Details for: BCL6

Gene ID: 604

Symbol: BCL6

Ensembl ID: ENSG00000113916

Description: BCL6 transcription repressor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 286.4762
    Cell Significance Index: -44.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 175.7980
    Cell Significance Index: -44.5900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 91.6711
    Cell Significance Index: -43.2800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 87.5800
    Cell Significance Index: -35.5800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 80.3192
    Cell Significance Index: -41.3200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.2980
    Cell Significance Index: -35.6100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.1651
    Cell Significance Index: -44.5900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.4618
    Cell Significance Index: -41.4200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 14.2336
    Cell Significance Index: 96.4400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.7532
    Cell Significance Index: -30.1000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.7529
    Cell Significance Index: -39.1700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.4140
    Cell Significance Index: -45.0400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 9.5413
    Cell Significance Index: 153.9500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 9.1281
    Cell Significance Index: 222.7200
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 3.2895
    Cell Significance Index: 14.3200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 2.8915
    Cell Significance Index: 36.4100
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 2.8598
    Cell Significance Index: 3.7000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.3910
    Cell Significance Index: 278.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.2017
    Cell Significance Index: 61.5300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.8227
    Cell Significance Index: 16.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.6747
    Cell Significance Index: 128.5200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.4013
    Cell Significance Index: 36.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3640
    Cell Significance Index: 270.7000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.3383
    Cell Significance Index: 26.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.2784
    Cell Significance Index: 36.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0850
    Cell Significance Index: 127.9500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.9828
    Cell Significance Index: 16.5600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.8911
    Cell Significance Index: 12.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8403
    Cell Significance Index: 151.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7894
    Cell Significance Index: 78.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7004
    Cell Significance Index: 632.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.5997
    Cell Significance Index: 380.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5692
    Cell Significance Index: 69.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4460
    Cell Significance Index: 20.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4151
    Cell Significance Index: 183.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4104
    Cell Significance Index: 66.7500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4009
    Cell Significance Index: 7.4100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.3903
    Cell Significance Index: 0.8800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.3266
    Cell Significance Index: 4.6900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3176
    Cell Significance Index: 22.4600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3156
    Cell Significance Index: 594.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2931
    Cell Significance Index: 37.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2791
    Cell Significance Index: 100.1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2707
    Cell Significance Index: 29.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2656
    Cell Significance Index: 13.8000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2390
    Cell Significance Index: 5.0900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2353
    Cell Significance Index: 11.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2236
    Cell Significance Index: 344.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2226
    Cell Significance Index: 10.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2135
    Cell Significance Index: 393.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1855
    Cell Significance Index: 25.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1278
    Cell Significance Index: 25.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1213
    Cell Significance Index: 66.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1175
    Cell Significance Index: 53.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1144
    Cell Significance Index: 79.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0867
    Cell Significance Index: 54.1200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0398
    Cell Significance Index: 2.3900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0163
    Cell Significance Index: 0.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0021
    Cell Significance Index: 2.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0118
    Cell Significance Index: -0.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0182
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0227
    Cell Significance Index: -16.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0381
    Cell Significance Index: -6.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0415
    Cell Significance Index: -31.4400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0454
    Cell Significance Index: -33.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0525
    Cell Significance Index: -29.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0578
    Cell Significance Index: -2.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0732
    Cell Significance Index: -2.1100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0898
    Cell Significance Index: -1.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0938
    Cell Significance Index: -9.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0945
    Cell Significance Index: -12.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0966
    Cell Significance Index: -9.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1029
    Cell Significance Index: -2.2300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1039
    Cell Significance Index: -11.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1063
    Cell Significance Index: -15.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1248
    Cell Significance Index: -35.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1289
    Cell Significance Index: -27.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2483
    Cell Significance Index: -28.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2627
    Cell Significance Index: -18.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2888
    Cell Significance Index: -3.9400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3040
    Cell Significance Index: -7.6000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3252
    Cell Significance Index: -4.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3437
    Cell Significance Index: -9.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3498
    Cell Significance Index: -9.3400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3665
    Cell Significance Index: -3.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3792
    Cell Significance Index: -23.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4170
    Cell Significance Index: -25.6300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4662
    Cell Significance Index: -9.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4667
    Cell Significance Index: -24.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4887
    Cell Significance Index: -31.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4899
    Cell Significance Index: -38.8000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5090
    Cell Significance Index: -8.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5141
    Cell Significance Index: -28.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5337
    Cell Significance Index: -17.1000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5563
    Cell Significance Index: -35.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5704
    Cell Significance Index: -29.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5984
    Cell Significance Index: -40.2400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.6867
    Cell Significance Index: -5.6000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.8541
    Cell Significance Index: -12.6100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8626
    Cell Significance Index: -19.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** BCL6 is a transcriptional repressor that exhibits the following key characteristics: 1. **POZ domain**: BCL6 contains a POZ domain, which is a conserved domain that mediates protein-protein interactions and DNA binding. 2. **Specific DNA binding**: BCL6 binds to specific DNA sequences, which are typically found in the promoter regions of target genes. 3. **Transcriptional repression**: BCL6 represses transcription by recruiting co-repressors and inhibiting the activity of transcriptional activators. 4. **Cellular expression**: BCL6 is highly expressed in immune cells, particularly in B cells, where it regulates cell proliferation, differentiation, and survival. 5. **Regulation of immune responses**: BCL6 regulates immune responses by modulating the expression of genes involved in B cell development, activation, and differentiation. **Pathways and Functions** BCL6 is involved in various cellular pathways and functions, including: 1. **B cell development and differentiation**: BCL6 regulates B cell development, differentiation, and survival by modulating the expression of genes involved in these processes. 2. **Immune responses**: BCL6 regulates immune responses by modulating the expression of genes involved in B cell activation, proliferation, and differentiation. 3. **Apoptosis**: BCL6 regulates apoptosis by modulating the expression of genes involved in this process. 4. **Cell growth and proliferation**: BCL6 regulates cell growth and proliferation by modulating the expression of genes involved in these processes. 5. **Transcriptional regulation**: BCL6 regulates transcription by recruiting co-repressors and inhibiting the activity of transcriptional activators. **Clinical Significance** Dysregulation of BCL6 has been implicated in various diseases, including: 1. **Cancer**: BCL6 is often overexpressed in cancer, including B cell lymphomas and leukemias. 2. **Autoimmune disorders**: BCL6 is involved in the regulation of immune responses, and dysregulation of BCL6 has been implicated in autoimmune disorders, such as rheumatoid arthritis and lupus. 3. **Inflammatory diseases**: BCL6 is involved in the regulation of inflammatory responses, and dysregulation of BCL6 has been implicated in inflammatory diseases, such as atherosclerosis and inflammatory bowel disease. In summary, BCL6 is a transcriptional repressor that plays a crucial role in regulating gene expression in various cellular contexts, including B cell development, immune responses, and apoptosis. Its dysregulation has been implicated in various diseases, including cancer, autoimmune disorders, and inflammatory diseases.

Genular Protein ID: 1818439118

Symbol: BCL6_HUMAN

Name: B-cell lymphoma 6 protein

UniProtKB Accession Codes:

P41182 A7E241 B8PSA7 D3DNV5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 64 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 5 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8220427

Title: LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas.

PubMed ID: 8220427

DOI: 10.1038/ng0993-66

PubMed ID: 8235596

Title: Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma.

PubMed ID: 8235596

DOI: 10.1126/science.8235596

PubMed ID: 8274740

Title: Gene involved in the 3q27 translocation associated with B-cell lymphoma, BCL5, encodes a Kruppel-like zinc-finger protein.

PubMed ID: 8274740

PubMed ID: 8506375

Title: Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas.

PubMed ID: 8506375

DOI: 10.1073/pnas.90.11.5262

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9649500

Title: Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor.

PubMed ID: 9649500

DOI: 10.1101/gad.12.13.1953

PubMed ID: 10469447

Title: Nonrandom fusion of L-plastin(LCP1) and LAZ3(BCL6) genes by t(3;13)(q27;q14) chromosome translocation in two cases of B-cell non-Hodgkin lymphoma.

PubMed ID: 10469447

DOI: 10.1002/(sici)1098-2264(199910)26:2<97::aid-gcc1>3.3.co;2-0

PubMed ID: 10753856

Title: The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3;7)(q27;p12) translocation in a patient with diffuse large B-cell lymphoma.

PubMed ID: 10753856

PubMed ID: 10981963

Title: BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control.

PubMed ID: 10981963

DOI: 10.1016/s1074-7613(00)00020-0

PubMed ID: 12414651

Title: Characterization of t(3;6)(q27;p21) breakpoints in B-cell non-Hodgkin's lymphoma and construction of the histone H4/BCL6 fusion gene, leading to altered expression of Bcl-6.

PubMed ID: 12414651

PubMed ID: 12402037

Title: Acetylation inactivates the transcriptional repressor BCL6.

PubMed ID: 12402037

DOI: 10.1038/ng1018

PubMed ID: 11821949

Title: The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma.

PubMed ID: 11821949

DOI: 10.1038/sj.onc.1205099

PubMed ID: 12504096

Title: Point mutations in BCL6 DNA-binding domain reveal distinct roles for the six zinc fingers.

PubMed ID: 12504096

DOI: 10.1016/s0006-291x(02)02873-5

PubMed ID: 12590135

Title: The histone deacetylase 9 gene encodes multiple protein isoforms.

PubMed ID: 12590135

DOI: 10.1074/jbc.m212935200

PubMed ID: 15454082

Title: MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation.

PubMed ID: 15454082

DOI: 10.1016/j.cell.2004.09.014

PubMed ID: 15577913

Title: The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B-cells.

PubMed ID: 15577913

DOI: 10.1038/nature03147

PubMed ID: 16142238

Title: BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells.

PubMed ID: 16142238

DOI: 10.1038/ni1245

PubMed ID: 16455075

Title: Plastic downregulation of the transcriptional repressor BCL6 during maturation of human dendritic cells.

PubMed ID: 16455075

DOI: 10.1016/j.yexcr.2005.12.020

PubMed ID: 17828269

Title: Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells.

PubMed ID: 17828269

DOI: 10.1038/ni1508

PubMed ID: 18212045

Title: CtBP is an essential corepressor for BCL6 autoregulation.

PubMed ID: 18212045

DOI: 10.1128/mcb.01400-07

PubMed ID: 23166356

Title: BCL6 positively regulates AID and germinal center gene expression via repression of miR-155.

PubMed ID: 23166356

DOI: 10.1084/jem.20121387

PubMed ID: 22113614

Title: FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas.

PubMed ID: 22113614

DOI: 10.1038/nature10688

PubMed ID: 23911289

Title: A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters.

PubMed ID: 23911289

DOI: 10.1016/j.celrep.2013.06.016

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 30190310

Title: Dimerization quality control ensures neuronal development and survival.

PubMed ID: 30190310

DOI: 10.1126/science.aap8236

PubMed ID: 14690607

Title: Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain.

PubMed ID: 14690607

DOI: 10.1016/s1097-2765(03)00454-4

PubMed ID: 19052359

Title: Structure of the wild-type human BCL6 POZ domain.

PubMed ID: 19052359

DOI: 10.1107/s1744309108036063

PubMed ID: 18280243

Title: Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer.

PubMed ID: 18280243

DOI: 10.1016/j.molcel.2007.12.026

PubMed ID: 20385364

Title: A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo.

PubMed ID: 20385364

DOI: 10.1016/j.ccr.2009.12.050

Sequence Information:

  • Length: 706
  • Mass: 78846
  • Checksum: E38D83C213DAE2D0
  • Sequence:
    • MASPADSCIQ FTRHASDVLL NLNRLRSRDI LTDVVIVVSR EQFRAHKTVL MACSGLFYSI 
FTDQLKCNLS VINLDPEINP EGFCILLDFM YTSRLNLREG NIMAVMATAM YLQMEHVVDT 
CRKFIKASEA EMVSAIKPPR EEFLNSRMLM PQDIMAYRGR EVVENNLPLR SAPGCESRAF 
APSLYSGLST PPASYSMYSH LPVSSLLFSD EEFRDVRMPV ANPFPKERAL PCDSARPVPG 
EYSRPTLEVS PNVCHSNIYS PKETIPEEAR SDMHYSVAEG LKPAAPSARN APYFPCDKAS 
KEEERPSSED EIALHFEPPN APLNRKGLVS PQSPQKSDCQ PNSPTESCSS KNACILQASG 
SPPAKSPTDP KACNWKKYKF IVLNSLNQNA KPEGPEQAEL GRLSPRAYTA PPACQPPMEP 
ENLDLQSPTK LSASGEDSTI PQASRLNNIV NRSMTGSPRS SSESHSPLYM HPPKCTSCGS 
QSPQHAEMCL HTAGPTFPEE MGETQSEYSD SSCENGAFFC NECDCRFSEE ASLKRHTLQT 
HSDKPYKCDR CQASFRYKGN LASHKTVHTG EKPYRCNICG AQFNRPANLK THTRIHSGEK 
PYKCETCGAR FVQVAHLRAH VLIHTGEKPY PCEICGTRFR HLQTLKSHLR IHTGEKPYHC 
EKCNLHFRHK SQLRLHLRQK HGAITNTKVQ YRVSATDLPP ELPKAC

Genular Protein ID: 2663400634

Symbol: B5B0A5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B5B0A5

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 2

Citations:

PubMed ID: 18675787

Title: Alternative splicing generates a short BCL6 (BCL6S) isoform encoding a compact repressor.

PubMed ID: 18675787

DOI: 10.1016/j.bbrc.2008.07.116

Sequence Information:

  • Length: 650
  • Mass: 72253
  • Checksum: 4F0169D0F2FB0B02
  • Sequence:
    • MASPADSCIQ FTRHASDVLL NLNRLRSRDI LTDVVIVVSR EQFRAHKTVL MACSGLFYSI 
FTDQLKCNLS VINLDPEINP EGFCILLDFM YTSRLNLREG NIMAVMATAM YLQMEHVVDT 
CRKFIKASEA EMVSAIKPPR EEFLNSRMLM PQDIMAYRGR EVVENNLPLR SAPGCESRAF 
APSLYSGLST PPASYSMYSH LPVSSLLFSD EEFRDVRMPV ANPFPKERAL PCDSARPVPG 
EYSRPTLEVS PNVCHSNIYS PKETIPEEAR SDMHYSVAEG LKPAAPSARN APYFPCDKAS 
KEEERPSSED EIALHFEPPN APLNRKGLVS PQSPQKSDCQ PNSPTEACSS KNACILQASG 
SPPAKSPTDP KACNWKKYKF IVLNSLNQNA KPGGPEQAEL GRLSPRAYTA PPACQPPMEP 
ENLDLQSPTK LSASGEDSTI PQASRLNNIV NRSMTGSPRS SSESHSPLYM HPPKCTSCGS 
QSPQHAEMCL HTAGPTFAEE MGETQSEYSD SSCGEKPYRC NICGAQFNRP ANLKTHTRIH 
SGEKPYKCET CGARFVQVAH LRAHVLIHTG EKPYPCEICG TRFRHLQTLK SHLRIHTGEK 
PYHCEKCNLH FRHKSQLRLH LRQKHGAITN TKVQYRVSAT DLPPELPKAC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.