BCL6 | ENSG00000113916 | NCBI 604

Details for: BCL6

Gene ID: 604

Symbol: BCL6

Ensembl ID: ENSG00000113916

Description: BCL6 transcription repressor

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Foxo-mediated transcription
(R-HSA-9614085)
Foxo-mediated transcription of cell death genes
(R-HSA-9614657)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by interleukins
(R-HSA-449147)
Tp53 regulates transcription of cell death genes
(R-HSA-5633008)
Tp53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
(R-HSA-6803205)
Transcriptional regulation by tp53
(R-HSA-3700989)
Actin cytoskeleton organization
(GO:0030036)
B cell proliferation
(GO:0042100)
Cell-matrix adhesion
(GO:0007160)
Cell morphogenesis
(GO:0000902)
Cell motility
(GO:0048870)
Chromatin binding
(GO:0003682)
Chromatin dna binding
(GO:0031490)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor binding
(GO:0140297)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna damage response
(GO:0006974)
Erythrocyte development
(GO:0048821)
Germinal center formation
(GO:0002467)
Golgi apparatus
(GO:0005794)
Heterochromatin formation
(GO:0031507)
Identical protein binding
(GO:0042802)
Inflammatory response
(GO:0006954)
Intronic transcription regulatory region sequence-specific dna binding
(GO:0001161)
Isotype switching to ige isotypes
(GO:0048289)
Metal ion binding
(GO:0046872)
Negative regulation of b cell apoptotic process
(GO:0002903)
Negative regulation of cell-matrix adhesion
(GO:0001953)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cellular senescence
(GO:2000773)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of isotype switching to ige isotypes
(GO:0048294)
Negative regulation of leukocyte proliferation
(GO:0070664)
Negative regulation of mast cell cytokine production
(GO:0032764)
Negative regulation of mitotic cell cycle dna replication
(GO:1903464)
Negative regulation of notch signaling pathway
(GO:0045746)
Negative regulation of plasma cell differentiation
(GO:1900099)
Negative regulation of rho protein signal transduction
(GO:0035024)
Negative regulation of t-helper 2 cell differentiation
(GO:0045629)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Paraspeckles
(GO:0042382)
Plasma cell differentiation
(GO:0002317)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of cell motility
(GO:2000147)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of regulatory t cell differentiation
(GO:0045591)
Protein binding
(GO:0005515)
Protein localization
(GO:0008104)
Pyramidal neuron differentiation
(GO:0021859)
Regulation of cell differentiation
(GO:0045595)
Regulation of cell population proliferation
(GO:0042127)
Regulation of cytokine production
(GO:0001817)
Regulation of germinal center formation
(GO:0002634)
Regulation of immune response
(GO:0050776)
Regulation of immune system process
(GO:0002682)
Regulation of inflammatory response
(GO:0050727)
Regulation of memory t cell differentiation
(GO:0043380)
Regulation of t cell proliferation
(GO:0042129)
Replication fork
(GO:0005657)
Rho protein signal transduction
(GO:0007266)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Spermatogenesis
(GO:0007283)
T-helper 2 cell differentiation
(GO:0045064)
Transcription by rna polymerase ii
(GO:0006366)
Transcription corepressor binding
(GO:0001222)
Type 2 immune response
(GO:0042092)

Other Information

Proteins

B-cell lymphoma 6 protein
B5B0A5_HUMAN

Genular Protein ID: 1818439118

Symbol: BCL6_HUMAN

Name: B-cell lymphoma 6 protein

UniProtKB Accession Codes:

P41182 A7E241 B8PSA7 D3DNV5

Database IDs:

Citations:

PubMed ID: 8220427

Title: LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas.

PubMed ID: 8220427

DOI: 10.1038/ng0993-66

PubMed ID: 8235596

Title: Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma.

PubMed ID: 8235596

DOI: 10.1126/science.8235596

PubMed ID: 8274740

Title: Gene involved in the 3q27 translocation associated with B-cell lymphoma, BCL5, encodes a Kruppel-like zinc-finger protein.

PubMed ID: 8274740

PubMed ID: 8506375

Title: Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas.

PubMed ID: 8506375

DOI: 10.1073/pnas.90.11.5262

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9649500

Title: Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor.

PubMed ID: 9649500

DOI: 10.1101/gad.12.13.1953

PubMed ID: 10469447

Title: Nonrandom fusion of L-plastin(LCP1) and LAZ3(BCL6) genes by t(3;13)(q27;q14) chromosome translocation in two cases of B-cell non-Hodgkin lymphoma.

PubMed ID: 10469447

DOI: 10.1002/(sici)1098-2264(199910)26:2<97::aid-gcc1>3.3.co;2-0

PubMed ID: 10753856

Title: The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3;7)(q27;p12) translocation in a patient with diffuse large B-cell lymphoma.

PubMed ID: 10753856

PubMed ID: 10981963

Title: BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control.

PubMed ID: 10981963

DOI: 10.1016/s1074-7613(00)00020-0

PubMed ID: 12414651

Title: Characterization of t(3;6)(q27;p21) breakpoints in B-cell non-Hodgkin's lymphoma and construction of the histone H4/BCL6 fusion gene, leading to altered expression of Bcl-6.

PubMed ID: 12414651

PubMed ID: 12402037

Title: Acetylation inactivates the transcriptional repressor BCL6.

PubMed ID: 12402037

DOI: 10.1038/ng1018

PubMed ID: 11821949

Title: The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma.

PubMed ID: 11821949

DOI: 10.1038/sj.onc.1205099

PubMed ID: 12504096

Title: Point mutations in BCL6 DNA-binding domain reveal distinct roles for the six zinc fingers.

PubMed ID: 12504096

DOI: 10.1016/s0006-291x(02)02873-5

PubMed ID: 12590135

Title: The histone deacetylase 9 gene encodes multiple protein isoforms.

PubMed ID: 12590135

DOI: 10.1074/jbc.m212935200

PubMed ID: 15454082

Title: MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation.

PubMed ID: 15454082

DOI: 10.1016/j.cell.2004.09.014

PubMed ID: 15577913

Title: The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B-cells.

PubMed ID: 15577913

DOI: 10.1038/nature03147

PubMed ID: 16142238

Title: BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells.

PubMed ID: 16142238

DOI: 10.1038/ni1245

PubMed ID: 16455075

Title: Plastic downregulation of the transcriptional repressor BCL6 during maturation of human dendritic cells.

PubMed ID: 16455075

DOI: 10.1016/j.yexcr.2005.12.020

PubMed ID: 17828269

Title: Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells.

PubMed ID: 17828269

DOI: 10.1038/ni1508

PubMed ID: 18212045

Title: CtBP is an essential corepressor for BCL6 autoregulation.

PubMed ID: 18212045

DOI: 10.1128/mcb.01400-07

PubMed ID: 23166356

Title: BCL6 positively regulates AID and germinal center gene expression via repression of miR-155.

PubMed ID: 23166356

DOI: 10.1084/jem.20121387

PubMed ID: 22113614

Title: FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas.

PubMed ID: 22113614

DOI: 10.1038/nature10688

PubMed ID: 23911289

Title: A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters.

PubMed ID: 23911289

DOI: 10.1016/j.celrep.2013.06.016

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 30190310

Title: Dimerization quality control ensures neuronal development and survival.

PubMed ID: 30190310

DOI: 10.1126/science.aap8236

PubMed ID: 14690607

Title: Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain.

PubMed ID: 14690607

DOI: 10.1016/s1097-2765(03)00454-4

PubMed ID: 19052359

Title: Structure of the wild-type human BCL6 POZ domain.

PubMed ID: 19052359

DOI: 10.1107/s1744309108036063

PubMed ID: 18280243

Title: Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer.

PubMed ID: 18280243

DOI: 10.1016/j.molcel.2007.12.026

PubMed ID: 20385364

Title: A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo.

PubMed ID: 20385364

DOI: 10.1016/j.ccr.2009.12.050

Sequence Information:

Length: 706
Mass: 78846
Checksum: E38D83C213DAE2D0
Sequence:

MASPADSCIQ FTRHASDVLL NLNRLRSRDI LTDVVIVVSR EQFRAHKTVL MACSGLFYSI 
FTDQLKCNLS VINLDPEINP EGFCILLDFM YTSRLNLREG NIMAVMATAM YLQMEHVVDT 
CRKFIKASEA EMVSAIKPPR EEFLNSRMLM PQDIMAYRGR EVVENNLPLR SAPGCESRAF 
APSLYSGLST PPASYSMYSH LPVSSLLFSD EEFRDVRMPV ANPFPKERAL PCDSARPVPG 
EYSRPTLEVS PNVCHSNIYS PKETIPEEAR SDMHYSVAEG LKPAAPSARN APYFPCDKAS 
KEEERPSSED EIALHFEPPN APLNRKGLVS PQSPQKSDCQ PNSPTESCSS KNACILQASG 
SPPAKSPTDP KACNWKKYKF IVLNSLNQNA KPEGPEQAEL GRLSPRAYTA PPACQPPMEP 
ENLDLQSPTK LSASGEDSTI PQASRLNNIV NRSMTGSPRS SSESHSPLYM HPPKCTSCGS 
QSPQHAEMCL HTAGPTFPEE MGETQSEYSD SSCENGAFFC NECDCRFSEE ASLKRHTLQT 
HSDKPYKCDR CQASFRYKGN LASHKTVHTG EKPYRCNICG AQFNRPANLK THTRIHSGEK 
PYKCETCGAR FVQVAHLRAH VLIHTGEKPY PCEICGTRFR HLQTLKSHLR IHTGEKPYHC 
EKCNLHFRHK SQLRLHLRQK HGAITNTKVQ YRVSATDLPP ELPKAC

Genular Protein ID: 2663400634

Symbol: B5B0A5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B5B0A5

Database IDs:

Citations:

PubMed ID: 18675787

Title: Alternative splicing generates a short BCL6 (BCL6S) isoform encoding a compact repressor.

PubMed ID: 18675787

DOI: 10.1016/j.bbrc.2008.07.116

Sequence Information:

Length: 650
Mass: 72253
Checksum: 4F0169D0F2FB0B02
Sequence:

MASPADSCIQ FTRHASDVLL NLNRLRSRDI LTDVVIVVSR EQFRAHKTVL MACSGLFYSI 
FTDQLKCNLS VINLDPEINP EGFCILLDFM YTSRLNLREG NIMAVMATAM YLQMEHVVDT 
CRKFIKASEA EMVSAIKPPR EEFLNSRMLM PQDIMAYRGR EVVENNLPLR SAPGCESRAF 
APSLYSGLST PPASYSMYSH LPVSSLLFSD EEFRDVRMPV ANPFPKERAL PCDSARPVPG 
EYSRPTLEVS PNVCHSNIYS PKETIPEEAR SDMHYSVAEG LKPAAPSARN APYFPCDKAS 
KEEERPSSED EIALHFEPPN APLNRKGLVS PQSPQKSDCQ PNSPTEACSS KNACILQASG 
SPPAKSPTDP KACNWKKYKF IVLNSLNQNA KPGGPEQAEL GRLSPRAYTA PPACQPPMEP 
ENLDLQSPTK LSASGEDSTI PQASRLNNIV NRSMTGSPRS SSESHSPLYM HPPKCTSCGS 
QSPQHAEMCL HTAGPTFAEE MGETQSEYSD SSCGEKPYRC NICGAQFNRP ANLKTHTRIH 
SGEKPYKCET CGARFVQVAH LRAHVLIHTG EKPYPCEICG TRFRHLQTLK SHLRIHTGEK 
PYHCEKCNLH FRHKSQLRLH LRQKHGAITN TKVQYRVSAT DLPPELPKAC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BCL6

Associated with

Other Information

LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas. PubMed ID: 8220427

Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma. PubMed ID: 8235596

Gene involved in the 3q27 translocation associated with B-cell lymphoma, BCL5, encodes a Kruppel-like zinc-finger protein. PubMed ID: 8274740

Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas. PubMed ID: 8506375

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor. PubMed ID: 9649500

Nonrandom fusion of L-plastin(LCP1) and LAZ3(BCL6) genes by t(3;13)(q27;q14) chromosome translocation in two cases of B-cell non-Hodgkin lymphoma. PubMed ID: 10469447

The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3;7)(q27;p12) translocation in a patient with diffuse large B-cell lymphoma. PubMed ID: 10753856

BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. PubMed ID: 10981963

Characterization of t(3;6)(q27;p21) breakpoints in B-cell non-Hodgkin's lymphoma and construction of the histone H4/BCL6 fusion gene, leading to altered expression of Bcl-6. PubMed ID: 12414651

Acetylation inactivates the transcriptional repressor BCL6. PubMed ID: 12402037

The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma. PubMed ID: 11821949

Point mutations in BCL6 DNA-binding domain reveal distinct roles for the six zinc fingers. PubMed ID: 12504096

The histone deacetylase 9 gene encodes multiple protein isoforms. PubMed ID: 12590135

MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation. PubMed ID: 15454082

The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B-cells. PubMed ID: 15577913

BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells. PubMed ID: 16142238

Plastic downregulation of the transcriptional repressor BCL6 during maturation of human dendritic cells. PubMed ID: 16455075

Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells. PubMed ID: 17828269

CtBP is an essential corepressor for BCL6 autoregulation. PubMed ID: 18212045

BCL6 positively regulates AID and germinal center gene expression via repression of miR-155. PubMed ID: 23166356

FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas. PubMed ID: 22113614

A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters. PubMed ID: 23911289

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Dimerization quality control ensures neuronal development and survival. PubMed ID: 30190310

Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain. PubMed ID: 14690607

Structure of the wild-type human BCL6 POZ domain. PubMed ID: 19052359

Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer. PubMed ID: 18280243

A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo. PubMed ID: 20385364

Alternative splicing generates a short BCL6 (BCL6S) isoform encoding a compact repressor. PubMed ID: 18675787