BCL2L1 | ENSG00000171552 | NCBI 598

Details for: BCL2L1

Associated with

Apoptosis
(R-HSA-109581)
Bh3-only proteins associate with and inactivate anti-apoptotic bcl-2 members
(R-HSA-111453)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Flt3 signaling in disease
(R-HSA-9682385)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Inflammasomes
(R-HSA-622312)
Innate immune system
(R-HSA-168249)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Nfe2l2 regulating tumorigenic genes
(R-HSA-9818030)
Nuclear events mediated by nfe2l2
(R-HSA-9759194)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Programmed cell death
(R-HSA-5357801)
Raf/map kinase cascade
(R-HSA-5673001)
Ras processing
(R-HSA-9648002)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-1-mediated effects on programmed cell death
(R-HSA-9692913)
Sars-cov infections
(R-HSA-9679506)
Signaling by flt3 itd and tkd mutants
(R-HSA-9703648)
Signaling by interleukins
(R-HSA-449147)
Signal transduction
(R-HSA-162582)
Stat5 activation downstream of flt3 itd mutants
(R-HSA-9702518)
The nlrp1 inflammasome
(R-HSA-844455)
Viral infection pathways
(R-HSA-9824446)
Apoptotic mitochondrial changes
(GO:0008637)
Apoptotic process in bone marrow cell
(GO:0071839)
Bcl-2 family protein complex
(GO:0097136)
Bh3 domain binding
(GO:0051434)
Cellular response to alkaloid
(GO:0071312)
Cellular response to amino acid stimulus
(GO:0071230)
Cellular response to gamma radiation
(GO:0071480)
Centrosome
(GO:0005813)
Channel activity
(GO:0015267)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to virus
(GO:0051607)
Dendritic cell apoptotic process
(GO:0097048)
Dendritic cell proliferation
(GO:0044565)
Ectopic germ cell programmed cell death
(GO:0035234)
Endocytosis
(GO:0006897)
Endoplasmic reticulum
(GO:0005783)
Epithelial cell proliferation
(GO:0050673)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Fertilization
(GO:0009566)
Germ cell development
(GO:0007281)
Hepatocyte apoptotic process
(GO:0097284)
Identical protein binding
(GO:0042802)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
In utero embryonic development
(GO:0001701)
Male gonad development
(GO:0008584)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial matrix
(GO:0005759)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrion
(GO:0005739)
Negative regulation of anoikis
(GO:2000811)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of autophagy
(GO:0010507)
Negative regulation of dendritic cell apoptotic process
(GO:2000669)
Negative regulation of developmental process
(GO:0051093)
Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
(GO:1902236)
Negative regulation of execution phase of apoptosis
(GO:1900118)
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
(GO:2001240)
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
(GO:1902042)
Negative regulation of intrinsic apoptotic signaling pathway
(GO:2001243)
Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage
(GO:1902230)
Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
(GO:1901029)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of protein localization to plasma membrane
(GO:1903077)
Negative regulation of release of cytochrome c from mitochondria
(GO:0090201)
Negative regulation of reproductive process
(GO:2000242)
Neuron apoptotic process
(GO:0051402)
Nuclear membrane
(GO:0031965)
Ovarian follicle development
(GO:0001541)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of mononuclear cell proliferation
(GO:0032946)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of cytokinesis
(GO:0032465)
Regulation of growth
(GO:0040008)
Regulation of mitochondrial membrane permeability
(GO:0046902)
Regulation of mitochondrial membrane potential
(GO:0051881)
Release of cytochrome c from mitochondria
(GO:0001836)
Response to cycloheximide
(GO:0046898)
Response to cytokine
(GO:0034097)
Spermatogenesis
(GO:0007283)
Synaptic vesicle membrane
(GO:0030672)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

choroid plexus epithelial cell CL0000706

CSI 19.65

rCSI 32.18%

PRS 20.23
lung ciliated cell CL1000271

CSI 13.37

rCSI 15.46%

PRS 19.4
pancreatic ductal cell CL0002079

CSI 12.23

rCSI 23.78%

PRS 26.92
kidney connecting tubule epithelial cell CL1000768

CSI 11.16

rCSI 28.32%

PRS 20
plasmacytoid dendritic cell, human CL0001058

CSI 10.36

rCSI 7.23%

PRS 27.7
alternatively activated macrophage CL0000890

CSI 10.17

rCSI 12.79%

PRS 38.8
thymocyte CL0000893

CSI 9.95

rCSI 35.36%

PRS 66.51
enteroendocrine cell CL0000164

CSI 9.83

rCSI 13.44%

PRS 28.83
cholangiocyte CL1000488

CSI 7.37

rCSI 44.17%

PRS 42.96
intrahepatic cholangiocyte CL0002538

CSI 6.92

rCSI 16.61%

PRS 43.55
megakaryocyte CL0000556

CSI 6.63

rCSI 28.77%

PRS 42.42
radial glial cell CL0000681

CSI 5.44

rCSI 7.56%

PRS 26.34
ciliated cell CL0000064

CSI 5.25

rCSI 8.5%

PRS 26.05
cerebral cortex endothelial cell CL1001602

CSI 4.97

rCSI 8.59%

PRS 20.05
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 4.56

rCSI 6.46%

PRS 24.23
cerebral cortex neuron CL0010012

CSI 4.55

rCSI 18.54%

PRS 26.53
glioblast CL0000030

CSI 4.28

rCSI 6.83%

PRS 22.28
alveolar macrophage CL0000583

CSI 4.22

rCSI 6.96%

PRS 30.58
myofibroblast cell CL0000186

CSI 4.22

rCSI 5.85%

PRS 34.39
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 4

rCSI 9.12%

PRS 26.38
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 3.87

rCSI 3.8%

PRS 39.62
lung pericyte CL0009089

CSI 3.77

rCSI 9.94%

PRS 31.1
chondrocyte CL0000138

CSI 3.75

rCSI 5.97%

PRS 21.99
retinal blood vessel endothelial cell CL0002585

CSI 3.38

rCSI 5.4%

PRS 28.61
fibroblast of lung CL0002553

CSI 3.22

rCSI 2.99%

PRS 26.14
retinal rod cell CL0000604

CSI 3.15

rCSI 5.55%

PRS 25.39
ionocyte CL0005006

CSI 3.11

rCSI 3.33%

PRS 24.11
group 3 innate lymphoid cell CL0001071

CSI 3.1

rCSI 2.33%

PRS 27.98
pulmonary ionocyte CL0017000

CSI 3.04

rCSI 3.71%

PRS 32.31
fibroblast of cardiac tissue CL0002548

CSI 3.04

rCSI 14.57%

PRS 22.57
pulmonary capillary endothelial cell CL4028001

CSI 3.02

rCSI 5.75%

PRS 40.51
effector CD8-positive, alpha-beta T cell CL0001050

CSI 2.86

rCSI 2.17%

PRS 34.43
renal alpha-intercalated cell CL0005011

CSI 2.84

rCSI 3.8%

PRS 33.08
regular atrial cardiac myocyte CL0002129

CSI 2.81

rCSI 9.05%

PRS 26.88
neuroblast (sensu Vertebrata) CL0000031

CSI 2.8

rCSI 3.59%

PRS 24.96
erythrocyte CL0000232

CSI 2.79

rCSI 6.33%

PRS 33.28
pulmonary artery endothelial cell CL1001568

CSI 2.73

rCSI 3.72%

PRS 37.99
melanocyte CL0000148

CSI 2.58

rCSI 1.91%

PRS 22.37
deuterosomal cell CL4033044

CSI 2.57

rCSI 8.7%

PRS 38.98
double negative thymocyte CL0002489

CSI 2.55

rCSI 1.77%

PRS 31.48
precursor B cell CL0000817

CSI 2.47

rCSI 2.16%

PRS 34.22
enterocyte CL0000584

CSI 2.47

rCSI 3.98%

PRS 37.7
enteroendocrine cell of small intestine CL0009006

CSI 2.41

rCSI 5.31%

PRS 38.66
secretory cell CL0000151

CSI 2.4

rCSI 2.51%

PRS 26.81
endocardial cell CL0002350

CSI 2.29

rCSI 10.98%

PRS 30.81
small pre-B-II cell CL0000954

CSI 2.25

rCSI 2.16%

PRS 49.51
cerebellar granule cell CL0001031

CSI 2.18

rCSI 3.21%

PRS 24.07
epithelial cell of proximal tubule CL0002306

CSI 2.17

rCSI 5.3%

PRS 25.11
brush cell of tracheobronchial tree CL0002075

CSI 2.16

rCSI 6.42%

PRS 35.42
T follicular helper cell CL0002038

CSI 2.09

rCSI 1.56%

PRS 39.88
Mueller cell CL0000636

CSI 2.08

rCSI 4.74%

PRS 22.33
midzonal region hepatocyte CL0019028

CSI 2.06

rCSI 4.83%

PRS 36.08
mature T cell CL0002419

CSI 2.04

rCSI 1.58%

PRS 38.16
epithelial cell of lower respiratory tract CL0002632

CSI 2.04

rCSI 1.58%

PRS 25.43
lung macrophage CL1001603

CSI 2.03

rCSI 4.53%

PRS 30.62
pro-B cell CL0000826

CSI 1.98

rCSI 1.64%

PRS 26.54
differentiation-committed oligodendrocyte precursor CL4023059

CSI 1.95

rCSI 3.55%

PRS 22.34
periportal region hepatocyte CL0019026

CSI 1.95

rCSI 7.59%

PRS 34.87
vascular leptomeningeal cell CL4023051

CSI 1.95

rCSI 3.41%

PRS 20.32
stem cell CL0000034

CSI 1.92

rCSI 1.86%

PRS 19.4
pancreatic D cell CL0000173

CSI 1.92

rCSI 1.89%

PRS 28
neural crest cell CL0011012

CSI 1.91

rCSI 1.51%

PRS 18.03
interstitial cell of Cajal CL0002088

CSI 1.91

rCSI 2.43%

PRS 30.02
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 1.86

rCSI 16.07%

PRS 35.05
contractile cell CL0000183

CSI 1.84

rCSI 5.43%

PRS 25.01
ciliated epithelial cell CL0000067

CSI 1.83

rCSI 1.61%

PRS 19.15
interneuron CL0000099

CSI 1.82

rCSI 3.65%

PRS 19.42
Bergmann glial cell CL0000644

CSI 1.78

rCSI 2.44%

PRS 25.48
rod bipolar cell CL0000751

CSI 1.77

rCSI 3.18%

PRS 21.7
pancreatic A cell CL0000171

CSI 1.76

rCSI 1.85%

PRS 27.73
conjunctival epithelial cell CL1000432

CSI 1.74

rCSI 2.66%

PRS 26.29
elicited macrophage CL0000861

CSI 1.74

rCSI 1.6%

PRS 31.08
cardiac neuron CL0010022

CSI 1.73

rCSI 5.55%

PRS 22.26
luminal epithelial cell of mammary gland CL0002326

CSI 1.73

rCSI 3.15%

PRS 39.3
colon epithelial cell CL0011108

CSI 1.71

rCSI 1.79%

PRS 24.44
mononuclear phagocyte CL0000113

CSI 1.71

rCSI 3.76%

PRS 29.77
astrocyte of the cerebral cortex CL0002605

CSI 1.7

rCSI 3.82%

PRS 16.5
multi-ciliated epithelial cell CL0005012

CSI 1.7

rCSI 1.7%

PRS 22.37
double-positive, alpha-beta thymocyte CL0000809

CSI 1.7

rCSI 1.73%

PRS 36.74
nasal mucosa goblet cell CL0002480

CSI 1.7

rCSI 1.97%

PRS 36.88
dendritic cell, human CL0001056

CSI 1.69

rCSI 2.6%

PRS 31.26
erythroblast CL0000765

CSI 1.68

rCSI 4.46%

PRS 38.83
Kupffer cell CL0000091

CSI 1.64

rCSI 3.75%

PRS 25.53
perivascular cell CL4033054

CSI 1.64

rCSI 2.24%

PRS 29.48
hematopoietic stem cell CL0000037

CSI 1.63

rCSI 1.08%

PRS 30.63
activated type II NK T cell CL0000931

CSI 1.63

rCSI 1.83%

PRS 40.59
endothelial cell of vascular tree CL0002139

CSI 1.63

rCSI 8.9%

PRS 36
kidney distal convoluted tubule epithelial cell CL1000849

CSI 1.62

rCSI 17.11%

PRS 31.5
pancreatic acinar cell CL0002064

CSI 1.61

rCSI 2.13%

PRS 28.7
epithelial cell of lung CL0000082

CSI 1.6

rCSI 1.33%

PRS 24.89
intestinal tuft cell CL0019032

CSI 1.6

rCSI 2.45%

PRS 29.79
retinal pigment epithelial cell CL0002586

CSI 1.6

rCSI 3.18%

PRS 27.05
epithelial cell CL0000066

CSI 1.59

rCSI 2.44%

PRS 33.24
respiratory hillock cell CL4030023

CSI 1.59

rCSI 2.83%

PRS 41.25
adipocyte CL0000136

CSI 1.59

rCSI 2.04%

PRS 25.12
goblet cell CL0000160

CSI 1.58

rCSI 1.5%

PRS 27.38
hepatic stellate cell CL0000632

CSI 1.58

rCSI 5.91%

PRS 21.97
adventitial cell CL0002503

CSI 1.56

rCSI 3.72%

PRS 37.66
myeloid leukocyte CL0000766

CSI 1.55

rCSI 1.43%

PRS 27.25
blood vessel endothelial cell CL0000071

CSI 1.55

rCSI 3.21%

PRS 25.83

medium spiny neuron CL1001474

CSI 0.1

rCSI 0.5%

PRS 15.3%
vein endothelial cell of respiratory system CL4033008

CSI 0.1

rCSI 0.5%

PRS 47.2%
epithelial cell of urethra CL1000296

CSI 0.2

rCSI 3.7%

PRS 59.4%
erythroid progenitor cell CL0000038

CSI 0.2

rCSI 1.1%

PRS 37.1%
central nervous system neuron CL2000029

CSI 0.2

rCSI 1.8%

PRS 16.7%
respiratory goblet cell CL0002370

CSI 0.3

rCSI 2.7%

PRS 47.0%
blood vessel smooth muscle cell CL0019018

CSI 0.3

rCSI 2.3%

PRS 24.8%
regular ventricular cardiac myocyte CL0002131

CSI 0.3

rCSI 2.1%

PRS 20.8%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 0.4

rCSI 2.0%

PRS 16.7%
megakaryocyte-erythroid progenitor cell CL0000050

CSI 0.4

rCSI 0.4%

PRS 23.8%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 0.4

rCSI 1.5%

PRS 15.0%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 0.4

rCSI 2.1%

PRS 34.3%
primitive red blood cell CL0002355

CSI 0.4

rCSI 2.3%

PRS 41.7%
S cone cell CL0003050

CSI 0.4

rCSI 1.9%

PRS 24.7%
lymphoid lineage restricted progenitor cell CL0000838

CSI 0.4

rCSI 1.7%

PRS 42.2%
eye photoreceptor cell CL0000287

CSI 0.5

rCSI 5.1%

PRS 55.3%
type B pancreatic cell CL0000169

CSI 0.5

rCSI 1.0%

PRS 24.1%
L6b glutamatergic cortical neuron CL4023038

CSI 0.5

rCSI 1.4%

PRS 16.7%
peripheral nervous system neuron CL2000032

CSI 0.5

rCSI 0.6%

PRS 22.7%
podocyte CL0000653

CSI 0.5

rCSI 2.0%

PRS 25.4%
colon goblet cell CL0009039

CSI 0.5

rCSI 1.2%

PRS 37.9%
microcirculation associated smooth muscle cell CL0008035

CSI 0.5

rCSI 1.4%

PRS 29.2%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 0.6

rCSI 1.8%

PRS 18.2%
large pre-B-II cell CL0000957

CSI 0.6

rCSI 1.7%

PRS 41.4%
kidney collecting duct intercalated cell CL1001432

CSI 0.6

rCSI 4.2%

PRS 40.4%
Hofbauer cell CL3000001

CSI 0.6

rCSI 1.1%

PRS 33.2%
placental villous trophoblast CL2000060

CSI 0.6

rCSI 1.0%

PRS 24.6%
peptic cell CL0000155

CSI 0.6

rCSI 6.3%

PRS 57.9%
mammary gland epithelial cell CL0002327

CSI 0.6

rCSI 2.3%

PRS 42.8%
intestinal crypt stem cell of small intestine CL0009017

CSI 0.7

rCSI 1.7%

PRS 33.7%
near-projecting glutamatergic cortical neuron CL4023012

CSI 0.7

rCSI 2.5%

PRS 16.5%
effector CD4-positive, alpha-beta T cell CL0001044

CSI 0.7

rCSI 1.9%

PRS 38.8%
pulmonary alveolar type 1 cell CL0002062

CSI 0.7

rCSI 4.2%

PRS 31.3%
IgG plasma cell CL0000985

CSI 0.8

rCSI 0.9%

PRS 43.6%
GABAergic neuron CL0000617

CSI 0.8

rCSI 2.5%

PRS 19.0%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 0.8

rCSI 1.9%

PRS 15.6%
retinal ganglion cell CL0000740

CSI 0.8

rCSI 1.7%

PRS 18.8%
parietal epithelial cell CL1000452

CSI 0.8

rCSI 2.1%

PRS 21.8%
macroglial cell CL0000126

CSI 0.8

rCSI 2.1%

PRS 31.8%
glycinergic amacrine cell CL4030028

CSI 0.8

rCSI 2.1%

PRS 26.1%
retina horizontal cell CL0000745

CSI 0.8

rCSI 1.3%

PRS 24.0%
luminal cell of prostate epithelium CL0002340

CSI 0.9

rCSI 4.7%

PRS 42.8%
renal interstitial pericyte CL1001318

CSI 0.9

rCSI 2.4%

PRS 24.4%
glandular epithelial cell CL0000150

CSI 0.9

rCSI 2.3%

PRS 48.0%
dopaminergic neuron CL0000700

CSI 0.9

rCSI 5.1%

PRS 16.0%
platelet CL0000233

CSI 0.9

rCSI 3.8%

PRS 40.7%
CD14-low, CD16-positive monocyte CL0002396

CSI 0.9

rCSI 0.7%

PRS 24.6%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 0.9

rCSI 2.4%

PRS 24.1%
paneth cell of epithelium of small intestine CL1000343

CSI 0.9

rCSI 2.6%

PRS 39.6%
myeloid dendritic cell CL0000782

CSI 0.9

rCSI 1.4%

PRS 39.0%
late pro-B cell CL0002048

CSI 1.0

rCSI 2.4%

PRS 60.6%
cardiac endothelial cell CL0010008

CSI 1.0

rCSI 3.9%

PRS 24.4%
lung secretory cell CL1000272

CSI 1.0

rCSI 2.4%

PRS 24.4%
erythroid lineage cell CL0000764

CSI 1.0

rCSI 6.3%

PRS 50.1%
mucus secreting cell CL0000319

CSI 1.0

rCSI 1.6%

PRS 33.5%
neuroendocrine cell CL0000165

CSI 1.0

rCSI 3.9%

PRS 46.6%
tracheal goblet cell CL1000329

CSI 1.0

rCSI 2.2%

PRS 47.2%
tuft cell of colon CL0009041

CSI 1.0

rCSI 2.4%

PRS 46.9%
indirect pathway medium spiny neuron CL4023029

CSI 1.0

rCSI 24.6%

PRS 15.6%
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 1.0

rCSI 3.2%

PRS 37.6%
BEST4+ enteroycte CL4030026

CSI 1.1

rCSI 1.3%

PRS 28.0%
respiratory suprabasal cell CL4033048

CSI 1.1

rCSI 1.4%

PRS 30.1%
retinal cone cell CL0000573

CSI 1.1

rCSI 1.7%

PRS 20.1%
lamp5 GABAergic cortical interneuron CL4023011

CSI 1.1

rCSI 1.8%

PRS 15.9%
direct pathway medium spiny neuron CL4023026

CSI 1.1

rCSI 26.1%

PRS 14.7%
basal cell CL0000646

CSI 1.1

rCSI 1.5%

PRS 28.3%
squamous epithelial cell CL0000076

CSI 1.1

rCSI 2.7%

PRS 31.6%
respiratory basal cell CL0002633

CSI 1.2

rCSI 1.2%

PRS 30.8%
hepatocyte CL0000182

CSI 1.2

rCSI 2.1%

PRS 24.3%
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 1.2

rCSI 2.0%

PRS 47.1%
transit amplifying cell of colon CL0009011

CSI 1.2

rCSI 1.4%

PRS 29.9%
duct epithelial cell CL0000068

CSI 1.2

rCSI 1.7%

PRS 27.8%
lung neuroendocrine cell CL1000223

CSI 1.2

rCSI 1.7%

PRS 29.7%
sncg GABAergic cortical interneuron CL4023015

CSI 1.2

rCSI 1.9%

PRS 17.3%
tracheobronchial smooth muscle cell CL0019019

CSI 1.2

rCSI 2.1%

PRS 33.3%
keratinocyte CL0000312

CSI 1.2

rCSI 1.0%

PRS 30.7%
intermediate monocyte CL0002393

CSI 1.2

rCSI 1.8%

PRS 26.7%
centrilobular region hepatocyte CL0019029

CSI 1.2

rCSI 3.1%

PRS 37.7%
M cell of gut CL0000682

CSI 1.2

rCSI 1.3%

PRS 42.2%
VIP GABAergic cortical interneuron CL4023016

CSI 1.3

rCSI 1.5%

PRS 15.7%
fraction A pre-pro B cell CL0002045

CSI 1.3

rCSI 1.4%

PRS 49.1%
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 1.3

rCSI 1.4%

PRS 22.6%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.3

rCSI 2.3%

PRS 15.6%
club cell CL0000158

CSI 1.3

rCSI 1.9%

PRS 29.0%
pulmonary alveolar type 2 cell CL0002063

CSI 1.3

rCSI 2.1%

PRS 37.2%
sst GABAergic cortical interneuron CL4023017

CSI 1.3

rCSI 1.7%

PRS 16.5%
acinar cell CL0000622

CSI 1.4

rCSI 2.0%

PRS 34.0%
kidney interstitial alternatively activated macrophage CL1000695

CSI 1.4

rCSI 3.6%

PRS 24.7%
pvalb GABAergic cortical interneuron CL4023018

CSI 1.4

rCSI 1.8%

PRS 14.9%
promyelocyte CL0000836

CSI 1.4

rCSI 2.1%

PRS 35.6%
cardiac muscle cell CL0000746

CSI 1.4

rCSI 2.1%

PRS 20.5%
retinal bipolar neuron CL0000748

CSI 1.4

rCSI 2.7%

PRS 19.2%
ependymal cell CL0000065

CSI 1.4

rCSI 2.9%

PRS 14.5%
renal beta-intercalated cell CL0002201

CSI 1.4

rCSI 3.4%

PRS 29.0%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 1.5

rCSI 3.5%

PRS 18.4%
colonocyte CL1000347

CSI 1.5

rCSI 2.1%

PRS 34.3%
mucous neck cell CL0000651

CSI 1.5

rCSI 2.2%

PRS 39.8%
fallopian tube secretory epithelial cell CL4030006

CSI 1.5

rCSI 1.5%

PRS 27.0%
corneal epithelial cell CL0000575

CSI 1.5

rCSI 4.4%

PRS 43.4%
blood vessel endothelial cell CL0000071

CSI 1.6

rCSI 3.2%

PRS 25.8%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [BCL2L1](/details-gene/598), or BCL2 like 1, is a protein-coding gene located on chromosome 20q11.21. It encodes the protein Bcl-xL, a pivotal member of the B-cell lymphoma 2 (Bcl-2) family of apoptosis regulators. Functioning primarily as an anti-apoptotic protein, [BCL2L1](/details-gene/598) is a dominant regulator of programmed cell death across a wide range of cell types ([Link](https://doi.org/10.1016/0092-8674(93)90508-n)). Its mechanism involves preventing the release of mitochondrial apoptogenic factors, such as cytochrome c, thereby blocking the intrinsic apoptosis pathway. Expression data indicates its high significance in diverse cell populations, including epithelial cells like [choroid plexus epithelial cell](/details-cell/CL0000706) and [lung ciliated cell](/details-cell/CL1000271), as well as key immune cells such as [plasmacytoid dendritic cell, human](/details-cell/CL0001058) and [alternatively activated macrophage](/details-cell/CL0000890), highlighting its fundamental role in tissue homeostasis and immune cell survival. Dysregulation of [BCL2L1](/details-gene/598) is implicated in various pathologies, particularly cancer ([OMIM: 600039](https://omim.org/entry/600039)). ## Cellular Roles and Expression Landscape The expression profile of [BCL2L1](/details-gene/598) underscores its widespread importance in maintaining cellular viability across multiple organ systems. **Overall**, the gene shows prominent significance in several distinct cellular contexts. It is a key marker in specialized epithelial populations, with the highest significance observed in [choroid plexus epithelial cell](/details-cell/CL0000706) (CSI: 19.65), followed by [lung ciliated cell](/details-cell/CL1000271) (CSI: 13.37), [pancreatic ductal cell](/details-cell/CL0002079) (CSI: 12.23), and [cholangiocyte](/details-cell/CL1000488) (CSI: 7.37). This pattern suggests a critical role in protecting barrier and secretory tissues that are subject to high turnover or environmental stress. Concurrently, [BCL2L1](/details-gene/598) is highly significant within the immune system. Its expression is notable in [plasmacytoid dendritic cell, human](/details-cell/CL0001058) (CSI: 10.36), [alternatively activated macrophage](/details-cell/CL0000890) (CSI: 10.17), and [thymocyte](/details-cell/CL0000893) (CSI: 9.95). This expression profile is consistent with its established role in regulating the survival and development of lymphocytes and myeloid cells. Its prominence in hematopoietic precursors like [megakaryocyte](/details-cell/CL0000556) (CSI: 6.63) further points to its involvement in hematopoiesis. The broad yet specific expression pattern highlights [BCL2L1](/details-gene/598) as a crucial homeostatic factor essential for both epithelial integrity and immune function. ## Pathways and Molecular Function [BCL2L1](/details-gene/598) is a central node in the regulation of programmed cell death, primarily through the [Intrinsic pathway for apoptosis](/details-reactome/R-HSA-109606). Its molecular function is characterized by its ability to bind to and antagonize pro-apoptotic proteins of the same family, such as Bax and Bak ([Link](https://doi.org/10.1073/pnas.92.17.7834)). This interaction prevents mitochondrial outer membrane permeabilization, a key commitment step in apoptosis. Consistent with this role, Gene Ontology terms heavily associate [BCL2L1](/details-gene/598) with the [Negative regulation of apoptotic process](/details-go/GO:0043066), specifically the [negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway](/details-go/GO:1901029) and the subsequent [negative regulation of release of cytochrome c from mitochondria](/details-go/GO:0090201). The protein itself is localized to critical sites for this function, including the [mitochondrial outer membrane](/details-go/GO:0005741) and the [endoplasmic reticulum](/details-go/GO:0005783). Beyond its canonical role in apoptosis, [BCL2L1](/details-gene/598) is implicated in broader signaling networks. Reactome pathways highlight its involvement in the [Immune system](/details-reactome/R-HSA-168256), particularly [Cytokine signaling in immune system](/details-reactome/R-HSA-1280215) and the regulation of [Inflammasomes](/details-reactome/R-HSA-622312). Research has shown it can interact with NALP1 to regulate caspase-1 activation, linking apoptosis machinery to inflammatory responses ([Link](https://doi.org/10.1016/j.cell.2007.01.045)). This dual function places [BCL2L1](/details-gene/598) at the intersection of cell survival and innate immunity. ## Research Directions The function of [BCL2L1](/details-gene/598) as a key survival factor in diverse cell types makes its dysregulation a critical area of investigation for numerous diseases, from cancer to inflammatory and neurodegenerative disorders. **Proposed Hypotheses:** 1. Given its high significance in [choroid plexus epithelial cell](/details-cell/CL0000706) and its documented role in the [negative regulation of neuron apoptotic process](/details-go/GO:0043524), [BCL2L1](/details-gene/598) likely plays a crucial role in maintaining the integrity of the blood-cerebrospinal fluid barrier and protecting against neuroinflammation. Downregulation or dysfunction of [BCL2L1](/details-gene/598) in these cells could increase susceptibility to neurodegenerative conditions by compromising barrier function and promoting neuronal apoptosis. 2. The high CSI score in [alternatively activated macrophage](/details-cell/CL0000890), combined with its involvement in [cytokine signaling](/details-reactome/R-HSA-1280215), suggests that [BCL2L1](/details-gene/598) is a key determinant of M2 macrophage survival and function. It may be selectively upregulated during M2 polarization to sustain their long-term presence in tissues, thereby influencing chronic inflammation, fibrosis, and tumor microenvironments. **Suggested Experimental Approach:** To test the hypothesis regarding the role of [BCL2L1](/details-gene/598) in M2 macrophage polarization (Hypothesis 2), a conditional knockout approach would be highly informative. Bone marrow-derived macrophages could be isolated from mice with a floxed *Bcl2l1* allele and crossed with a myeloid-specific Cre-driver line (e.g., Lyz2-Cre). These cells, alongside wild-type controls, would be polarized towards an M2 phenotype using IL-4 stimulation. The impact of *Bcl2l1* deletion could be assessed by measuring cell viability via flow cytometry, quantifying the expression of M2 markers (e.g., *Arg1*, *Cd206*) with qPCR and western blot, and evaluating functional outputs such as phagocytic capacity and cytokine secretion profile using ELISA or multiplex assays. **Therapeutic Potential:** As a potent anti-apoptotic protein, [BCL2L1](/details-gene/598) is a well-established and highly attractive therapeutic target for **inhibition**, particularly in oncology. Many cancers overexpress [BCL2L1](/details-gene/598) to evade apoptosis, making its inhibition a promising strategy to re-sensitize tumor cells to chemotherapy or induce cell death directly. The development of small-molecule inhibitors that function as "BH3 mimetics" to block the protective function of Bcl-xL is an active area of drug discovery. Such therapies could have broad applications across various malignancies that demonstrate a dependency on [BCL2L1](/details-gene/598) for survival.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Bcl-2-like protein 1
Q5TE63_HUMAN

Genular Protein ID: 2822370414

Symbol: B2CL1_HUMAN

Name: Bcl-2-like protein 1

UniProtKB Accession Codes:

Q07817 E1P5L6 Q5CZ89 Q5TE65 Q92976

Database IDs:

Citations:

PubMed ID: 8358789

Title: bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death.

PubMed ID: 8358789

DOI: 10.1016/0092-8674(93)90508-n

PubMed ID: 9675101

Title: Identification of a human cDNA encoding a novel Bcl-x isoform.

PubMed ID: 9675101

DOI: 10.1006/bbrc.1998.8907

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7644501

Title: Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.

PubMed ID: 7644501

DOI: 10.1073/pnas.92.17.7834

PubMed ID: 8596636

Title: Bax-independent inhibition of apoptosis by Bcl-XL.

PubMed ID: 8596636

DOI: 10.1038/379554a0

PubMed ID: 9435230

Title: Modulation of cell death by Bcl-xL through caspase interaction.

PubMed ID: 9435230

DOI: 10.1073/pnas.95.2.554

PubMed ID: 10772918

Title: Characterization of Bax-sigma, a cell death-inducing isoform of Bax.

PubMed ID: 10772918

DOI: 10.1006/bbrc.2000.2537

PubMed ID: 11714801

Title: The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis.

PubMed ID: 11714801

DOI: 10.4049/jimmunol.167.11.6366

PubMed ID: 11463391

Title: PUMA induces the rapid apoptosis of colorectal cancer cells.

PubMed ID: 11463391

DOI: 10.1016/s1097-2765(01)00213-1

PubMed ID: 12011449

Title: Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis.

PubMed ID: 12011449

DOI: 10.1073/pnas.102182299

PubMed ID: 17046835

Title: PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex.

PubMed ID: 17046835

DOI: 10.1074/jbc.m606539200

PubMed ID: 16509771

Title: IAN family critically regulates survival and development of T lymphocytes.

PubMed ID: 16509771

DOI: 10.1371/journal.pbio.0040103

PubMed ID: 17418785

Title: Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1.

PubMed ID: 17418785

DOI: 10.1016/j.cell.2007.01.045

PubMed ID: 19917720

Title: Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis.

PubMed ID: 19917720

DOI: 10.1128/mcb.00882-09

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21840391

Title: Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints.

PubMed ID: 21840391

DOI: 10.1016/j.cellsig.2011.07.017

PubMed ID: 22498477

Title: The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death.

PubMed ID: 22498477

DOI: 10.4161/auto.19084

PubMed ID: 21567405

Title: Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain.

PubMed ID: 21567405

DOI: 10.1002/jcp.22836

PubMed ID: 23055042

Title: Human Bop is a novel BH3-only member of the Bcl-2 protein family.

PubMed ID: 23055042

DOI: 10.1007/s13238-012-2069-7

PubMed ID: 23792689

Title: A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis.

PubMed ID: 23792689

DOI: 10.1038/ncb2791

PubMed ID: 25296756

Title: Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop.

PubMed ID: 25296756

DOI: 10.1074/jbc.m114.567792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27013495

Title: The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis.

PubMed ID: 27013495

DOI: 10.15252/embr.201541392

PubMed ID: 29507230

Title: Transmembrane E3 ligase RNF183 mediates ER stress-induced apoptosis by degrading Bcl-xL.

PubMed ID: 29507230

DOI: 10.1073/pnas.1716439115

PubMed ID: 8692274

Title: X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death.

PubMed ID: 8692274

DOI: 10.1038/381335a0

PubMed ID: 9020082

Title: Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis.

PubMed ID: 9020082

DOI: 10.1126/science.275.5302.983

PubMed ID: 11206074

Title: Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies.

PubMed ID: 11206074

DOI: 10.1110/ps.9.12.2528

PubMed ID: 14534311

Title: Bcl-XL mutations suppress cellular sensitivity to antimycin A.

PubMed ID: 14534311

DOI: 10.1074/jbc.m306021200

PubMed ID: 15902208

Title: An inhibitor of Bcl-2 family proteins induces regression of solid tumours.

PubMed ID: 15902208

DOI: 10.1038/nature03579

PubMed ID: 16368107

Title: BCL-XL dimerization by three-dimensional domain swapping.

PubMed ID: 16368107

DOI: 10.1016/j.jmb.2005.11.032

PubMed ID: 17337444

Title: Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein.

PubMed ID: 17337444

DOI: 10.1074/jbc.m700492200

PubMed ID: 17256834

Title: Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.

PubMed ID: 17256834

DOI: 10.1021/jm061152t

PubMed ID: 21639858

Title: Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL.

PubMed ID: 21639858

DOI: 10.1042/bj20110257

PubMed ID: 23340338

Title: PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.

PubMed ID: 23340338

DOI: 10.1038/nchembio.1166

Sequence Information:

Length: 233
Mass: 26049
Checksum: E09D3CDD851AE9BE
Sequence:

MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA INGNPSWHLA 
DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR YRRAFSDLTS QLHITPGTAY 
QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL CVESVDKEMQ VLVSRIAAWM ATYLNDHLEP 
WIQENGGWDT FVELYGNNAA AESRKGQERF NRWFLTGMTV AGVVLLGSLF SRK

Genular Protein ID: 2281429197

Symbol: Q5TE63_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5TE63

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

Length: 170
Mass: 18894
Checksum: 75D1FC01EC06AD47
Sequence:

MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA INGNPSWHLA 
DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR YRRAFSDLTS QLHITPGTAY 
QSFEQDTFVE LYGNNAAAES RKGQERFNRW FLTGMTVAGV VLLGSLFSRK

	Overall overall
	Acute kidney failure MONDO0002492
	Alzheimer disease MONDO0004975
	Amyotrophic lateral sclerosis MONDO0004976
	Basal cell carcinoma MONDO0020804
	Bipolar disorder MONDO0004985
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Breast UBERON0000310
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Choroid plexus UBERON0001886
	Chronic kidney disease MONDO0005300
	Colon UBERON0001155
	Colorectal cancer MONDO0005575
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar disorder UBERON0009834_MONDO0004985
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Fovea centralis UBERON0001786
	\|— Fovea centralis Healthy UBERON0001786_PATO0000461
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Leukoencephalopathy, diffuse hereditary, with spheroids 1 MONDO0800027
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung adenocarcinoma MONDO0005061
	Lymph node UBERON0000029
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neocortex UBERON0001950
	\|— Neocortex Healthy UBERON0001950_PATO0000461
	Neuroblastoma MONDO0005072
	Occipital cortex UBERON0016540
	Parkinson disease MONDO0005180
	Peripheral region of retina UBERON0013682
	\|— Peripheral region of retina Healthy UBERON0013682_PATO0000461
	Placenta UBERON0001987
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Primary motor cortex UBERON0001384
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Sigmoid colon UBERON0001159
	Skin of body UBERON0002097
	Small cell lung carcinoma MONDO0008433
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Upper lobe of left lung UBERON0008952
	Vascular dementia MONDO0004648

Details for: BCL2L1

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. PubMed ID: 8358789

Identification of a human cDNA encoding a novel Bcl-x isoform. PubMed ID: 9675101

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. PubMed ID: 7644501

Bax-independent inhibition of apoptosis by Bcl-XL. PubMed ID: 8596636

Modulation of cell death by Bcl-xL through caspase interaction. PubMed ID: 9435230

Characterization of Bax-sigma, a cell death-inducing isoform of Bax. PubMed ID: 10772918

The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis. PubMed ID: 11714801

PUMA induces the rapid apoptosis of colorectal cancer cells. PubMed ID: 11463391

Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis. PubMed ID: 12011449

PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex. PubMed ID: 17046835

IAN family critically regulates survival and development of T lymphocytes. PubMed ID: 16509771

Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1. PubMed ID: 17418785

Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis. PubMed ID: 19917720

Initial characterization of the human central proteome. PubMed ID: 21269460

Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints. PubMed ID: 21840391

The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death. PubMed ID: 22498477

Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain. PubMed ID: 21567405

Human Bop is a novel BH3-only member of the Bcl-2 protein family. PubMed ID: 23055042

A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. PubMed ID: 23792689

Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop. PubMed ID: 25296756

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis. PubMed ID: 27013495

Transmembrane E3 ligase RNF183 mediates ER stress-induced apoptosis by degrading Bcl-xL. PubMed ID: 29507230

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. PubMed ID: 8692274

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis. PubMed ID: 9020082

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies. PubMed ID: 11206074

Bcl-XL mutations suppress cellular sensitivity to antimycin A. PubMed ID: 14534311

An inhibitor of Bcl-2 family proteins induces regression of solid tumours. PubMed ID: 15902208

BCL-XL dimerization by three-dimensional domain swapping. PubMed ID: 16368107

Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. PubMed ID: 17337444

Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL. PubMed ID: 17256834

Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL. PubMed ID: 21639858

PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. PubMed ID: 23340338

The sequence of the human genome. PubMed ID: 11181995

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. PubMed ID: 26871637