Details for: BCL3
Gene ID: 602
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: BCL3
Ensembl ID: ENSG00000069399
Description: BCL3 transcription coactivator
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 16.9rCSI 24.72%PRS 35.81
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CSI 12.64rCSI 9.39%PRS 45.94
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CSI 12.25rCSI 18.82%PRS 39.45
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CSI 11.86rCSI 9.59%PRS 33.9
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CSI 11.2rCSI 17.69%PRS 34.25
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CSI 8.9rCSI 11.66%PRS 45.68
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CSI 8.65rCSI 12.47%PRS 47.41
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CSI 8.09rCSI 7.03%PRS 41.55
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CSI 7.88rCSI 25.56%PRS 37.52
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CSI 7.84rCSI 12.52%PRS 36.55
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CSI 7.32rCSI 11.19%PRS 41.9
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CSI 6.95rCSI 38.87%PRS 48.46
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CSI 6.91rCSI 18.24%PRS 39.66
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CSI 5.94rCSI 11.32%PRS 49.75
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CSI 5.6rCSI 5.29%PRS 34.72
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CSI 5.6rCSI 22.58%PRS 32.58
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CSI 5.08rCSI 6.29%PRS 30.02
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CSI 4.6rCSI 13.31%PRS 55.03
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CSI 3.86rCSI 2.92%PRS 44.48
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CSI 3.62rCSI 5.53%PRS 51.13
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CSI 3.46rCSI 4.71%PRS 46.21
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CSI 3.43rCSI 7.54%PRS 37.35
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CSI 3.25rCSI 4.76%PRS 43.14
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CSI 3.05rCSI 3.2%PRS 31.39
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CSI 2.83rCSI 2.34%PRS 32.09
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CSI 2.71rCSI 4.14%PRS 33.89
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CSI 2.62rCSI 2.27%PRS 37.07
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CSI 2.56rCSI 2.04%PRS 54.29
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CSI 2.45rCSI 5.61%PRS 33.15
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CSI 2.37rCSI 5.56%PRS 44.03
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CSI 2.28rCSI 3.16%PRS 40.39
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CSI 2.26rCSI 1.99%PRS 38.15
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CSI 2.24rCSI 2.34%PRS 34.25
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CSI 2.24rCSI 2.81%PRS 46.71
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CSI 2.17rCSI 4.63%PRS 48.42
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CSI 2.16rCSI 5.13%PRS 39.29
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CSI 2.16rCSI 2.95%PRS 37.55
-
CSI 2.15rCSI 4.29%PRS 51.14
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CSI 2.15rCSI 1.67%PRS 33.23
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CSI 2.13rCSI 2.05%PRS 25.89
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CSI 2.12rCSI 1.6%PRS 36.13
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CSI 2.11rCSI 5.05%PRS 51.25
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CSI 2.08rCSI 1.93%PRS 33.43
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CSI 2rCSI 3.64%PRS 48.78
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CSI 1.97rCSI 1.6%PRS 34.52
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CSI 1.91rCSI 4.18%PRS 43
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CSI 1.84rCSI 1.83%PRS 28.92
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CSI 1.83rCSI 1.62%PRS 33.2
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CSI 1.8rCSI 1.58%PRS 42.74
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CSI 1.8rCSI 2.19%PRS 40.56
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CSI 1.78rCSI 1.49%PRS 38.41
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CSI 1.75rCSI 2.05%PRS 46.7
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CSI 1.72rCSI 6.7%PRS 43.38
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CSI 1.72rCSI 1.2%PRS 35.27
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CSI 1.71rCSI 1.28%PRS 47.68
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CSI 1.7rCSI 3.04%PRS 49.51
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CSI 1.7rCSI 4.06%PRS 45.35
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CSI 1.66rCSI 1.72%PRS 38.95
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CSI 1.65rCSI 1.51%PRS 39.61
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CSI 1.64rCSI 2.04%PRS 44.47
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CSI 1.63rCSI 2.38%PRS 35.19
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CSI 1.6rCSI 1.85%PRS 25.54
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CSI 1.59rCSI 3.29%PRS 32.75
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CSI 1.54rCSI 3.82%PRS 31.88
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CSI 1.53rCSI 2.34%PRS 49.8
-
CSI 1.53rCSI 2.19%PRS 41.46
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CSI 1.51rCSI 2.06%PRS 18.19
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CSI 1.5rCSI 1.99%PRS 37.12
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CSI 1.48rCSI 1.85%PRS 35.92
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CSI 1.46rCSI 1.26%PRS 43.74
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CSI 1.45rCSI 2.34%PRS 44.2
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CSI 1.44rCSI 1.93%PRS 55.8
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CSI 1.42rCSI 3.73%PRS 56.69
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CSI 1.42rCSI 1.71%PRS 39.99
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CSI 1.41rCSI 9.7%PRS 54.1
-
CSI 1.36rCSI 1.71%PRS 42.19
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CSI 1.35rCSI 1.45%PRS 31.49
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CSI 1.35rCSI 1.57%PRS 44.34
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CSI 1.3rCSI 2.34%PRS 31.91
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CSI 1.3rCSI 1.25%PRS 34.46
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CSI 1.28rCSI 3.82%PRS 58.52
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CSI 1.25rCSI 3.26%PRS 44.41
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CSI 1.25rCSI 1.32%PRS 49.44
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CSI 1.24rCSI 1.58%PRS 38.04
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CSI 1.23rCSI 2.68%PRS 54.42
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CSI 1.19rCSI 1.73%PRS 48.42
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CSI 1.16rCSI 3.13%PRS 42.15
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CSI 1.16rCSI 2.05%PRS 41.77
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CSI 1.07rCSI 2.4%PRS 39.03
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CSI 1.07rCSI 1.82%PRS 54.69
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CSI 1.06rCSI 4.22%PRS 56.44
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CSI 1.04rCSI 1.57%PRS 34.76
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CSI 0.99rCSI 5.58%PRS 69.15
-
CSI 0.99rCSI 1.4%PRS 43.41
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CSI 0.95rCSI 1.15%PRS 34.35
-
CSI 0.89rCSI 1.53%PRS 42.62
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CSI 0.86rCSI 1.67%PRS 34.94
-
CSI 0.86rCSI 4.6%PRS 50.15
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CSI 0.79rCSI 2.22%PRS 48.25
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CSI 0.76rCSI 5.59%PRS 63.63
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CSI 0.3rCSI 1.1%PRS 51.3%
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CSI 0.3rCSI 0.7%PRS 42.2%
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CSI 0.4rCSI 3.0%PRS 62.6%
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CSI 0.6rCSI 2.0%PRS 45.2%
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CSI 0.6rCSI 1.8%PRS 36.5%
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CSI 0.6rCSI 3.3%PRS 44.7%
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CSI 0.6rCSI 2.2%PRS 50.0%
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CSI 0.7rCSI 2.0%PRS 51.6%
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CSI 0.7rCSI 3.5%PRS 43.0%
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CSI 0.7rCSI 2.6%PRS 47.8%
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CSI 0.8rCSI 5.6%PRS 63.6%
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CSI 0.8rCSI 2.2%PRS 48.3%
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CSI 0.9rCSI 4.6%PRS 50.2%
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CSI 0.9rCSI 1.7%PRS 34.9%
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CSI 0.9rCSI 1.5%PRS 42.6%
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CSI 1.0rCSI 1.2%PRS 34.4%
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CSI 1.0rCSI 1.4%PRS 43.4%
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CSI 1.0rCSI 5.6%PRS 69.2%
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CSI 1.0rCSI 1.6%PRS 34.8%
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CSI 1.1rCSI 4.2%PRS 56.4%
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CSI 1.1rCSI 1.8%PRS 54.7%
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CSI 1.1rCSI 2.4%PRS 39.0%
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CSI 1.2rCSI 2.1%PRS 41.8%
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CSI 1.2rCSI 3.1%PRS 42.2%
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CSI 1.2rCSI 1.7%PRS 48.4%
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CSI 1.2rCSI 2.7%PRS 54.4%
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CSI 1.2rCSI 1.6%PRS 38.0%
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CSI 1.3rCSI 1.3%PRS 49.4%
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CSI 1.3rCSI 3.3%PRS 44.4%
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CSI 1.3rCSI 3.8%PRS 58.5%
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CSI 1.3rCSI 1.3%PRS 34.5%
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CSI 1.3rCSI 2.3%PRS 31.9%
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CSI 1.4rCSI 1.6%PRS 44.3%
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CSI 1.4rCSI 1.5%PRS 31.5%
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CSI 1.4rCSI 1.7%PRS 42.2%
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CSI 1.4rCSI 9.7%PRS 54.1%
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CSI 1.4rCSI 1.7%PRS 40.0%
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CSI 1.4rCSI 3.7%PRS 56.7%
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CSI 1.4rCSI 1.9%PRS 55.8%
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CSI 1.5rCSI 2.3%PRS 44.2%
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CSI 1.5rCSI 1.3%PRS 43.7%
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CSI 1.5rCSI 1.9%PRS 35.9%
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CSI 1.5rCSI 2.0%PRS 37.1%
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CSI 1.5rCSI 2.1%PRS 18.2%
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CSI 1.5rCSI 2.2%PRS 41.5%
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CSI 1.5rCSI 2.3%PRS 49.8%
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CSI 1.5rCSI 3.8%PRS 31.9%
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CSI 1.6rCSI 3.3%PRS 32.8%
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CSI 1.6rCSI 1.9%PRS 25.5%
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CSI 1.6rCSI 2.4%PRS 35.2%
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CSI 1.6rCSI 2.0%PRS 44.5%
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CSI 1.7rCSI 1.5%PRS 39.6%
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CSI 1.7rCSI 1.7%PRS 39.0%
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CSI 1.7rCSI 4.1%PRS 45.4%
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CSI 1.7rCSI 3.0%PRS 49.5%
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CSI 1.7rCSI 1.3%PRS 47.7%
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CSI 1.7rCSI 1.2%PRS 35.3%
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CSI 1.7rCSI 6.7%PRS 43.4%
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CSI 1.8rCSI 2.1%PRS 46.7%
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CSI 1.8rCSI 1.5%PRS 38.4%
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CSI 1.8rCSI 2.2%PRS 40.6%
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CSI 1.8rCSI 1.6%PRS 42.7%
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CSI 1.8rCSI 1.6%PRS 33.2%
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CSI 1.8rCSI 1.8%PRS 28.9%
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CSI 1.9rCSI 4.2%PRS 43.0%
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CSI 2.0rCSI 1.6%PRS 34.5%
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CSI 2.0rCSI 3.6%PRS 48.8%
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CSI 2.1rCSI 1.9%PRS 33.4%
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CSI 2.1rCSI 5.1%PRS 51.3%
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CSI 2.1rCSI 1.6%PRS 36.1%
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CSI 2.1rCSI 2.1%PRS 25.9%
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CSI 2.2rCSI 1.7%PRS 33.2%
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CSI 2.2rCSI 4.3%PRS 51.1%
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CSI 2.2rCSI 3.0%PRS 37.6%
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CSI 2.2rCSI 5.1%PRS 39.3%
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CSI 2.2rCSI 4.6%PRS 48.4%
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CSI 2.2rCSI 2.8%PRS 46.7%
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CSI 2.2rCSI 2.3%PRS 34.3%
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CSI 2.3rCSI 2.0%PRS 38.2%
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CSI 2.3rCSI 3.2%PRS 40.4%
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CSI 2.4rCSI 5.6%PRS 44.0%
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CSI 2.5rCSI 5.6%PRS 33.2%
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CSI 2.6rCSI 2.0%PRS 54.3%
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CSI 2.6rCSI 2.3%PRS 37.1%
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CSI 2.7rCSI 4.1%PRS 33.9%
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CSI 2.8rCSI 2.3%PRS 32.1%
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CSI 3.1rCSI 3.2%PRS 31.4%
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CSI 3.3rCSI 4.8%PRS 43.1%
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CSI 3.4rCSI 7.5%PRS 37.4%
-
CSI 3.5rCSI 4.7%PRS 46.2%
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CSI 3.6rCSI 5.5%PRS 51.1%
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CSI 3.9rCSI 2.9%PRS 44.5%
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CSI 4.6rCSI 13.3%PRS 55.0%
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CSI 5.1rCSI 6.3%PRS 30.0%
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CSI 5.6rCSI 22.6%PRS 32.6%
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CSI 5.6rCSI 5.3%PRS 34.7%
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CSI 5.9rCSI 11.3%PRS 49.8%
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CSI 6.9rCSI 18.2%PRS 39.7%
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CSI 7.0rCSI 38.9%PRS 48.5%
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CSI 7.3rCSI 11.2%PRS 41.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 961947900
Symbol: BCL3_HUMAN
Name: B-cell lymphoma 3 protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2180580
Title: The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control.
PubMed ID: 2180580
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7896265
Title: Genomic structure of the candidate proto-oncogene BCL3.
PubMed ID: 7896265
PubMed ID: 8453667
Title: The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers.
PubMed ID: 8453667
PubMed ID: 10469655
Title: NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes.
PubMed ID: 10469655
PubMed ID: 10362352
Title: The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators.
PubMed ID: 10362352
PubMed ID: 12730195
Title: Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination.
PubMed ID: 12730195
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 11707390
Title: Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family.
PubMed ID: 11707390
PubMed ID: 15469820
Title: GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity.
PubMed ID: 15469820
Sequence Information:
- Length: 454
- Mass: 47584
- Checksum: 385F5320DB72C0E0
- Sequence:
MPRCPAGAMD EGPVDLRTRP KAAGLPGAAL PLRKRPLRAP SPEPAAPRGA AGLVVPLDPL RGGCDLPAVP GPPHGLARPE ALYYPGALLP LYPTRAMGSP FPLVNLPTPL YPMMCPMEHP LSADIAMATR ADEDGDTPLH IAVVQGNLPA VHRLVNLFQQ GGRELDIYNN LRQTPLHLAV ITTLPSVVRL LVTAGASPMA LDRHGQTAAH LACEHRSPTC LRALLDSAAP GTLDLEARNY DGLTALHVAV NTECQETVQL LLERGADIDA VDIKSGRSPL IHAVENNSLS MVQLLLQHGA NVNAQMYSGS SALHSASGRG LLPLVRTLVR SGADSSLKNC HNDTPLMVAR SRRVIDILRG KATRPASTSQ PDPSPDRSAN TSPESSSRLS SNGLLSASPS SSPSQSPPRD PPGFPMAPPN FFLPSPSPPA FLPFAGVLRG PGRPVPPSPA PGGS
Genular Protein ID: 84958022
Symbol: B7Z3N9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 356
- Mass: 38515
- Checksum: 89BE4A384BF065AD
- Sequence:
MEEGRERNRS WPPAECQSLP RVRLFTPTKE ETAQRGEVFG QGHPARALLP LYPTRAMGSP FPLVNLPTPL YPMMCPMEHP LSADIAMATR ADEDGDTPLH IAVVQGNLPA VHRLVNLFQQ GGRELDIYNN LRQTPLHLAV ITTLPSVVRL LVTAGASPMA LDRHGQTAAH LACEHRSPTC LRALLDSAAP GTLDLEARNY DGLTALHVAV NTECQETVQL LLERGADIDA VDIKSGRSPL IHAVENNSLS MVQLLLQHGA NVNAQMYSGS SALHSASGRG LLPLVRTLVR SGADSSLKNC HNDTPLMVAR SRRVSRGSCG HAPCTRVSAG WLQASVPERR GVRVSVPLRG GEWVSL