Mcl1 | ENSRNOG00000063678 | NCBI 60430

Details for: Mcl1

Gene ID: 60430

Symbol: Mcl1

Ensembl ID: ENSRNOG00000063678

Description: MCL1 apoptosis regulator, BCL2 family member

Associated with

Apoptotic mitochondrial changes
(GO:0008637)
Bcl-2 family protein complex
(GO:0097136)
Bh3 domain binding
(GO:0051434)
Bh domain binding
(GO:0051400)
Cell differentiation
(GO:0030154)
Channel activity
(GO:0015267)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna damage response
(GO:0006974)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Membrane
(GO:0016020)
Mitochondrial fusion
(GO:0008053)
Mitochondrial matrix
(GO:0005759)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrion
(GO:0005739)
Negative regulation of anoikis
(GO:2000811)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of autophagy
(GO:0010507)
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
(GO:2001240)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
(GO:1903378)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Regulation of apoptotic process
(GO:0042981)
Release of cytochrome c from mitochondria
(GO:0001836)
Response to cytokine
(GO:0034097)
Transmembrane transport
(GO:0055085)

Other Information

Proteins

Induced myeloid leukemia cell differentiation protein Mcl-1 homolog

Genular Protein ID: 3243988376

Symbol: MCL1_RAT

Name: Induced myeloid leukemia cell differentiation protein Mcl-1 homolog

UniProtKB Accession Codes:

Q9Z1P3 Q6AYY5 Q9R289

Database IDs:

Citations:

PubMed ID: 10579309

Title: Characterization of the antiapoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ovary.

PubMed ID: 10579309

DOI: 10.1210/endo.140.12.7171

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 330
Mass: 35214
Checksum: C4A9DEB41897258E
Sequence:

MFGLRRNAVI GLNLYCGGAS LGAGGGSPAG TRLAAEEAKA RREGGGEAAL LPGARVVARP 
PPVGAEDPDV TASAERRLLK SPGLLAVPPE EMAASAAAIM SPEEELDGCE PEVLSKRPAV 
LPLLERVSEA AKSSGADGSL PSTPPPPEEE DDELYRQSLE IISRYLREQA TGSKDAKPLG 
EAGAAGRRAL ETLRRVGDGV QRNHETAFQG MLRKLDIKNE DDVKSFSRVM THVFKDGVTN 
WGRIVTLISF GAFVAKHLKS INQESCIEPL AESITDVLVR TKRDWLVKQR GWDGFVEFFH 
VQDLEGGIRN VLLAFAGVAG VGAGLAYLIR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.