Nr1h4 | ENSRNOG00000007197 | NCBI 60351

Details for: Nr1h4

Gene ID: 60351

Symbol: Nr1h4

Ensembl ID: ENSRNOG00000007197

Description: nuclear receptor subfamily 1, group H, member 4

Associated with

Bile acid and bile salt metabolism
(R-RNO-194068)
Biological oxidations
(R-RNO-211859)
Cytochrome p450 - arranged by substrate type
(R-RNO-211897)
Endogenous sterols
(R-RNO-211976)
Gene expression (transcription)
(R-RNO-74160)
Generic transcription pathway
(R-RNO-212436)
Metabolism
(R-RNO-1430728)
Metabolism of lipids
(R-RNO-556833)
Metabolism of proteins
(R-RNO-392499)
Metabolism of steroids
(R-RNO-8957322)
Nuclear receptor transcription pathway
(R-RNO-383280)
Phase i - functionalization of compounds
(R-RNO-211945)
Post-translational protein modification
(R-RNO-597592)
Recycling of bile acids and salts
(R-RNO-159418)
Rna polymerase ii transcription
(R-RNO-73857)
Sumo e3 ligases sumoylate target proteins
(R-RNO-3108232)
Sumoylation
(R-RNO-2990846)
Sumoylation of intracellular receptors
(R-RNO-4090294)
Synthesis of bile acids and bile salts
(R-RNO-192105)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
(R-RNO-193368)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
(R-RNO-193807)
Bile acid and bile salt transport
(GO:0015721)
Bile acid binding
(GO:0032052)
Bile acid metabolic process
(GO:0008206)
Bile acid receptor activity
(GO:0038181)
Bile acid signaling pathway
(GO:0038183)
Cell-cell junction assembly
(GO:0007043)
Cell differentiation
(GO:0030154)
Chenodeoxycholic acid binding
(GO:1902122)
Cholesterol homeostasis
(GO:0042632)
Defense response to bacterium
(GO:0042742)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Double-stranded dna binding
(GO:0003690)
Glucose homeostasis
(GO:0042593)
Intracellular bile acid receptor signaling pathway
(GO:0038185)
Intracellular glucose homeostasis
(GO:0001678)
Intracellular receptor signaling pathway
(GO:0030522)
Intracellular triglyceride homeostasis
(GO:0035356)
Leukocyte migration involved in inflammatory response
(GO:0002523)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of canonical nf-kappab signal transduction
(GO:0043124)
Negative regulation of collagen biosynthetic process
(GO:0032966)
Negative regulation of interleukin-1 production
(GO:0032692)
Negative regulation of interleukin-2 production
(GO:0032703)
Negative regulation of interleukin-6 production
(GO:0032715)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of triglyceride biosynthetic process
(GO:0010868)
Negative regulation of tumor necrosis factor-mediated signaling pathway
(GO:0010804)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Negative regulation of type ii interferon production
(GO:0032689)
Negative regulation of very-low-density lipoprotein particle remodeling
(GO:0010903)
Notch signaling pathway
(GO:0007219)
Nuclear receptor activity
(GO:0004879)
Nuclear retinoid x receptor binding
(GO:0046965)
Peptide binding
(GO:0042277)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus
(GO:0035774)
Positive regulation of interleukin-17 production
(GO:0032740)
Protein-containing complex binding
(GO:0044877)
Regulation of carbohydrate metabolic process
(GO:0006109)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of lipid storage
(GO:0010883)
Regulation of low-density lipoprotein particle clearance
(GO:0010988)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Regulation of urea metabolic process
(GO:0034255)
Response to estrogen
(GO:0043627)
Response to glucose
(GO:0009749)
Response to lipopolysaccharide
(GO:0032496)
Response to nutrient levels
(GO:0031667)
Response to organic cyclic compound
(GO:0014070)
Response to xenobiotic stimulus
(GO:0009410)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Toll-like receptor 9 signaling pathway
(GO:0034162)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coregulator binding
(GO:0001221)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Genular Protein ID: 3132183272

Symbol: NR1H4_RAT

Name: Bile acid receptor

UniProtKB Accession Codes:

Q62735

Database IDs:

Citations:

PubMed ID: 7774010

Title: Identification of a nuclear receptor that is activated by farnesol metabolites.

PubMed ID: 7774010

DOI: 10.1016/0092-8674(95)90530-8

PubMed ID: 10744760

Title: Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor.

PubMed ID: 10744760

DOI: 10.1074/jbc.275.14.10638

PubMed ID: 12917342

Title: BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation.

PubMed ID: 12917342

DOI: 10.1128/mcb.23.17.6210-6220.2003

PubMed ID: 20305288

Title: Bile acids regulate hepatic gluconeogenic genes and farnesoid X receptor via G(alpha)i-protein-coupled receptors and the AKT pathway.

PubMed ID: 20305288

DOI: 10.1194/jlr.m004929

PubMed ID: 12718893

Title: Structural basis for bile acid binding and activation of the nuclear receptor FXR.

PubMed ID: 12718893

DOI: 10.1016/s1097-2765(03)00112-6

Sequence Information:

Length: 469
Mass: 53935
Checksum: 2BEAF5847D9E403C
Sequence:

MNLIGPSHLQ ATDEFALSEN LFGVLTEHAA GPLGQNLDLE SYSPYNNVQF PQVQPQISSS 
SYYSNLGFYP QQPEDWYSPG LYELRRMPTE SVYQGETEVS EMPVTKKPRM AASSAGRIKG 
DELCVVCGDR ASGYHYNALT CEGCKGFFRR SITKNAVYKC KNGGNCVMDM YMRRKCQDCR 
LRKCREMGML AECLLTEIQC KSKRLRKNVK QHADQTVNED SEGRDLRQVT STTKLCREKT 
ELTVDQQTLL DYIMDSYSKQ RMPQEITNKI LKEEFSAEEN FLILTEMATS HVQILVEFTK 
RLPGFQTLDH EDQIALLKGS AVEAMFLRSA EIFNKKLPAG HADLLEERIR KSGISDEYIT 
PMFSFYKSVG ELKMTQEEYA LLTAIVILSP DRQYIKDREA VEKLQEPLLD VLQKLCKIYQ 
PENPQHFACL LGRLTELRTF NHHHAEMLMS WRVNDHKFTP LLCEIWDVQ

Genular Protein ID: 1180577764

Symbol: A0A8L2Q4E9_RAT

Name: N/A

UniProtKB Accession Codes:

A0A8L2Q4E9

Database IDs:

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

Sequence Information:

Length: 473
Mass: 54387
Checksum: 0D0D122EB0692474
Sequence:

MNLIGPSHLQ ATDEFALSEN LFGVLTEHAA GPLGQNLDLE SYSPYNNVQF PQVQPQISSS 
SYYSNLGFYP QQPEDWYSPG LYELRRMPTE SVYQGETEVS EMPVTKKPRM AASSAGRIKG 
DELCVVCGDR ASGYHYNALT CEGCKGFFRR SITKNAVYKC KNGGNCVMDM YMRRKCQDCR 
LRKCREMGML AECMYTGLLT EIQCKSKRLR KNVKQHADQT VNEDSEGRDL RQVTSTTKLC 
REKTELTVDQ QTLLDYIMDS YSKQRMPQEI TNKILKEEFS AEENFLILTE MATSHVQILV 
EFTKRLPGFQ TLDHEDQIAL LKGSAVEAMF LRSAEIFNKK LPAGHADLLE ERIRKSGISD 
EYITPMFSFY KSVGELKMTQ EEYALLTAIV ILSPDRQYIK DREAVEKLQE PLLDVLQKLC 
KIYQPENPQH FACLLGRLTE LRTFNHHHAE MLMSWRVNDH KFTPLLCEIW DVQ

Genular Protein ID: 1081180070

Symbol: A0A0G2K6D2_RAT

Name: N/A

UniProtKB Accession Codes:

A0A0G2K6D2

Database IDs:

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

Sequence Information:

Length: 512
Mass: 58752
Checksum: CC08AF9927285883
Sequence:

MELISKPHQP LAPVTSYLGS FSVAVRKLRM VMQFQGLENP IQISLQHSHR LSGFASDRMS 
SKPAKGVLTE HAAGPLGQNL DLESYSPYNN VQFPQVQPQI SSSSYYSNLG FYPQQPEDWY 
SPGLYELRRM PTESVYQGET EVSEMPVTKK PRMAASSAGR IKGDELCVVC GDRASGYHYN 
ALTCEGCKGF FRRSITKNAV YKCKNGGNCV MDMYMRRKCQ DCRLRKCREM GMLAECLLTE 
IQCKSKRLRK NVKQHADQTV NEDSEGRDLR QVTSTTKLCR EKTELTVDQQ TLLDYIMDSY 
SKQRMPQEIT NKILKEEFSA EENFLILTEM ATSHVQILVE FTKRLPGFQT LDHEDQIALL 
KGSAVEAMFL RSAEIFNKKL PAGHADLLEE RIRKSGISDE YITPMFSFYK SVGELKMTQE 
EYALLTAIVI LSPDRQYIKD REAVEKLQEP LLDVLQKLCK IYQPENPQHF ACLLGRLTEL 
RTFNHHHAEM LMSWRVNDHK FTPLLCEIWD VQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nr1h4

Associated with

Other Information

Identification of a nuclear receptor that is activated by farnesol metabolites. PubMed ID: 7774010

Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor. PubMed ID: 10744760

BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation. PubMed ID: 12917342

Bile acids regulate hepatic gluconeogenic genes and farnesoid X receptor via G(alpha)i-protein-coupled receptors and the AKT pathway. PubMed ID: 20305288

Structural basis for bile acid binding and activation of the nuclear receptor FXR. PubMed ID: 12718893

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. PubMed ID: 15057822

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. PubMed ID: 15057822

Database document:

PubMed ID: 7774010

PubMed ID: 10744760

PubMed ID: 12917342

PubMed ID: 20305288

PubMed ID: 12718893

PubMed ID: 15057822

PubMed ID: 15057822