ACTB | ENSG00000075624 | NCBI 60

Details for: ACTB

Gene ID: 60

Symbol: ACTB

Ensembl ID: ENSG00000075624

Description: actin beta

Associated with

Adherens junctions interactions
(R-HSA-418990)
Axon guidance
(R-HSA-422475)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Cell-cell communication
(R-HSA-1500931)
Cell-cell junction organization
(R-HSA-421270)
Cell-extracellular matrix interactions
(R-HSA-446353)
Cell junction organization
(R-HSA-446728)
Chaperonin-mediated protein folding
(R-HSA-390466)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Cooperation of prefoldin and tric/cct in actin and tubulin folding
(R-HSA-389958)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Dna damage recognition in gg-ner
(R-HSA-5696394)
Dna repair
(R-HSA-73894)
Eph-ephrin mediated repulsion of cells
(R-HSA-3928665)
Eph-ephrin signaling
(R-HSA-2682334)
Ephb-mediated forward signaling
(R-HSA-3928662)
Epigenetic regulation of gene expression
(R-HSA-212165)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Folding of actin by cct/tric
(R-HSA-390450)
Formation of annular gap junctions
(R-HSA-196025)
Gap junction degradation
(R-HSA-190873)
Gap junction trafficking
(R-HSA-190828)
Gap junction trafficking and regulation
(R-HSA-157858)
Gene expression (transcription)
(R-HSA-74160)
Global genome nucleotide excision repair (gg-ner)
(R-HSA-5696399)
Hats acetylate histones
(R-HSA-3214847)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interaction between l1 and ankyrins
(R-HSA-445095)
L1cam interactions
(R-HSA-373760)
Leishmania infection
(R-HSA-9658195)
Leishmania phagocytosis
(R-HSA-9664417)
Map2k and mapk activation
(R-HSA-5674135)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Nervous system development
(R-HSA-9675108)
Nucleotide excision repair
(R-HSA-5696398)
Oncogenic mapk signaling
(R-HSA-6802957)
Paradoxical activation of raf signaling by kinase inactive braf
(R-HSA-6802955)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prefoldin mediated transfer of substrate to cct/tric
(R-HSA-389957)
Protein folding
(R-HSA-391251)
Raf/map kinase cascade
(R-HSA-5673001)
Recycling pathway of l1
(R-HSA-437239)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Rhof gtpase cycle
(R-HSA-9035034)
Rho gtpase cycle
(R-HSA-9012999)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Rho gtpases activate iqgaps
(R-HSA-5626467)
Rho gtpases activate wasps and waves
(R-HSA-5663213)
Sensory perception
(R-HSA-9709957)
Sensory processing of sound
(R-HSA-9659379)
Sensory processing of sound by inner hair cells of the cochlea
(R-HSA-9662360)
Sensory processing of sound by outer hair cells of the cochlea
(R-HSA-9662361)
Signaling by braf and raf1 fusions
(R-HSA-6802952)
Signaling by high-kinase activity braf mutants
(R-HSA-6802948)
Signaling by moderate kinase activity braf mutants
(R-HSA-6802946)
Signaling by raf1 mutants
(R-HSA-9656223)
Signaling by ras mutants
(R-HSA-6802949)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by vegf
(R-HSA-194138)
Signaling downstream of ras mutants
(R-HSA-9649948)
Signal transduction
(R-HSA-162582)
Translocation of slc2a4 (glut4) to the plasma membrane
(R-HSA-1445148)
Uch proteinases
(R-HSA-5689603)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Vesicle-mediated transport
(R-HSA-5653656)
Atp binding
(GO:0005524)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Kinesin binding
(GO:0019894)
Morphogenesis of a polarized epithelium
(GO:0001738)
Nitric-oxide synthase binding
(GO:0050998)
Nucleosomal dna binding
(GO:0031492)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Structural constituent of cytoskeleton
(GO:0005200)
Structural constituent of postsynaptic actin cytoskeleton
(GO:0098973)
Tat protein binding
(GO:0030957)
Tau protein binding
(GO:0048156)

Other Information

Proteins

Actin, cytoplasmic 1

Genular Protein ID: 2192474367

Symbol: ACTB_HUMAN

Name: Actin, cytoplasmic 1

UniProtKB Accession Codes:

P60709 P02570 P70514 P99021 Q11211 Q64316 Q75MN2 Q96B34 Q96HG5

Database IDs:

Citations:

PubMed ID: 6322116

Title: Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA.

PubMed ID: 6322116

DOI: 10.1093/nar/12.3.1687

PubMed ID: 2994062

Title: Molecular structure of the human cytoplasmic beta-actin gene: interspecies homology of sequences in the introns.

PubMed ID: 2994062

DOI: 10.1073/pnas.82.18.6133

PubMed ID: 1734024

Title: Direct proof that the primary site of action of cytochalasin on cell motility processes is actin.

PubMed ID: 1734024

DOI: 10.1083/jcb.116.4.933

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 6842590

Title: Complementary DNA sequence of a human cytoplasmic actin. Interspecies divergence of 3' non-coding regions.

PubMed ID: 6842590

DOI: 10.1016/0022-2836(83)90117-1

PubMed ID: 11687588

Title: Nuclear DNA helicase II/RNA helicase A binds to filamentous actin.

PubMed ID: 11687588

DOI: 10.1074/jbc.m109393200

PubMed ID: 14592989

Title: Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes.

PubMed ID: 14592989

DOI: 10.1093/emboj/cdg565

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15328537

Title: Emerin caps the pointed end of actin filaments: evidence for an actin cortical network at the nuclear inner membrane.

PubMed ID: 15328537

DOI: 10.1371/journal.pbio.0020231

PubMed ID: 16139798

Title: Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.

PubMed ID: 16139798

DOI: 10.1016/j.bbrc.2005.08.132

PubMed ID: 17823310

Title: HGAL, a lymphoma prognostic biomarker, interacts with the cytoskeleton and mediates the effects of IL-6 on cell migration.

PubMed ID: 17823310

DOI: 10.1182/blood-2007-04-087775

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 18765789

Title: Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex.

PubMed ID: 18765789

DOI: 10.1101/gad.471408

PubMed ID: 19015515

Title: Connecting actin monomers by iso-peptide bond is a toxicity mechanism of the Vibrio cholerae MARTX toxin.

PubMed ID: 19015515

DOI: 10.1073/pnas.0808082105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19377461

Title: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.

PubMed ID: 19377461

DOI: 10.1038/nature07954

PubMed ID: 24336203

Title: Retraction: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.

PubMed ID: 24336203

DOI: 10.1038/nature12896

PubMed ID: 21969592

Title: Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition.

PubMed ID: 21969592

DOI: 10.1073/pnas.1103318108

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 21555369

Title: Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes.

PubMed ID: 21555369

DOI: 10.1158/0008-5472.can-10-3504

PubMed ID: 23673617

Title: ALKBH4-dependent demethylation of actin regulates actomyosin dynamics.

PubMed ID: 23673617

DOI: 10.1038/ncomms2863

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26228148

Title: ACD toxin-produced actin oligomers poison formin-controlled actin polymerization.

PubMed ID: 26228148

DOI: 10.1126/science.aab4090

PubMed ID: 28604741

Title: A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-kappaB degradation and cell growth suppression in neuroblastoma.

PubMed ID: 28604741

DOI: 10.1038/onc.2017.181

PubMed ID: 30028079

Title: NAT6 acetylates the N-terminus of different forms of actin.

PubMed ID: 30028079

DOI: 10.1111/febs.14605

PubMed ID: 29925947

Title: Nuclear ARP2/3 drives DNA break clustering for homology-directed repair.

PubMed ID: 29925947

DOI: 10.1038/s41586-018-0237-5

PubMed ID: 29581253

Title: NAA80 is actin's N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility.

PubMed ID: 29581253

DOI: 10.1073/pnas.1718336115

PubMed ID: 30526847

Title: SETD3 protein is the actin-specific histidine N-methyltransferase.

PubMed ID: 30526847

DOI: 10.7554/elife.37921

PubMed ID: 29343822

Title: The MICALs are a Family of F-actin Dismantling Oxidoreductases Conserved from Drosophila to Humans.

PubMed ID: 29343822

DOI: 10.1038/s41598-017-17943-5

PubMed ID: 36173861

Title: Actin maturation requires the ACTMAP/C19orf54 protease.

PubMed ID: 36173861

DOI: 10.1126/science.abq5082

PubMed ID: 30785395

Title: Structural insights into SETD3-mediated histidine methylation on beta-actin.

PubMed ID: 30785395

DOI: 10.7554/elife.43676

PubMed ID: 30626964

Title: SETD3 is an actin histidine methyltransferase that prevents primary dystocia.

PubMed ID: 30626964

DOI: 10.1038/s41586-018-0821-8

PubMed ID: 31388018

Title: Structural basis for the target specificity of actin histidine methyltransferase SETD3.

PubMed ID: 31388018

DOI: 10.1038/s41467-019-11554-6

PubMed ID: 32503840

Title: Characterization of SETD3 methyltransferase-mediated protein methionine methylation.

PubMed ID: 32503840

DOI: 10.1074/jbc.ra120.014072

PubMed ID: 31911441

Title: An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation.

PubMed ID: 31911441

DOI: 10.1074/jbc.ra119.012319

PubMed ID: 16685646

Title: A mutation of beta -actin that alters depolymerization dynamics is associated with autosomal dominant developmental malformations, deafness, and dystonia.

PubMed ID: 16685646

DOI: 10.1086/504271

PubMed ID: 22366783

Title: De novo mutations in the actin genes ACTB and ACTG1 cause Baraitser-Winter syndrome.

PubMed ID: 22366783

DOI: 10.1038/ng.1091

Sequence Information:

Length: 375
Mass: 41737
Checksum: 6AFD05CA94E360E2
Sequence:

MDDDIAALVV DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK DSYVGDEAQS 
KRGILTLKYP IEHGIVTNWD DMEKIWHHTF YNELRVAPEE HPVLLTEAPL NPKANREKMT 
QIMFETFNTP AMYVAIQAVL SLYASGRTTG IVMDSGDGVT HTVPIYEGYA LPHAILRLDL 
AGRDLTDYLM KILTERGYSF TTTAEREIVR DIKEKLCYVA LDFEQEMATA ASSSSLEKSY 
ELPDGQVITI GNERFRCPEA LFQPSFLGME SCGIHETTFN SIMKCDVDIR KDLYANTVLS 
GGTTMYPGIA DRMQKEITAL APSTMKIKII APPERKYSVW IGGSILASLS TFQQMWISKQ 
EYDESGPSIV HRKCF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ACTB

Associated with

Other Information

Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA. PubMed ID: 6322116

Molecular structure of the human cytoplasmic beta-actin gene: interspecies homology of sequences in the introns. PubMed ID: 2994062

Direct proof that the primary site of action of cytochalasin on cell motility processes is actin. PubMed ID: 1734024

The DNA sequence of human chromosome 7. PubMed ID: 12853948

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

Complementary DNA sequence of a human cytoplasmic actin. Interspecies divergence of 3' non-coding regions. PubMed ID: 6842590

Nuclear DNA helicase II/RNA helicase A binds to filamentous actin. PubMed ID: 11687588

Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes. PubMed ID: 14592989

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Emerin caps the pointed end of actin filaments: evidence for an actin cortical network at the nuclear inner membrane. PubMed ID: 15328537

Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. PubMed ID: 16139798

HGAL, a lymphoma prognostic biomarker, interacts with the cytoskeleton and mediates the effects of IL-6 on cell migration. PubMed ID: 17823310

Molecular composition of IMP1 ribonucleoprotein granules. PubMed ID: 17289661

Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex. PubMed ID: 18765789

Connecting actin monomers by iso-peptide bond is a toxicity mechanism of the Vibrio cholerae MARTX toxin. PubMed ID: 19015515

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. PubMed ID: 19377461

Retraction: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. PubMed ID: 24336203

Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition. PubMed ID: 21969592

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes. PubMed ID: 21555369

ALKBH4-dependent demethylation of actin regulates actomyosin dynamics. PubMed ID: 23673617

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

ACD toxin-produced actin oligomers poison formin-controlled actin polymerization. PubMed ID: 26228148

A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-kappaB degradation and cell growth suppression in neuroblastoma. PubMed ID: 28604741

NAT6 acetylates the N-terminus of different forms of actin. PubMed ID: 30028079

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair. PubMed ID: 29925947

NAA80 is actin's N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility. PubMed ID: 29581253

SETD3 protein is the actin-specific histidine N-methyltransferase. PubMed ID: 30526847

The MICALs are a Family of F-actin Dismantling Oxidoreductases Conserved from Drosophila to Humans. PubMed ID: 29343822

Actin maturation requires the ACTMAP/C19orf54 protease. PubMed ID: 36173861

Structural insights into SETD3-mediated histidine methylation on beta-actin. PubMed ID: 30785395

SETD3 is an actin histidine methyltransferase that prevents primary dystocia. PubMed ID: 30626964

Structural basis for the target specificity of actin histidine methyltransferase SETD3. PubMed ID: 31388018

Characterization of SETD3 methyltransferase-mediated protein methionine methylation. PubMed ID: 32503840

An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation. PubMed ID: 31911441

A mutation of beta -actin that alters depolymerization dynamics is associated with autosomal dominant developmental malformations, deafness, and dystonia. PubMed ID: 16685646

De novo mutations in the actin genes ACTB and ACTG1 cause Baraitser-Winter syndrome. PubMed ID: 22366783