. PubMed ID: 16509771

Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1. PubMed ID: 17418785

Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis. PubMed ID: 19917720

Initial characterization of the human central proteome. PubMed ID: 21269460

Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints. PubMed ID: 21840391

The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death. PubMed ID: 22498477

Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain. PubMed ID: 21567405

Human Bop is a novel BH3-only member of the Bcl-2 protein family. PubMed ID: 23055042

A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. PubMed ID: 23792689

Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop. PubMed ID: 25296756

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis. PubMed ID: 27013495

Transmembrane E3 ligase RNF183 mediates ER stress-induced apoptosis by degrading Bcl-xL. PubMed ID: 29507230

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. PubMed ID: 8692274

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis. PubMed ID: 9020082

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies. PubMed ID: 11206074

Bcl-XL mutations suppress cellular sensitivity to antimycin A. PubMed ID: 14534311

An inhibitor of Bcl-2 family proteins induces regression of solid tumours. PubMed ID: 15902208

BCL-XL dimerization by three-dimensional domain swapping. PubMed ID: 16368107

Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. PubMed ID: 17337444

Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL. PubMed ID: 17256834

Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL. PubMed ID: 21639858

PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. PubMed ID: 23340338

The sequence of the human genome. PubMed ID: 11181995

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. PubMed ID: 26871637