BCL3 | ENSG00000069399 | NCBI 602

Details for: BCL3

Gene ID: 602

Symbol: BCL3

Ensembl ID: ENSG00000069399

Description: BCL3 transcription coactivator

Associated with

Antimicrobial humoral response
(GO:0019730)
Bcl3-bcl10 complex
(GO:0032996)
Bcl3/nf-kappab2 complex
(GO:0033257)
Canonical nf-kappab signal transduction
(GO:0007249)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to bacterium
(GO:0042742)
Defense response to protozoan
(GO:0042832)
Dna-binding transcription factor binding
(GO:0140297)
Dna damage response
(GO:0006974)
Dna damage response, signal transduction by p53 class mediator
(GO:0030330)
Extracellular matrix organization
(GO:0030198)
Follicular dendritic cell differentiation
(GO:0002268)
Germinal center formation
(GO:0002467)
Histone deacetylase binding
(GO:0042826)
Humoral immune response mediated by circulating immunoglobulin
(GO:0002455)
Intracellular membrane-bounded organelle
(GO:0043231)
Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
(GO:0042771)
Marginal zone b cell differentiation
(GO:0002315)
Midbody
(GO:0030496)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of interleukin-8 production
(GO:0032717)
Negative regulation of nf-kappab transcription factor activity
(GO:0032088)
Negative regulation of receptor signaling pathway via jak-stat
(GO:0046426)
Negative regulation of t cell apoptotic process
(GO:0070233)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of interleukin-10 production
(GO:0032733)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of translation
(GO:0045727)
Positive regulation of type ii interferon production
(GO:0032729)
Protein-containing complex
(GO:0032991)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein import into nucleus
(GO:0006606)
Regulation of apoptotic process
(GO:0042981)
Regulation of dna binding
(GO:0051101)
Regulation of non-canonical nf-kappab signal transduction
(GO:1901222)
Response to uv-c
(GO:0010225)
Response to virus
(GO:0009615)
Spleen development
(GO:0048536)
T-helper 1 type immune response
(GO:0042088)
T-helper 2 cell differentiation
(GO:0045064)
T cell apoptotic process
(GO:0070231)
Transcription coactivator activity
(GO:0003713)
Transcription corepressor activity
(GO:0003714)

Other Information

Proteins

B-cell lymphoma 3 protein
B7Z3N9_HUMAN

Genular Protein ID: 961947900

Symbol: BCL3_HUMAN

Name: B-cell lymphoma 3 protein

UniProtKB Accession Codes:

P20749

Database IDs:

Citations:

PubMed ID: 2180580

Title: The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control.

PubMed ID: 2180580

DOI: 10.1016/0092-8674(90)90347-h

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7896265

Title: Genomic structure of the candidate proto-oncogene BCL3.

PubMed ID: 7896265

DOI: 10.1006/geno.1994.1588

PubMed ID: 8453667

Title: The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers.

PubMed ID: 8453667

DOI: 10.1016/0092-8674(93)90401-b

PubMed ID: 10469655

Title: NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes.

PubMed ID: 10469655

DOI: 10.1093/emboj/18.17.4766

PubMed ID: 10362352

Title: The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators.

PubMed ID: 10362352

DOI: 10.1038/sj.onc.1202717

PubMed ID: 12730195

Title: Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination.

PubMed ID: 12730195

DOI: 10.1074/jbc.m303518200

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 11707390

Title: Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family.

PubMed ID: 11707390

DOI: 10.1093/emboj/20.22.6180

PubMed ID: 15469820

Title: GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity.

PubMed ID: 15469820

DOI: 10.1016/j.molcel.2004.09.004

Sequence Information:

Length: 454
Mass: 47584
Checksum: 385F5320DB72C0E0
Sequence:

MPRCPAGAMD EGPVDLRTRP KAAGLPGAAL PLRKRPLRAP SPEPAAPRGA AGLVVPLDPL 
RGGCDLPAVP GPPHGLARPE ALYYPGALLP LYPTRAMGSP FPLVNLPTPL YPMMCPMEHP 
LSADIAMATR ADEDGDTPLH IAVVQGNLPA VHRLVNLFQQ GGRELDIYNN LRQTPLHLAV 
ITTLPSVVRL LVTAGASPMA LDRHGQTAAH LACEHRSPTC LRALLDSAAP GTLDLEARNY 
DGLTALHVAV NTECQETVQL LLERGADIDA VDIKSGRSPL IHAVENNSLS MVQLLLQHGA 
NVNAQMYSGS SALHSASGRG LLPLVRTLVR SGADSSLKNC HNDTPLMVAR SRRVIDILRG 
KATRPASTSQ PDPSPDRSAN TSPESSSRLS SNGLLSASPS SSPSQSPPRD PPGFPMAPPN 
FFLPSPSPPA FLPFAGVLRG PGRPVPPSPA PGGS

Genular Protein ID: 84958022

Symbol: B7Z3N9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z3N9

Database IDs:

Sequence Information:

Length: 356
Mass: 38515
Checksum: 89BE4A384BF065AD
Sequence:

MEEGRERNRS WPPAECQSLP RVRLFTPTKE ETAQRGEVFG QGHPARALLP LYPTRAMGSP 
FPLVNLPTPL YPMMCPMEHP LSADIAMATR ADEDGDTPLH IAVVQGNLPA VHRLVNLFQQ 
GGRELDIYNN LRQTPLHLAV ITTLPSVVRL LVTAGASPMA LDRHGQTAAH LACEHRSPTC 
LRALLDSAAP GTLDLEARNY DGLTALHVAV NTECQETVQL LLERGADIDA VDIKSGRSPL 
IHAVENNSLS MVQLLLQHGA NVNAQMYSGS SALHSASGRG LLPLVRTLVR SGADSSLKNC 
HNDTPLMVAR SRRVSRGSCG HAPCTRVSAG WLQASVPERR GVRVSVPLRG GEWVSL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BCL3

Associated with

Other Information

The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control. PubMed ID: 2180580

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Genomic structure of the candidate proto-oncogene BCL3. PubMed ID: 7896265

The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers. PubMed ID: 8453667

NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes. PubMed ID: 10469655

The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators. PubMed ID: 10362352

Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination. PubMed ID: 12730195

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family. PubMed ID: 11707390

GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity. PubMed ID: 15469820