Details for: BCL2L2

Gene ID: 599

Symbol: BCL2L2

Ensembl ID: ENSG00000129473

Description: BCL2 like 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.43
    Marker Score: 837
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.15
    Marker Score: 2710
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.14
    Marker Score: 2314
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.09
    Marker Score: 2073
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.09
    Marker Score: 16981
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.06
    Marker Score: 1287
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.05
    Marker Score: 339
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.01
    Marker Score: 317
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71788
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48012
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.98
    Marker Score: 2223
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.96
    Marker Score: 8236
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 494
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 448
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.95
    Marker Score: 58168
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.93
    Marker Score: 1973
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.92
    Marker Score: 1426
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2730
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5085
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 315
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5272
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.84
    Marker Score: 1704
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 801
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.81
    Marker Score: 678
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.81
    Marker Score: 7660
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.75
    Marker Score: 27529
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 384
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.73
    Marker Score: 2808.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 549.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 288
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.72
    Marker Score: 2464
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.7
    Marker Score: 945
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 625
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2871
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.67
    Marker Score: 6295.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.67
    Marker Score: 25307
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.66
    Marker Score: 977
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.64
    Marker Score: 1567
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.63
    Marker Score: 299
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.63
    Marker Score: 12452
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.61
    Marker Score: 646
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.6
    Marker Score: 449.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.6
    Marker Score: 6147
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.59
    Marker Score: 188
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.59
    Marker Score: 356
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.57
    Marker Score: 8492
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.55
    Marker Score: 576
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 433
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.53
    Marker Score: 4082
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.52
    Marker Score: 925
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.52
    Marker Score: 3395
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.52
    Marker Score: 347
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.51
    Marker Score: 2116
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.51
    Marker Score: 544
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.51
    Marker Score: 4419
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.5
    Marker Score: 249
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.5
    Marker Score: 463
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.5
    Marker Score: 221
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.49
    Marker Score: 311
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.49
    Marker Score: 126
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.48
    Marker Score: 765.5
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.48
    Marker Score: 222
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.46
    Marker Score: 134
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.46
    Marker Score: 241
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.46
    Marker Score: 1220
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.45
    Marker Score: 502
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.45
    Marker Score: 300
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.45
    Marker Score: 285.5
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.45
    Marker Score: 262
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.45
    Marker Score: 285
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.44
    Marker Score: 186
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.44
    Marker Score: 529
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.44
    Marker Score: 2786
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.43
    Marker Score: 189
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.43
    Marker Score: 419
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.43
    Marker Score: 161
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.43
    Marker Score: 9205
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.43
    Marker Score: 97
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.43
    Marker Score: 2095
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.42
    Marker Score: 1773
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.42
    Marker Score: 399
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.4
    Marker Score: 96
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4
    Marker Score: 397
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4
    Marker Score: 13524
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.39
    Marker Score: 748
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.39
    Marker Score: 390
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.39
    Marker Score: 1451
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.39
    Marker Score: 3372
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.39
    Marker Score: 89
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.38
    Marker Score: 219
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.38
    Marker Score: 957
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.38
    Marker Score: 1528
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.37
    Marker Score: 264
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.37
    Marker Score: 427.5
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.37
    Marker Score: 615
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.37
    Marker Score: 149

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Other Information

**Key characteristics:** * BCL2L2 is a protein with a molecular weight of approximately 170 kDa. * It is a transmembrane protein that is expressed in the mitochondria of cells. * It is a key regulator of apoptosis. * It is involved in the regulation of immune responses and inflammation. **Pathways and functions:** * BCL2L2 is involved in the extrinsic apoptotic signaling pathway in the absence of a ligand. * It is also involved in the intrinsic apoptotic signaling pathway in response to DNA damage. * It is involved in the regulation of mitochondrial membrane permeability and release of cytochrome c from mitochondria. * It is involved in the regulation of protein-protein interactions. **Clinical significance:** * Mutations in BCL2L2 have been linked to a number of human diseases, including cancer and autoimmune disorders. * BCL2L2 inhibitors are being investigated as a treatment for cancer and other diseases that are characterized by uncontrolled cell growth. **Additional information:** * BCL2L2 is a conserved protein that is found in mammals. * It is expressed in high levels in cells that are in the process of apoptosis. * It is a key regulator of the immune response to injury or infection.

Genular Protein ID: 2524631309

Symbol: B2CL2_HUMAN

Name: Bcl-2-like protein 2

UniProtKB Accession Codes:

Q92843 A8K0F4 Q2M3U0 Q5U0H4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEMBL 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 10 EPD 1 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 2 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 2 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 2 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 5 PRINTS 2 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 2 UCSC 1 UniProtKB 1 VEuPathDB 2 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8761287

Title: Bcl-w, a novel member of the Bcl-2 family, promotes cell survival.

PubMed ID: 8761287

PubMed ID: 9039502

Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

PubMed ID: 9039502

DOI: 10.1093/dnares/3.5.321

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11423909

Title: Tissue expression and subcellular localization of the pro-survival molecule Bcl-w.

PubMed ID: 11423909

DOI: 10.1038/sj.cdd.4400835

PubMed ID: 12952938

Title: Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity.

PubMed ID: 12952938

DOI: 10.1083/jcb.200302144

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 12660157

Title: The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity.

PubMed ID: 12660157

DOI: 10.1093/emboj/cdg144

PubMed ID: 12651847

Title: Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix.

PubMed ID: 12651847

DOI: 10.1074/jbc.m301798200

Sequence Information:

  • Length: 193
  • Mass: 20746
  • Checksum: 3542243A532B1762
  • Sequence:
    • MATPASAPDT RALVADFVGY KLRQKGYVCG AGPGEGPAAD PLHQAMRAAG DEFETRFRRT 
FSDLAAQLHV TPGSAQQRFT QVSDELFQGG PNWGRLVAFF VFGAALCAES VNKEMEPLVG 
QVQEWMVAYL ETQLADWIHS SGGWAEFTAL YGDGALEEAR RLREGNWASV RTVLTGAVAL 
GALVTVGAFF ASK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.