Details for: BCL2L2

Gene ID: 599

Symbol: BCL2L2

Ensembl ID: ENSG00000129473

Description: BCL2 like 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 95.8564
    Cell Significance Index: -14.9100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 58.5468
    Cell Significance Index: -14.8500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 30.6065
    Cell Significance Index: -14.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.5146
    Cell Significance Index: -15.4300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.3008
    Cell Significance Index: -14.2000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.9204
    Cell Significance Index: -15.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.3467
    Cell Significance Index: 446.6000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.2069
    Cell Significance Index: -4.8300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3699
    Cell Significance Index: 18.6900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1314
    Cell Significance Index: 67.9200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.1041
    Cell Significance Index: 8.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.0261
    Cell Significance Index: 27.5000
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.9803
    Cell Significance Index: 11.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9586
    Cell Significance Index: 104.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7556
    Cell Significance Index: 39.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7475
    Cell Significance Index: 121.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6850
    Cell Significance Index: 137.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.6230
    Cell Significance Index: 179.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5296
    Cell Significance Index: 15.2600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4745
    Cell Significance Index: 7.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4699
    Cell Significance Index: 21.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4670
    Cell Significance Index: 84.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4043
    Cell Significance Index: 27.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4043
    Cell Significance Index: 25.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3840
    Cell Significance Index: 47.2200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.3673
    Cell Significance Index: 3.0900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3409
    Cell Significance Index: 9.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3361
    Cell Significance Index: 120.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2831
    Cell Significance Index: 13.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2772
    Cell Significance Index: 47.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2725
    Cell Significance Index: 246.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.2591
    Cell Significance Index: 161.7700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2231
    Cell Significance Index: 22.0700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1634
    Cell Significance Index: 1.5100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1590
    Cell Significance Index: 8.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1551
    Cell Significance Index: 21.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1203
    Cell Significance Index: 65.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1183
    Cell Significance Index: 2.5200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1082
    Cell Significance Index: 47.8500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1024
    Cell Significance Index: 2.5600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1017
    Cell Significance Index: 5.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0679
    Cell Significance Index: 104.5800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0639
    Cell Significance Index: 86.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0480
    Cell Significance Index: 6.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0446
    Cell Significance Index: 5.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0437
    Cell Significance Index: 8.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0353
    Cell Significance Index: 65.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0332
    Cell Significance Index: 2.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0255
    Cell Significance Index: 1.9000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0207
    Cell Significance Index: 39.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0019
    Cell Significance Index: 0.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0008
    Cell Significance Index: 0.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0005
    Cell Significance Index: -0.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0005
    Cell Significance Index: -0.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0015
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0018
    Cell Significance Index: -1.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0024
    Cell Significance Index: -1.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0040
    Cell Significance Index: -2.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0087
    Cell Significance Index: -0.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0109
    Cell Significance Index: -6.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0183
    Cell Significance Index: -8.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0265
    Cell Significance Index: -0.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0272
    Cell Significance Index: -0.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0292
    Cell Significance Index: -6.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0328
    Cell Significance Index: -3.3500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0390
    Cell Significance Index: -0.8100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0508
    Cell Significance Index: -0.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0515
    Cell Significance Index: -7.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0630
    Cell Significance Index: -7.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0638
    Cell Significance Index: -2.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0659
    Cell Significance Index: -3.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0749
    Cell Significance Index: -8.8300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0861
    Cell Significance Index: -3.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0877
    Cell Significance Index: -1.9200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0976
    Cell Significance Index: -1.3700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1016
    Cell Significance Index: -1.6300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1064
    Cell Significance Index: -12.1500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1255
    Cell Significance Index: -9.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1299
    Cell Significance Index: -13.5300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1317
    Cell Significance Index: -1.5700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1326
    Cell Significance Index: -1.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1413
    Cell Significance Index: -3.9500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1484
    Cell Significance Index: -3.4300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1538
    Cell Significance Index: -2.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1538
    Cell Significance Index: -10.3400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1601
    Cell Significance Index: -3.8400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1670
    Cell Significance Index: -3.2600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1700
    Cell Significance Index: -2.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1719
    Cell Significance Index: -10.5400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2084
    Cell Significance Index: -3.1400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2168
    Cell Significance Index: -5.8000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2212
    Cell Significance Index: -2.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2248
    Cell Significance Index: -7.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2352
    Cell Significance Index: -5.1000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2434
    Cell Significance Index: -3.4900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.2503
    Cell Significance Index: -2.5900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2509
    Cell Significance Index: -3.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2548
    Cell Significance Index: -6.7000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2581
    Cell Significance Index: -3.6200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2612
    Cell Significance Index: -9.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BCL2L2 shares structural and functional similarities with other Bcl-2 family members, including BCL2 and BAX. It contains a BH domain, which is essential for homodimerization and heterodimerization with other Bcl-2 family proteins. BCL2L2 is also characterized by its ability to regulate mitochondrial outer membrane permeability, thereby modulating the release of cytochrome c and the activation of the caspase cascade. This protein exhibits a unique ability to bind to both pro-apoptotic and anti-apoptotic Bcl-2 family members, thereby fine-tuning the apoptotic response. **Pathways and Functions:** BCL2L2 is involved in several key cellular pathways, including: 1. **Apoptotic signaling pathway:** BCL2L2 regulates the intrinsic and extrinsic apoptotic pathways by modulating mitochondrial outer membrane permeability and cytochrome c release. 2. **Cellular response to stress:** BCL2L2 is induced in response to various forms of cellular stress, including DNA damage, oxidative stress, and endoplasmic reticulum stress. 3. **Cell proliferation and differentiation:** BCL2L2 regulates cell proliferation and differentiation in various cell types, including immune cells and lens epithelial cells. 4. **Neurotransmission and neuronal survival:** BCL2L2 is expressed in the nervous system and regulates neurotransmission and neuronal survival by modulating the activity of GABAergic interneurons. **Clinical Significance:** Dysregulation of BCL2L2 has been implicated in various diseases, including: 1. **Cancer:** Overexpression of BCL2L2 has been observed in several types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative diseases:** BCL2L2 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where dysregulation of mitochondrial function and apoptosis contributes to disease progression. 3. **Inflammatory disorders:** BCL2L2 is involved in the regulation of immune responses and has been implicated in inflammatory disorders, such as multiple sclerosis and rheumatoid arthritis. In conclusion, BCL2L2 is a multifunctional protein that plays a critical role in regulating apoptosis, cellular stress response, and other cellular processes. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of BCL2L2 function and its potential as a therapeutic target.

Genular Protein ID: 2524631309

Symbol: B2CL2_HUMAN

Name: Bcl-2-like protein 2

UniProtKB Accession Codes:

Q92843 A8K0F4 Q2M3U0 Q5U0H4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEMBL 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 10 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 2 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 2 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 2 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRINTS 2 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 2 UCSC 1 VEuPathDB 2 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8761287

Title: Bcl-w, a novel member of the Bcl-2 family, promotes cell survival.

PubMed ID: 8761287

PubMed ID: 9039502

Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

PubMed ID: 9039502

DOI: 10.1093/dnares/3.5.321

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11423909

Title: Tissue expression and subcellular localization of the pro-survival molecule Bcl-w.

PubMed ID: 11423909

DOI: 10.1038/sj.cdd.4400835

PubMed ID: 12952938

Title: Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity.

PubMed ID: 12952938

DOI: 10.1083/jcb.200302144

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 12660157

Title: The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity.

PubMed ID: 12660157

DOI: 10.1093/emboj/cdg144

PubMed ID: 12651847

Title: Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix.

PubMed ID: 12651847

DOI: 10.1074/jbc.m301798200

Sequence Information:

  • Length: 193
  • Mass: 20746
  • Checksum: 3542243A532B1762
  • Sequence:
    • MATPASAPDT RALVADFVGY KLRQKGYVCG AGPGEGPAAD PLHQAMRAAG DEFETRFRRT 
FSDLAAQLHV TPGSAQQRFT QVSDELFQGG PNWGRLVAFF VFGAALCAES VNKEMEPLVG 
QVQEWMVAYL ETQLADWIHS SGGWAEFTAL YGDGALEEAR RLREGNWASV RTVLTGAVAL 
GALVTVGAFF ASK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.