Details for: APOBEC3G

Gene ID: 60489

Symbol: APOBEC3G

Ensembl ID: ENSG00000239713

Description: apolipoprotein B mRNA editing enzyme catalytic subunit 3G

Associated with

Other Information

Genular Protein ID: 237150312

Symbol: ABC3G_HUMAN

Name: DNA dC->dU-editing enzyme APOBEC-3G

UniProtKB Accession Codes:

Q9HC16 B2RDR9 Q45F02 Q5TF77 Q7Z2N1 Q7Z2N4 Q9H9H8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 10 EMDB 2 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 29 PDBsum 20 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 3 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14557625

Title: The human immunodeficiency virus type 1 Vif protein reduces intracellular expression and inhibits packaging of APOBEC3G (CEM15), a cellular inhibitor of virus infectivity.

PubMed ID: 14557625

DOI: 10.1128/jvi.77.21.11398-11407.2003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11863358

Title: An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22.

PubMed ID: 11863358

DOI: 10.1006/geno.2002.6718

PubMed ID: 12167863

Title: Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein.

PubMed ID: 12167863

DOI: 10.1038/nature00939

PubMed ID: 12808466

Title: Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts.

PubMed ID: 12808466

DOI: 10.1038/nature01709

PubMed ID: 12809610

Title: DNA deamination mediates innate immunity to retroviral infection.

PubMed ID: 12809610

DOI: 10.1016/s0092-8674(03)00423-9

PubMed ID: 12808465

Title: The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA.

PubMed ID: 12808465

DOI: 10.1038/nature01707

PubMed ID: 12859895

Title: Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif.

PubMed ID: 12859895

DOI: 10.1016/s0092-8674(03)00515-4

PubMed ID: 12970355

Title: The enzymatic activity of CEM15/Apobec-3G is essential for the regulation of the infectivity of HIV-1 virion but not a sole determinant of its antiviral activity.

PubMed ID: 12970355

DOI: 10.1074/jbc.c300376200

PubMed ID: 14527406

Title: HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability.

PubMed ID: 14527406

DOI: 10.1016/s1097-2765(03)00353-8

PubMed ID: 14528301

Title: HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation.

PubMed ID: 14528301

DOI: 10.1038/nm946

PubMed ID: 14528300

Title: The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif.

PubMed ID: 14528300

DOI: 10.1038/nm945

PubMed ID: 12683974

Title: Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business.

PubMed ID: 12683974

DOI: 10.1016/s0168-9525(03)00054-4

PubMed ID: 14557052

Title: Death and the retrovirus.

PubMed ID: 14557052

DOI: 10.1016/j.molmed.2003.08.008

PubMed ID: 14565218

Title: HIV-1 Vif: counteracting innate antiretroviral defenses.

PubMed ID: 14565218

DOI: 10.1016/j.ymthe.2003.08.010

PubMed ID: 15054139

Title: A single amino acid substitution in human APOBEC3G antiretroviral enzyme confers resistance to HIV-1 virion infectivity factor-induced depletion.

PubMed ID: 15054139

DOI: 10.1073/pnas.0400830101

PubMed ID: 15031497

Title: Inhibition of hepatitis B virus replication by APOBEC3G.

PubMed ID: 15031497

DOI: 10.1126/science.1092066

PubMed ID: 16527742

Title: APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons.

PubMed ID: 16527742

DOI: 10.1016/j.cub.2006.01.031

PubMed ID: 17020885

Title: Reversed functional organization of mouse and human APOBEC3 cytidine deaminase domains.

PubMed ID: 17020885

DOI: 10.1074/jbc.m604980200

PubMed ID: 16378963

Title: Restriction of foamy viruses by APOBEC cytidine deaminases.

PubMed ID: 16378963

DOI: 10.1128/jvi.80.2.605-614.2006

PubMed ID: 16699599

Title: Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies.

PubMed ID: 16699599

DOI: 10.1371/journal.ppat.0020041

PubMed ID: 18304004

Title: The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements.

PubMed ID: 18304004

DOI: 10.1146/annurev.immunol.26.021607.090350

PubMed ID: 18448976

Title: Hepatitis B: modern concepts in pathogenesis--APOBEC3 cytidine deaminases as effectors in innate immunity against the hepatitis B virus.

PubMed ID: 18448976

DOI: 10.1097/qco.0b013e3282fe1bb2

PubMed ID: 18842592

Title: APOBEC3G subunits self-associate via the C-terminal deaminase domain.

PubMed ID: 18842592

DOI: 10.1074/jbc.m803726200

PubMed ID: 18667511

Title: Two regions within the amino-terminal half of APOBEC3G cooperate to determine cytoplasmic localization.

PubMed ID: 18667511

DOI: 10.1128/jvi.02471-07

PubMed ID: 18836454

Title: Phosphorylation of APOBEC3G by protein kinase A regulates its interaction with HIV-1 Vif.

PubMed ID: 18836454

DOI: 10.1038/nsmb.1497

PubMed ID: 19458006

Title: Restriction of equine infectious anemia virus by equine APOBEC3 cytidine deaminases.

PubMed ID: 19458006

DOI: 10.1128/jvi.00015-09

PubMed ID: 19008196

Title: APOBEC3G: an intracellular centurion.

PubMed ID: 19008196

DOI: 10.1098/rstb.2008.0193

PubMed ID: 20219927

Title: APOBEC3F and APOBEC3G inhibit HIV-1 DNA integration by different mechanisms.

PubMed ID: 20219927

DOI: 10.1128/jvi.02358-09

PubMed ID: 20335265

Title: Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs.

PubMed ID: 20335265

DOI: 10.1128/jvi.00134-10

PubMed ID: 20308164

Title: Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction.

PubMed ID: 20308164

DOI: 10.1093/nar/gkq174

PubMed ID: 20510315

Title: APOBEC3G directly binds Hepatitis B virus core protein in cell and cell free systems.

PubMed ID: 20510315

DOI: 10.1016/j.virusres.2010.05.009

PubMed ID: 21659520

Title: Phosphorylation directly regulates the intrinsic DNA cytidine deaminase activity of activation-induced deaminase and APOBEC3G protein.

PubMed ID: 21659520

DOI: 10.1074/jbc.m111.235721

PubMed ID: 21123384

Title: Structure-function analyses point to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities.

PubMed ID: 21123384

DOI: 10.1128/jvi.01651-10

PubMed ID: 21835787

Title: Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1.

PubMed ID: 21835787

DOI: 10.1128/jvi.05238-11

PubMed ID: 21239176

Title: APOBEC3G: a double agent in defense.

PubMed ID: 21239176

DOI: 10.1016/j.tibs.2010.12.003

PubMed ID: 21489586

Title: Functional analysis of the two cytidine deaminase domains in APOBEC3G.

PubMed ID: 21489586

DOI: 10.1016/j.virol.2011.03.014

PubMed ID: 22787460

Title: Antiviral mechanism and biochemical basis of the human APOBEC3 family.

PubMed ID: 22787460

DOI: 10.3389/fmicb.2012.00250

PubMed ID: 22912627

Title: Retroelements versus APOBEC3 family members: No great escape from the magnificent seven.

PubMed ID: 22912627

DOI: 10.3389/fmicb.2012.00275

PubMed ID: 22791714

Title: APOBEC3G inhibits microRNA-mediated repression of translation by interfering with the interaction between Argonaute-2 and MOV10.

PubMed ID: 22791714

DOI: 10.1074/jbc.m112.354001

PubMed ID: 22301159

Title: The cellular antiviral protein APOBEC3G interacts with HIV-1 reverse transcriptase and inhibits its function during viral replication.

PubMed ID: 22301159

DOI: 10.1128/jvi.06594-11

PubMed ID: 22915799

Title: HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies.

PubMed ID: 22915799

DOI: 10.1128/jvi.00595-12

PubMed ID: 23001005

Title: The APOBEC3C crystal structure and the interface for HIV-1 Vif binding.

PubMed ID: 23001005

DOI: 10.1038/nsmb.2378

PubMed ID: 22807680

Title: Endogenous origins of HIV-1 G-to-A hypermutation and restriction in the nonpermissive T cell line CEM2n.

PubMed ID: 22807680

DOI: 10.1371/journal.ppat.1002800

PubMed ID: 22546055

Title: Emerging complexities of APOBEC3G action on immunity and viral fitness during HIV infection and treatment.

PubMed ID: 22546055

DOI: 10.1186/1742-4690-9-35

PubMed ID: 22001110

Title: Functions and regulation of the APOBEC family of proteins.

PubMed ID: 22001110

DOI: 10.1016/j.semcdb.2011.10.004

PubMed ID: 23097438

Title: APOBEC3G restricts HIV-1 to a greater extent than APOBEC3F and APOBEC3DE in human primary CD4+ t cells and macrophages.

PubMed ID: 23097438

DOI: 10.1128/jvi.00676-12

PubMed ID: 23152537

Title: The suppression of HIV-1 infection by APOBEC3 proteins in primary human CD4+ T cells is associated with the inhibition of processive reverse transcription as well as excessive cytidine deamination.

PubMed ID: 23152537

DOI: 10.1128/jvi.02587-12

PubMed ID: 18288108

Title: Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G.

PubMed ID: 18288108

DOI: 10.1038/nature06638

PubMed ID: 18849968

Title: Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications.

PubMed ID: 18849968

DOI: 10.1038/nature07357

PubMed ID: 19153609

Title: Structure, interaction and real-time monitoring of the enzymatic reaction of wild-type APOBEC3G.

PubMed ID: 19153609

DOI: 10.1038/emboj.2008.290

PubMed ID: 22181350

Title: First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G.

PubMed ID: 22181350

DOI: 10.1021/cb200440y

Sequence Information:

  • Length: 384
  • Mass: 46408
  • Checksum: 60525DC3B7D903D6
  • Sequence:
    • MKPHFRNTVE RMYRDTFSYN FYNRPILSRR NTVWLCYEVK TKGPSRPPLD AKIFRGQVYS 
ELKYHPEMRF FHWFSKWRKL HRDQEYEVTW YISWSPCTKC TRDMATFLAE DPKVTLTIFV 
ARLYYFWDPD YQEALRSLCQ KRDGPRATMK IMNYDEFQHC WSKFVYSQRE LFEPWNNLPK 
YYILLHIMLG EILRHSMDPP TFTFNFNNEP WVRGRHETYL CYEVERMHND TWVLLNQRRG 
FLCNQAPHKH GFLEGRHAEL CFLDVIPFWK LDLDQDYRVT CFTSWSPCFS CAQEMAKFIS 
KNKHVSLCIF TARIYDDQGR CQEGLRTLAE AGAKISIMTY SEFKHCWDTF VDHQGCPFQP 
WDGLDEHSQD LSGRLRAILQ NQEN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.