Tsc1 | ENSRNOG00000011470 | NCBI 60445

Details for: Tsc1

Gene ID: 60445

Symbol: Tsc1

Ensembl ID: ENSRNOG00000011470

Description: TSC complex subunit 1

Associated with

Autophagy
(R-RNO-9612973)
Energy dependent regulation of mtor by lkb1-ampk
(R-RNO-380972)
Gene expression (transcription)
(R-RNO-74160)
Generic transcription pathway
(R-RNO-212436)
Inhibition of tsc complex formation by pkb
(R-RNO-165181)
Macroautophagy
(R-RNO-1632852)
Membrane trafficking
(R-RNO-199991)
Mtor signalling
(R-RNO-165159)
Rab regulation of trafficking
(R-RNO-9007101)
Rna polymerase ii transcription
(R-RNO-73857)
Signal transduction
(R-RNO-162582)
Tbc/rabgaps
(R-RNO-8854214)
Tp53 regulates metabolic genes
(R-RNO-5628897)
Transcriptional regulation by tp53
(R-RNO-3700989)
Vesicle-mediated transport
(R-RNO-5653656)
Actin filament
(GO:0005884)
Adaptive immune response
(GO:0002250)
Adult locomotory behavior
(GO:0008344)
Associative learning
(GO:0008306)
Atpase inhibitor activity
(GO:0042030)
Cardiac muscle cell differentiation
(GO:0055007)
Cell-matrix adhesion
(GO:0007160)
Cell cortex
(GO:0005938)
Cell population proliferation
(GO:0008283)
Cell projection
(GO:0042995)
Cell projection organization
(GO:0030030)
Cellular response to decreased oxygen levels
(GO:0036294)
Cellular response to starvation
(GO:0009267)
Cerebral cortex development
(GO:0021987)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Glucose import
(GO:0046323)
Growth cone
(GO:0030426)
Hippocampus development
(GO:0021766)
Hsp70 protein binding
(GO:0030544)
Hsp90 protein binding
(GO:0051879)
Kidney development
(GO:0001822)
Lamellipodium
(GO:0030027)
Lipid droplet
(GO:0005811)
Lysosomal membrane
(GO:0005765)
Membrane
(GO:0016020)
Memory t cell differentiation
(GO:0043379)
Myelination
(GO:0042552)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of cell size
(GO:0045792)
Negative regulation of cellular response to oxidative stress
(GO:1900408)
Negative regulation of macroautophagy
(GO:0016242)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of torc1 signaling
(GO:1904262)
Negative regulation of tor signaling
(GO:0032007)
Negative regulation of translation
(GO:0017148)
Nervous system development
(GO:0007399)
Neural tube closure
(GO:0001843)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of focal adhesion assembly
(GO:0051894)
Positive regulation of macroautophagy
(GO:0016239)
Positive regulation of stress fiber assembly
(GO:0051496)
Postsynaptic density
(GO:0014069)
Potassium ion transport
(GO:0006813)
Protein-containing complex
(GO:0032991)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein folding chaperone complex
(GO:0101031)
Protein stabilization
(GO:0050821)
Regulation of cell-matrix adhesion
(GO:0001952)
Regulation of cell cycle
(GO:0051726)
Regulation of focal adhesion assembly
(GO:0051893)
Regulation of stress fiber assembly
(GO:0051492)
Regulation of translation
(GO:0006417)
Response to insulin
(GO:0032868)
Response to nutrient levels
(GO:0031667)
Response to peptide
(GO:1901652)
Synapse organization
(GO:0050808)
Tsc1-tsc2 complex
(GO:0033596)

Other Information

Proteins

TSC1_RAT

Genular Protein ID: 4207737944

Symbol: TSC1_RAT

Name: N/A

UniProtKB Accession Codes:

Q9Z136

Database IDs:

Citations:

PubMed ID: 10029074

Title: Isolation and characterization of a rat homologue of the human tuberous sclerosis 1 gene (Tsc1) and analysis of its mutations in rat renal carcinomas.

PubMed ID: 10029074

PubMed ID: 9809973

Title: Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles.

PubMed ID: 9809973

PubMed ID: 16707451

Title: Regulation of microtubule-dependent protein transport by the TSC2/mammalian target of rapamycin pathway.

PubMed ID: 16707451

DOI: 10.1158/0008-5472.can-05-4510

Sequence Information:

Length: 1163
Mass: 129022
Checksum: CB5AE6A12AE3B0A1
Sequence:

MAQLANIGEL LSMLDSSTLG VRDDVTTIFK ESLNSERGPM LVNTLVDYYL ETNSQPVLHI 
LTTLQEPHDK HLLDKMNEYV GKAATRLSIL SLLGHVVRLQ PSWKHKLSQA PLLPSLLKCL 
KMDTDVVVLT TGVLVLITML PMIPQSGKQH LLDFFDIFGR LSSWCLKKPG HVTEVYLVHL 
HASVYALFHR LYGMYPCNFV SFLRSHYSMK ENVETFEEVV KPMMEHVRIH PELVTGSKDH 
ELDPRRWKTL ETHDVVIECA KISLDPTEAS YEDGDAVSHQ LSACFPHRSA DVTTSSYVDT 
QNSYGGATST PSSTSRLMLF STPGQLPQSL SSLSTRPLPE PLQASLWSPS AVCGMTTPPT 
SPGNVPADLS HPYSKAFGTT TGGKGTPSGT PATSPPPAPP CPQDDCAHGP ASQASATPPR 
KEERADSSRP YLPRQQDVPS DRGLEDLPGS KGSVTLRNLP DFLGDLASEE DSIEKDKEEA 
AISKELSEIT TAEADPVAPR GGFDSPFYRD SLSGSQRKTH SAASGTQGFS VNPEPLHSSL 
DKHGPDTPKQ AFTPIDPPSG SADASPAGDR DRQTSLETSI LTPSPCKIPP QRGVSFGSGQ 
LPPYDHLFEV ALPKTACHFV SKKTEELLKK AKGNPEEDCV PSTSPMEVLD RLLEQGAGAH 
SKELSRLSLP SKSVDWTHFG GSPPSDEIRT LRDQLLLLHN QLLYERFKRQ QHALRNRRLL 
RKVIRAAALE EHNAAMKDQL KLQEKDIQMW KVSLQKEQAR YSQLQQQRDT MVTQLHSQIR 
QLQHDREEFY NQSQELQTKL EDCRSMIAEL RVELKKANSK VCHTELLLSQ VSQKLSNSES 
VQQQMEFLNR QLLVLGEVNE LYLEQLQSKH PDTTKEVEMM KTAYRKELEK NRSHLLQQNQ 
RLDASQRRVL ELESLLAKKD HLLLEQKKYL EDVKSQASGQ LLAAESRYEA QRKITRVLEL 
EILDLYGRLE KDGRLQKLEE DRAEAAEAAE ERLDCCTDGC SDSLLGHNEE AAGHNGETRT 
SRPGGTRASC GGRVTGGSSS SSSELSTPEK PPNQRFSSRW EPTMGEPSSS IPTTVGSLPS 
SKSFLGMKTR ELFRNKSESQ CDEDGMTMSS FSETLKTELG KDSAGMENKT PPSLDAPHPS 
SPSSDSMGQL HIMDYNETHH EHS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.