Details for: BCL3

Gene ID: 602

Symbol: BCL3

Ensembl ID: ENSG00000069399

Description: BCL3 transcription coactivator

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 154.4888
    Cell Significance Index: -24.0300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 88.6284
    Cell Significance Index: -22.4800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 50.6436
    Cell Significance Index: -23.9100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 44.9955
    Cell Significance Index: -23.1500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 35.6248
    Cell Significance Index: -23.9100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.6114
    Cell Significance Index: -24.1800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.7593
    Cell Significance Index: -23.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.1200
    Cell Significance Index: -24.1500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.0469
    Cell Significance Index: -12.4300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.8152
    Cell Significance Index: -8.3500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.0678
    Cell Significance Index: 18.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3634
    Cell Significance Index: 37.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.3336
    Cell Significance Index: 38.4300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.2925
    Cell Significance Index: 22.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1704
    Cell Significance Index: 60.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0982
    Cell Significance Index: 81.8500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.0237
    Cell Significance Index: 11.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9760
    Cell Significance Index: 44.2400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7699
    Cell Significance Index: 14.2300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7165
    Cell Significance Index: 77.9400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7103
    Cell Significance Index: 42.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6598
    Cell Significance Index: 107.3100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6467
    Cell Significance Index: 9.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5726
    Cell Significance Index: 26.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5340
    Cell Significance Index: 69.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4802
    Cell Significance Index: 22.3900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4787
    Cell Significance Index: 12.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2776
    Cell Significance Index: 250.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2354
    Cell Significance Index: 8.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2226
    Cell Significance Index: 6.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2169
    Cell Significance Index: 4.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2057
    Cell Significance Index: 25.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2055
    Cell Significance Index: 39.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1911
    Cell Significance Index: 104.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1560
    Cell Significance Index: 28.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1548
    Cell Significance Index: 68.4500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1383
    Cell Significance Index: 2.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1231
    Cell Significance Index: 3.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1002
    Cell Significance Index: 11.8200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0973
    Cell Significance Index: 67.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0953
    Cell Significance Index: 13.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0810
    Cell Significance Index: 16.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0712
    Cell Significance Index: 3.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0667
    Cell Significance Index: 6.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0586
    Cell Significance Index: 10.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0360
    Cell Significance Index: 4.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0235
    Cell Significance Index: 1.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0085
    Cell Significance Index: 15.7400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0082
    Cell Significance Index: 15.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0033
    Cell Significance Index: 5.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0001
    Cell Significance Index: 0.0600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0024
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0059
    Cell Significance Index: -3.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0072
    Cell Significance Index: -4.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0072
    Cell Significance Index: -5.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0077
    Cell Significance Index: -5.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0120
    Cell Significance Index: -6.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0182
    Cell Significance Index: -24.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0232
    Cell Significance Index: -8.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0267
    Cell Significance Index: -19.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0287
    Cell Significance Index: -2.2000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0494
    Cell Significance Index: -0.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0539
    Cell Significance Index: -15.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0582
    Cell Significance Index: -5.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0596
    Cell Significance Index: -12.5500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0601
    Cell Significance Index: -6.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0634
    Cell Significance Index: -7.2600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0660
    Cell Significance Index: -0.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0686
    Cell Significance Index: -8.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0763
    Cell Significance Index: -11.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0821
    Cell Significance Index: -16.4700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1215
    Cell Significance Index: -7.8400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1343
    Cell Significance Index: -5.5000
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.1475
    Cell Significance Index: -2.0200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1556
    Cell Significance Index: -0.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1624
    Cell Significance Index: -5.2000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1768
    Cell Significance Index: -2.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1860
    Cell Significance Index: -4.0300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.2130
    Cell Significance Index: -1.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2184
    Cell Significance Index: -22.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2264
    Cell Significance Index: -5.6600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2407
    Cell Significance Index: -5.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2486
    Cell Significance Index: -13.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2723
    Cell Significance Index: -21.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2856
    Cell Significance Index: -17.5100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3665
    Cell Significance Index: -9.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3667
    Cell Significance Index: -24.6600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3941
    Cell Significance Index: -5.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3950
    Cell Significance Index: -10.5900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4019
    Cell Significance Index: -4.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4076
    Cell Significance Index: -25.0500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4288
    Cell Significance Index: -15.7400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.4406
    Cell Significance Index: -4.6000
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.4450
    Cell Significance Index: -2.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4603
    Cell Significance Index: -25.8300
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.4710
    Cell Significance Index: -2.9200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4831
    Cell Significance Index: -14.2300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5054
    Cell Significance Index: -13.2900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5067
    Cell Significance Index: -10.5100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5366
    Cell Significance Index: -15.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BCL3 is a 55-kDa protein that belongs to the BTB/POZ family of transcriptional regulators. It is highly expressed in various cell types, including immune cells, epithelial cells, and stem cells. BCL3 has a unique ability to interact with other transcription factors, such as NF-kB and AP-1, to regulate gene expression. Its expression is regulated by various signaling pathways, including those involved in immune responses and cell differentiation. **Pathways and Functions:** BCL3 is involved in multiple signaling pathways, including: 1. **Antimicrobial humoral response:** BCL3 is required for the expression of genes involved in humoral immunity, including immunoglobulin genes and complement components. 2. **Canonical NF-κB signaling:** BCL3 interacts with NF-κB to regulate the expression of genes involved in inflammation and immune responses. 3. **Apoptosis:** BCL3 regulates the expression of anti-apoptotic genes, such as BCL-2, to prevent excessive cell death. 4. **Cell differentiation:** BCL3 is required for the differentiation of immune cells, including B cells and T cells. 5. **DNA damage response:** BCL3 is involved in the regulation of DNA damage response pathways, including those mediated by p53 and ATM. **Clinical Significance:** BCL3 has been implicated in various immune-related diseases, including: 1. **Autoimmune disorders:** BCL3 has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, where dysregulation of immune responses leads to tissue damage. 2. **Cancer:** BCL3 has been implicated in the development and progression of various cancers, including lymphomas and leukemias, where dysregulation of apoptosis and cell growth is a hallmark. 3. **Infectious diseases:** BCL3 has been shown to play a role in the regulation of immune responses to infections, including those caused by viruses and bacteria. 4. **Immunodeficiency disorders:** BCL3 has been linked to immunodeficiency disorders, such as X-linked lymphoproliferative disease, where defective BCL3 function leads to impaired immune responses. In conclusion, BCL3 is a complex protein that plays a crucial role in regulating various aspects of the immune response. Its dysregulation has been implicated in various immune-related diseases, highlighting the importance of its study in understanding the mechanisms of immune regulation and disease.

Genular Protein ID: 961947900

Symbol: BCL3_HUMAN

Name: B-cell lymphoma 3 protein

UniProtKB Accession Codes:

P20749

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 50 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2180580

Title: The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control.

PubMed ID: 2180580

DOI: 10.1016/0092-8674(90)90347-h

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7896265

Title: Genomic structure of the candidate proto-oncogene BCL3.

PubMed ID: 7896265

DOI: 10.1006/geno.1994.1588

PubMed ID: 8453667

Title: The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers.

PubMed ID: 8453667

DOI: 10.1016/0092-8674(93)90401-b

PubMed ID: 10469655

Title: NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes.

PubMed ID: 10469655

DOI: 10.1093/emboj/18.17.4766

PubMed ID: 10362352

Title: The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators.

PubMed ID: 10362352

DOI: 10.1038/sj.onc.1202717

PubMed ID: 12730195

Title: Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination.

PubMed ID: 12730195

DOI: 10.1074/jbc.m303518200

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 11707390

Title: Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family.

PubMed ID: 11707390

DOI: 10.1093/emboj/20.22.6180

PubMed ID: 15469820

Title: GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity.

PubMed ID: 15469820

DOI: 10.1016/j.molcel.2004.09.004

Sequence Information:

  • Length: 454
  • Mass: 47584
  • Checksum: 385F5320DB72C0E0
  • Sequence:
    • MPRCPAGAMD EGPVDLRTRP KAAGLPGAAL PLRKRPLRAP SPEPAAPRGA AGLVVPLDPL 
RGGCDLPAVP GPPHGLARPE ALYYPGALLP LYPTRAMGSP FPLVNLPTPL YPMMCPMEHP 
LSADIAMATR ADEDGDTPLH IAVVQGNLPA VHRLVNLFQQ GGRELDIYNN LRQTPLHLAV 
ITTLPSVVRL LVTAGASPMA LDRHGQTAAH LACEHRSPTC LRALLDSAAP GTLDLEARNY 
DGLTALHVAV NTECQETVQL LLERGADIDA VDIKSGRSPL IHAVENNSLS MVQLLLQHGA 
NVNAQMYSGS SALHSASGRG LLPLVRTLVR SGADSSLKNC HNDTPLMVAR SRRVIDILRG 
KATRPASTSQ PDPSPDRSAN TSPESSSRLS SNGLLSASPS SSPSQSPPRD PPGFPMAPPN 
FFLPSPSPPA FLPFAGVLRG PGRPVPPSPA PGGS

Genular Protein ID: 84958022

Symbol: B7Z3N9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z3N9

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 356
  • Mass: 38515
  • Checksum: 89BE4A384BF065AD
  • Sequence:
    • MEEGRERNRS WPPAECQSLP RVRLFTPTKE ETAQRGEVFG QGHPARALLP LYPTRAMGSP 
FPLVNLPTPL YPMMCPMEHP LSADIAMATR ADEDGDTPLH IAVVQGNLPA VHRLVNLFQQ 
GGRELDIYNN LRQTPLHLAV ITTLPSVVRL LVTAGASPMA LDRHGQTAAH LACEHRSPTC 
LRALLDSAAP GTLDLEARNY DGLTALHVAV NTECQETVQL LLERGADIDA VDIKSGRSPL 
IHAVENNSLS MVQLLLQHGA NVNAQMYSGS SALHSASGRG LLPLVRTLVR SGADSSLKNC 
HNDTPLMVAR SRRVSRGSCG HAPCTRVSAG WLQASVPERR GVRVSVPLRG GEWVSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.