Details for: BCL6
Gene ID: 604
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: BCL6
Ensembl ID: ENSG00000113916
Description: BCL6 transcription repressor
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 31.78rCSI 40.81%PRS 51.08
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CSI 23.67rCSI 37.64%PRS 50.15
-
CSI 19.9rCSI 51.46%PRS 52.89
-
CSI 18.1rCSI 14.62%PRS 68.26
-
CSI 12.64rCSI 41.13%PRS 58.73
-
CSI 11.26rCSI 25.24%PRS 40.71
-
CSI 9.46rCSI 23.42%PRS 56.08
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CSI 8.03rCSI 11.74%PRS 61.91
-
CSI 7.35rCSI 16.41%PRS 65.33
-
CSI 7.26rCSI 13%PRS 56.86
-
CSI 7.11rCSI 10.86%PRS 67
-
CSI 6.67rCSI 5.8%PRS 68.18
-
CSI 5.87rCSI 14.11%PRS 65.92
-
CSI 5.72rCSI 22.85%PRS 74.94
-
CSI 5.52rCSI 10.04%PRS 50.21
-
CSI 5.51rCSI 8.86%PRS 42.24
-
CSI 5.36rCSI 11.83%PRS 44.25
-
CSI 5.23rCSI 27.49%PRS 63.56
-
CSI 5.04rCSI 7.97%PRS 59.69
-
CSI 4.91rCSI 3.88%PRS 44.68
-
CSI 4.65rCSI 3.61%PRS 59.28
-
CSI 4.34rCSI 12.82%PRS 56.47
-
CSI 4.2rCSI 6.06%PRS 67.36
-
CSI 4.17rCSI 21.35%PRS 62.98
-
CSI 4.01rCSI 16.17%PRS 56.38
-
CSI 3.94rCSI 21.95%PRS 69.57
-
CSI 3.82rCSI 3.68%PRS 57.99
-
CSI 3.79rCSI 8.35%PRS 61.75
-
CSI 3.62rCSI 10.3%PRS 56.09
-
CSI 3.49rCSI 4.34%PRS 38.11
-
CSI 3.37rCSI 2.55%PRS 71.33
-
CSI 3.27rCSI 2.82%PRS 63.94
-
CSI 3.27rCSI 13.9%PRS 52.42
-
CSI 3.14rCSI 9.31%PRS 68.01
-
CSI 3.11rCSI 2.4%PRS 57.7
-
CSI 2.99rCSI 3.27%PRS 61.75
-
CSI 2.98rCSI 4.08%PRS 63.51
-
CSI 2.94rCSI 2.18%PRS 50.46
-
CSI 2.93rCSI 9.38%PRS 55.26
-
CSI 2.84rCSI 4.02%PRS 54.07
-
CSI 2.72rCSI 2.53%PRS 57.9
-
CSI 2.71rCSI 3.75%PRS 59.59
-
CSI 2.67rCSI 3.42%PRS 62.56
-
CSI 2.62rCSI 2.74%PRS 57.95
-
CSI 2.56rCSI 13.78%PRS 70.78
-
CSI 2.53rCSI 3.08%PRS 65.42
-
CSI 2.49rCSI 1.87%PRS 62.63
-
CSI 2.48rCSI 5.83%PRS 63.8
-
CSI 2.48rCSI 2.87%PRS 65.92
-
CSI 2.44rCSI 13.67%PRS 65.8
-
CSI 2.44rCSI 19.83%PRS 50.92
-
CSI 2.42rCSI 3.69%PRS 58.36
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CSI 2.41rCSI 2.22%PRS 58.79
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CSI 2.37rCSI 2.28%PRS 48.23
-
CSI 2.37rCSI 2.86%PRS 66.38
-
CSI 2.36rCSI 4.89%PRS 55.06
-
CSI 2.32rCSI 5.3%PRS 49.82
-
CSI 2.3rCSI 4.32%PRS 46.34
-
CSI 2.3rCSI 3.78%PRS 63.13
-
CSI 2.21rCSI 3.88%PRS 49.88
-
CSI 2.21rCSI 3.53%PRS 50.67
-
CSI 2.2rCSI 3.56%PRS 54.73
-
CSI 2.19rCSI 5.53%PRS 66.25
-
CSI 2.18rCSI 4.89%PRS 76.07
-
CSI 2.17rCSI 3.13%PRS 69
-
CSI 2.17rCSI 8.11%PRS 49.99
-
CSI 2.15rCSI 4.11%PRS 73.2
-
CSI 2.13rCSI 2.12%PRS 51.11
-
CSI 2.09rCSI 2.17%PRS 63.34
-
CSI 2.08rCSI 4.77%PRS 57.49
-
CSI 2.08rCSI 3.06%PRS 51.87
-
CSI 2.08rCSI 1.69%PRS 58.33
-
CSI 2.06rCSI 1.54%PRS 72.68
-
CSI 2.06rCSI 3.17%PRS 66.42
-
CSI 2.05rCSI 7.98%PRS 64.05
-
CSI 2.03rCSI 2.98%PRS 69.34
-
CSI 2.02rCSI 2.52%PRS 68.51
-
CSI 2rCSI 4.06%PRS 37.77
-
CSI 1.95rCSI 4.63%PRS 62.01
-
CSI 1.92rCSI 6.24%PRS 58.78
-
CSI 1.92rCSI 1.69%PRS 45.73
-
CSI 1.91rCSI 2.04%PRS 56.76
-
CSI 1.89rCSI 2.19%PRS 47.79
-
CSI 1.89rCSI 2.34%PRS 53.97
-
CSI 1.87rCSI 4.46%PRS 59.05
-
CSI 1.79rCSI 1.48%PRS 56.64
-
CSI 1.75rCSI 3.09%PRS 54.86
-
CSI 1.73rCSI 2.32%PRS 58.33
-
CSI 1.73rCSI 4.51%PRS 62.6
-
CSI 1.73rCSI 1.45%PRS 62.52
-
CSI 1.66rCSI 2.35%PRS 63.69
-
CSI 1.62rCSI 2.44%PRS 61.31
-
CSI 1.58rCSI 6.16%PRS 77.82
-
CSI 1.57rCSI 2.76%PRS 66.37
-
CSI 1.56rCSI 1.43%PRS 66.37
-
CSI 1.55rCSI 2.68%PRS 47.92
-
CSI 1.51rCSI 2.34%PRS 65.86
-
CSI 1.5rCSI 1.96%PRS 71.13
-
CSI 1.49rCSI 2.28%PRS 73.64
-
CSI 1.47rCSI 2.16%PRS 54.39
-
CSI 0.2rCSI 4.4%PRS 49.1%
-
CSI 0.3rCSI 2.9%PRS 73.8%
-
CSI 0.3rCSI 2.4%PRS 73.9%
-
CSI 0.4rCSI 7.7%PRS 50.4%
-
CSI 0.4rCSI 1.3%PRS 61.8%
-
CSI 0.4rCSI 5.9%PRS 49.5%
-
CSI 0.5rCSI 1.8%PRS 38.5%
-
CSI 0.5rCSI 3.1%PRS 77.6%
-
CSI 0.5rCSI 3.2%PRS 49.7%
-
CSI 0.7rCSI 3.4%PRS 74.6%
-
CSI 0.7rCSI 1.2%PRS 40.0%
-
CSI 0.7rCSI 2.3%PRS 44.1%
-
CSI 0.8rCSI 6.0%PRS 67.2%
-
CSI 0.8rCSI 1.9%PRS 54.7%
-
CSI 0.8rCSI 3.1%PRS 49.0%
-
CSI 0.8rCSI 2.8%PRS 62.9%
-
CSI 0.9rCSI 2.6%PRS 59.3%
-
CSI 0.9rCSI 2.6%PRS 76.7%
-
CSI 0.9rCSI 2.5%PRS 53.6%
-
CSI 0.9rCSI 1.7%PRS 73.7%
-
CSI 1.0rCSI 2.0%PRS 60.4%
-
CSI 1.0rCSI 6.3%PRS 78.8%
-
CSI 1.0rCSI 1.4%PRS 64.0%
-
CSI 1.1rCSI 1.7%PRS 61.7%
-
CSI 1.1rCSI 2.8%PRS 49.2%
-
CSI 1.1rCSI 2.8%PRS 77.2%
-
CSI 1.1rCSI 3.1%PRS 77.2%
-
CSI 1.1rCSI 3.2%PRS 71.6%
-
CSI 1.1rCSI 5.4%PRS 57.7%
-
CSI 1.2rCSI 2.4%PRS 76.9%
-
CSI 1.2rCSI 1.9%PRS 69.0%
-
CSI 1.2rCSI 5.4%PRS 76.6%
-
CSI 1.2rCSI 2.3%PRS 68.4%
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CSI 1.2rCSI 1.7%PRS 52.0%
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CSI 1.2rCSI 2.7%PRS 72.7%
-
CSI 1.3rCSI 2.2%PRS 66.8%
-
CSI 1.3rCSI 1.2%PRS 72.3%
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CSI 1.3rCSI 5.1%PRS 62.4%
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CSI 1.3rCSI 2.5%PRS 77.3%
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CSI 1.3rCSI 4.3%PRS 56.5%
-
CSI 1.4rCSI 1.7%PRS 41.2%
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CSI 1.4rCSI 2.4%PRS 39.0%
-
CSI 1.4rCSI 2.0%PRS 47.9%
-
CSI 1.4rCSI 2.0%PRS 73.7%
-
CSI 1.4rCSI 3.3%PRS 66.9%
-
CSI 1.4rCSI 3.7%PRS 61.8%
-
CSI 1.4rCSI 3.8%PRS 66.7%
-
CSI 1.4rCSI 1.7%PRS 39.8%
-
CSI 1.4rCSI 2.8%PRS 60.5%
-
CSI 1.5rCSI 2.2%PRS 63.2%
-
CSI 1.5rCSI 2.2%PRS 54.4%
-
CSI 1.5rCSI 2.3%PRS 73.6%
-
CSI 1.5rCSI 2.0%PRS 71.1%
-
CSI 1.5rCSI 2.3%PRS 65.9%
-
CSI 1.6rCSI 2.7%PRS 47.9%
-
CSI 1.6rCSI 1.4%PRS 66.4%
-
CSI 1.6rCSI 2.8%PRS 66.4%
-
CSI 1.6rCSI 6.2%PRS 77.8%
-
CSI 1.6rCSI 2.4%PRS 61.3%
-
CSI 1.7rCSI 2.4%PRS 63.7%
-
CSI 1.7rCSI 1.5%PRS 62.5%
-
CSI 1.7rCSI 4.5%PRS 62.6%
-
CSI 1.7rCSI 2.3%PRS 58.3%
-
CSI 1.8rCSI 3.1%PRS 54.9%
-
CSI 1.8rCSI 1.5%PRS 56.6%
-
CSI 1.9rCSI 4.5%PRS 59.1%
-
CSI 1.9rCSI 2.3%PRS 54.0%
-
CSI 1.9rCSI 2.2%PRS 47.8%
-
CSI 1.9rCSI 2.0%PRS 56.8%
-
CSI 1.9rCSI 1.7%PRS 45.7%
-
CSI 1.9rCSI 6.2%PRS 58.8%
-
CSI 2.0rCSI 4.6%PRS 62.0%
-
CSI 2.0rCSI 4.1%PRS 37.8%
-
CSI 2.0rCSI 2.5%PRS 68.5%
-
CSI 2.0rCSI 3.0%PRS 69.3%
-
CSI 2.1rCSI 8.0%PRS 64.1%
-
CSI 2.1rCSI 3.2%PRS 66.4%
-
CSI 2.1rCSI 1.5%PRS 72.7%
-
CSI 2.1rCSI 1.7%PRS 58.3%
-
CSI 2.1rCSI 3.1%PRS 51.9%
-
CSI 2.1rCSI 4.8%PRS 57.5%
-
CSI 2.1rCSI 2.2%PRS 63.3%
-
CSI 2.1rCSI 2.1%PRS 51.1%
-
CSI 2.2rCSI 4.1%PRS 73.2%
-
CSI 2.2rCSI 8.1%PRS 50.0%
-
CSI 2.2rCSI 3.1%PRS 69.0%
-
CSI 2.2rCSI 4.9%PRS 76.1%
-
CSI 2.2rCSI 5.5%PRS 66.3%
-
CSI 2.2rCSI 3.6%PRS 54.7%
-
CSI 2.2rCSI 3.5%PRS 50.7%
-
CSI 2.2rCSI 3.9%PRS 49.9%
-
CSI 2.3rCSI 3.8%PRS 63.1%
-
CSI 2.3rCSI 4.3%PRS 46.3%
-
CSI 2.3rCSI 5.3%PRS 49.8%
-
CSI 2.4rCSI 4.9%PRS 55.1%
-
CSI 2.4rCSI 2.9%PRS 66.4%
-
CSI 2.4rCSI 2.3%PRS 48.2%
-
CSI 2.4rCSI 2.2%PRS 58.8%
-
CSI 2.4rCSI 3.7%PRS 58.4%
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CSI 2.4rCSI 19.8%PRS 50.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1818439118
Symbol: BCL6_HUMAN
Name: B-cell lymphoma 6 protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8220427
Title: LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas.
PubMed ID: 8220427
DOI: 10.1038/ng0993-66
PubMed ID: 8235596
Title: Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma.
PubMed ID: 8235596
PubMed ID: 8274740
Title: Gene involved in the 3q27 translocation associated with B-cell lymphoma, BCL5, encodes a Kruppel-like zinc-finger protein.
PubMed ID: 8274740
PubMed ID: 8506375
Title: Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas.
PubMed ID: 8506375
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9649500
Title: Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor.
PubMed ID: 9649500
PubMed ID: 10469447
Title: Nonrandom fusion of L-plastin(LCP1) and LAZ3(BCL6) genes by t(3;13)(q27;q14) chromosome translocation in two cases of B-cell non-Hodgkin lymphoma.
PubMed ID: 10469447
DOI: 10.1002/(sici)1098-2264(199910)26:2<97::aid-gcc1>3.3.co;2-0
PubMed ID: 10753856
Title: The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3;7)(q27;p12) translocation in a patient with diffuse large B-cell lymphoma.
PubMed ID: 10753856
PubMed ID: 10981963
Title: BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control.
PubMed ID: 10981963
PubMed ID: 12414651
Title: Characterization of t(3;6)(q27;p21) breakpoints in B-cell non-Hodgkin's lymphoma and construction of the histone H4/BCL6 fusion gene, leading to altered expression of Bcl-6.
PubMed ID: 12414651
PubMed ID: 12402037
Title: Acetylation inactivates the transcriptional repressor BCL6.
PubMed ID: 12402037
DOI: 10.1038/ng1018
PubMed ID: 11821949
Title: The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma.
PubMed ID: 11821949
PubMed ID: 12504096
Title: Point mutations in BCL6 DNA-binding domain reveal distinct roles for the six zinc fingers.
PubMed ID: 12504096
PubMed ID: 12590135
Title: The histone deacetylase 9 gene encodes multiple protein isoforms.
PubMed ID: 12590135
PubMed ID: 15454082
Title: MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation.
PubMed ID: 15454082
PubMed ID: 15577913
Title: The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B-cells.
PubMed ID: 15577913
DOI: 10.1038/nature03147
PubMed ID: 16142238
Title: BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells.
PubMed ID: 16142238
DOI: 10.1038/ni1245
PubMed ID: 16455075
Title: Plastic downregulation of the transcriptional repressor BCL6 during maturation of human dendritic cells.
PubMed ID: 16455075
PubMed ID: 17828269
Title: Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells.
PubMed ID: 17828269
DOI: 10.1038/ni1508
PubMed ID: 18212045
Title: CtBP is an essential corepressor for BCL6 autoregulation.
PubMed ID: 18212045
DOI: 10.1128/mcb.01400-07
PubMed ID: 23166356
Title: BCL6 positively regulates AID and germinal center gene expression via repression of miR-155.
PubMed ID: 23166356
DOI: 10.1084/jem.20121387
PubMed ID: 22113614
Title: FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas.
PubMed ID: 22113614
DOI: 10.1038/nature10688
PubMed ID: 23911289
Title: A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters.
PubMed ID: 23911289
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 30190310
Title: Dimerization quality control ensures neuronal development and survival.
PubMed ID: 30190310
PubMed ID: 14690607
Title: Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain.
PubMed ID: 14690607
PubMed ID: 19052359
Title: Structure of the wild-type human BCL6 POZ domain.
PubMed ID: 19052359
PubMed ID: 18280243
Title: Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer.
PubMed ID: 18280243
PubMed ID: 20385364
Title: A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo.
PubMed ID: 20385364
Sequence Information:
- Length: 706
- Mass: 78846
- Checksum: E38D83C213DAE2D0
- Sequence:
MASPADSCIQ FTRHASDVLL NLNRLRSRDI LTDVVIVVSR EQFRAHKTVL MACSGLFYSI FTDQLKCNLS VINLDPEINP EGFCILLDFM YTSRLNLREG NIMAVMATAM YLQMEHVVDT CRKFIKASEA EMVSAIKPPR EEFLNSRMLM PQDIMAYRGR EVVENNLPLR SAPGCESRAF APSLYSGLST PPASYSMYSH LPVSSLLFSD EEFRDVRMPV ANPFPKERAL PCDSARPVPG EYSRPTLEVS PNVCHSNIYS PKETIPEEAR SDMHYSVAEG LKPAAPSARN APYFPCDKAS KEEERPSSED EIALHFEPPN APLNRKGLVS PQSPQKSDCQ PNSPTESCSS KNACILQASG SPPAKSPTDP KACNWKKYKF IVLNSLNQNA KPEGPEQAEL GRLSPRAYTA PPACQPPMEP ENLDLQSPTK LSASGEDSTI PQASRLNNIV NRSMTGSPRS SSESHSPLYM HPPKCTSCGS QSPQHAEMCL HTAGPTFPEE MGETQSEYSD SSCENGAFFC NECDCRFSEE ASLKRHTLQT HSDKPYKCDR CQASFRYKGN LASHKTVHTG EKPYRCNICG AQFNRPANLK THTRIHSGEK PYKCETCGAR FVQVAHLRAH VLIHTGEKPY PCEICGTRFR HLQTLKSHLR IHTGEKPYHC EKCNLHFRHK SQLRLHLRQK HGAITNTKVQ YRVSATDLPP ELPKAC
Genular Protein ID: 2663400634
Symbol: B5B0A5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 18675787
Title: Alternative splicing generates a short BCL6 (BCL6S) isoform encoding a compact repressor.
PubMed ID: 18675787
Sequence Information:
- Length: 650
- Mass: 72253
- Checksum: 4F0169D0F2FB0B02
- Sequence:
MASPADSCIQ FTRHASDVLL NLNRLRSRDI LTDVVIVVSR EQFRAHKTVL MACSGLFYSI FTDQLKCNLS VINLDPEINP EGFCILLDFM YTSRLNLREG NIMAVMATAM YLQMEHVVDT CRKFIKASEA EMVSAIKPPR EEFLNSRMLM PQDIMAYRGR EVVENNLPLR SAPGCESRAF APSLYSGLST PPASYSMYSH LPVSSLLFSD EEFRDVRMPV ANPFPKERAL PCDSARPVPG EYSRPTLEVS PNVCHSNIYS PKETIPEEAR SDMHYSVAEG LKPAAPSARN APYFPCDKAS KEEERPSSED EIALHFEPPN APLNRKGLVS PQSPQKSDCQ PNSPTEACSS KNACILQASG SPPAKSPTDP KACNWKKYKF IVLNSLNQNA KPGGPEQAEL GRLSPRAYTA PPACQPPMEP ENLDLQSPTK LSASGEDSTI PQASRLNNIV NRSMTGSPRS SSESHSPLYM HPPKCTSCGS QSPQHAEMCL HTAGPTFAEE MGETQSEYSD SSCGEKPYRC NICGAQFNRP ANLKTHTRIH SGEKPYKCET CGARFVQVAH LRAHVLIHTG EKPYPCEICG TRFRHLQTLK SHLRIHTGEK PYHCEKCNLH FRHKSQLRLH LRQKHGAITN TKVQYRVSAT DLPPELPKAC