Details for: BCL6

Gene ID: 604

Symbol: BCL6

Ensembl ID: ENSG00000113916

Description: BCL6 transcription repressor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 6.2
    Marker Score: 15527
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 5.01
    Marker Score: 3297
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 3.65
    Marker Score: 1335
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.88
    Marker Score: 61523
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.7
    Marker Score: 3111
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.63
    Marker Score: 1732
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.47
    Marker Score: 723
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.45
    Marker Score: 3292
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.43
    Marker Score: 1352.5
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.35
    Marker Score: 2846
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.29
    Marker Score: 9596
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.1
    Marker Score: 1139
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.1
    Marker Score: 1172
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.95
    Marker Score: 1730
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.95
    Marker Score: 6931
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.93
    Marker Score: 2062
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.91
    Marker Score: 604
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.9
    Marker Score: 1104
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.85
    Marker Score: 3276
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.85
    Marker Score: 2093
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.83
    Marker Score: 474
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.82
    Marker Score: 2005
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.81
    Marker Score: 3968
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.7
    Marker Score: 740
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.68
    Marker Score: 1459
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.68
    Marker Score: 1122
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.67
    Marker Score: 56947
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.57
    Marker Score: 361
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.55
    Marker Score: 447
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.55
    Marker Score: 1927.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.53
    Marker Score: 1608
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.49
    Marker Score: 1014
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.49
    Marker Score: 2859
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167598
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.43
    Marker Score: 10653
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4
    Marker Score: 4152.5
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.38
    Marker Score: 669
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.38
    Marker Score: 3138
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.37
    Marker Score: 30559
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.36
    Marker Score: 2006
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.35
    Marker Score: 390
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.34
    Marker Score: 658
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.33
    Marker Score: 3265.5
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.32
    Marker Score: 916
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.3
    Marker Score: 20950
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.27
    Marker Score: 534
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.27
    Marker Score: 19942
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.26
    Marker Score: 6208
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.26
    Marker Score: 429
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.26
    Marker Score: 311
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.25
    Marker Score: 10886
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.24
    Marker Score: 69562
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.23
    Marker Score: 46583
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.22
    Marker Score: 2865
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.21
    Marker Score: 5022
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.21
    Marker Score: 597
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.21
    Marker Score: 726
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.21
    Marker Score: 689
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.2
    Marker Score: 1854
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.19
    Marker Score: 1288
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.19
    Marker Score: 2166
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.15
    Marker Score: 371
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.14
    Marker Score: 1089
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.13
    Marker Score: 1456
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.12
    Marker Score: 286
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.12
    Marker Score: 521
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 1.11
    Marker Score: 336
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.09
    Marker Score: 2223
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.09
    Marker Score: 552
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.09
    Marker Score: 287.5
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.04
    Marker Score: 1752
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.02
    Marker Score: 384
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71707
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47931
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.99
    Marker Score: 311
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30393
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.98
    Marker Score: 660.5
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.97
    Marker Score: 6247
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.97
    Marker Score: 563
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.97
    Marker Score: 12979
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.96
    Marker Score: 1182
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.95
    Marker Score: 6179.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.95
    Marker Score: 1171
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.94
    Marker Score: 3084.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 484
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.93
    Marker Score: 5580
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.91
    Marker Score: 3906
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2704
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.89
    Marker Score: 1375
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.89
    Marker Score: 3059
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.89
    Marker Score: 755
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.87
    Marker Score: 316
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.87
    Marker Score: 376
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.87
    Marker Score: 508
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.85
    Marker Score: 562
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.85
    Marker Score: 12723

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Other Information

**Key characteristics:** * BCL6 is a protein with a molecular weight of approximately 120 kDa. * It is a member of the BCL6 family of transcription repressors. * BCL6 is expressed in a variety of cell types, including immune cells, cancer cells, and normal cells. * It is a key regulator of apoptosis in response to various stimuli, including DNA damage, growth factor deprivation, and cytokines. **Pathways and functions:** * BCL6 binds to DNA sequences known as the BCL6 response element (BRE) in the promoters of various cell death genes. * Upon binding to BRE, BCL6 recruits the co-repressor protein p53 to the nucleus, leading to the inhibition of cell death gene expression. * BCL6 also regulates the expression of anti-apoptotic genes, such as BCL2, BCLX1, and PUMA. * In addition to its role in cell death, BCL6 has been shown to play a role in regulating inflammation and immune responses. **Clinical significance:** * Mutations in the BCL6 gene have been linked to the development of various human cancers, including leukemia, lymphoma, and solid tumors. * Targeting BCL6 has emerged as a promising therapeutic strategy for cancer treatment. * Several drugs, such as ABT-737 and A131, are currently being evaluated in clinical trials for the treatment of cancer. **Overall, BCL6 is a critical regulator of cell death that plays a significant role in maintaining cellular homeostasis and preventing the development of cancer.**

Genular Protein ID: 1818439118

Symbol: BCL6_HUMAN

Name: B-cell lymphoma 6 protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8220427

Title: LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas.

PubMed ID: 8220427

DOI: 10.1038/ng0993-66

PubMed ID: 8235596

Title: Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma.

PubMed ID: 8235596

DOI: 10.1126/science.8235596

PubMed ID: 8274740

Title: Gene involved in the 3q27 translocation associated with B-cell lymphoma, BCL5, encodes a Kruppel-like zinc-finger protein.

PubMed ID: 8274740

PubMed ID: 8506375

Title: Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas.

PubMed ID: 8506375

DOI: 10.1073/pnas.90.11.5262

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9649500

Title: Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor.

PubMed ID: 9649500

DOI: 10.1101/gad.12.13.1953

PubMed ID: 10469447

Title: Nonrandom fusion of L-plastin(LCP1) and LAZ3(BCL6) genes by t(3;13)(q27;q14) chromosome translocation in two cases of B-cell non-Hodgkin lymphoma.

PubMed ID: 10469447

DOI: 10.1002/(sici)1098-2264(199910)26:2<97::aid-gcc1>3.3.co;2-0

PubMed ID: 10753856

Title: The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3;7)(q27;p12) translocation in a patient with diffuse large B-cell lymphoma.

PubMed ID: 10753856

PubMed ID: 10981963

Title: BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control.

PubMed ID: 10981963

DOI: 10.1016/s1074-7613(00)00020-0

PubMed ID: 12414651

Title: Characterization of t(3;6)(q27;p21) breakpoints in B-cell non-Hodgkin's lymphoma and construction of the histone H4/BCL6 fusion gene, leading to altered expression of Bcl-6.

PubMed ID: 12414651

PubMed ID: 12402037

Title: Acetylation inactivates the transcriptional repressor BCL6.

PubMed ID: 12402037

DOI: 10.1038/ng1018

PubMed ID: 11821949

Title: The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma.

PubMed ID: 11821949

DOI: 10.1038/sj.onc.1205099

PubMed ID: 12504096

Title: Point mutations in BCL6 DNA-binding domain reveal distinct roles for the six zinc fingers.

PubMed ID: 12504096

DOI: 10.1016/s0006-291x(02)02873-5

PubMed ID: 12590135

Title: The histone deacetylase 9 gene encodes multiple protein isoforms.

PubMed ID: 12590135

DOI: 10.1074/jbc.m212935200

PubMed ID: 15454082

Title: MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation.

PubMed ID: 15454082

DOI: 10.1016/j.cell.2004.09.014

PubMed ID: 15577913

Title: The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B-cells.

PubMed ID: 15577913

DOI: 10.1038/nature03147

PubMed ID: 16142238

Title: BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells.

PubMed ID: 16142238

DOI: 10.1038/ni1245

PubMed ID: 16455075

Title: Plastic downregulation of the transcriptional repressor BCL6 during maturation of human dendritic cells.

PubMed ID: 16455075

DOI: 10.1016/j.yexcr.2005.12.020

PubMed ID: 17828269

Title: Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells.

PubMed ID: 17828269

DOI: 10.1038/ni1508

PubMed ID: 18212045

Title: CtBP is an essential corepressor for BCL6 autoregulation.

PubMed ID: 18212045

DOI: 10.1128/mcb.01400-07

PubMed ID: 23166356

Title: BCL6 positively regulates AID and germinal center gene expression via repression of miR-155.

PubMed ID: 23166356

DOI: 10.1084/jem.20121387

PubMed ID: 22113614

Title: FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas.

PubMed ID: 22113614

DOI: 10.1038/nature10688

PubMed ID: 23911289

Title: A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters.

PubMed ID: 23911289

DOI: 10.1016/j.celrep.2013.06.016

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 30190310

Title: Dimerization quality control ensures neuronal development and survival.

PubMed ID: 30190310

DOI: 10.1126/science.aap8236

PubMed ID: 14690607

Title: Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain.

PubMed ID: 14690607

DOI: 10.1016/s1097-2765(03)00454-4

PubMed ID: 19052359

Title: Structure of the wild-type human BCL6 POZ domain.

PubMed ID: 19052359

DOI: 10.1107/s1744309108036063

PubMed ID: 18280243

Title: Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer.

PubMed ID: 18280243

DOI: 10.1016/j.molcel.2007.12.026

PubMed ID: 20385364

Title: A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo.

PubMed ID: 20385364

DOI: 10.1016/j.ccr.2009.12.050

Sequence Information:

  • Length: 706
  • Mass: 78846
  • Checksum: E38D83C213DAE2D0
  • Sequence:
  • MASPADSCIQ FTRHASDVLL NLNRLRSRDI LTDVVIVVSR EQFRAHKTVL MACSGLFYSI 
    FTDQLKCNLS VINLDPEINP EGFCILLDFM YTSRLNLREG NIMAVMATAM YLQMEHVVDT 
    CRKFIKASEA EMVSAIKPPR EEFLNSRMLM PQDIMAYRGR EVVENNLPLR SAPGCESRAF 
    APSLYSGLST PPASYSMYSH LPVSSLLFSD EEFRDVRMPV ANPFPKERAL PCDSARPVPG 
    EYSRPTLEVS PNVCHSNIYS PKETIPEEAR SDMHYSVAEG LKPAAPSARN APYFPCDKAS 
    KEEERPSSED EIALHFEPPN APLNRKGLVS PQSPQKSDCQ PNSPTESCSS KNACILQASG 
    SPPAKSPTDP KACNWKKYKF IVLNSLNQNA KPEGPEQAEL GRLSPRAYTA PPACQPPMEP 
    ENLDLQSPTK LSASGEDSTI PQASRLNNIV NRSMTGSPRS SSESHSPLYM HPPKCTSCGS 
    QSPQHAEMCL HTAGPTFPEE MGETQSEYSD SSCENGAFFC NECDCRFSEE ASLKRHTLQT 
    HSDKPYKCDR CQASFRYKGN LASHKTVHTG EKPYRCNICG AQFNRPANLK THTRIHSGEK 
    PYKCETCGAR FVQVAHLRAH VLIHTGEKPY PCEICGTRFR HLQTLKSHLR IHTGEKPYHC 
    EKCNLHFRHK SQLRLHLRQK HGAITNTKVQ YRVSATDLPP ELPKAC

Genular Protein ID: 2663400634

Symbol: B5B0A5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 18675787

Title: Alternative splicing generates a short BCL6 (BCL6S) isoform encoding a compact repressor.

PubMed ID: 18675787

DOI: 10.1016/j.bbrc.2008.07.116

Sequence Information:

  • Length: 650
  • Mass: 72253
  • Checksum: 4F0169D0F2FB0B02
  • Sequence:
  • MASPADSCIQ FTRHASDVLL NLNRLRSRDI LTDVVIVVSR EQFRAHKTVL MACSGLFYSI 
    FTDQLKCNLS VINLDPEINP EGFCILLDFM YTSRLNLREG NIMAVMATAM YLQMEHVVDT 
    CRKFIKASEA EMVSAIKPPR EEFLNSRMLM PQDIMAYRGR EVVENNLPLR SAPGCESRAF 
    APSLYSGLST PPASYSMYSH LPVSSLLFSD EEFRDVRMPV ANPFPKERAL PCDSARPVPG 
    EYSRPTLEVS PNVCHSNIYS PKETIPEEAR SDMHYSVAEG LKPAAPSARN APYFPCDKAS 
    KEEERPSSED EIALHFEPPN APLNRKGLVS PQSPQKSDCQ PNSPTEACSS KNACILQASG 
    SPPAKSPTDP KACNWKKYKF IVLNSLNQNA KPGGPEQAEL GRLSPRAYTA PPACQPPMEP 
    ENLDLQSPTK LSASGEDSTI PQASRLNNIV NRSMTGSPRS SSESHSPLYM HPPKCTSCGS 
    QSPQHAEMCL HTAGPTFAEE MGETQSEYSD SSCGEKPYRC NICGAQFNRP ANLKTHTRIH 
    SGEKPYKCET CGARFVQVAH LRAHVLIHTG EKPYPCEICG TRFRHLQTLK SHLRIHTGEK 
    PYHCEKCNLH FRHKSQLRLH LRQKHGAITN TKVQYRVSAT DLPPELPKAC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.