Nrxn1 | ENSRNOG00000050220 | NCBI 60391

Details for: Nrxn1

Gene ID: 60391

Symbol: Nrxn1

Ensembl ID: ENSRNOG00000050220

Description: neurexin 1

Associated with

Acetylcholine receptor binding
(GO:0033130)
Adult behavior
(GO:0030534)
Angiogenesis
(GO:0001525)
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
(GO:0016339)
Calcium-dependent protein binding
(GO:0048306)
Calcium channel regulator activity
(GO:0005246)
Calcium ion binding
(GO:0005509)
Cell-cell adhesion involved in synapse maturation
(GO:0090125)
Cell adhesion molecule binding
(GO:0050839)
Cell surface
(GO:0009986)
Cellular response to calcium ion
(GO:0071277)
Cerebellar granule cell differentiation
(GO:0021707)
Chemical synaptic transmission
(GO:0007268)
Circadian rhythm
(GO:0007623)
Endocytic vesicle
(GO:0030139)
Endoplasmic reticulum
(GO:0005783)
Establishment of protein localization
(GO:0045184)
Filopodium assembly
(GO:0046847)
Gamma-aminobutyric acid receptor clustering
(GO:0097112)
Gephyrin clustering involved in postsynaptic density assembly
(GO:0097116)
Guanylate kinase-associated protein clustering
(GO:0097117)
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
(GO:0007157)
Learning
(GO:0007612)
Maintenance of synapse structure
(GO:0099558)
Membrane
(GO:0016020)
Negative regulation of filopodium assembly
(GO:0051490)
Negative regulation of gene expression
(GO:0010629)
Neuroligin clustering involved in postsynaptic membrane assembly
(GO:0097118)
Neuroligin family protein binding
(GO:0097109)
Neuromuscular junction
(GO:0031594)
Neuromuscular process controlling balance
(GO:0050885)
Neuron cell-cell adhesion
(GO:0007158)
Neuron maturation
(GO:0042551)
Neuron projection development
(GO:0031175)
Neuron projection morphogenesis
(GO:0048812)
Neurotransmitter secretion
(GO:0007269)
Nmda glutamate receptor clustering
(GO:0097114)
Nuclear membrane
(GO:0031965)
Nucleolus
(GO:0005730)
Plasma membrane
(GO:0005886)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of excitatory postsynaptic potential
(GO:2000463)
Positive regulation of fibroblast growth factor receptor signaling pathway
(GO:0045743)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of neuromuscular synaptic transmission
(GO:1900075)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of presynaptic active zone assembly
(GO:1905520)
Positive regulation of protein kinase a signaling
(GO:0010739)
Positive regulation of protein localization to plasma membrane
(GO:1903078)
Positive regulation of synapse assembly
(GO:0051965)
Positive regulation of synapse maturation
(GO:0090129)
Positive regulation of synaptic transmission, gabaergic
(GO:0032230)
Positive regulation of synaptic transmission, glutamatergic
(GO:0051968)
Postsynaptic density protein 95 clustering
(GO:0097119)
Postsynaptic membrane assembly
(GO:0097104)
Prepulse inhibition
(GO:0060134)
Presynapse assembly
(GO:0099054)
Presynaptic membrane assembly
(GO:0097105)
Protein-containing complex
(GO:0032991)
Protein-containing complex assembly involved in synapse maturation
(GO:0090126)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein localization to synapse
(GO:0035418)
Receptor localization to synapse
(GO:0097120)
Regulation of grooming behavior
(GO:2000821)
Regulation of insulin secretion involved in cellular response to glucose stimulus
(GO:0061178)
Regulation of postsynaptic density assembly
(GO:0099151)
Regulation of postsynaptic specialization assembly
(GO:0099150)
Regulation of presynapse assembly
(GO:1905606)
Regulation of synaptic vesicle cycle
(GO:0098693)
Regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
(GO:0150036)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Social behavior
(GO:0035176)
Synapse assembly
(GO:0007416)
Synapse maturation
(GO:0060074)
Synaptic membrane adhesion
(GO:0099560)
Synaptic vesicle clustering
(GO:0097091)
Transmembrane signaling receptor activity
(GO:0004888)
Type 1 fibroblast growth factor receptor binding
(GO:0005105)
Vesicle
(GO:0031982)
Vesicle docking involved in exocytosis
(GO:0006904)
Vocalization behavior
(GO:0071625)
Vocal learning
(GO:0042297)

Other Information

Proteins

Neurexin-1

Genular Protein ID: 2314320081

Symbol: NRX1A_RAT

Name: Neurexin-1

UniProtKB Accession Codes:

Q63372

Database IDs:

Citations:

PubMed ID: 1621094

Title: Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin.

PubMed ID: 1621094

DOI: 10.1126/science.1621094

PubMed ID: 7695896

Title: Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons.

PubMed ID: 7695896

DOI: 10.1016/0896-6273(95)90306-2

PubMed ID: 9856994

Title: Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit.

PubMed ID: 9856994

DOI: 10.1074/jbc.273.52.34716

PubMed ID: 8786425

Title: CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins.

PubMed ID: 8786425

DOI: 10.1523/jneurosci.16-08-02488.1996

PubMed ID: 10197529

Title: Neurexins are functional alpha-latrotoxin receptors.

PubMed ID: 10197529

DOI: 10.1016/s0896-6273(00)80704-7

PubMed ID: 11470830

Title: A stoichiometric complex of neurexins and dystroglycan in brain.

PubMed ID: 11470830

DOI: 10.1083/jcb.200105003

PubMed ID: 12040031

Title: CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with Caskin 1, a novel CASK-binding protein.

PubMed ID: 12040031

DOI: 10.1523/jneurosci.22-11-04264.2002

PubMed ID: 20064387

Title: LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation.

PubMed ID: 20064387

DOI: 10.1016/j.neuron.2009.12.012

PubMed ID: 20064388

Title: LRRTM2 interacts with Neurexin1 and regulates excitatory synapse formation.

PubMed ID: 20064388

DOI: 10.1016/j.neuron.2009.12.019

PubMed ID: 25385611

Title: Structure of Crumbs tail in complex with the PALS1 PDZ-SH3-GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complex.

PubMed ID: 25385611

DOI: 10.1073/pnas.1416515111

PubMed ID: 18093522

Title: Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions.

PubMed ID: 18093522

DOI: 10.1016/j.neuron.2007.12.002

Sequence Information:

Length: 1530
Mass: 167923
Checksum: 548109BAF05119FC
Sequence:

MGTALVQHGG CCLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC ESEMSFQLKT 
RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP ATLLADTPVN DGAWHSVRIR 
RQFRNTTLYI DRAEAKWVEV KSKRRDMTVF SGLFVGGLPP ELRAAALKLT LASVREREPF 
KGWIRDVRVN SSQALPVDGS EVKLDEEPPN SGGGSPCEAG DEGDGGVCLN GGVCSVVDDQ 
AVCDCSRTGF RGKDCSQEDN NVEGLAHLMM GDQGKSKEDN NVEGLAHLMM GDQGKEEYIA 
TFKGSEYFCY DLSQNPIQSS SDEITLSFKT LQRNGLMLHT GKSADYVNLA LKNGAVSLVI 
NLGSGAFEAL VEPVNGKFND NAWHDVKVTR NLRQHSGIGH AMVNKLHCSV TISVDGILTT 
TGYTQEDYTM LGSDDFFYVG GSPSTADLPG SPVSNNFMGC LKEVVYKNND VRLELSRLAK 
QGDPKMKIHG VVAFKCENVA TLDPITFETP ESFISLPKWN AKKTGSISFD FRTTEPNGLI 
LFSHGKPRHQ KDAKHPQMIK VDFFAIEMLD GHLYLLLDMG SGTIKIKALQ KKVNDGEWYH 
VDFQRDGRSG TISVNTLRTP YTAPGESEIL DLDDELYLGG LPENKAGLVF PTEVWTALLN 
YGYVGCIRDL FIDGQSKDIR QMAEIQSTAG VKPSCSRETA KPCLSNPCKN NGMCRDGWNR 
YVCDCSGTGY LGRSCEREAT VLSYDGSMFM KIQLPVVMHT EAEDVSLRFR SQRAYGILMA 
TTSRDSADTL RLELDAGRVK LTVNLDCIRI NCNSSKGPET LFAGYNLNDN EWHTVRVVRR 
GKSLKLTVDD QQAMTGQMAG DHTRLEFHNI ETGIITERRY LSSVPSNFIG HLQSLTFNGM 
AYIDLCKNGD IDYCELNARF GFRNIIADPV TFKTKSSYVA LATLQAYTSM HLFFQFKTTS 
LDGLILYNSG DGNDFIVVEL VKGYLHYVFD LGNGANLIKG SSNKPLNDNQ WHNVMISRDT 
SNLHTVKIDT KITTQITAGA RNLDLKSDLY IGGVAKETYK SLPKLVHAKE GFQGCLASVD 
LNGRLPDLIS DALFCNGQIE RGCEGPSTTC QEDSCSNQGV CLQQWDGFSC DCSMTSFSGP 
LCNDPGTTYI FSKGGGQITH KWPPNDRPST RADRLAIGFS TVQKEAVLVR VDSSSGLGDY 
LELHIHQGKI GVKFNVGTDD IAIEESNAII NDGKYHVVRF TRSGGNATLQ VDSWPVIERY 
PAGNNDNERL AIARQRIPYR LGRVVDEWLL DKGRQLTIFN SQATIIIGGK EQGQPFQGQL 
SGLYYNGLKV LNMAAENDAN IAIVGNVRLV GEVPSSMTTE STATAMQSEM STSIMETTTT 
LATSTARRGK PPTKEPISQT TDDILVASAE CPSDDEDIDP CEPSSGGLAN PTRVGGREPY 
PGSAEVIRES SSTTGMVVGI VAAAALCILI LLYAMYKYRN RDEGSYHVDE SRNYISNSAQ 
SNGAVVKEKQ PSSAKSANKN KKNKDKEYYV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nrxn1

Associated with

Other Information

Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin. PubMed ID: 1621094

Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons. PubMed ID: 7695896

Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit. PubMed ID: 9856994

CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins. PubMed ID: 8786425

Neurexins are functional alpha-latrotoxin receptors. PubMed ID: 10197529

A stoichiometric complex of neurexins and dystroglycan in brain. PubMed ID: 11470830

CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with Caskin 1, a novel CASK-binding protein. PubMed ID: 12040031

LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation. PubMed ID: 20064387

LRRTM2 interacts with Neurexin1 and regulates excitatory synapse formation. PubMed ID: 20064388

Structure of Crumbs tail in complex with the PALS1 PDZ-SH3-GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complex. PubMed ID: 25385611

Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions. PubMed ID: 18093522