ACTB | ENSG00000075624 | NCBI 60

Details for: ACTB

Gene ID: 60

Symbol: ACTB

Ensembl ID: ENSG00000075624

Description: actin beta

Associated with

Adherens junctions interactions
(R-HSA-418990)
Axon guidance
(R-HSA-422475)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Cell-cell communication
(R-HSA-1500931)
Cell-cell junction organization
(R-HSA-421270)
Cell-extracellular matrix interactions
(R-HSA-446353)
Cell junction organization
(R-HSA-446728)
Chaperonin-mediated protein folding
(R-HSA-390466)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Cooperation of prefoldin and tric/cct in actin and tubulin folding
(R-HSA-389958)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Dna damage recognition in gg-ner
(R-HSA-5696394)
Dna repair
(R-HSA-73894)
Eph-ephrin mediated repulsion of cells
(R-HSA-3928665)
Eph-ephrin signaling
(R-HSA-2682334)
Ephb-mediated forward signaling
(R-HSA-3928662)
Epigenetic regulation of gene expression
(R-HSA-212165)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Folding of actin by cct/tric
(R-HSA-390450)
Formation of annular gap junctions
(R-HSA-196025)
Gap junction degradation
(R-HSA-190873)
Gap junction trafficking
(R-HSA-190828)
Gap junction trafficking and regulation
(R-HSA-157858)
Gene expression (transcription)
(R-HSA-74160)
Global genome nucleotide excision repair (gg-ner)
(R-HSA-5696399)
Hats acetylate histones
(R-HSA-3214847)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interaction between l1 and ankyrins
(R-HSA-445095)
L1cam interactions
(R-HSA-373760)
Leishmania infection
(R-HSA-9658195)
Leishmania phagocytosis
(R-HSA-9664417)
Map2k and mapk activation
(R-HSA-5674135)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Mitf-m-dependent gene expression
(R-HSA-9856651)
Mitf-m-regulated melanocyte development
(R-HSA-9730414)
Nervous system development
(R-HSA-9675108)
Nucleotide excision repair
(R-HSA-5696398)
Oncogenic mapk signaling
(R-HSA-6802957)
Paradoxical activation of raf signaling by kinase inactive braf
(R-HSA-6802955)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prefoldin mediated transfer of substrate to cct/tric
(R-HSA-389957)
Protein folding
(R-HSA-391251)
Raf/map kinase cascade
(R-HSA-5673001)
Recycling pathway of l1
(R-HSA-437239)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of mitf-m-dependent genes involved in pigmentation
(R-HSA-9824585)
Rhof gtpase cycle
(R-HSA-9035034)
Rho gtpase cycle
(R-HSA-9012999)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Rho gtpases activate iqgaps
(R-HSA-5626467)
Rho gtpases activate wasps and waves
(R-HSA-5663213)
Sensory perception
(R-HSA-9709957)
Sensory processing of sound
(R-HSA-9659379)
Sensory processing of sound by inner hair cells of the cochlea
(R-HSA-9662360)
Sensory processing of sound by outer hair cells of the cochlea
(R-HSA-9662361)
Signaling by braf and raf1 fusions
(R-HSA-6802952)
Signaling by high-kinase activity braf mutants
(R-HSA-6802948)
Signaling by moderate kinase activity braf mutants
(R-HSA-6802946)
Signaling by raf1 mutants
(R-HSA-9656223)
Signaling by ras mutants
(R-HSA-6802949)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by vegf
(R-HSA-194138)
Signaling downstream of ras mutants
(R-HSA-9649948)
Signal transduction
(R-HSA-162582)
Translocation of slc2a4 (glut4) to the plasma membrane
(R-HSA-1445148)
Uch proteinases
(R-HSA-5689603)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Vesicle-mediated transport
(R-HSA-5653656)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Identical protein binding
(GO:0042802)
Kinesin binding
(GO:0019894)
Nucleosomal dna binding
(GO:0031492)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Structural constituent of cytoskeleton
(GO:0005200)
Tat protein binding
(GO:0030957)
Tau protein binding
(GO:0048156)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 1812.3989
Cell Significance Index: -281.9100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 1155.5200
Cell Significance Index: -293.0900
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 870.2320
Cell Significance Index: -358.4900
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 814.0411
Cell Significance Index: -330.7100
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 732.0555
Cell Significance Index: -345.6200
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 696.7735
Cell Significance Index: -358.4100
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 518.3286
Cell Significance Index: -347.8100
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 352.0634
Cell Significance Index: -336.1300
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 267.4711
Cell Significance Index: -329.7800
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 97.3415
Cell Significance Index: -298.9800
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 90.4145
Cell Significance Index: -356.7800
Cell Name: mononuclear cell (CL0000842)
Fold Change: 68.4053
Cell Significance Index: 284.7000
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 60.9069
Cell Significance Index: -133.3000
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 23.9505
Cell Significance Index: -64.1600
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 19.0752
Cell Significance Index: 352.5600
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 12.5732
Cell Significance Index: 369.2600
Cell Name: granulosa cell (CL0000501)
Fold Change: 12.5203
Cell Significance Index: 329.2200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 10.8318
Cell Significance Index: 509.0900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 10.7378
Cell Significance Index: 1266.3200
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 10.5268
Cell Significance Index: 28.2000
Cell Name: odontoblast (CL0000060)
Fold Change: 7.9674
Cell Significance Index: 1021.3800
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 7.6898
Cell Significance Index: 160.9600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 7.6338
Cell Significance Index: 1048.3300
Cell Name: lactocyte (CL0002325)
Fold Change: 6.9633
Cell Significance Index: 899.6100
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 6.4035
Cell Significance Index: 477.2500
Cell Name: cell in vitro (CL0001034)
Fold Change: 6.0928
Cell Significance Index: 3327.4500
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 5.9967
Cell Significance Index: 105.9700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 5.9607
Cell Significance Index: 2635.3700
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 5.7702
Cell Significance Index: 157.0600
Cell Name: early pro-B cell (CL0002046)
Fold Change: 5.4894
Cell Significance Index: 354.1500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 5.2078
Cell Significance Index: 640.3500
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 4.8170
Cell Significance Index: 51.1800
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 4.6836
Cell Significance Index: 243.9600
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 4.6760
Cell Significance Index: 842.9300
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 4.5242
Cell Significance Index: 57.9400
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 4.0494
Cell Significance Index: 212.6100
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 4.0272
Cell Significance Index: 284.8200
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 2.7123
Cell Significance Index: 94.2500
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 2.3028
Cell Significance Index: 1743.0500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 2.0374
Cell Significance Index: 586.2200
Cell Name: colon goblet cell (CL0009039)
Fold Change: 2.0358
Cell Significance Index: 201.3900
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.5774
Cell Significance Index: 17.9200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.4434
Cell Significance Index: 67.3000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.3821
Cell Significance Index: 277.2400
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.3583
Cell Significance Index: 269.5500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.0232
Cell Significance Index: 27.3200
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.8665
Cell Significance Index: 9.4200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.7069
Cell Significance Index: 120.7100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.6957
Cell Significance Index: 1309.8300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4362
Cell Significance Index: 83.0100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3829
Cell Significance Index: 137.3500
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.3693
Cell Significance Index: 42.1500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.2638
Cell Significance Index: 193.4000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1577
Cell Significance Index: 2.6400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0341
Cell Significance Index: 15.4800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0400
Cell Significance Index: -4.0900
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1876
Cell Significance Index: -138.9800
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.1943
Cell Significance Index: -358.4000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.2068
Cell Significance Index: -318.4100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.2634
Cell Significance Index: -358.1400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.3297
Cell Significance Index: -205.8900
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.3913
Cell Significance Index: -248.5200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.4618
Cell Significance Index: -35.4400
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.4929
Cell Significance Index: -278.0000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.8623
Cell Significance Index: -181.6300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -1.2210
Cell Significance Index: -35.0000
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.4669
Cell Significance Index: -90.1600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -1.8454
Cell Significance Index: -95.8700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -1.8456
Cell Significance Index: -300.1700
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -1.9471
Cell Significance Index: -283.0400
Cell Name: pro-T cell (CL0000827)
Fold Change: -2.0003
Cell Significance Index: -51.1000
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -2.0671
Cell Significance Index: -236.8200
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -2.0727
Cell Significance Index: -241.5500
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -2.1669
Cell Significance Index: -235.6900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -2.2321
Cell Significance Index: -232.4200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -2.5910
Cell Significance Index: -72.4100
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -2.8232
Cell Significance Index: -24.2600
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -2.9835
Cell Significance Index: -200.6100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -3.0134
Cell Significance Index: -238.6600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -3.0852
Cell Significance Index: -173.1300
Cell Name: peg cell (CL4033014)
Fold Change: -3.1913
Cell Significance Index: -73.7300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -3.3939
Cell Significance Index: -153.8400
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -3.8913
Cell Significance Index: -104.0900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -3.9761
Cell Significance Index: -127.3500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -4.0504
Cell Significance Index: -87.7500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -4.4077
Cell Significance Index: -154.8800
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -4.4191
Cell Significance Index: -75.7300
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -4.7503
Cell Significance Index: -81.8900
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -5.2268
Cell Significance Index: -329.4300
Cell Name: kidney cell (CL1000497)
Fold Change: -5.5184
Cell Significance Index: -44.0600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -5.5403
Cell Significance Index: -75.5900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -5.6650
Cell Significance Index: -347.3200
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -5.9096
Cell Significance Index: -88.5500
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -6.5284
Cell Significance Index: -186.3000
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -6.8038
Cell Significance Index: -105.2700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -6.8721
Cell Significance Index: -303.9700
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -6.9296
Cell Significance Index: -204.1100
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -6.9621
Cell Significance Index: -58.4800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -6.9918
Cell Significance Index: -174.7800
Cell Name: theca cell (CL0000503)
Fold Change: -7.0000
Cell Significance Index: -41.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** Actin Beta is a beta-actin isoform that is characterized by its high expression levels in cells, particularly in the cytoplasm. It is a monomeric actin protein that is involved in various cellular processes, including: 1. **Cytoskeletal dynamics**: Actin Beta is a key component of the cytoskeleton, which provides structural support, shape, and mechanical stability to cells. 2. **Cell signaling**: Actin Beta is involved in signaling pathways that regulate cell growth, differentiation, and migration. 3. **Cell-cell interactions**: Actin Beta plays a crucial role in cell-cell interactions, including adhesion, migration, and wound healing. 4. **Protein binding**: Actin Beta interacts with various proteins, including myosin, tropomyosin, and actin-associated proteins, to regulate cytoskeletal dynamics. **Pathways and Functions** Actin Beta is involved in various signaling pathways and cellular processes, including: 1. **Adherens junction interactions**: Actin Beta is involved in the formation and maintenance of adherens junctions, which are critical for cell-cell adhesion and tissue integrity. 2. **Axon guidance**: Actin Beta is involved in axon guidance and neuronal development, particularly in the formation of axons and synapses. 3. **Cell-extracellular matrix interactions**: Actin Beta interacts with extracellular matrix proteins to regulate cell migration, adhesion, and proliferation. 4. **Chaperonin-mediated protein folding**: Actin Beta is involved in the folding and assembly of actin filaments, which is essential for cytoskeletal dynamics. 5. **Rho GTPase cycle**: Actin Beta is involved in the Rho GTPase cycle, which regulates cytoskeletal dynamics, cell migration, and cell proliferation. **Clinical Significance** Dysregulation of Actin Beta has been implicated in various diseases, including: 1. **Cancer**: Alterations in Actin Beta expression and function have been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Neurological disorders**: Actin Beta mutations have been associated with neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular disease**: Actin Beta dysregulation has been implicated in cardiovascular disease, including hypertension and atherosclerosis. 4. **Infectious diseases**: Actin Beta is involved in the pathogenesis of infectious diseases, including Leishmania infection and parasitic infections. In conclusion, Actin Beta is a multifunctional protein that plays a critical role in various cellular processes, including cytoskeletal dynamics, cell signaling, and cell-cell interactions. Its dysregulation has been implicated in various diseases, making it an important target for therapeutic interventions.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Actin, cytoplasmic 1

Genular Protein ID: 2192474367

Symbol: ACTB_HUMAN

Name: Actin, cytoplasmic 1

UniProtKB Accession Codes:

P60709 P02570 P70514 P99021 Q11211 Q64316 Q75MN2 Q96B34 Q96HG5

Database IDs:

Citations:

PubMed ID: 6322116

Title: Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA.

PubMed ID: 6322116

DOI: 10.1093/nar/12.3.1687

PubMed ID: 2994062

Title: Molecular structure of the human cytoplasmic beta-actin gene: interspecies homology of sequences in the introns.

PubMed ID: 2994062

DOI: 10.1073/pnas.82.18.6133

PubMed ID: 1734024

Title: Direct proof that the primary site of action of cytochalasin on cell motility processes is actin.

PubMed ID: 1734024

DOI: 10.1083/jcb.116.4.933

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 6842590

Title: Complementary DNA sequence of a human cytoplasmic actin. Interspecies divergence of 3' non-coding regions.

PubMed ID: 6842590

DOI: 10.1016/0022-2836(83)90117-1

PubMed ID: 11687588

Title: Nuclear DNA helicase II/RNA helicase A binds to filamentous actin.

PubMed ID: 11687588

DOI: 10.1074/jbc.m109393200

PubMed ID: 14592989

Title: Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes.

PubMed ID: 14592989

DOI: 10.1093/emboj/cdg565

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15328537

Title: Emerin caps the pointed end of actin filaments: evidence for an actin cortical network at the nuclear inner membrane.

PubMed ID: 15328537

DOI: 10.1371/journal.pbio.0020231

PubMed ID: 16139798

Title: Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.

PubMed ID: 16139798

DOI: 10.1016/j.bbrc.2005.08.132

PubMed ID: 17823310

Title: HGAL, a lymphoma prognostic biomarker, interacts with the cytoskeleton and mediates the effects of IL-6 on cell migration.

PubMed ID: 17823310

DOI: 10.1182/blood-2007-04-087775

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 18765789

Title: Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex.

PubMed ID: 18765789

DOI: 10.1101/gad.471408

PubMed ID: 19015515

Title: Connecting actin monomers by iso-peptide bond is a toxicity mechanism of the Vibrio cholerae MARTX toxin.

PubMed ID: 19015515

DOI: 10.1073/pnas.0808082105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19377461

Title: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.

PubMed ID: 19377461

DOI: 10.1038/nature07954

PubMed ID: 24336203

Title: Retraction: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.

PubMed ID: 24336203

DOI: 10.1038/nature12896

PubMed ID: 21969592

Title: Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition.

PubMed ID: 21969592

DOI: 10.1073/pnas.1103318108

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 21555369

Title: Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes.

PubMed ID: 21555369

DOI: 10.1158/0008-5472.can-10-3504

PubMed ID: 23673617

Title: ALKBH4-dependent demethylation of actin regulates actomyosin dynamics.

PubMed ID: 23673617

DOI: 10.1038/ncomms2863

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26228148

Title: ACD toxin-produced actin oligomers poison formin-controlled actin polymerization.

PubMed ID: 26228148

DOI: 10.1126/science.aab4090

PubMed ID: 28604741

Title: A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-kappaB degradation and cell growth suppression in neuroblastoma.

PubMed ID: 28604741

DOI: 10.1038/onc.2017.181

PubMed ID: 30028079

Title: NAT6 acetylates the N-terminus of different forms of actin.

PubMed ID: 30028079

DOI: 10.1111/febs.14605

PubMed ID: 29925947

Title: Nuclear ARP2/3 drives DNA break clustering for homology-directed repair.

PubMed ID: 29925947

DOI: 10.1038/s41586-018-0237-5

PubMed ID: 29581253

Title: NAA80 is actin's N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility.

PubMed ID: 29581253

DOI: 10.1073/pnas.1718336115

PubMed ID: 30526847

Title: SETD3 protein is the actin-specific histidine N-methyltransferase.

PubMed ID: 30526847

DOI: 10.7554/elife.37921

PubMed ID: 29343822

Title: The MICALs are a Family of F-actin Dismantling Oxidoreductases Conserved from Drosophila to Humans.

PubMed ID: 29343822

DOI: 10.1038/s41598-017-17943-5

PubMed ID: 36173861

Title: Actin maturation requires the ACTMAP/C19orf54 protease.

PubMed ID: 36173861

DOI: 10.1126/science.abq5082

PubMed ID: 30785395

Title: Structural insights into SETD3-mediated histidine methylation on beta-actin.

PubMed ID: 30785395

DOI: 10.7554/elife.43676

PubMed ID: 30626964

Title: SETD3 is an actin histidine methyltransferase that prevents primary dystocia.

PubMed ID: 30626964

DOI: 10.1038/s41586-018-0821-8

PubMed ID: 31388018

Title: Structural basis for the target specificity of actin histidine methyltransferase SETD3.

PubMed ID: 31388018

DOI: 10.1038/s41467-019-11554-6

PubMed ID: 32503840

Title: Characterization of SETD3 methyltransferase-mediated protein methionine methylation.

PubMed ID: 32503840

DOI: 10.1074/jbc.ra120.014072

PubMed ID: 31911441

Title: An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation.

PubMed ID: 31911441

DOI: 10.1074/jbc.ra119.012319

PubMed ID: 10411937

Title: A heterozygous mutation of beta-actin associated with neutrophil dysfunction and recurrent infection.

PubMed ID: 10411937

DOI: 10.1073/pnas.96.15.8693

PubMed ID: 16685646

Title: A mutation of beta -actin that alters depolymerization dynamics is associated with autosomal dominant developmental malformations, deafness, and dystonia.

PubMed ID: 16685646

DOI: 10.1086/504271

PubMed ID: 22366783

Title: De novo mutations in the actin genes ACTB and ACTG1 cause Baraitser-Winter syndrome.

PubMed ID: 22366783

DOI: 10.1038/ng.1091

PubMed ID: 25255767

Title: Molecular mechanisms of disease-related human beta-actin mutations p.R183W and p.E364K.

PubMed ID: 25255767

DOI: 10.1111/febs.13068

PubMed ID: 28487785

Title: Pathogenic Variant in ACTB, p.Arg183Trp, Causes Juvenile-Onset Dystonia, Hearing Loss, and Developmental Delay without Midline Malformation.

PubMed ID: 28487785

DOI: 10.1155/2017/9184265

PubMed ID: 28347698

Title: Postzygotic Mutations in Beta-Actin Are Associated with Becker's Nevus and Becker's Nevus Syndrome.

PubMed ID: 28347698

DOI: 10.1016/j.jid.2017.03.017

PubMed ID: 29788902

Title: Dystonia-deafness syndrome caused by ACTB p.Arg183Trp heterozygosity shows striatal dopaminergic dysfunction and response to pallidal stimulation.

PubMed ID: 29788902

DOI: 10.1186/s11689-018-9235-z

PubMed ID: 30315159

Title: Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia.

PubMed ID: 30315159

DOI: 10.1038/s41467-018-06713-0

PubMed ID: 30451859

Title:

PubMed ID: 30451859

DOI: 10.1038/s41467-018-07404-6

PubMed ID: 30733661

Title: Could Dissimilar Phenotypic Effects of ACTB Missense Mutations Reflect the Actin Conformational Change? Two Novel Mutations and Literature Review.

PubMed ID: 30733661

DOI: 10.1159/000492267

PubMed ID: 32170967

Title: Post-zygotic ACTB mutations underlie congenital smooth muscle hamartomas.

PubMed ID: 32170967

DOI: 10.1111/cup.13683

PubMed ID: 35005077

Title: Dystonia-Deafness Syndrome: ACTB Pathogenic Variant in an Argentinean Family.

PubMed ID: 35005077

DOI: 10.1002/mdc3.13358

Sequence Information:

Length: 375
Mass: 41737
Checksum: 6AFD05CA94E360E2
Sequence:

MDDDIAALVV DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK DSYVGDEAQS 
KRGILTLKYP IEHGIVTNWD DMEKIWHHTF YNELRVAPEE HPVLLTEAPL NPKANREKMT 
QIMFETFNTP AMYVAIQAVL SLYASGRTTG IVMDSGDGVT HTVPIYEGYA LPHAILRLDL 
AGRDLTDYLM KILTERGYSF TTTAEREIVR DIKEKLCYVA LDFEQEMATA ASSSSLEKSY 
ELPDGQVITI GNERFRCPEA LFQPSFLGME SCGIHETTFN SIMKCDVDIR KDLYANTVLS 
GGTTMYPGIA DRMQKEITAL APSTMKIKII APPERKYSVW IGGSILASLS TFQQMWISKQ 
EYDESGPSIV HRKCF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ACTB

Associated with

Cells (max top 100)

Other Information

Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA. PubMed ID: 6322116

Molecular structure of the human cytoplasmic beta-actin gene: interspecies homology of sequences in the introns. PubMed ID: 2994062

Direct proof that the primary site of action of cytochalasin on cell motility processes is actin. PubMed ID: 1734024

The DNA sequence of human chromosome 7. PubMed ID: 12853948

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

Complementary DNA sequence of a human cytoplasmic actin. Interspecies divergence of 3' non-coding regions. PubMed ID: 6842590

Nuclear DNA helicase II/RNA helicase A binds to filamentous actin. PubMed ID: 11687588

Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes. PubMed ID: 14592989

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Emerin caps the pointed end of actin filaments: evidence for an actin cortical network at the nuclear inner membrane. PubMed ID: 15328537

Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. PubMed ID: 16139798

HGAL, a lymphoma prognostic biomarker, interacts with the cytoskeleton and mediates the effects of IL-6 on cell migration. PubMed ID: 17823310

Molecular composition of IMP1 ribonucleoprotein granules. PubMed ID: 17289661

Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex. PubMed ID: 18765789

Connecting actin monomers by iso-peptide bond is a toxicity mechanism of the Vibrio cholerae MARTX toxin. PubMed ID: 19015515

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. PubMed ID: 19377461

Retraction: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. PubMed ID: 24336203

Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition. PubMed ID: 21969592

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes. PubMed ID: 21555369

ALKBH4-dependent demethylation of actin regulates actomyosin dynamics. PubMed ID: 23673617

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

ACD toxin-produced actin oligomers poison formin-controlled actin polymerization. PubMed ID: 26228148

A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-kappaB degradation and cell growth suppression in neuroblastoma. PubMed ID: 28604741

NAT6 acetylates the N-terminus of different forms of actin. PubMed ID: 30028079

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair. PubMed ID: 29925947

NAA80 is actin's N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility. PubMed ID: 29581253

SETD3 protein is the actin-specific histidine N-methyltransferase. PubMed ID: 30526847

The MICALs are a Family of F-actin Dismantling Oxidoreductases Conserved from Drosophila to Humans. PubMed ID: 29343822

Actin maturation requires the ACTMAP/C19orf54 protease. PubMed ID: 36173861

Structural insights into SETD3-mediated histidine methylation on beta-actin. PubMed ID: 30785395

SETD3 is an actin histidine methyltransferase that prevents primary dystocia. PubMed ID: 30626964

Structural basis for the target specificity of actin histidine methyltransferase SETD3. PubMed ID: 31388018

Characterization of SETD3 methyltransferase-mediated protein methionine methylation. PubMed ID: 32503840

An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation. PubMed ID: 31911441

A heterozygous mutation of beta-actin associated with neutrophil dysfunction and recurrent infection. PubMed ID: 10411937

A mutation of beta -actin that alters depolymerization dynamics is associated with autosomal dominant developmental malformations, deafness, and dystonia. PubMed ID: 16685646

De novo mutations in the actin genes ACTB and ACTG1 cause Baraitser-Winter syndrome. PubMed ID: 22366783

Molecular mechanisms of disease-related human beta-actin mutations p.R183W and p.E364K. PubMed ID: 25255767

Pathogenic Variant in ACTB, p.Arg183Trp, Causes Juvenile-Onset Dystonia, Hearing Loss, and Developmental Delay without Midline Malformation. PubMed ID: 28487785

Postzygotic Mutations in Beta-Actin Are Associated with Becker's Nevus and Becker's Nevus Syndrome. PubMed ID: 28347698

Dystonia-deafness syndrome caused by ACTB p.Arg183Trp heterozygosity shows striatal dopaminergic dysfunction and response to pallidal stimulation. PubMed ID: 29788902

Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia. PubMed ID: 30315159